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Results 151 - 200 of 1921
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Chi Yingkai - - 2013
Although some evidence has been documented on EGFR/PI3K mediation of Akt activation in breast cancers, ILK and DNA-PK have not been investigated so far. The aim of this study was to analyze the expression of phosphorylated Akt (pAkt) in breast cancer, with respect to its upstream regulators. The immunostaining of ...
Iwata Sachiko - - 2013
AIM: The aim of this study was to investigate the direct relationship of sleep schedule and sleep quality variables between healthy preschool children and their parents, focusing on the influence of the difference in bedtime between each other. METHODS: Forty-seven Japanese 5-year-old children and their primary parent were studied. The ...
Turner Anthony P F - - 2013
This review is based on the Theophilus Redwood Medal and Award lectures, delivered to Royal Society of Chemistry meetings in the UK and Ireland in 2012, and presents a personal overview of the field of biosensors. The biosensors industry is now worth billions of United States dollars, the topic attracts ...
Rodríguez-Muñoz Yolanda - - 2013
BACKGROUND: Monocytes are essential precursors of antigen-presenting cells, such as macrophages and dendritic cells, and contribute to the pathogenesis of chronic inflammatory diseases and cancer. AIMS: As Tie2-expressing monocytes (TEMs) are increased in the peripheral blood of patients with chronic hepatitis C (CHC), we aimed to examine the expression of ...
Claverie Fanny - - 2013
A method has been developed for the fast and easy determination of Pb, Sr, Ba, Ni, Cu, and Zn, which are of geological and environmental interest, in solid samples by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICPMS) using a spinning sample platform. The platform, containing a sample and a ...
Xue Zhongfeng - - 2013
Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disease. Beta-amyloid (Aβ) plays an important role in the pathogenesis of AD. Autophagy is a self-degradative process and its related protein Beclin-1 is involved in the initiation of autophagy. However, the role of Beclin-1 in the pathogenesis of AD is rarely ...
van Nuijs Alexander L N - - 2013
Recently it was demonstrated that the analysis of drugs of abuse (DOA) in wastewater can be used to track their use in communities. This paper presents the optimization, validation, and application of an analytical procedure based on solid-phase extraction (SPE) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for ...
Iype E - - 2013
Parameterization of a molecular dynamics force field is essential in realistically modeling the physicochemical processes involved in a molecular system. This step is often challenging when the equations involved in describing the force field are complicated as well as when the parameters are mostly empirical. ReaxFF is one such reactive ...
Stefanov Ivan Valentinov - - 2013
Determination of nutritionally important trans MUFA, CLA and OBCFA milk fatty acids (often present in amounts lower than 1.0 g/100g of total fat) using fast and non-destructive analytical methods would enhance their use as diagnostic tools in dairy herd and human health management. Here, PLS regression using ATR/FTIR spectra indicated ...
Shimabukuro Kozue - - 2013
Bovine torovirus (BToV)-Aichi, recently isolated in cultured cells, showed hemagglutination (HA) activity, although the virus has a truncated hemagglutinin-esterase (HE) protein, judging from its gene structure, indicating the existence of another viral protein with HA activity. We examined whether the spike (S) protein possesses HA activity. A BToV antiserum used ...
Aqai Payam - - 2013
A generic high-throughput bioaffinity liquid chromatography-mass spectrometry (BioMS) approach was developed and applied for the screening and identification of known and unknown recombinant human sex hormone-binding globulin (rhSHBG)-binding designer steroids in dietary supplements. For screening, a semi-automated competitive inhibition binding assay was combined with fast ultra-high-performance-LC-electrospray ionization-triple-quadrupole-MS (UPLC-QqQ-MS). 17β-Testosterone-D3 was ...
Kim Young Eun - - 2013
Musculoskeletal problems are very common and are an important contributor to poor quality of life in Parkinson's disease. However, they are under-appreciated, under-evaluated, and under-treated. This paper will address the prevalence of musculoskeletal problems in Parkinson's disease, and review the clinical characteristics of selected musculoskeletal conditions, such as shoulder problems, ...
Cordell Rebecca L - - 2013
A static headspace gas chromatography coupled mass spectrometry (GC-MS) method was developed and fully validated for the quantitative measurement of acetaldehyde, acetone, methanol, ethanol and acetic acid in the headspace of micro-volumes of blood using n-propanol as an internal standard. The linearity of the method was established over the range ...
Shi Youmin - - 2013
A novel near-infrared (NIR) fluorescent probe based on cyanine dyes was designed and synthesized to detect nitroreductase (NTR) activity. Upon reaction with NTR, the nitro-group of p-nitrobenzyl moiety was reduced to amino-group and therefore renews the π-electron conjugation of the dye, resulting in the intense NIR fluorescent emission (708 nm). ...
Borlido Luís - - 2013
Monoclonal antibodies are important therapeutic proteins. One of the challenges facing large-scale production of monoclonal antibodies is separation efficiency - a way to increase this separation efficiency is by using magnetic stimuli-responsive polymer nanoparticles. In this work thermo-responsive magnetic particles composed of a magnetic poly(methyl methacrylate) core with a poly(N-isopropylacrylamide-co-acrylic ...
Hoffmann Michael - - 2013
As a committee of the National Academy of Engineering recognized, ethics education should foster the ability of students to analyze complex decision situations and ill-structured problems. Building on the NAE's insights, we report about an innovative teaching approach that has two main features: first, it places the emphasis on deliberation ...
Singla Neha - - 2013
Aluminum (Al) has been considered as one of the most abundant elements and comprises nearly 8 % of the Earth's crust. Despite of its immense presence, studies regarding the molecular basis of its interaction with the physiological system are rather sparse. On the other hand, zinc (Zn), an essential micronutrient, has ...
Chou Cheng-Hung - - 2013
Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is strongly expressed in extremely invasive lung carcinoma. We showed in our previous study that SCUBE3 triggers the transforming growth factor-β pathway and subsequently promotes tumor angiogenesis and the epithelial-mesenchymal transition (EMT). However, the role of SCUBE3 in early tumor expansion hasn't been fully ...
Schumann Marcel - - 2013
Molecular docking of small-molecules is an important procedure for computer-aided drug design. Modeling receptor side chain flexibility is often important or even crucial, as it allows the receptor to adopt new conformations as induced by ligand binding. However, the accurate and efficient incorporation of receptor side chain flexibility has proven ...
Maggiori Léon - - 2013
Surgery is a key feature of IBD management. Up to 70% of patients with Crohn's disease and 35% of patients with ulcerative colitis will require surgery during the course of their disease. This Review provides an overview of IBD surgical management, focusing on the potential benefits and drawbacks of laparoscopy ...
Ramanan V K - - 2013
Deposition of amyloid-β (Aβ) in the cerebral cortex is thought to be a pivotal event in Alzheimer's disease (AD) pathogenesis with a significant genetic contribution. Molecular imaging can provide an early noninvasive phenotype, but small samples have prohibited genome-wide association studies (GWAS) of cortical Aβ load until now. We employed ...
Yu Yue-Na - - 2013
Enantioselective synthesis of potentially useful chiral 3-aryl-1-indanones was achieved through a rhodium-catalyzed asymmetric intramolecular 1,4-addition of pinacolborane chalcone derivatives using extraordinary simple MonoPhos as chiral ligand under relatively mild conditions. This novel protocol offers an easy access to a wide variety of enantioenriched 3-aryl-1-indanone derivatives in high yields (up to ...
Weldon Kimberly B - - 2013
Face recognition in humans is a complex cognitive skill that requires sensitivity to unique configurations of eyes, mouth, and other facial features. The Thatcher illusion has been used to demonstrate the importance of orientation when processing configural information within faces. Transforming an upright face so that the eyes and mouth ...
Corradini Claudio - - 2013
Functional foods are one of the most interesting areas of research and innovation in the food industry. A functional food or functional ingredient is considered to be any food or food component that provides health benefits beyond basic nutrition. Recently, consumers have shown interest in natural bioactive compounds as functional ...
Stover Angela M - - 2013
PURPOSE: To empirically determine clinically meaningful cut-scores on the 0-10 response scale of the revised Piper Fatigue Scale (PFS-R) and its shorter version (PFS-12). Breast cancer survivors were classified (i.e., none, mild, moderate, or severe fatigue) based on the cut-scores, and relationships between these cut-scores and decrements in health-related quality ...
Badrov Mark B - - 2013
This study aimed to determine whether: (a) isometric handgrip (IHG) training lowers resting blood pressure (BP), (b) cardiovascular reactivity to a serial subtraction (SST), IHG (IHGT), and cold pressor (CPT) task predicts this hypotensive response, and (c) cardiovascular reactivity is attenuated posttraining. Resting BP and cardiovascular reactivity to a SST, ...
Fox Matthew F - - 2013
ABSTRACT Our group has previously demonstrated that expression of the cytokine SCF by leukemic blasts is a frequent finding in pre-B acute lymphoblastic leukemia (ALL). Whether SCF expression is a feature of other B cell malignancies and whether cross talk from the local microenvironment modulates malignant cell SCF production is, ...
Casteele Niels Vande - - 2013
OBJECTIVES:Infliximab (IFX) is successfully used in the treatment of inflammatory bowel diseases but some patients generate antibodies to IFX (ATI) jeopardizing the pharmacokinetics of the drug. Little is known about the factors influencing ATI formation and whether or not this immune reaction is permanent. Our aim was to investigate the ...
Mack Korrie L - - 2013
We recently reported that a computationally designed catalyst nicknamed AlleyCat facilitates C-H proton abstraction in Kemp elimination at neutral pH in a selective and calcium-dependent fashion by a factor of approximately 100,000 (Korendovych et al. in Proc. Natl. Acad. Sci. USA 108:6823, 2011). Kemp elimination produced a colored product that ...
Shimizu Takao - - 2013
An increase of the Curie temperature, T(C), was demonstrated for BaTiO(3) (BTO) epitaxial thin films grown by a pulsed laser deposition technique on (001) and (110) SrTiO(3) (STO) substrates. The T(C) values for the BTO films on (001) and (110) STO were determined, from the temperature dependence of the lattice ...
Vather Ryash - - 2013
BACKGROUND: Prolonged post-operative ileus (PPOI) occurs in up to 25% of patients following major elective abdominal surgery. It is associated with a higher risk of developing post-operative complications, prolongs hospital stay and confers a significant financial load on health-care institutions. Literature outlining best-practice management strategies for PPOI is nebulous. The ...
D'Hulst Gommaar - - 2013
Hypoxia-induced muscle wasting has been observed in several environmental and pathological conditions. However, the molecular mechanisms behind this loss of muscle mass are far from being completely elucidated, certainly in vivo. When studying the regulation of muscle mass by environmental hypoxia, many confounding factors have to be taken into account, ...
Avilés-Nieto Jonathan N - - 2013
The objective of this experiment was to evaluate the effect of supplementing increasing levels of Gliricidia sepium hay (GS) with different levels of inclusion of Buffel grass (BG) hay on digestibility by hair sheep lambs (2.5 to 3.5 months of age). Eight male lambs were used in a replicated 4 × 4 Latin ...
Karaman Rafik - - 2013
DFT calculations for the acid-catalyzed hydrolysis of several maleamic acid amide derivatives revealed that the reaction rate-limiting step is determined on the nature of the amine leaving group. Further, it was established that when the amine leaving group was a secondary amine, acyclovir or cefuroxime moiety the tetrahedral intermediate formation ...
Tsukahara Satoshi - - 2013
The present study proposed a novel microscope method for the determination of the surface tension of liquids through measurements of the forced oscillation of the small surface, which was induced with a rod electrode by applying an alternating current (ac) voltage. The electrode bottom was placed 200 μm above the ...
Cheung Angela M - - 2013
QUESTION In recently postmenopausal women, what are the long-term effects of hormone replacement therapy (HRT) on cardiovascular (CV) outcomes? METHODS DESIGN Randomized controlled trial (RCT) (Danish Osteoporosis Prevention Study [DOPS]). ClinicalTrials.gov NCT00252408. ALLOCATION Unclear allocation concealment.* BLINDING Blinded* (outcome assessors). FOLLOW-UP PERIOD 10 years of therapy and 16 years follow-up ...
Lin Bai-Xue - - 2013
N-Acetyl-D-neuraminic acid (Neu5Ac) has attracted considerable interest due to its promising potential applications in medicine. Significant efforts have been made in whole-cell biocatalyst for Neu5Ac production, but the processes often result in suboptimal performance due to poor expression of enzymes, imbalances of pathway components, disturbance of competing pathways, and barriers ...
Fuss Ivan J - - 2013
PURPOSE: Patients with Common Variable Immunodeficiency (CVID) are subject to the development of a liver disease syndrome known as nodular regenerative hyperplasia (NRH). The purpose of this study was to define the characteristics and course of this complication of CVID. METHODS: CVID patients were evaluated by retrospective and prospective clinical ...
Ali Zarqa - - 2013
INTRODUCTION: The prevalence of bronchopulmonary dysplasia (BPD), one of the most frequently occurring complications following preterm birth, is increasing due to increased survival of preterm infants. METHODS: Systematic literature review. CONCLUSION: The etiology is multifactorial, with prematurity being a prerequisite for the development of BPD. Over time, there have been ...
Liu J - - 2013
A new immobilization strategy of catalases on natural fibers was reported in this paper. Catalase (CAT) from Bacillus subtilis was assembled into multiple layers together with poly(diallyldimethylammonium chloride) (PDDA) on wool fabrics via layer-by-layer (LBL) electrostatic self-assembly deposition. The mechanism and structural evaluation of LBL electrostatic self-assembly were studied in ...
Shimokawa Tetsuya - - 2013
Prosaposin (PSAP) is as a trophic factor and an activator protein for sphingolipid hydrolase in lysosomes. We generated a specific antibody to PSAP and examined the spatiotemporal distribution of PSAP-immunoreactive (PSAP-IR) cells in the lymphatic tissues of Wistar rats. Immunoblots of tissue homogenates separated electrophoretically showed a single band for ...
Nikolaidis Christos - - 2013
The 'Agios Philippos' lead-zinc mine in the Kirki region (NE Greece) is now closed, but its legacy of heavy metal contamination remains at the site. At present, management of the contaminated land is of major concern. The area is in a reclamation process and requires immediate remediation action, whereas human ...
Eloot Liesbeth - - 2013
OBJECTIVES: The purpose of this study was to assess patient-specific organ doses and cancer risk with 3D-rotational acquisitions versus the current standard of multiple single-plane coronary angiography. BACKGROUND: Catheter-based coronary angiography remains one of the most commonly performed diagnostic invasive procedures delivering a relatively high radiation dose to the patient. ...
Thoma Daniel S - - 2013
OBJECTIVE: To compare the clinical and radiographic outcomes of implants and implant-supported reconstructions using a 1-piece (STM) and a 2-piece (BRA) dental implant system. MATERIAL AND METHODS: Sixty patients were randomly assigned to receive STM or BRA implants. The implants restored with fixed or removable prostheses. Baseline measurements (day of ...
Kim Hak-Joon - - 2013
A novel positive-polarity electrostatic precipitator (ESP) was developed using an ionization stage (0.4 x 0.4 x 0.14 m(3) ) with 16 carbon fiber ionizers in each channel and a collection stage (0.4 x 0.4 x 0.21 m(3) ) with parallel metallic plates. The single-pass collection efficiency and clean air delivery ...
Aissat Abdel - - 2013
With the increased number of identified nucleotide sequence variations in genes, the current challenge is to classify them as disease-causing or neutral. These variants of unknown clinical significance can alter multiple processes, from gene transcription to RNA splicing or protein function. Using an approach combining several in silico tools, we ...
Ebata Shigeto - - 2013
BACKGROUND: Minimally invasive posterior spinal endoscopic surgery has increased in popularity. However, a steep learning curve may result in a high frequency of complications. Additionally, device failure may occur during routine use. We retrospectively investigated the incidence of such safety issues in a population of patients undergoing endoscopic spinal surgery ...
Rader Jeanne I - - 2013
Dietary supplements containing dried roots or extracts of the roots and/or rhizomes of blue cohosh (Caulophyllum thalictroides) are widely available. This botanical has a long history of use by Native Americans and its use continues to the present day. The primary constituents of blue cohosh are its alkaloids and saponins. ...
Chew Gina - - 2013
Subtle variations in the isotopic composition of elements carry unique information about physical and chemical processes in nature and are now exploited widely in diverse areas of research. Reliable measurement of natural isotope abundance variations is among the biggest challenges in inorganic mass spectrometry as they are highly sensitive to ...
Starks Tyrel J - - 2013
Much research has examined the impact of HIV-associated stigma on HIV-positive individuals, but little work has explored its impact on HIV-negative persons. However, many gay and bisexual men may imagine the stigma they would experience upon seroconverting, and this anticipated stigma may be associated with negative mental health. Such concerns ...
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