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Results 101 - 150 of 1922
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Lam Thach D - - 2013
Background: The risk of stroke in patients with asymptomatic carotid stenosis (ACS) is now so low that it is important to have methods to identify those patients most likely to benefit from intervention, or who may require special consideration in choice of medical therapy. We studied the prediction of stroke, ...
El-Gengaihi Souad E - - 2013
ABSTRACT This study was designed to investigate the potential of Physalis peruviana root as a functional food with hepato-renal protective effects against fibrosis. The chemical composition of the plant root suggested the presence of alkaloids, withanolides and flavonoids. Five compounds were isolated and their structures elucidated by different spectral analysis ...
Szeto Wilson Y - - 2013
Thoracic endovascular aortic repair has emerged as an effective therapy for a variety of thoracic aortic pathologic entities. However, endograft failure remains a concern, and its treatment is often challenging. We examined our experience with endograft failure and its treatment by endovascular and open repair. From January 2000 to January ...
Behpour Amir M - - 2013
A systematic review was performed to assess whether cerebral blood flow with different imaging modalities could identify brain abnormalities in children with sickle cell disease where structural magnetic resonance imaging and transcranial Doppler velocity appeared normal. A total of 11 studies were identified which reported cerebral blood flow abnormalities alongside ...
Pulickal Anoop S - - 2013
We report a 14-month old child with multiple episodes of febrile status epilepticus, followed by chorea and developmental regression, caused by human herpes virus-6 encephalitis. Chorea has been described as a complication of relapsing herpes simplex virus I infection, but not as a manifestation of human herpes virus-6 infection. It ...
Del Campo Marta L - - 2013
Plant phenolics are generally thought to play significant roles in plant defense against herbivores and pathogens. Many plant taxa, including Solanaceae, are rich in phenolic compounds and some insect herbivores have been shown to acquire phenolics from their hosts to use them as protection against their natural enemies. Here we ...
Ulbricht Catherine - - 2013
ABSTRACT An evidence-based systematic review of tongkat ali (Eurycoma longifolia) by the Natural Standard Research Collaboration consolidates the safety and efficacy data available in the scientific literature using a validated, reproducible grading rationale. This article includes written and statistical analysis of clinical trials, plus a compilation of expert opinion, folkloric ...
Upjohn M M - - 2013
The relative merits and potential complementarity of participatory methods and classical epidemiological techniques in veterinary-related research is a current topic of discussion. Few reported studies have applied both methodologies within the same research framework to enable direct comparison. The aim of this study was to compare issues identified by a ...
Cheshire Nick - - 2013
Endografting for the treatment of thoracic aortic pathology continues to gain popularity; in some countries, numbers of endovascular aortic repairs now exceed those of open surgical cases. The skills and understanding of open surgical teams are not always translated into endovascular intervention teams, which may be led by cardiologists or ...
Warren Sharon A - - 2013
A systematic review/meta-analysis of literature addressing a possible association between traumatic injury and onset of multiple sclerosis was conducted. Medline, Embase, Cochrane DSR, Ovid HealthStar, CINAHL, ISI Web of Science and Scopus were searched for analytical studies from 1950 to 2011. Two investigators independently reviewed articles for inclusion, assessing their ...
- - 2013
MODERATOR: Joseph E. Bavaria, MD, Philadelphia, Pa. PANELISTS: Randall B. Griepp, MD, Mount Sinai School of Medicine, New York, NY; David Spielvogel, MD, Westchester Medical Center, Valhalla, NY; Yukata Okita, MD, Kobe University, Kobe, Japan; Hitoshi Ogino, MD, PhD, Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Japan; ...
Svensson Lars G - - 2013
Percutaneous transcatheter aortic valve replacement was introduced in 2002, but its effectiveness remained to be assessed. A prospective, randomized trial (the Placement of Aortic Transcatheter Valves, or PARTNER) was designed with 2 arms: PARTNER A (n = 699) for high-risk surgical patients (Society of Thoracic Surgeons score >10%, surgeon assessed risk of mortality >15%) ...
Blachier Martin - - 2013
To survey the burden of liver disease in Europe and its causes 260 epidemiological studies published in the last five years were reviewed. The incidence and prevalence of cirrhosis and primary liver cancer are key to understand the burden of liver disease. They represent the end-stage of liver pathology and ...
Horn Morten A - - 2013
To investigate X-linked adrenoleukodystrophy in an unselected population, we performed a population based, cross-sectional prevalence study, supplemented by a retrospective study of deceased subjects. Sixty-three subjects (34 males, 29 females) belonging to 22 kindreds were included. Thirty-nine subjects (13 males, 26 females) were alive, and 24 (21 males, 3 females) ...
Gray J - - 2013
It has been more than 40 years since a major position paper on clinical pharmacology was published by the World Health Organization (WHO). A recent publication, Clinical Pharmacology in Health Care, Teaching, and Research, provides a current vision of the discipline suitable for the twenty-first century.
Lima Lidiane Oliveira - - 2013
Does progressive resistance exercise improve strength and measures of physical performance in people with Parkinson's disease? Systematic review with meta-analysis of randomised and quasi-randomised controlled trials. People with Parkinson's disease, regardless of gender or level of disability. Progressive resistance exercise, defined as involving repetitive, strong, or effortful muscle contractions and ...
Peiris Casey L - - 2013
Are ambulant patients who are admitted for inpatient rehabilitation for a lower limb orthopaedic condition active enough to meet current physical activity guidelines? Prospective observational study. Adults admitted for inpatient rehabilitation for a lower limb orthopaedic condition who were cognitively alert and able to walk independently or with assistance. Participants ...
McClellan Rebekah - - 2013
To review the evidence about whether physical activity exercise programs improve health indicators in adult patients after they have completed their main treatment related to cancer. PubMed, CINAHL and Google Scholar were searched up to September, 2011. This search was supplemented by searching the Cochrane Library for systematic reviews and ...
Wickerson Lisa - - 2013
In patients immediately following lung transplant, does three months of supervised exercise training confer changes in physical activity during daily life, functional exercise capacity, muscle force, health-related quality of life (HRQL), or forced expiratory volume in one second (FEV(1))? Randomised, controlled trial with concealed allocation in which investigators responsible for ...
Villafañe Jorge H - - 2013
In people with thumb carpometacarpal osteoarthritis, does radial nerve mobilisation to the affected hand reduce pressure pain sensitivity in the contralateral hand? Secondary analysis of data from a randomised trial with concealed allocation, assessor blinding, and intention-to-treat analysis. Sixty people with thumb CMC osteoarthritis in the dominant hand aged 70-90 ...
Tsang William W N - - 2013
Does Tai Chi improve postural control in patients with Parkinson's disease? Randomised, controlled trial and blinded outcome assessment. University clinic in USA. Individuals with Parkinson's disease (Hoehn and Yahr Stage 1-4) between the age of 40 and 85 years, and ability to walk with or without an assistive device were ...
Leaver Andrew M - - 2013
What is the clinical course of a new episode of non-specific neck pain in people who are treated with multimodal physical therapies in a primary care setting? Observational study with 3-month follow-up, run in conjunction with a randomised trial. 181 adults who consulted a physiotherapist or chiropractor for a new ...
Kaur Gurpreet - - 2013
How accurately do physiotherapists estimate how long stroke survivors spend in physiotherapy sessions and the amount of time stroke survivors are engaged in physical activity during physiotherapy sessions? Does the mode of therapy (individual sessions or group circuit classes) affect the accuracy of therapists' estimates? Observational study embedded within a ...
Fernhall Bo - - 2013
Does aerobic exercise improve peak VO(2), quality of life, all-cause mortality, and cardiovascular morbidity in patients with chronic heart failure with mild to moderate symptoms? Randomised, controlled trial with blinded outcome assessment. Hospital and community settings in Italy. Patients with chronic heart failure who were clinically stable, had a left ...
McNicholl Ian R - - 2013
When individualizing therapy for HIV-positive patients and for those in whom the 'preferred regimens' of the US Department of Health and Human Services HIV treatment guidelines are not appropriate, a once-daily non-nucleoside with a fixed-dose combination of two nucleosides may be considered in patients who are adherence challenged, intolerant to ...
Abraham Cherrie Z - - 2013
To present an initial experience with a new modular transfemoral multibranched stent-graft for treating aortic arch aneurysms. Six patients, considered high risk for open surgery, were treated with a custom-made branched stent-graft. Two patients had aortic arch aneurysms, three had descending thoracic aortic aneurysms involving the distal arch, and one ...
Gologorsky Rebecca C - - 2013
We report unusual cases of brainstem encephalitis in two young boys. Both presented with acute febrile illness, progressive encephalopathy, and marked cerebrospinal fluid pleocytosis. Case one shared some of the clinical features that have been seen in previously reported cases of brainstem encephalitis, such as ophthalmoplegia, ataxia, and progressive encephalopathy. ...
Sanmaneechai Oranee O Saul R. Korey Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA. - - 2013
We report the case of an adolescent girl with anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis who presented with focal seizures and hemichorea, followed by agitation, speech disturbance, mutism, and autonomic dysfunction. The institution of immunotherapy and removal of an ovarian cystadenofibroma led to full resolution of her symptoms with disappearance of serum NMDAR ...
Saneto Russell P RP Division of Pediatric Neurology and Neurology, Seattle Children's Hospital/University of Washington, Seattle, WA 98105, USA. - - 2013
Alpers-Huttenlocher syndrome is an uncommon mitochondrial disease most often associated with mutations in the mitochondrial DNA replicase, polymerase-γ. Alterations in enzyme activity result in reduced levels or deletions in mitochondrial DNA. Phenotypic manifestations occur when the functional content of mitochondrial DNA reaches a critical nadir. The tempo of disease progression ...
Dawson Anton A Department of Pharmacology and Toxicology, Virginia Commonwealth University, MCV Campus, Box 980613, Richmond, VA 23298-0613, USA. - - 2013
The high co-morbidity between alcohol (ethanol) and nicotine abuse suggests that nicotinic acetylcholine receptors (nAChRs), thought to underlie nicotine dependence, may also be involved in alcohol dependence. The β2* nAChR subtype serves as a potential interface for these interactions since they are the principle mediators of nicotine dependence and have ...
Shen Guofeng G Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, - - 2013
Air pollutants from residential solid fuel combustion are attracting growing public concern. Field measured emission factors (EFs) of various air pollutants for solid fuels are close to the reality and urgently needed for better emission estimations. In this study, emission factors of particulate matter (PM), organic carbon (OC), elemental carbon ...
Silva Parreira Patrícia do Carmo Pdo C Universidade Cidade de São Paulo, - - 2013
Chronic low back pain is a common condition. A new intervention that is popular in sports has been used in patients with low back pain. This technique is based on the use of elastic tapes that are fixed on the skin of patients using different tensions and is named Kinesio ...
Yamazaki Hiroshi H Showa Pharmaceutical University , Machida, Tokyo, Japan. - - 2013
In vivo drug interactions of the teratogen thalidomide with the model cytochrome P450 (P450) 3A substrate midazolam were investigated in mice with humanized livers. The clearance of midazolam (administered intravenously, 10 mg kg(-1)) in chimeric mice was enhanced by orally co-administered thalidomide (100 mg kg(-1)). A larger area under the ...
Cohen Amy N AN VA Desert Pacific Mental Illness Research Education and Clinical Center, - - 2013
Evidence-based services improve outcomes in schizophrenia, but most patients at mental health clinics do not receive such services. This gap in care has been perpetuated by a lack of routinely collected data on patients' clinical status and the treatments they receive. However, routine data collection can be completed by patients ...
Lecavalier-Barsoum Magali M Radiation Oncology Department, McGill University Health Center, Canada. - - 2013
Stereotactic radiosurgery (SRS) is known to safely result in a high obliteration rate for small and medium sized arteriovenous malformations (AVM). To evaluate the long-term outcome of patients treated with SRS, with special emphasis given to obliteration and toxicity rates. We performed a review of 43 cerebral AVM patients, treated ...
Krist Mark R MR Department of Rehabilitation, Nursing Science & Sports, University Medical Centre, Utrecht, The Netherlands. - - 2013
Is an injury prevention program consisting of 10 exercises designed to improve stability, muscle strength, co-ordination, and flexibility of the trunk, hip and leg muscles (known as The11) cost effective in adult male amateur soccer players? Cost-effectiveness analysis of a cluster-randomised controlled trial. 479 adult male amateur soccer players aged ...
Guo Haixun H College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, - - 2013
The purpose of this study was to examine the melanoma targeting and imaging properties of new (99m)Tc-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone (α-MSH) peptides using bifunctional chelating agents. MAG3-GGNle-CycMSH(hex), AcCG3-GGNle-CycMSH(hex), and HYNIC-GGNle-CycMSH(hex) peptides were synthesized, and their melanocortin-1 (MC1) receptor binding affinities were determined in B16/F1 melanoma cells. The biodistribution ...
Nerone Vincent S VS Ohio State University Wexner Medical Center, Columbus, OH, USA. - - 2013
The prevalence of lower extremity reamputation in diabetic patients has been well-documented. We sought to determine the risk factors for major lower extremity amputation (LEA) after minor foot amputation in diabetic patients. We studied 163 diabetic patients who had undergone an initial minor foot amputation and then had undergone at ...
Gabrys Charles M CM Department of Chemistry, Michigan State University , East Lansing, Michigan 48824, United - - 2013
Fusion of the human immunodeficiency virus (HIV) membrane and the host cell membrane is an initial step of infection of the host cell. Fusion is catalyzed by gp41, which is an integral membrane protein of HIV. The fusion peptide (FP) is the ∼25 N-terminal residues of gp41 and is a ...
Mosberg Henry I HI Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States. - - 2013
We have previously described opioid peptidomimetic, 1, employing a tetrahydroquinoline scaffold and modeled on a series of cyclic tetrapeptide opioid agonists. We have recently described modifications to these peptides that confer a μ opioid receptor (MOR) agonist, δ opioid receptor (DOR) antagonist profile, which has been shown to reduce the ...
Platzman Ilia - - 2013
Activation, ex vivo expansion of T cells, differentiation into a regulatory subset, and its phenotype-specific high-throughput selection represent major challenges in immunobiology. In part, this is due to the lack of technical means to synthesize suitable 3D extracellular systems to imitate ex vivo the cellular interactions between T cells and ...
Szepes Attila A Bács-Kiskun Megyei Kórház, a Szegedi Tudományegyetem Általános Orvostudományi Kar Oktató Kórháza Belgyógyászati Osztály. - - 2013
Sphincter of Oddi dysfunction usually occurs after cholecystectomy, but it can sometimes be detected in patients with intact gallbladder too. The diagnostic value of the non-invasive functional tests is not established in this group of patients and the effects of sphincterotomy on transpapillary bile outflow and gallbladder motility are unknown. ...
Buzás György Miklós - - 2013
After a short overview of the history of probiotics, the author presents the development of human intestinal microflora based on the newest genetic data and the microbiological features of main probiotics. The indications of probiotic administration have been defined and extended in recent years. The author reviews significant results of ...
Feldman Karolina - - 2013
Glucocorticoids play an important role in the regulation of carbohydrate and amino acid metabolism, they modulate the function of the immune system, and contribute to stress response. Increased and decreased production of glucocorticoids causes specific diseases. In addition to systemic hypo- or hypercortisolism, alteration of local synthesis and metabolism of ...
Takubo K - - 2013
The definition of early carcinoma of the esophagus has changed with time on the basis of new data. As from 2007 an early carcinoma is defined as an intramucosal carcinoma with or without metastasis. In the subclassification based on invasion depth, m1 and m2 squamous cell carcinomas have no metastasis ...
Lerman Gilad M - - 2013
Great hopes rest on surface plasmon polaritons' (SPPs) potential to bring new functionalities and applications into various branches of optics. In this paper, we demonstrate a pin cushion structure capable of coupling light from free space into SPPs, split them based on the polarization content of the illuminating beam of ...
Zaganas Ioannis - - 2013
Glutamate dehydrogenase (GDH) uses ammonia to reversibly convert α-ketoglutarate to glutamate using NADP(H) and NAD(H) as cofactors. While GDH in most mammals is encoded by a single GLUD1 gene, humans and other primates have acquired a GLUD2 gene with distinct tissue expression profile. The two human isoenzymes (hGDH1 and hGDH2), ...
Veits L - - 2013
Lymphocytic esophagitis is a rare, ill-defined inflammatory disease of the esophagus and is characterized by an increased number of intraepithelial lymphocytes. Up to now no distinct clinical symptom or endoscopic finding could be linked to histopathological changes. Hence lymphocytic esophagitis remains a diagnosis by exclusion after ruling out other possible ...
Wang P-M - - 2013
PURPOSE: The aim of this article is to report the dosimetric and clinical findings in the treatment of primary hepatocellular carcinoma (HCC) with volumetric modulated arc therapy (VMAT, RapidArc). METHODS AND MATERIALS: A total of 138 patients were investigated. Dose prescription ranged from 45-66 Gy. Most patients (88.4 %) presented AJCC stage III ...
Selig H F - - 2013
BACKGROUND: Few data exist on the epidemiological characteristics of thermal injuries in prehospital emergency care, especially in the context of air rescue. Therefore, this study aimed to analyze the epidemiology of pediatric and adult thermal injuries in the helicopter emergency medical service (HEMS) run by the Austrian automobile motorcycle touring ...
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