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Results 401 - 450 of 4307
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Dragano Nathalia R V - - 2013
The peel of the native Brazilian fruit jaboticaba is rich in anthocyanins, which are known for their anti-obesity effects in animal models. The aim of the present study was to evaluate the effects of freeze-dried jaboticaba peel powder (FDJPP) on a number of metabolic parameters in a model of diet-induced ...
Li W - - 2013
Cervical cancer is the most common genital malignancy and the high-risk human papillomaviruses (HPV type 16, 18 and 31, and so on) are major agents for its cause. A key switch for the onset of cervical cancers by HPVs is the cellular degradation of the tumor-suppressor p53 that is mediated ...
Wang Fan - - 2013
Inflammatory lung diseases are characterized by chronic inflammation and oxidant/antioxidant imbalance. Exposure to some kinds of volatile organic compounds (VOCs) leads to lung inflammation, oxidative stress, and immune modulation. However, it is suspected that sub-chronic exposure to low-dose VOCs mixture induces or aggravates lung inflammation. To clarify the effect of ...
Rawan Abu Omar - - 2013
Bacterial meningitis is an uncommon life threatening disease with serious complications, including neurological disabilities such as hearing loss, visual impairment, seizures, and learning disabilities. The heart, kidneys, and adrenal glands might also be involved, particularly when the causative organism is Neisseria meningitidis. Cardiac arrhythmias have been rarely described. We report ...
Ozkiraz Servet - - 2013
Abstract Objective: Low Apgar score is strongly associated with the incidence of transient tachypnea of the newborn (TTN) and other respiratory diseases of newborn. We aimed to investigate the relationship between hypoxia determinants and the prolonged oxygen and respiratory support requirement even if the Apgar scores were normal. Methods: Retrospective ...
Giacomet V - - 2013
Abstract This multicenter, prospective, observational study assessed the global economic impact of HIV care in a large cohort of HIV-infected children and adolescents in Italy. Three pediatric departments of reference participated on a voluntary basis. Centers were asked to enroll all their children during the period April 2010-March 2011. At ...
Margerison-Zilko C E - - 2013
OBJECTIVE: Toexamine the associations between poverty dynamics and the long-term risk of developing overweight or obesity. DESIGN AND METHODS: Our data are a representative sample of U.S. children from the National Longitudinal Survey of Youth 1979 Child and Young Adult Survey (1986-2008). We used survival analysis to compare risk of ...
He Liangcan - - 2013
Of cores! Core-shell Au@metal-organic-framework-5 (MOF-5) nanoparticles (NPs), in which a single Au NP core is coated with a uniform MOF-5 shell, were prepared by a facile one-pot method. The diameter of the Au NP core and the thickness of the MOF-5 shell are easily tuned by controlling the reaction conditions. ...
Luconi Lapo - - 2013
Neutral Zr(IV) and Hf(IV) diamido complexes stabilized by unsymmetrical dianionic N,C,N' pincer ligands have been prepared through the simplest and convenient direct metal-induced C(aryl) H bond activation. Simple ligand modification has contributed to highlight the non-innocent role played by the donor atom set in the control of the cyclometallation kinetics. ...
Huynh T M L - - 2013
This study demonstrated the prevalence of Porcine circovirus type 2 (PCV2) among pig farms in Vietnam. Analyses of the genome, capsid protein and phylogeny classified all 30 Vietnamese PCV2 strains as the PCV2b genotype, belonging to the clusters of 1A, 1B, 1C and recombinant forms. Each viral genome was 1767 ...
Karino Yasuhito - - 2013
Transfer energetics from pure water to a urea-water mixture is examined for a set of amino acid analog solutes by using molecular dynamics simulation and free-energy calculation. The free energy of transfer from pure-water solvent to 8 M urea-water mixed solvent is calculated for each solute, and the urea-water mixture ...
Timms Nicole - - 2013
Chemical modification has been used to introduce the unnatural amino acid γ-thialysine in place of the catalytically important Lys165 in the enzyme N-acetylneuraminic acid lyase (NAL). The Staphylococcus aureus nanA gene, encoding NAL, was cloned and expressed in E. coli. The protein, purified in high yield, has all the properties ...
Nakamae Toshio T Department of Orthopaedic Surgery, JA Hiroshima General Hospital, Hiroshima, Japan. - - 2013
The number of cases of osteoporotic vertebral compression fracture (OVCF) with intravertebral cleft (IVC) with delayed neurologic deficit (DND) is increasing as the population ages. However, the cause of DND is poorly understood, and no definitive treatment of the disease has been established. The purpose of this study was to ...
Pérez Yolanda - - 2013
c-Src is a non-receptor tyrosine kinase involved in numerous signal transduction pathways. The kinase, SH3 and SH2 domains of c-Src are attached to the membrane-anchoring SH4 domain through the flexible Unique domain. Here we show intra- and intermolecular interactions involving the Unique and SH3 domains suggesting the presence of a ...
Shigehisa Hiroki - - 2013
Hard core made easy: The pentacyclic core of trichodermatide A was stereoselectively synthesized from a bis(1,3-cyclohexanedione) derivative by a ring-closing reaction followed by an intramolecular ketal formation (see scheme; PPTS=pyridinium p-toluenesulfonate). The first total synthesis of trichodermatide A was then completed by the introduction of three hydroxy groups.
Frank Sebastian M - - 2013
Most visual activities, whether reading, driving, or playing video games, require rapid detection and identification of learned patterns defined by arbitrary conjunctions of visual features. Initially, such detection is slow and inefficient, but it can become fast and efficient with training. To determine how the brain learns to process conjunctions ...
Ong B L - - 2013
SUMMARY A cross-sectional study was conducted from 10 January to 9 April 2012, to determine the seroprevalence of tuberculosis (TB) of all captive Asian elephants and their handlers in six locations in Peninsular Malaysia. In addition, trunk-wash samples were examined for tubercle bacillus by culture and polymerase chain reaction (PCR). ...
Huang Zhiquan - - 2013
Head and neck cancer is the sixth most common cancer in the world and most of them are squamous cell carcinomas. High frequency of cisplatin resistance in head and neck squamous cell carcinoma (HNSCC) leads to tumor relapse and irresponsiveness to cisplatin-based chemotherapy. However, the mechanisms underlying cisplatin resistance is ...
Hughes Philippa - - 2013
BACKGROUND: Sheffield Profile for Assessment and Referral for Care (SPARC) was developed in response to concerns that palliative care may not be reaching all people who could benefit from it. Acceptability of the tool is an important step in developing its future use. AIMS: To elicit the views of a ...
Arensman M D MD Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, - - 2014
Developmental and cancer models show Wnt/β-catenin-dependent signaling mediates diverse phenotypic outcomes in the pancreas that are dictated by context, duration and strength of activation. While generally assumed to be pro-tumorigenic, it is unclear to what extent dysregulation of Wnt/β-catenin signaling impacts tumor progression in pancreatic adenocarcinoma (PDAC). In the present ...
Wang Hualei - - 2013
ABSTRACT: BACKGROUND: A nitrilase-mediated pathway has significant advantages in the production of optically pure (R)-(-)-mandelic acid. However, unwanted byproduct, low enantioselectivity, and specific activity reduce its value in practical applications. An ideal nitrilase that can efficiently hydrolyze mandelonitrile to optically pure (R)-(-)-mandelic acid without the unwanted byproduct is needed. RESULTS: ...
Wang Yi Y Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, - - 2013
To investigate the effects of advanced glycation end products (AGEs) on calcification in human aortic smooth muscle cells (HASMCs) in vitro and the underlying mechanisms. AGEs were artificially prepared. Calcification of HASMCs was induced by adding inorganic phosphate (Pi, 2 mmol/L) in the media, and observed with Alizarin red staining. ...
Patenaude Andrea F - - 2013
OBJECTIVE: The objectives of this study are to determine (i) what daughters, ages 18-24 years, of BRCA1/2 mutation carriers understand about their 50% chance of carrying a BRCA1/2 mutation and about risk reduction or management options for mutation carriers, (ii) the extent and nature of daughters' cancer-related distress, and (iii) the ...
Erhardt Sascha A - - 2013
(Acetoxymethyl)silanes 2, 7 a-c, and 10 a-c with at least one alkoxy group, of the general formula (AcOCH(2) )Si(OR)(3-n) (CH(3) )(n) (R: Me, Et, iPr; n=0, 1, 2), were synthesized from the corresponding (chloromethyl)silanes 1, 6 a-c, and 9 a-c by treatment with potassium acetate under phase-transfer-catalysis conditions. These compounds were found to provide ...
Guichelaar Mmj - - 2013
OBJECTIVE: Allelic variation (rs738409C→G) in adiponutrin (PNPLA3) has been associated with hepatic steatosis, and liver fibrosis. The physiologic impact of the PNPLA3 G allele may be exacerbated in patients with severe obesity. In this study, we investigated the interactions of PNPLA3 rs738409 with a broad panel of metabolic and histologic ...
Tiong Erica A - - 2013
Distant relative: The configuration of the quaternary stereocenter in puraquinonic acid is defined by groups far removed from the point of asymmetry. The use of a bicyclic thioglycolate lactam to set the quaternary stereocenter at an early stage cuts the length of the synthesis of the natural product by nearly ...
Olschewski Martin - - 2013
Back and forth: Femtosecond two-dimensional infrared exchange spectroscopy was used to study the dynamics of the reversal of an intramolecular hydrogen bond. The H-bond reversal resembles a flip-flop motion that is facilitated by two concerted disrotatory torsional isomerizations and that occurs on a time scale of about 2 ps.
Zhu Xuena X Nanobioengineering/Bioelectronics Lab, Department of Biomedical Engineering, Florida International University, 10555 West Flagler Street, Miami, FL 33174, - - 2013
The increased utilization of nanomaterials could affect human health and the environment due to increased exposure. Several mechanisms regarding the negative effects of nanomaterials have been proposed, one of the most discussed being oxidative stress. Many studies have shown that some metal oxide nanoparticles can enhance reactive oxygen species generation, ...
van Gastel W A - - 2013
BACKGROUND: Cannabis use is associated with increased risk for psychotic-like experiences (PLEs) and psychotic disorders. It remains unclear whether this relationship is causal or due to confounding. Method A total of 1929 young adults aged 18-30 years participated in a nationwide internet-based survey in The Netherlands and gave information on ...
Yachida S - - 2013
Efficient metastasis is believed as the result of multiple genetic, epigenetic and/or post-translational events in the lifetime of a carcinoma. At the genetic level, these events may be categorized into those that occur during carcinogenesis, and those that occur during subclonal evolution. This review summarizes current knowledge of the genetics ...
Liu Jing-Min - - 2013
The simplicity of the green-synthesized routine and the availability of surface modification of diverse bioactive molecules make noble metal nanostructures highly suitable as multifunctional biomaterials for biological and biomedical application. Here we report the preparation of trypsin stabilized gold nanoclusters (try-AuNCs) with near-infrared fluorescence for biosensing heparin based on surface ...
Gomes Caio Perez - - 2013
PROBLEM: Gestational diabetes mellitus (GDM) is an inflammatory condition that involves unbalanced cytokine production. We carried out a systematic review on the relationship between GDM and maternal circulating levels of cytokines in the 2nd/3rd trimesters. METHOD OF STUDY: Three electronic databases (MEDLINE, EMBASE and LILACS), were searched. Duplicate study selection, ...
Pompa Marianna - - 2013
Gluten protein composition and expression level influence dough properties and are cultivar and environment dependent. In order to broaden the knowledge of durum wheat gluten proteome, three cultivars were compared in two different growing seasons by a proteomic approach. Cultivar specific and differentially expressed spots in the two years were ...
Laakso Sanna - - 2013
Sepsis is associated with high morbidity and mortality rates worldwide. Rapid and reliable diagnostic methods are needed for efficient and evidence-based treatment of septic patients. Recently, new molecular tools have emerged to complement the conventional culture-based diagnostic methods. In this study, we used spiked whole blood samples to evaluate together ...
Chan Sunney I - - 2013
TONs of copper fun: There is considerable interest in developing catalysts to harness the abundant natural supply of methane for various industrial applications. Two tricopper complexes capable of mediating efficient oxidation of methane to methanol under ambient conditions were tested: a biomimetic tricopper complex and a tricopper-peptide species derived from ...
Hook Andrew L AL Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, NG72RD, - - 2013
A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacterial material. The coverage of three bacterial species, Pseudomonas aeruginosa, Staphylococcus aureus, and uropathogenic Escherichia coli is assessed.
Bastakoti Bishnu Prasad - - 2013
We have developed core-shell-corona-type polymeric micelles that can integrate multiple functions in one system, including the capability of accommodating hydrophobic dyes into core and hydrophilic drug into the shell, as well as pH-triggered drug-release. The neutral and hydrophilic corona sterically stabilizes the multifunctional polymeric micelles in aqueous solution. The mineralization ...
Seitz Miriam - - 2013
Promiscuous enzymes: The substrate promiscuity of squalene-hopene cyclases has been explored and applied in the enzyme-catalyzed synthesis of heterocyclic terpenoids. Features of this work include cyclization reactions without pyrophosphate activation, and stereospecific ring closure of substrates of varying chain length and terminal nucleophile. This provides a biocatalytic alternative to traditional ...
Schéle Erik - - 2013
Interleukin-1 (IL-1) and interleukin-6 (IL-6) are immune modulating cytokines that also affect metabolic functions, as both IL-1 receptor I deficient (IL1RI -/-) and IL-6 deficient (IL-6 -/-) mice develop late-onset obesity and leptin resistance. Both IL-1 and IL-6 appear to target the central nervous system (CNS) to increase energy expenditure. ...
Zupan Jure - - 2013
At high cell density or under low nutrient conditions, yeast collectively adapt their metabolism by secreting aromatic alcohols in what is known as quorum sensing. However, the mechanisms and role of quorum sensing in yeast are poorly understood, and the methodology behind this process is not well established. Here, we ...
Valdés Alberto - - 2013
Nowadays, new solutions focused on the replacement of reagents hazardous to human health are highly demanded in laboratories and Green Chemistry. In the present work, GelGreen, a new non-hazardous DNA staining reagent, has been assayed for the first time to analyze double-stranded DNA by capillary gel electrophoresis (CGE) with laser ...
Seya Tsukasa - - 2013
Many forms of RNA duplexes with agonistic activity for pattern-recognition receptors have been reported, some of which are candidates for adjuvant immunotherapy for cancer. These RNA duplexes induce cytokines, interferons (IFNs) and cellular effectors mainly via two distinct pathways, TLR3/TICAM-1 and MDA5/MAVS. We determined which pathway of innate immunity predominantly ...
Cao Xuefei - - 2013
Traditionally, long reaction time was required in the synthesis of cellulose esters (CEs). In this work, DMSO/aqueous NaOH or KOH was introduced as an efficient reaction system for rapidly synthesizing CEs by transesterification. Interesingly, cellulose could rapidly reacted with vinyl acetate, vinyl propionate, and vinyl butyrate and synthesized cellulose acetate, ...
Sarafraz-Yazdi Ali - - 2013
In this research, the headspace solid-phase microextraction coupled with gas chromatography flam ionization detector was applied for the determination of some monocyclic aromatic amines in real water and urine samples. A sol-gel technique was applied for the preparation of the solid-phase microextraction fibers. Two different sol-gel coating [poly(ethylene glycol) and ...
Liu Yanni - - 2013
Pediatric patients with obsessive-compulsive disorder (OCD) show an increased electrophysiological response to errors that is thought to be localized to the posterior medial prefrontal cortex (pMFC). However, the relation of this response, the error-related negativity (ERN), to underlying brain structures remains unknown. In an examination of 20 pediatric OCD patients ...
Anderson Jeffrey S - - 2013
Very low-frequency blood oxygen level-dependent (BOLD) fluctuations have emerged as a valuable tool for describing brain anatomy, neuropathology, and development. Such fluctuations exhibit power law frequency dynamics, with largest amplitude at lowest frequencies. The biophysical mechanisms generating such fluctuations are poorly understood. Using publicly available data from 1,019 subjects of ...
Brewitz Lennart - - 2013
A concise and largely catalysis-based approach to the potent algal toxin polycavernoside A (1) is described that intercepts a late-stage intermediate of a previous total synthesis; from there on, this challenging target can be reached in a small number of steps. Key to success was a sequence of a molybdenum-catalyzed ring-closing ...
Wan Nazaimoon W M - - 2013
AIM: The prevalence of diabetes mellitus among Malaysians aged ≥ 30 years of age has increased by more than twofold over a 20-year period. This study aimed to determine the current status and to evaluate the diagnostic usefulness of the HbA(1c) cut-off point of 48 mmol/mol (6.5%). METHODS: Using a two-stage stratified sampling ...
Lindsay Richard G - - 2013
Toric intraocular lenses (IOLs) are increasingly being used at the time of cataract surgery to treat regular refractive astigmatism. This paper outlines the contact lens management of a patient with keratoconus, who had marked residual astigmatism post-operatively due to implantation of a toric IOL during cataract surgery. It is strongly ...
Novak N - - 2013
BACKGROUND: Monocyte differentiation into dendritic cells or macrophages and recruitment to peripheral organs in chronic inflammatory diseases are directed by allergen challenge via FcεRI as well as the nature of soluble factors in the microenvironment. High-affinity receptor for IgE stimulation of effector cells results in the release of histamine, which ...
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