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Results 201 - 250 of 4302
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Hughes Philippa - - 2013
BACKGROUND: Sheffield Profile for Assessment and Referral for Care (SPARC) was developed in response to concerns that palliative care may not be reaching all people who could benefit from it. Acceptability of the tool is an important step in developing its future use. AIMS: To elicit the views of a ...
Arensman M D - - 2013
Developmental and cancer models show Wnt/β-catenin-dependent signaling mediates diverse phenotypic outcomes in the pancreas that are dictated by context, duration and strength of activation. While generally assumed to be pro-tumorigenic, it is unclear to what extent dysregulation of Wnt/β-catenin signaling impacts tumor progression in pancreatic adenocarcinoma (PDAC). In the present ...
Wang Hualei - - 2013
ABSTRACT: BACKGROUND: A nitrilase-mediated pathway has significant advantages in the production of optically pure (R)-(-)-mandelic acid. However, unwanted byproduct, low enantioselectivity, and specific activity reduce its value in practical applications. An ideal nitrilase that can efficiently hydrolyze mandelonitrile to optically pure (R)-(-)-mandelic acid without the unwanted byproduct is needed. RESULTS: ...
Wang Yi - - 2013
Aim:To investigate the effects of advanced glycation end products (AGEs) on calcification in human aortic smooth muscle cells (HASMCs) in vitro and the underlying mechanisms.Methods:AGEs were artificially prepared. Calcification of HASMCs was induced by adding inorganic phosphate (Pi, 2 mmol/L) in the media, and observed with Alizarin red staining. The ...
Cieślak Jacek - - 2013
The reaction of 2-cyano-2-methyl propanal with 2'-O-aminooxymethylribonucleosides leads to stable and yet reversible 2'-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)ribonucleosides. Following N-protection of the nucleobases, 5'-dimethoxytritylation and 3'-phosphitylation, the resulting 2'-protected ribonucleoside phosphoramidite monomers are employed in the solid-phase synthesis of three chimeric RNA sequences, each differing in their ratios of purine/pyrimidine. When the activation of ...
Sharma Sandeep K - - 2013
Chitosan-NiO nanocomposite (CNC) is shown to be a potential dielectric material with promising properties. CNCs containing NiO nanoparticles (0.2, 0.6, 1, 2, 5 wt %) are prepared through chemical methods. The inclusion of NiO nanoparticles in the chitosan matrix is confirmed by scanning electron microscopy (SEM) and X-ray diffraction. The morphology of ...
Singer F - - 2013
BACKGROUND: Prediction of asthma in young children with respiratory symptoms is hampered by the lack of objective measures applicable in clinical routine. In this prospective study in a preschool children cohort, we assessed whether the fraction of exhaled nitric oxide (FeNO), a biomarker of airway inflammation, is associated with asthma ...
Zanardo Vincenzo - - 2013
Abstract BACKGROUND: There is no study to support a relationship between placental transfusion and active management techniques of the second stage of labor. OBJECTIVE: To examine the association between head-to-body delivery by 'two-step' approach (which includes waiting for the next contraction to deliver the shoulders) and its effect on the ...
Rojas Galeno J - - 2013
ABSTRACT Background: Mild cognitive impairment (MCI) is a transitional state between normal aging and dementia. Identifying this condition would allow early interventions that may reduce the rate of progression to Alzheimer's disease (AD). We examined the efficacy of a six-month cognitive intervention program (CIP) in patients with MCI and to ...
Wai Kan Kassel Tsang - - 2013
ABSTRACT: Stenotrophomonas maltophilia (S. maltophilia) is a rare but yet important global emerging nosocomial pathogen with intrinsic multi-drug resistance. To the best of our knowledge, there was only one case report describing the imaging features of S. maltophilia pneumonia in computed tomography (CT) of thorax. In this article we are ...
Petruzzella Emanuele - - 2013
The initial aim of the present work was the synthesis of the axial disuccinato Pt(IV) derivative of [PtCl(2)(cis-1,4-DACH)] (Kiteplatin, 1 in Figure 1 ) (DACH = diaminocyclohexane), which contains an isomeric form of the diamine ligand present in oxaliplatin (i.e., 1R,2R-DACH). The interest in this compound stems from its activity ...
He Liangcan - - 2013
Of cores! Core-shell Au@metal-organic-framework-5 (MOF-5) nanoparticles (NPs), in which a single Au NP core is coated with a uniform MOF-5 shell, were prepared by a facile one-pot method. The diameter of the Au NP core and the thickness of the MOF-5 shell are easily tuned by controlling the reaction conditions. ...
Luconi Lapo - - 2013
Neutral Zr(IV) and Hf(IV) diamido complexes stabilized by unsymmetrical dianionic N,C,N' pincer ligands have been prepared through the simplest and convenient direct metal-induced C(aryl) H bond activation. Simple ligand modification has contributed to highlight the non-innocent role played by the donor atom set in the control of the cyclometallation kinetics. ...
Huynh T M L - - 2013
This study demonstrated the prevalence of Porcine circovirus type 2 (PCV2) among pig farms in Vietnam. Analyses of the genome, capsid protein and phylogeny classified all 30 Vietnamese PCV2 strains as the PCV2b genotype, belonging to the clusters of 1A, 1B, 1C and recombinant forms. Each viral genome was 1767 ...
Wang Fan - - 2013
Inflammatory lung diseases are characterized by chronic inflammation and oxidant/antioxidant imbalance. Exposure to some kinds of volatile organic compounds (VOCs) leads to lung inflammation, oxidative stress, and immune modulation. However, it is suspected that sub-chronic exposure to low-dose VOCs mixture induces or aggravates lung inflammation. To clarify the effect of ...
Stuart Gregory L - - 2013
AIMS: The efficacy of batterer intervention programs to reduce intimate partner violence (IPV) is questionable with individuals with alcohol problems particularly unlikely to benefit. We examined whether adding adjunctive alcohol intervention to batterer intervention reduced the likelihood of substance use and violence relative to batterer intervention alone. DESIGN: Randomized clinical ...
Rawan Abu Omar - - 2013
Bacterial meningitis is an uncommon life threatening disease with serious complications, including neurological disabilities such as hearing loss, visual impairment, seizures, and learning disabilities. The heart, kidneys, and adrenal glands might also be involved, particularly when the causative organism is Neisseria meningitidis. Cardiac arrhythmias have been rarely described. We report ...
Ozkiraz Servet - - 2013
Abstract Objective: Low Apgar score is strongly associated with the incidence of transient tachypnea of the newborn (TTN) and other respiratory diseases of newborn. We aimed to investigate the relationship between hypoxia determinants and the prolonged oxygen and respiratory support requirement even if the Apgar scores were normal. Methods: Retrospective ...
Giacomet V - - 2013
Abstract This multicenter, prospective, observational study assessed the global economic impact of HIV care in a large cohort of HIV-infected children and adolescents in Italy. Three pediatric departments of reference participated on a voluntary basis. Centers were asked to enroll all their children during the period April 2010-March 2011. At ...
Kim Hun Young - - 2013
Synthesizing the synthons: The development of α-acylvinyl anion synthons has been achieved using direct α-vinyl enolization of α,β-unsaturated ketones under mild reaction conditions. The synthetic utility of such synthons has been demonstrated in intermolecular aldol and aldol condensation reactions, which provide synthetically useful allenyl ketone and enyne derivatives.
Ceylan Cavit - - 2013
Objectives: To show renal parenchymal injury depending on extracorporeal shock wave lithotripsy (ESWL). Methods: The patients with one renal stone and in whom ESWL is planned among the patients in whom renal stone was determined. Their 24-h urine samples were collected just before and after the ESWL treatment. Cit (citrate), ...
Oguzhan Nilufer - - 2013
Aim: Contrast-induced nephropathy (CIN) is a relatively common and serious complication, which occurs after the administration of contrast materials to patients. Although the pathophysiology of CIN is not exactly understood, ischemia of the medulla, oxidative stress, and direct toxicity of the contrast material are some of the factors that are ...
Hu Zhi-Peng - - 2013
Aim:ΦC31 integrase mediates site-specific recombination between two short sequences, attP and attB, in phage and bacterial genomes, which is a promising tool in gene regulation-based therapy since the zinc finger structure is probably the DNA recognizing domain that can further be engineered. The aim of this study was to screen ...
Konstantinidou Valentini - - 2013
The present review discusses and summarizes the up-to-date body of knowledge concerning human nutrigenomic studies with Mediterranean diet (MedDiet) and olive oil (OO) interventions, at real-life doses and conditions. A literature review was carried out until March 2012. Original articles assessing the nutrigenomic effect of the MedDiet and its main ...
Venneti Sriram - - 2013
H3F3A mutations are seen in ∼30% of pediatric glioblastoma (GBMs) and involve either the lysine residue at position 27 (K27M) or glycine at position 34 (G34R/V). Sixteen genes encode histone H3, each variant differing in only a few amino acids. Therefore how mutations in a single H3 gene contribute to ...
Matsumoto Yuka - - 2013
Biologics such as tumor necrosis factor (TNF) inhibitors are highly effective for treating severe psoriasis, and an increasing number of patients benefit from them. However, subsidiary subjects have arisen in the course of treatment which may directly impact the continued use of these drugs in a given case. In this ...
Zhao Qian - - 2013
Organoclays are highly sorptive engineered materials that can be used as amendments in barrier systems or geosynthetic liners. The performance of confining and isolating the non-polar organic contaminants by those barrier/lining systems is essentially controlled by the process of organic contaminant mass transport in nano-pore of organoclays. In this paper, ...
Townsend Nell S - - 2013
Cationic pnictogen/carbon cages are formed from reaction of 2,4,6-tri-tert-butyl-1,3,5-triphosphabenzene with the carbene mimics EX(2) (+) (E=P, As). For E=P, 1,4-addition to the hetereoaromatic compound is observed, whereas for E=As, cage complexes are formed.
Stumpf M T - - 2013
A total of twelve lactating Jersey cows were used in a 5-week experiment to determine the effects of severe feed restriction on the permeability of mammary gland cell tight junctions (TJs) and its effects on milk stability to the alcohol test. During the first 2 weeks, cows were managed and ...
Hamsten C - - 2013
Patients with IgE antibodies against the carbohydrate epitope galactose-α-1,3-galactose (α-Gal) have reported severe allergic reactions after consumption of red meat. Investigations have revealed associations between IgE to α-Gal and tick bites. We provide the first direct evidence that α-Gal is present within ticks thus potentially explaining the relationship between tick ...
Sánchez Maria Gabriela - - 2013
Serotonin (5-HT) is an important brain neurotransmitter implicated in mental and neurodegenerative diseases that is modulated by ovarian hormones. Nevertheless, the effect of oestrogens on 5-HT neurotransmission in the primate caudate nucleus, putamen and nucleus accumbens, major components of the basal ganglia, and the anterior cerebral cortex, mainly the frontal ...
Srinivasan Murali - - 2013
OBJECTIVE: The aim of this review was to test the hypothesis that 6 mm micro-rough short Straumann(®) implants provide predictable survival rates and verify that most failures occurring are early failures. MATERIALS AND METHODS: A PubMed and hand search was performed to identify studies involving micro-rough 6-mm-short implants published between January ...
Vasanthakumar Ajithkumar - - 2013
Streptomyces are a major group of soil bacteria that produce wide range of bioactive compounds including antibiotics. Daunorubicin is a chemotherapeutic agent for treatment of certain types of cancer, which is produced as a secondary metabolite by S. peucetius. Owing to the significance of this drug in treating cancer, understanding ...
Vessby Bengt - - 2013
Δ9-Desaturase (stearoyl-CoA desaturase 1, SCD-1) regulates the desaturation of SFA, mainly stearic and palmitic, to MUFA. Δ6-Desaturase (D6D) and Δ5-desaturase (D5D) are involved in the metabolism of linoleic and α-linolenic acid to polyunsaturated metabolites. The objective of the present study was to study the effects of different types of dietary ...
Lu X - - 2013
Birt-Hogg-Dubé (BHD) syndrome, is a dominantly inherited familial cancer syndrome associated with susceptibility to renal cell carcinoma (RCC) caused by inactivating mutations in the folliculin (FLCN) gene. The precise functions of the FLCN gene product are still under investigation but RCC from BHD patients show loss of the wild-type allele ...
Zhou C - - 2013
Pituitary tumor-transforming gene (PTTG), the index mammalian securin, is abundantly expressed in several tumors and regulates tumor growth and progression. Molecular mechanisms elucidating PTTG regulation and actions remain elusive. Here, we provide evidence that PTTG acts as a signal transducer and activator of transcription factor 3 (STAT3) target gene. Total ...
Sarafraz-Yazdi Ali - - 2013
In this research, the headspace solid-phase microextraction coupled with gas chromatography flam ionization detector was applied for the determination of some monocyclic aromatic amines in real water and urine samples. A sol-gel technique was applied for the preparation of the solid-phase microextraction fibers. Two different sol-gel coating [poly(ethylene glycol) and ...
Liu Yanni - - 2013
Pediatric patients with obsessive-compulsive disorder (OCD) show an increased electrophysiological response to errors that is thought to be localized to the posterior medial prefrontal cortex (pMFC). However, the relation of this response, the error-related negativity (ERN), to underlying brain structures remains unknown. In an examination of 20 pediatric OCD patients ...
Anderson Jeffrey S - - 2013
Very low-frequency blood oxygen level-dependent (BOLD) fluctuations have emerged as a valuable tool for describing brain anatomy, neuropathology, and development. Such fluctuations exhibit power law frequency dynamics, with largest amplitude at lowest frequencies. The biophysical mechanisms generating such fluctuations are poorly understood. Using publicly available data from 1,019 subjects of ...
Brewitz Lennart - - 2013
A concise and largely catalysis-based approach to the potent algal toxin polycavernoside A (1) is described that intercepts a late-stage intermediate of a previous total synthesis; from there on, this challenging target can be reached in a small number of steps. Key to success was a sequence of a molybdenum-catalyzed ring-closing ...
Wan Nazaimoon W M - - 2013
AIM: The prevalence of diabetes mellitus among Malaysians aged ≥ 30 years of age has increased by more than twofold over a 20-year period. This study aimed to determine the current status and to evaluate the diagnostic usefulness of the HbA(1c) cut-off point of 48 mmol/mol (6.5%). METHODS: Using a two-stage stratified sampling ...
Lindsay Richard G - - 2013
Toric intraocular lenses (IOLs) are increasingly being used at the time of cataract surgery to treat regular refractive astigmatism. This paper outlines the contact lens management of a patient with keratoconus, who had marked residual astigmatism post-operatively due to implantation of a toric IOL during cataract surgery. It is strongly ...
Novak N - - 2013
BACKGROUND: Monocyte differentiation into dendritic cells or macrophages and recruitment to peripheral organs in chronic inflammatory diseases are directed by allergen challenge via FcεRI as well as the nature of soluble factors in the microenvironment. High-affinity receptor for IgE stimulation of effector cells results in the release of histamine, which ...
Nakanishi H - - 2013
MicroRNAs (miRNAs) have important roles in the initiation and progression of human cancer, but their role in head and neck cancer development and progression is not well defined. We aimed to determine whether specific miRNAs and their target mRNAs contribute to head and neck cancer pathogenesis and progression. To identify ...
Van Dyck Colin - - 2013
We report a combined Non-Equilibrium Green's Function - Density Functional Theory study of molecular junctions made of photochromic diarylethenes between gold electrodes. The impact of derivatization of the molecule on the transmission spectrum is assessed by introducing: (i) substituents on the diarylethene core; and (ii) linker substituents between the gold ...
Wang Lei-Lei - - 2013
Curcumin, the major extraction of turmeric, has been widely used in many countries for centuries both as a spice and as a medicine. In the last decade, researchers have found the beneficial effects of curcumin on multiple disorders are due to its antioxidative, anti-inflammatory, and antiproliferative properties, as well as ...
Frigiola Alessandra - - 2013
Introduction Patients with repaired tetralogy of Fallot have good long-term survival but less is known about the subjectively assessed quality of life or objectively measured functional status of those who have not required subsequent pulmonary valve replacement. We assessed these parameters in a group of children and adults free from ...
Lee Yong Ju - - 2013
Objective: We aimed to evaluate the association between eosinophilic inflammation in induced sputum and pulmonary function and persistent airflow limitation in children. Methods: A total of 92 asthmatic children and 72 controls were enrolled in this study. Eosinophil count (%) and eosinophil cationic protein (ECP) levels were measured in induced ...
Kong F - - 2013
Interrogating specific cellular activities often entails the dissection of posttranslational modifications or functional redundancy conferred by protein families, which demands more sophisticated research tools than simply eliminating a specific gene product by gene targeting or RNA interference. We have developed a novel methodology that involves engineering a single SCF(βTrCP)-based ubiquitin ...
Chang Soeun - - 2013
Here we report a tracking X-ray microscopy (TrXM) as a novel methodology by using upper right lung apices alveoli in live intact mice. By enabling tracking of individual alveolar movements during respiration, TrXM identifies alveolar dynamics: individual alveoli in the upper lung apices show a small size increment as 4.9 ...
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