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Hemmerlin Andréa - - 2013
Identification of regulatory enzymes is fundamental for engineering metabolic pathways such as the isoprenoid one. All too often, investigation of gene expression remains the major trend in unraveling regulation mechanisms of the isoprenoid cytosolic mevalonate and the plastid-localized methylerythritol phosphate metabolic pathways. But such metabolic regulatory enzymes are frequently multilevel-regulated, ...
Cheng Yung Sung - - 2013
Size-selective sampling is a health-related method to collect airborne particles based on penetration of inhaled particles into different regions of the human respiratory tract; thus, it is the most relevant sampling method to correlate health risks with occupational exposure. The current practice of sampling asbestos and other fibers is not ...
Mercati Francesco - - 2013
Single nucleotide polymorphisms (SNPs) and simple sequence repeats (SSR) are abundant and evenly distributed co-dominant molecular markers in plant genomes. SSRs are valuable for marker assisted breeding and positional cloning of genes associated traits of interest. Although several high throughput platforms have been developed to identify SNP and SSR markers ...
Salvioli Alessandra - - 2013
Omics tools constitute a powerful means of describing the complexity of plants and soil-borne microorganisms. Next generation sequencing technologies, coupled with emerging systems biology approaches, seem promising to represent a new strategy in the study of plant-microbe interactions. Arbuscular mycorrhizal fungi (AMF) are ubiquitous symbionts of plant roots, that provide ...
Stabley D D Department of Chemistry, Emory University, Atlanta, GA, - - 2013
Upon activation, the epidermal growth factor (EGF) receptor becomes phosphorylated and triggers a vast signaling network that has profound effects on cell growth. The EGF receptor is observed to assemble into clusters after ligand binding and tyrosine kinase autophosphorylation, but the role of these assemblies in the receptor signaling pathway ...
Langford Vaughan S - - 2013
People are using increasing amounts of siloxanes that ultimately end up in landfills and then in landfill gas and biogas digesters. Their presence poses difficulties for industries seeking to utilize the energy content of landfill and biogas, as the combustion process oxidises silicon to silicon dioxide that in turn damages ...
Song Wenlu - - 2013
Bisphenol A has been widely used in plastic containers and this has raised safety concerns for fetuses, infants, and young children. Aflatoxin B1, ochratoxin A, and patulin are among the most toxic regulated mycotoxins found as contaminants in agricultural crops and animal products. To facilitate the analysis of these chemicals ...
Oehlerich Markus - - 2013
Stable isotope ratio (δ(13) C, δ(18) O values) analyses of carbonates can be biased by CO(2) release from organic impurities. This is most critical for carbonate isotope analyses from bulk sediments containing comparably high amounts of organic matter (OM). Several methods have been developed to remove OM prior to analyses, ...
Le Fur C - - 2013
Sulfonamides such as sulfaquinoxaline (SQX) are among the most important antibiotic families due to their extensive use in veterinary medicine. The prediction of their fate under solar irradiation through the identification of the generated metabolites is required. However, unambiguous structural characterizations often remain a challenge particularly when several isomers could ...
Gustafsson Ove J R - - 2013
Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry provides the means to map the in situ distribution of tryptic peptides in formalin-fixed clinical tissue samples. The ability to analyze clinical samples is of great importance to further developments in the imaging field. However, there is a requirement in this field of ...
Wong Melody Yee-Man - - 2013
Despite various porous materials having been widely adopted as spraying tips for direct sample analysis using electrospray ionization mass spectrometry (ESI-MS), the effect of surface property and porosity of spraying tip materials on their analytical performances is not clear. Investigation of their relationships could provide insight into the proper choice ...
Matta Mary Elizabeth - - 2013
The oxygen isotope ratio (δ(18) O value) of aragonite fish otoliths is dependent on the temperature and the δ(18) O value of the ambient water and can thus reflect the environmental history of a fish. Secondary ion mass spectrometry (SIMS) offers a spatial-resolution advantage over conventional acid-digestion techniques for stable ...
Li Dian-Ge - - 2013
Structural characterization of biosynthetic precursors is very important in assigning enzymatic function to proteins that have been identified as functional homologs on the basis of sequence homology alone. The objective of this study is to demonstrate the use of electrospray ionization tandem mass spectrometry (ESI-MS/MS) as a powerful technique for ...
Viallon Vivian - - 2013
Road safety is a major concern in the West, especially in France. Among all the established risk factors for fatal crashes, speed is specific in two ways: every road-user is exposed to it, and it increases not only crash rates but also the severity of crashes. Thus, speed regulation is ...
Lachapelle Ugo - - 2013
There are multiple health and environmental benefits associated with increasing bicycling among children. However, the use of bicycles is also associated with severe injuries and fatalities. In order to reduce bicycle crashes, a bicycling education program was implemented in selected New Jersey schools and summer camps as part of the ...
Zhu Daxing D Division of Hematology-Oncology, Department of Medicine, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL 33136, - - 2013
Ocular adnexal mucosa associated lymphoid tissue lymphomas (OAMALTL) are the most common lymphomas of the eye. The potential roles for specific antigens in these lymphomas are still controversial. Previously we examined IGHV usage and mutations in Chlamydophila (C) psittaci-negative OAMALTL, demonstrating biased use of the IGHV4 family and IGHV4-34 gene ...
Tan Jia Yong JY Oral Sciences, Faculty of Dentistry, National University of Singapore, Singapore, - - 2013
The vertebrae mesoderm is a source of cells that forms a variety of tissues, including the heart, vasculature, and blood. Consequently, the derivation of various mesoderm-specific cell types from human embryonic stem cells (hESCs) has attracted the interest of many investigators owing to their therapeutic potential in clinical applications. However, ...
Luo John Z Q JZ Roger Williams Medical Center, Boston University, Providence, RI 02908, USA. - - 2013
A significant barrier to islet transplantation is the rapid loss of human islet function in vivo. The present study evaluates whether bone marrow (BM) could be used to support human islet survival and function in vivo. We cocultured human islets and BM for 3 weeks before transplantation into the left ...
Leaf David E DE Division of Nephrology, Columbia University Medical Center, New York, NY, USA. - - 2013
Numerous studies have evaluated the prevalence and importance of vitamin D deficiency among patients with chronic kidney disease and end-stage renal disease; however, little is known about vitamin D levels in acute kidney injury (AKI). We evaluated the association between vitamin D metabolites and clinical outcomes among patients with AKI. ...
Ding Song S Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109, - - 2013
The synthesis of a novel pharmacophore comprising a DNA-targeted platinum-acridine hybrid agent and estrogen receptor-targeted 4-hydroxy-N-desmethyltamoxifen (endoxifen) using carbamate coupling chemistry and its evaluation in breast cancer cell lines are described.
Thomas Avi T AT Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, California 94551, United States. - - 2013
Quantitation of low-abundance protein modifications involves significant analytical challenges, especially in biologically important applications, such as studying the role of post-translational modifications in biology and measurement of the effects of reactive drug metabolites. (14)C labeling combined with accelerator mass spectrometry (AMS) provides exquisite sensitivity for such experiments. Here, we demonstrate ...
Novoselova T V TV Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M6BQ, - - 2013
The melanocortin receptor (MCR) family consists of five G-protein-coupled receptors (MC1R-MC5R) with diverse physiological roles. MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function. The melanocortin receptor accessory protein (MRAP) ...
Laćan Goran G Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, - - 2013
The continuing spread of methamphetamine (METH) abuse has stimulated research aimed at understanding consequences of its prolonged exposure. Alterations in nigrostriatal dopamine (DA) system parameters have been characterized in experimental studies after discontinuation of long-term METH but fewer studies have included similar assessments during METH exposure. Here, we report METH ...
Friend Danielle M DM Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, Utah, - - 2013
Neurotoxic regimens of methamphetamine (METH) result in reactive microglia and astrocytes in striatum. Prior data indicate that rats with partial dopamine (DA) loss resulting from prior exposure to METH are resistant to further decreases in striatal DA when re-exposed to METH 30 days later. Such resistant animals also do not show ...
Mao Jinzhe J ABBL, BARC, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705, - - 2013
Peptidoglycan hydrolases are an effective new source of antimicrobials. A chimeric fusion protein of the Ply187 endopeptidase domain and LysK SH3b cell wall-binding domain is a potent agent against Staphylococcus aureus in four functional assays.
Aridgides Daniel D Graduate Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, - - 2013
Chronic Chagas cardiomyopathy (CCC), caused by the obligate intracellular protozoan parasite Trypanosoma cruzi, is a major cause of morbidity and mortality in Latin America. CCC begins when T. cruzi enters cardiac cells for intracellular multiplication and differentiation, a process that starts with recognition of host-cell entry receptors. However, the nature ...
Wu Jingyan J Department of Molecular Genetics, Ohio State University, Columbus, OH 43210, - - 2013
Conventional isolation and detection methods for small RNAs from yeast cells have been designed for a limited number of samples. In order to be able to conduct a genome-wide assessment of how each gene product impacts upon small RNAs, we developed a rapid method for analysing small RNAs from Saccharomyces ...
Radloff Robert R Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, - - 2013
Cytochrome P450 CYP2B6 is a highly polymorphic enzyme that metabolizes numerous drugs, pesticides, and environmental toxins. Sequence analysis of a Rwandese population identified eight functionally uncharacterized nonsynonymous variants c.329G>T (p.G110V), c.341T>C (p.I114T), c.444G>T (p.E148D), c.548T>G (p.V183G), c.637T>C (p.F213L), c.758G>A (p.R253H), c.835G>C (p.A279P), and c.1459C>A (p.R487S), and five novel alleles termed ...
Brini Marisa M Department of Comparative Biomedicine and Food Science, University of Padova, - - 2013
The Ca(2+) ATPases of the plasma membrane (PMCA pumps) export Ca(2+) from all eukaryotic cells. In mammals they are the products of four separate genes. PMCA types 1 and 4 are distributed ubiquitously; PMCA types 2 and 3 are restricted to some tissues, the most important being the nervous system. ...
Carrico Catherine A - - 2013
ABSTRACT: Cocooning is a strategy to protect infants from pertussis. This study explored the postpartum Tdap status of close newborn contacts during a primary care visit. The findings include a summary of the results and the implications for nurse practitioner practice to decrease the incidence of pertussis in the young ...
Zychowicz Michael E - - 2013
ABSTRACT: Hand or wrist pain is a common complaint in primary care. This pain can be very disabling and can signifi cantly impair a person's quality of life. With the appropriate clinical knowledge and skills, nurse practitioners can effectively evaluate, diagnose, and treat many of the common hand and wrist ...
Biswas C - - 2013
A multiplex nested PCR assay was developed by optimizing reaction components and reaction cycling parameters for simultaneous detection of Corchorus golden mosaic virus (CoGMV) and a phytoplasma (Group 16Sr V-C) causing little leaf and bunchy top in white jute (Corchorus capsularis). Three sets of specific primers viz. a CoGMV specific ...
Venneti Sriram S Cancer biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, - - 2013
H3F3A mutations are seen in ∼30% of pediatric glioblastoma (GBMs) and involve either the lysine residue at position 27 (K27M) or glycine at position 34 (G34R/V). Sixteen genes encode histone H3, each variant differing in only a few amino acids. Therefore, how mutations in a single H3 gene contribute to ...
Magnusson M M Department of Clinical Sciences, Lund University, Malmö, Sweden. - - 2013
Cystatin C is a novel marker of cardiovascular disease (CVD); however, the underlying mechanisms remain unclear. Here, we prospectively investigated whether plasma levels of cystatin C predict new-onset metabolic syndrome (MetS) as well as long-term progression and incidence of the different components of the MetS. Cystatin C was measured in ...
Zhao Lei L Department of Molecular and Experimental Medicine, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United - - 2013
The transthyretin amyloidoses are diseases of protein misfolding characterized by the extracellular deposition of fibrils and other aggregates of the homotetrameric protein transthyretin (TTR) in peripheral nerves, heart, and other tissues. Age is the major risk factor for the development of these diseases. We hypothesized that an age-associated increase in ...
Naticchia Matthew R MR Biochemistry and Molecular Biology Program, Departments of Biology and Chemistry, The College of Wooster, Wooster, Ohio 44691, United - - 2013
Thioredoxin protects cells against oxidative damage by reducing disulfide bonds in improperly oxidized proteins. Previously, we found that the baker's yeast cytosolic thioredoxin Trx2 undergoes cross-linking to form several protein-protein complexes in cells treated with the bifunctional electrophile divinyl sulfone (DVSF). Here, we report that the peroxiredoxin Tsa1 and the ...
Zuckier Lionel S - - 2013
Two categories of single-photon radiopharmaceuticals for brain perfusion exist, nonlipophilic and lipophilic compounds. The former are useful in performing simple flow examinations which today have application primarily in the determination of brain death. The latter also exhibit a parenchymal uptake phase that allows for evaluation of the distribution of blood ...
Yacoub Michael - - 2013
The purpose of this study was to determine whether surgical approach and patient demographics are important factors that influence lymph node retrieval. This was a retrospective review of patients receiving surgical treatment for colorectal cancer at a single institution. Two hundred three patients underwent resection for colorectal cancer. The total ...
Dowell Deborah - - 2013
The development of resistance to multiple antimicrobial agents has limited treatment options for gonorrhoea. The potential emergence of cephalosporin resistance in Neisseria gonorrhoeae and cephalosporin allergy in some patients make it necessary to evaluate the effectiveness of other available antimicrobial agents. Gentamicin is widely available in the USA and is ...
Ahn Roy - - 2013
Human trafficking is an increasingly well-recognized human rights violation that is estimated to involve more than 2 million victims worldwide each year. The health consequences of this issue bring victims into contact with health systems and healthcare providers, thus providing the potential for identification and intervention. A robust healthcare response, ...
Heyn Lena - - 2013
: Patients are experts of their own symptoms and worries, but tend not to express their concerns spontaneously in the consultation. Even when emotions are brought up, they are discussed briefly. : The objective of this study was to examine the impact of an interactive tailored patient assessment (Choice) on ...
Jenmalm M C - - 2013
The increasing allergy prevalence in affluent countries may be caused by reduced microbial stimulation and a decreased dietary ω-3/ω-6 long-chain polyunsaturated fatty acid (LCPUFA) ratio, resulting in an abnormal postnatal immune maturation. The timing of allergy-preventive probiotic and ω-3 LCPUFA interventions is critical, as early-life events occurring during critical windows ...
Kaczmarek Ingo - - 2013
Despite improvements in immunosuppressive therapy, the most advantageous combination for cardiac transplant recipients has not been established. This randomized controlled trial was performed to evaluate the efficacy and safety of 3 immunosuppressive protocols. Between 2003 and 2005, 78 de novo cardiac transplant recipients were randomized 2:2:1 to receive steroids and ...
Gann Bob - - 2013
In 2013 the NHS Commissioning Board launches its new integrated customer service platform. The new service utilises the full range of channels (web, telephone, apps etc) to provide access to information to support transparency, participation and transactions. Digital health services have proven benefits in informed choice, shared decision making and ...
Ottuso Patrick - - 2013
Numerous aquatic vertebrate species are known to cause cutaneous injury. While many of the injuries occur in regions that harbor such organisms, with the ability of people to travel long distances in short periods of time, these injuries may be seen worldwide. Also, with the increasing tendency of people to ...
Riezebos-Brilman Annelies - - 2013
Hepatitis E virus (HEV) genotype 3 has been identified in patients with autochthonous HEV infections in developed countries and is currently being recognized as an emerging zoonotic pathogen. HEV infection may lead to a chronic hepatitis in immune-compromised patients. We studied the incidence of HEV in adult lung transplant recipients ...
Silva Ana R - - 2013
One of the core applications of Microsoft's SenseCam is memory rehabilitation. Research has shown that it is an effective memory aid that can cue episodic memories. However, the extent to which SenseCam might improve aspects of memory beyond merely re-presenting forgotten events and locations has not been assessed. In line ...
Issa Maria C A - - 2013
Epidermal permeability alterations induced by ablative fractional resurfacing and low-frequency ultrasound technology may offer drug delivery for the treatment of hypertrophic scars through transepidermal drug delivery (TED). This technology can improve treatment efficacy and minimize side effects. To evaluate clinical response and side effects of TED technology in hypertrophic scars ...
Ghatak Abhijit - - 2013
Acute chest pain suggestive of ischemic cardiac origin, with a normal or nondiagnostic electrocardiogram and negative initial cardiac markers for myocardial necrosis represent a significant diagnostic dilemma for clinicians. Multiple imaging modalities play a pivotal role in early diagnosis and safe discharge of these patients. In this review, we compare ...
Sfakianaki Efrosyni - - 2013
Renal scintigraphy is a powerful imaging method that provides both functional and anatomic information, which is particularly useful in the acute care setting. In our institution, for the past 2 decades, we have used a 25-minute renal diuretic protocol, technetium-99m ((99m)Tc) mercaptoacetyltriglycine with simultaneous intravenous injection of furosemide, for all ...
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