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Results 451 - 500 of 4307
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Nakanishi H - - 2013
MicroRNAs (miRNAs) have important roles in the initiation and progression of human cancer, but their role in head and neck cancer development and progression is not well defined. We aimed to determine whether specific miRNAs and their target mRNAs contribute to head and neck cancer pathogenesis and progression. To identify ...
Van Dyck Colin - - 2013
We report a combined Non-Equilibrium Green's Function - Density Functional Theory study of molecular junctions made of photochromic diarylethenes between gold electrodes. The impact of derivatization of the molecule on the transmission spectrum is assessed by introducing: (i) substituents on the diarylethene core; and (ii) linker substituents between the gold ...
Dhamani Imran - - 2013
The aim of this research was to evaluate the ability to switch attention and selectively attend to relevant information in children (10-15 years) with persistent listening difficulties in noisy environments. A wide battery of clinical tests indicated that children with complaints of listening difficulties had otherwise normal hearing sensitivity and ...
Casarrubios Luis - - 2013
Cu(I) -catalyzed 1,3-cycloaddition of azides and alkynes (CuAAC) is one of the most powerful synthetic methodologies known. However, its use to prepare well-defined multimetallic structures is underdeveloped. Apart from the applications of this reaction to anchor different organometallic reagents to surfaces, polymers, and dendrimers, only isolated examples of CuAAC with ...
Li Jun Yuan - - 2013
OBJECTIVES: The aim of the study was to investigate the dose-dependent effect of radiation on dental implant stability and osseointegration using a series of quantitative analyses. MATERIAL AND METHODS: Six rabbits were randomly assigned to 15 and 30 Gy radiation groups. Each rabbit received radiation at the tibial and femoral metaphyseal ...
Waller Sarah E - - 2013
While high-power laser ablation of metal alloys indiscriminately produces gas-phase atomic ions in proportion to the abundance of the various metals in the alloy, gas-phase ions produced by moderate-power laser ablation sources coupled with molecular beams are formed by more complicated mechanisms. A mass spectrometric study that directly compares the ...
Moerkamp Asja T - - 2013
In recent years the multipotent extraembryonic endoderm (XEN) stem cells have been the center of much attention. In vivo, XEN cells contribute to the formation of the extraembryonic endoderm, visceral and parietal endoderm and later on, the yolk sac. Recent data have shown that the distinction between embryonic and extraembryonic ...
Barnett A Nicholas R AN Renal and Transplant Department, Guy's and St Thomas' NHS Foundation Trust, London, - - 2013
Rituximab is a chimeric anti-CD20 monoclonal antibody that leads to B cell depletion. It is not licensed for use in renal transplantation but is in widespread use in ABO blood group incompatible transplantation. It is an effective treatment for post-transplant lymphoproliferative disorder, and is also used in both HLA antibody ...
Hill Rachel A - - 2013
Neurodevelopmental psychiatric disorders such as schizophrenia may be caused by a combination of gene x environment, gene x gene and/or gene x sex interactions. Reduced expression of both Reelin and Brain-Derived Neurotrophic factor (BDNF) has been associated with schizophrenia in human post-mortem studies. However, it is unclear how Reelin and ...
Zhu Qin - - 2013
Abstract Affordances mean opportunities for action. These affordances are important for sports performance and relevant to the abilities developed by skilled athletes. In racquet sports such as badminton, different players prefer widely different string tension because it is believed to provide opportunities for effective strokes. The current study examined whether ...
Bonanni P Sebastian - - 2013
Devices that exploit electricity produced by electroactive bacteria such as Geobacter sulfurreducens have not yet been demonstrated beyond the laboratory scale. The current densities are far from the maximum that the bacteria can produce because fundamental properties such as the mechanism of extracellular electron transport and factors limiting cell respiration ...
Ma Jing-Xin - - 2013
Framework-isomeric three-dimensional (3D) Cd-Ln heterometallic metal-organic frameworks (HMOFs), {[Ln(2) (ODA)(6) Cd(3) (H(2) O)(6) ]⋅6 H(2) O}(n) (Ln=Gd (1 a) and Tb (1 b), ODA=oxydiacetic acid) and {[Cd(H(2) O)(6) ]⋅[Ln(2) (ODA)(6) Cd(2) ]⋅H(2) O}(n) (Ln=Gd (2 a), Tb (2 b)), with neutral and anionic pores, respectively, were designed based on a lanthanide metalloligand strategy and synthesized ...
Oropesa A L - - 2013
Environmental pollution with synthetic estrogens may pose a serious threat to reproduction of aquatic wildlife species. The current study describes the effects of 17α-ethynylestradiol (EE(2) ) on the structure of the testis in tench (Tinca tinca). Adult male tench were exposed to sublethal doses of EE(2) (50, 100, and 500 ...
Zhang Y - - 2013
Metabolic Syndrome (MetS)is a phenotype cluster predisposing to type 2 diabetes and cardiovascular diseases. In extended families of Northern European ancestry, we previously identified two significant QTLs 3q27 and 17p12 that werelinked with multiple representative traits of MetS. Todetermine the genetic basis of these linkage signals, QTL-specific genomic and transcriptomic ...
Mooney Bridget M - - 2013
Stem cells and cancer cells share certain characteristics, including the capacity to self-renew, differentiatie, and undergo epithelial-to-mesenchymal transition (EMT). The mechanisms underlying tumorigenesis retain similarities with processes in normal stem cell development. Comprehensive analysis and comparison of cancer cell and stem cell development will advance the study of cancer progression, ...
Jayasinghe Caren - - 2013
The biological behavior of VEGF-B, a ligand of the receptor VEGFR-1, is still enigmatic. Despite its high sequence homology to the better known angiogenetic factor VEGF-A, the function of VEGF-B has remained elusive. Especially, its role in tumor biology has thus far not been defined. In the present study we ...
Derosa G - - 2013
AIMS: To evaluate which triple oral therapy between metformin + pioglitazone + sitagliptin and metformin + pioglitazone + glibenclamide can be more useful in improving glycaemic control and should be preferred in clinical practice. METHODS: During the 2-year run-in period, patients were instructed to take metformin monotherapy for the first year, then a combination of metformin and pioglitazone ...
Bhagat Deepa - - 2013
Environment-friendly management of fruit flies involving pheromones is useful in reducing the undesirable pest populations responsible for decreasing the yield and the crop quality. A nanogel has been prepared from a pheromone, methyl eugenol (ME) using a low-molecular mass gelator. This was very stable at open ambient conditions and slowed ...
Ziegler Slava - - 2013
Identification and confirmation of bioactive small-molecule targets is a crucial, often decisive step both in academic and pharmaceutical research. Through the development and availability of several new experimental techniques, target identification is, in principle, feasible, and the number of successful examples steadily grows. However, a generic methodology that can successfully ...
Zhang Zhexu - - 2013
The inherently high magnetic anisotropy and nanoscale grain size in a Sm(5)Co(19) compound result in an intrinsic coercivity far higher than those of known Sm-Co compounds prior to orientation treatment. The combination of ultrahigh intrinsic coercivity, high Curie temperature and low coercivity temperature coefficient of nanocrystalline Sm(5)Co(19) as a single ...
Espinosa-de la Garza Carlos E - - 2013
Analytical platforms that characterize charge heterogeneity in therapeutic proteins, such as mAbs, are important tools that can be used to define quality attributes. CZE separates protein moieties close to their native state and is a valuable physicochemical analytical method that can be used in parallel with other orthogonal methods for ...
Ellse L - - 2013
Infestations by lice can be a significant clinical and welfare issue in the management of large animals. The limited range of commercial pediculicides available and the development of resistance have led to the need to explore alternative louse management approaches. The results of in vitro and in vivo trials undertaken ...
Rufini A A Medical Research Council, Toxicology Unit, Leicester University, Leicester, - - 2013
p53 functions as a transcription factor involved in cell-cycle control, DNA repair, apoptosis and cellular stress responses. However, besides inducing cell growth arrest and apoptosis, p53 activation also modulates cellular senescence and organismal aging. Senescence is an irreversible cell-cycle arrest that has a crucial role both in aging and as ...
Bailey Sean M - - 2013
Abstract Objective: Family-Centered Care (FCC), which includes involving parents in conversations about medical management, is increasingly employed in the neonatal intensive care unit (NICU). Our aim was to determine which care decisions are discussed by neonatologists with families most frequently and the percentage of clinicians influenced by such conversations. Methods: ...
Robbins Jessica Sloane - - 2013
This Article uses physical-organic studies on well-defined oligomers to establish design principles for creating aromatic poly(carbamates) that depolymerize from head-to-tail in low dielectric constant environments when exposed to specific applied signals. We show that either increasing electron density or decreasing the aromaticity of aromatic repeating units in poly(carbamates) increase the ...
Chaikittisilp Watcharop - - 2013
Make intergrowth, not war! Hierarchically organized MFI zeolites possessing micro-, meso-, and macroporosity in one structure were made by sequential intergrowth using a simple organic structure-directing agent (OSDA) without meso- or macroporogens. The use of an OSDA that imperfectly fit the zeolite framework generated very thin zeolite plates with 90° ...
Polsen Erik S - - 2013
The widespread potential application of vertically aligned carbon nanotube (CNT) forests have stimulated recent work on large-area chemical vapor deposition growth methods, but improved control of the catalyst particles is needed to overcome limitations to the monodispersity and packing density of the CNTs. In particular, traditional thin-film deposition methods are ...
Apostolakis Dimitrios - - 2013
OBJECTIVES: The superior alveolar canal with its contents is frequently reported as an anatomical point of consideration during lateral sinus floor elevation due to the danger of bleeding and of the subsequent impairment of vision of the surgical field. Malnutrition of the graft may also ensue. This radiographical study uses ...
Lee Jin-Gu - - 2013
Upon emerging from the ribosome exiting tunnel, polypeptide folding occurs immediately with the assistance of both ribosome-associated and free chaperones. While many chaperones known to date are dedicated folding catalysts, recent studies have revealed a novel chaperoning system that functions at the interface of protein biogenesis and quality control by ...
Sattler Elke - - 2013
Sentinel lymph node biopsy (SLNB) is commonly recommended for patients with primary Merkel cell carcinoma (MCC). However, it is critically discussed whether survival rates improve by SLNB in MCC patients in general or in subgroups of higher risk (e.g. with primary tumor size >1 cm). The present study correlates clinical data, ...
Reid Jennifer N S - - 2013
PROBLEM: Medical problems of most importance to reproductive health of women differ to some extent between the developed world and resource-disadvantaged countries. Nevertheless, many share a common link in microbial involvement. METHOD OF STUDY: A review of the peer-reviewed literature on microbiota, probiotics, and reproductive health. RESULTS: Indigenous and probiotic ...
Aggarwal A Vikas - - 2013
We present the efficient synthesis of a new molecular spoked-wheel structure (MSW-3). Two derivatives with diameters of approximately 4 nm have been prepared. By highlighting the importance of pseudo-high-dilution conditions during cyclization, we were able to access the compounds on a several hundred milligram scale. In addition to the standard characterization ...
Cui Xinjiang - - 2013
The N-alkylation of amines or ammonia with alcohols is a valuable route for the synthesis of N-alkyl amines. However, as a potentially clean and economic choice for N-alkyl amine synthesis, non-noble metal catalysts with high activity and good selectivity are rarely reported. Normally, they are severely limited due to low ...
Diekmann Ulf - - 2013
Pluripotent stem cells hold great promise for regenerative medicine, due to their unlimited self-renewal potential and the ability to differentiate into all somatic cell types. Differences between the rodent disease models and the situation in humans can be narrowed down with non-human primate models. The common marmoset monkey (Callithrix jacchus) ...
Yoon Seung-Yong - - 2013
AIMS: Dystrophic neurites are associated with β-amyloid (Aβ) plaques in the brains of Alzheimer's disease (AD) patients and are also found in some specific areas of normal, aged brains. This study assessed the molecular characteristics of dystrophic neurites in normal ageing and its difference from AD. METHODS: We compared the ...
Poater Jordi - - 2013
A clear link between the hydrocarbon and borohydride chemistries is established by showing that hydrocarbons and borohydrides have a common root regulated by the number of valence electrons in a confined space. Application of the proposed method to archetypal hydrocarbons leads to well-known borohydrides but, more importantly, it allows the ...
Bertoluzzi Luca - - 2013
The charge collection efficiency is one of the most critical parameters of photovoltaic devices. In this paper we provide the analysis and comparison between several approaches for the calculation of the collection efficiency of dye-sensitized solar cells. In addition, we point out that although it is reasonable to correlate transit ...
Yoon Bora - - 2013
Inkjet-printed paper-based volatile organic compound (VOC) sensor strips imaged with polydiacetylenes (PDAs) are developed. A microemulsion ink containing bisurethane-substituted diacetylene (DA) monomers, 4BCMU, was inkjet printed onto paper using a conventional inkjet office printer. UV irradiation of the printed image allowed fabrication of blue-colored poly-4BCMU on the paper and the ...
Gilmartin Daniel J - - 2013
Scaffolds have been reported to promote healing of hard-to-heal wounds such as burns and chronic ulcers. However, there has been little investigation into the cell biology of wound edge tissues in response to the scaffolds. Here, we assess the impact of collagen scaffolds on mouse full-thickness wound re-epithelialisation during the ...
Tietze Lutz F - - 2013
Fast and easy: Various helical tetrasubstituted alkenes were synthesized by a palladium-catalyzed domino process. The domino process consists of a Sonogashira reaction, a carbopalladation, and a direct CH functionalization.
Shukla A A Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, - - 2014
Cancer stroma has a profound influence on tumor development and progression. The conversion of fibroblasts to activated myofibroblasts is a hallmark of reactive tumor stroma. Among a number of factors involved in this conversion, transforming growth factor (TGF)-β has emerged as a major regulator. CLIC4, an integral protein in TGF-β ...
Prehn Richmond T - - 2013
ABSTRACT: According to Berenblum's two-stage hypothesis, the first stage in carcinogenesis is the production of benign premalignant lesions. Between this initiation stage and the formation of a malignant tumor there is often a long lag phase. We propose that this lag is caused by the delay in the formation of ...
Larrabee Glenn J - - 2013
Bigler et al. ( 2013 , The Clinical Neuropsychologist) contend that weak methodology and poor quality of the studies comprising our recent meta-analysis led us to miss detecting a subgroup of mild traumatic brain injury (mTBI) characterized by persisting symptomatic complaint and positive biomarkers for neurological damage. Our computation of ...
Lin Tzu-Pin - - 2013
A duel between lone pairs: A telluronium cation has been successfully installed in the coordination sphere of a palladium(II) complex. Despite the presence of a lone pair centered on the group 16 element, the telluronium ion acts as a Z-ligand and accepts a d-electron pair from the palladium atom.
Zhang Haojun - - 2013
Microbial bioproduction processes of 2-phenylethanol, an important rose-like flavor and fragrance compound that occurs naturally in the essential oils of many flowers and plants, are hindered by the growth inhibition it exerts towards the producing microorganism, mainly yeast. We show here for the first time that glycosylation of 2-phenylethanol with ...
Samaropoulos Xanthia F - - 2013
OBJECTIVE: Some obese individuals appear to be protected from developing type 2 diabetes mellitus and cardiovascular disease (CVD). This has led to characterizing body size phenotypes based on cardiometabolic risk factors specifically as obese or overweight, and as metabolically healthy (MH) or metabolically abnormal (MA) based upon blood pressure, lipids, ...
Albanese Francesco - - 2013
BACKGROUND: Canine subcutaneous dirofilariosis caused by Dirofilaria repens is an important cause of human dirofilariosis in the Old World. OBJECTIVES: To describe the clinical and pathological features of infestation by D. repens in dogs with cutaneous nodules and to discuss key diagnostic procedures. ANIMALS: Sixteen privately owned dogs of different breeds, ...
Rossi S - - 2013
Bluetongue (BT) was monitored in wildlife in France during two consecutive years corresponding to contrasting incidence rates in livestock: in 2008 at the peak of domestic outbreaks and in 2009 when very few outbreaks were observed. The disease status of 2 798 ruminants comprising 837 red deer (Cervus elaphus) was ...
Luzía França Eduardo - - 2013
Abstract Objective: The effects of low maternal hemoglobin levels on the immunological and nutritional components of breast milk at different maturation stages were investigated. Methods: Colostrum, transitional and mature milk were collected from 25 mothers with normal hemoglobin levels (control group) and 18 mothers with hemoglobin levels below 11 g/dL ...
Shi Jun - - 2013
Hollow multilayer microcapsules made of aliphatic poly(urethane-amine) (PUA) and sodium poly(styrene sulfonate) (PSS), templated on PSS-doped CaCO(3) particles, are prepared for pH-/thermally responsive drug delivery. The electrostatic interaction and hydrogen bonding under weak-acid conditions between aliphatic PUA and PSS contribute to the formation of multilayer microcapsules. Scanning electron microscopy (SEM) ...
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