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Takahashi Hidetoshi - - 2013
We compared the clinical efficacy of various psoriasis treatments among: (i) topical application of calcipotriol ointment twice daily (group I); (ii) topical application of calcipotriol ointment twice daily and narrowband ultraviolet B NB-UVB phototherapy once a week (group II); (iii) topical application of heparinoid ointment twice daily and NB-UVB phototherapy ...
Kwong L N - - 2013
The treatment of melanoma, the most aggressive form of skin cancer, is being revolutionized by the development of personalized targeted therapy approaches. Mutant-selective BRAF inhibitors and MEK inhibitors have demonstrated impressive clinical results in molecularly selected patients. However, emerging understanding of the molecular heterogeneity of this disease and the identification ...
Bort Guillaume - - 2013
Molecular systems that can be remotely controlled by light are gaining increasing importance in cell biology, physiology, and neurosciences because of the spatial and temporal precision that is achievable with laser microscopy. Two-photon excitation has significant advantages deep in biological tissues, but raises problems in the design of "smart" probes ...
Wei Wen-Ting - - 2013
Difunctionalization: Inexpensive and environmentally benign FeCl(3) catalyzes the oxidative 1,2-alkylarylation of activated alkenes with an aryl C(sp(2) )H bond and a C(sp(3) )H bond adjacent to a heteroatom. This reaction is a new strategy for the synthesis of oxindoles and makes use of DBU as ligand and TBHP as oxidant ...
Tsang Sai-Wing - - 2013
Using charge modulated electroabsorption spectroscopy (CMEAS), for the first time, the energy level alignment of a polymer:fullerene bulk heterojunction photovoltaic cell is directly measured. The charge-transfer excitons generated by the sub-bandgap optical pumping are coupled with the modulating electric field and introduce subtle changes in optical absorption in the sub-bandgap ...
Király István - - 2013
Large-conductance Ca(2+) -activated K(+) channels (BK(C) (a) ), located on the vascular smooth muscle, play an important role in regulation of vascular tone. In penile corpus cavernosum tissue, opening of BK(C) (a) channels leads to relaxation of corporal smooth muscle which is essential during erection; however, there is little information ...
Cai Yuqun - - 2013
There are two major classes of neurons in nervous systems: projection neurons and interneurons. During Drosophila nervous system development, a subpopulation of individual stem/progenitor cells gives rise to both motor neurons and interneurons. However, it remains unknown whether individual stem/progenitor cells in the mammalian brain also have the potential to ...
Hansen Anne - - 2013
Primary human megakaryocytes, the precursor cells of platelets, are difficult to collect and cultivate. Polymers that enrich these cells without affecting their regulation or function are of interest for basic research as well as for cord blood transplantation purposes since co-transplantation of enriched megakaryocyte concentrates increase the success of stem ...
Jin Liji - - 2013
In this paper, the anti-depressant effects of Acanthopanax senticosus extract (ASE) were studied using animal models of depression including the forced swimming and tail suspension tests. The anti-depressive mechanism of ASE was explored by monitoring the levels of monoamine neurotransmitters including 5-hydroxytrylamine (5-HT), norepinephrine (NE), and dopamine (DA), as well ...
Shao Jingjin - - 2013
OBJECTIVE: With the dramatic changes in Chinese society and economy, the average depressive symptoms of Chinese older adults might have changed across their birth cohort. This study aims to examine the changes in the depressive symptoms of Chinese older adults by analyzing data from 1987 to 2010. METHODS: The study ...
Wittenberg James B - - 2013
Climbing the cucurbit ladder: Cucurbit[6]uril dimers (connected gray cylinders; see scheme) were prepared by condensation of glycoluril hexamer with the appropriate tetraaldehydes. The self-assembly process between these dimers and oligoviologen compounds (blue) in water leads to a supramolecular ladder with the dimensions and molecular weight typical of small proteins.
Wolford Matthew F - - 2013
A catalyst free approach for nitrogen oxides (NO(x)) removal has been developed at the United States Naval Research Laboratory. Our goals were to assess the ability of pulsed electron beam to enhance NO(x) removal at potential lower capital cost with greater efficiency than other large scale NO(x) removal methods. Removal ...
Bhagat Deepa - - 2013
Environment-friendly management of fruit flies involving pheromones is useful in reducing the undesirable pest populations responsible for decreasing the yield and the crop quality. A nanogel has been prepared from a pheromone, methyl eugenol (ME) using a low-molecular mass gelator. This was very stable at open ambient conditions and slowed ...
Walker Cg - - 2013
OBJECTIVE: Overweight and obesity are associated with a dyslipidaemia which can be improved by weight loss. We examined whether genetic predisposition to an adverse lipid profile modifies such beneficial effects of weight loss on lipid levels in overweight and obese individuals. DESIGN AND METHODS: White European participants (n=374) who completed ...
Ziegler Slava - - 2013
Identification and confirmation of bioactive small-molecule targets is a crucial, often decisive step both in academic and pharmaceutical research. Through the development and availability of several new experimental techniques, target identification is, in principle, feasible, and the number of successful examples steadily grows. However, a generic methodology that can successfully ...
Zhang Zhexu - - 2013
The inherently high magnetic anisotropy and nanoscale grain size in a Sm(5)Co(19) compound result in an intrinsic coercivity far higher than those of known Sm-Co compounds prior to orientation treatment. The combination of ultrahigh intrinsic coercivity, high Curie temperature and low coercivity temperature coefficient of nanocrystalline Sm(5)Co(19) as a single ...
Espinosa-de la Garza Carlos E - - 2013
Analytical platforms that characterize charge heterogeneity in therapeutic proteins, such as mAbs, are important tools that can be used to define quality attributes. CZE separates protein moieties close to their native state and is a valuable physicochemical analytical method that can be used in parallel with other orthogonal methods for ...
Ellse L - - 2013
Infestations by lice can be a significant clinical and welfare issue in the management of large animals. The limited range of commercial pediculicides available and the development of resistance have led to the need to explore alternative louse management approaches. The results of in vitro and in vivo trials undertaken ...
Bailey Sean M - - 2013
Abstract Objective: Family-Centered Care (FCC), which includes involving parents in conversations about medical management, is increasingly employed in the neonatal intensive care unit (NICU). Our aim was to determine which care decisions are discussed by neonatologists with families most frequently and the percentage of clinicians influenced by such conversations. Methods: ...
Robbins Jessica Sloane - - 2013
This Article uses physical-organic studies on well-defined oligomers to establish design principles for creating aromatic poly(carbamates) that depolymerize from head-to-tail in low dielectric constant environments when exposed to specific applied signals. We show that either increasing electron density or decreasing the aromaticity of aromatic repeating units in poly(carbamates) increase the ...
Aggarwal A Vikas - - 2013
We present the efficient synthesis of a new molecular spoked-wheel structure (MSW-3). Two derivatives with diameters of approximately 4 nm have been prepared. By highlighting the importance of pseudo-high-dilution conditions during cyclization, we were able to access the compounds on a several hundred milligram scale. In addition to the standard characterization ...
Cui Xinjiang - - 2013
The N-alkylation of amines or ammonia with alcohols is a valuable route for the synthesis of N-alkyl amines. However, as a potentially clean and economic choice for N-alkyl amine synthesis, non-noble metal catalysts with high activity and good selectivity are rarely reported. Normally, they are severely limited due to low ...
Diekmann Ulf - - 2013
Pluripotent stem cells hold great promise for regenerative medicine, due to their unlimited self-renewal potential and the ability to differentiate into all somatic cell types. Differences between the rodent disease models and the situation in humans can be narrowed down with non-human primate models. The common marmoset monkey (Callithrix jacchus) ...
Yoon Seung-Yong - - 2013
AIMS: Dystrophic neurites are associated with β-amyloid (Aβ) plaques in the brains of Alzheimer's disease (AD) patients and are also found in some specific areas of normal, aged brains. This study assessed the molecular characteristics of dystrophic neurites in normal ageing and its difference from AD. METHODS: We compared the ...
Poater Jordi - - 2013
A clear link between the hydrocarbon and borohydride chemistries is established by showing that hydrocarbons and borohydrides have a common root regulated by the number of valence electrons in a confined space. Application of the proposed method to archetypal hydrocarbons leads to well-known borohydrides but, more importantly, it allows the ...
Zhu Daxing - - 2013
Ocular adnexal mucosa associated lymphoid tissue lymphomas (OAMALTL) are the most common lymphomas of the eye. The potential roles for specific antigens in these lymphomas are still controversial. Previously we examined IGHV usage and mutations IGHVin Chlamydophila (C) psittaci-negative OAMALTL, demonstrating biased use of the IGHV4 family and IGHV4-34 gene ...
Bertoluzzi Luca - - 2013
The charge collection efficiency is one of the most critical parameters of photovoltaic devices. In this paper we provide the analysis and comparison between several approaches for the calculation of the collection efficiency of dye-sensitized solar cells. In addition, we point out that although it is reasonable to correlate transit ...
Fuchs Franklin - - 2013
Cardiac muscle contraction is activated via the single Ca(2+)-binding site (site II) in the N-domain of troponin C (cTnC). The two Ca(2+)/Mg(2+) binding sites in the C-domain of cTnC (sites III and IV) have been considered to play a purely structural role in anchoring cTnC to the thin filament. However, ...
Zhang Jinying - - 2013
Carbon is a girl's best friend: Carbon-based nanowires have been produced during thermal annealing of diamantane-4,9-dicarboxylic acid in carbon nanotubes under hydrogen atmosphere. HR-TEM images, Raman spectra, and structural transformations observed under an intense electron beam suggest that the as-produced carbon-based nanowires are sp(3) diamond nanowires, consistent with our computational ...
Meier Katharina - - 2013
Theoretical-computational modeling with an eye to explaining experimental observations in regard to a particular chemical phenomenon or process requires choices concerning essential degrees of freedom and types of interactions and the generation of a Boltzmann ensemble or trajectories of configurations. Depending on the degrees of freedom that are essential to ...
Takahashi Hidetoshi - - 2013
Personality and emotional factors are supposed to influence the course of skin diseases, such as psoriasis and atopic dermatitis. Few reports exist, however, showing distinct personality traits among patients with psoriasis, atopic dermatitis patients and healthy controls. The aim of the present study was to examine personality differences among psoriasis ...
Macken W L - - 2013
BACKGROUND: Pneumococcal disease, especially in its invasive form, is a significant cause of morbidity and mortality worldwide. However, with the advent of vaccination, invasive disease is potentially avoidable. This study aimed to assess the documentation of pneumococcal vaccination status in elderly patients by healthcare professionals in a busy teaching hospital ...
Le Van Sang - - 2013
A cationic conjugated polyelectrolyte was designed and synthesized based on poly(fluorene-co-phenylene) containing 5 mol% benzothiadiazole (BT) as a low energy trap and 15-crown-5 as a recognizing group for potassium ions. A potassium ion can form a sandwich-type 2:1 Lewis acid-based complex with 15-crown-5, to cause the intermolecular aggregation of polymers. ...
Cai Xianlei - - 2013
To investigate the effects of different habitats and plant growth status on abundance, biomass and community structure of epiphytic microbes, Potamogeton malaianus Miq. at two different habitats (Gonghu Bay and East Taihu) in Lake Taihu were collected in June, August and November (corresponding to the period of development of submerged ...
Tietze Lutz F - - 2013
For the synthesis of (-)-diversonol (ent-1), an enantioselective domino-Wacker/carbonylation/methoxylation reaction and an enantioselective Wacker oxidation were used to give the chroman in high yield and 96 % and 93 % ee, respectively. Dihydroxylation at the vinyl moiety using the Sharpless procedure and a Wittig-Horner reaction followed by hydrogenation, benzylic oxidation, and an intramolecular ...
Shimoda Yasushi - - 2013
Triple play: The title reaction of an alkyl methyl ketone and two aldehydes using chiral (S)-binapo as a Lewis base catalyst allows access to 1,5-dihydroxy-3-pentanone derivatives with multiple chiral centers in good yields with high diastereo- and enantioselectivities in a single operation.
Cordero-Ramírez Jesús Damián - - 2013
Sinaloa state accounts for 23% of Mexico's tomato production. One constraint on this important crop is the Fusarium crown and root rot, caused by Fusarium oxysporum f. sp. radicis-lycopersici, which has been reported to reduce crop yield by up to 50%. In this study, we set out to identify bacterial ...
Park S - - 2013
Advances in lab-on-a-chip technologies enabled programmable, reconfigurable, and scalable manipulation of a variety of laboratory procedures. Samples, reagents, and fluids can be precisely controlled; buffer temperature, pH, and concentration control systems as well as a variety of detection systems can be integrated on a small chip. These advantages have attracted ...
Xia Haibing - - 2013
Big and small, short and tall: Nanoparticles (NPs) coated with pH-sensitive polymers underwent reversible chain growth as a result of varying electrostatic interparticle repulsion as determined by the pH value. Tuning of the pH value also enabled the coupling of differently sized NPs to form linear composite chains reminiscent of ...
Hafekost Katherine - - 2013
ABSTRACT: BACKGROUND: Despite the increasing understanding of the mechanisms relating to weight loss and maintenance, there are currently no validated public health interventions that are able to achieve sustained long-term weight loss or to stem the increasing prevalence of obesity in the population. We aimed to examine the models of ...
Xu Jie - - 2013
In order determine whether formate is a reaction intermediate of the direct pathway for formic acid oxidation at a Pt electrode, formic acid (HCOOH) oxidation at a Pt(111) electrode has been studied by normal and fast scan voltammetry in 0.1 M HClO(4) solutions with different HCOOH concentrations. The relationship between ...
Bonanni P Sebastian - - 2013
Devices that exploit electricity produced by electroactive bacteria such as Geobacter sulfurreducens have not yet been demonstrated beyond the laboratory scale. The current densities are far from the maximum that the bacteria can produce because fundamental properties such as the mechanism of extracellular electron transport and factors limiting cell respiration ...
Ma Jing-Xin - - 2013
Framework-isomeric three-dimensional (3D) Cd-Ln heterometallic metal-organic frameworks (HMOFs), {[Ln(2) (ODA)(6) Cd(3) (H(2) O)(6) ]⋅6 H(2) O}(n) (Ln=Gd (1 a) and Tb (1 b), ODA=oxydiacetic acid) and {[Cd(H(2) O)(6) ]⋅[Ln(2) (ODA)(6) Cd(2) ]⋅H(2) O}(n) (Ln=Gd (2 a), Tb (2 b)), with neutral and anionic pores, respectively, were designed based on a lanthanide metalloligand strategy and synthesized ...
Oropesa A L - - 2013
Environmental pollution with synthetic estrogens may pose a serious threat to reproduction of aquatic wildlife species. The current study describes the effects of 17α-ethynylestradiol (EE(2) ) on the structure of the testis in tench (Tinca tinca). Adult male tench were exposed to sublethal doses of EE(2) (50, 100, and 500 ...
Mooney Bridget M - - 2013
Stem cells and cancer cells share certain characteristics, including the capacity to self-renew, differentiatie, and undergo epithelial-to-mesenchymal transition (EMT). The mechanisms underlying tumorigenesis retain similarities with processes in normal stem cell development. Comprehensive analysis and comparison of cancer cell and stem cell development will advance the study of cancer progression, ...
Jayasinghe Caren - - 2013
The biological behavior of VEGF-B, a ligand of the receptor VEGFR-1, is still enigmatic. Despite its high sequence homology to the better known angiogenetic factor VEGF-A, the function of VEGF-B has remained elusive. Especially, its role in tumor biology has thus far not been defined. In the present study we ...
Derosa G - - 2013
AIMS: To evaluate which triple oral therapy between metformin + pioglitazone + sitagliptin and metformin + pioglitazone + glibenclamide can be more useful in improving glycaemic control and should be preferred in clinical practice. METHODS: During the 2-year run-in period, patients were instructed to take metformin monotherapy for the first year, then a combination of metformin and pioglitazone ...
Miles Luke A - - 2013
Bapineuzumab is a humanized antibody developed by Pfizer and Johnson & Johnson targeting the amyloid (Aβ) plaques that underlie Alzheimer's disease neuropathology. Here we report the crystal structure of a Fab-Aβ peptide complex that reveals Bapineuzumab surprisingly captures Aβ in a monomeric helical conformation at the N-terminus. Microscale thermophoresis suggests ...
Kim Dong Wook - - 2013
The synthesis of highly crystalline perovskite BaSnO(3) nanoparticles for use as photoanode materials in dye-sensitized solar cells (DSSCs) is reported, and the photovoltaic properties of DSSCs based on BaSnO(3) nanoparticles (BaSnO(3) cells) are demonstrated. The resulting DSSCs exhibit remarkably rapid charge collection and a DSSC fabricated with a BaSnO(3) film ...
Jones Paul - - 2013
During the past 30 years, there has been an increase in the incidence of cancer in adolescents. While recent studies have illustrated remarkable resilience in youth living with cancer, they can also face daunting acute and chronic adjustment struggles, cognitive and school problems, family and peer relational difficulties, depression, post-traumatic stress ...
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