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Carreiro Stephanie S Department of Emergency Medicine, The Alpert Medical School, Brown University, Providence, RI, USA, - - 2013
Intravenous lipid emulsion (ILE) is an adjunctive antidote used in selected critically ill poisoned patients. These patients may also require administration of advanced cardiac life support (ACLS) drugs. Limited data is available to describe interactions of ILE with standard ACLS drugs, specifically epinephrine. Twenty rats with intra-arterial and intravenous access ...
Darracq Michael A MA University of California, San Diego, San Diego, CA, USA, - - 2013
Hyperinsulinemia euglycemia (HIE) and intravenous fat emulsion (IFE) may be beneficial in the treatment of calcium channel (CCB) and beta receptor (BB) antagonist toxicity. Many poison control centers (PCC) now recommend use. Healthcare providers may be unfamiliar with these treatments and may not institute them despite recommendations. We sought to ...
Hetsroni Iftach I Department of Orthopedic Surgery, Meir General Hospital, Tsharnichovski Street 59, 44281, Kfar Saba, Israel. - - 2013
The anterior inferior iliac spine (AIIS) contributes to hip dysfunction in patients with symptomatic impingement and resection of a prominent AIIS can reportedly improve function. However, the variability of the AIIS morphology and whether that variability correlates with risk of associated symptomatic impingement are unclear. We characterized AIIS morphology in ...
Blaine Hannah H School of Psychology and Counseling, Queensland University of Technology, Brisbane, - - 2013
Diagnosis threat is a psychosocial factor that has been proposed to contribute to poor outcomes following mild traumatic brain injury (mTBI). This threat is thought to impair the cognitive test performance of individuals with mTBI because of negative injury stereotypes. University students (N=45, 62.2% female) with a history of mTBI ...
Otsuka Taketo T Department of Pediatrics, Sado General Hospital, Sado, Niigata, Japan. - - 2013
The first step in a bacterial disease is the establishment of nasopharyngeal carriage. We conducted a birth cohort study to identify factors associated with colonization in healthy children and evaluate the serotype distributions and resistances of Streptococcus pneumoniae/Haemophilus influenzae. Nasopharyngeal cultures were obtained from 349 subjects at 5 time points ...
Rowe Steven M SM Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294-0006, USA. - - 2013
Prostasin, a trypsin-like serine protease, is a channel-activating protease and major regulator of epithelial sodium channel-mediated sodium absorption. Its direct inhibition by camostat represents a potential approach to inhibiting sodium transport in cystic fibrosis (CF). To determine whether a topical formulation of camostat represents an efficacious and tolerable approach to ...
Bogan Rosalind R Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, - - 2013
Osteogenesis imperfecta type VI (OI type VI) has recently be linked to a mutation in the SERPINF1 gene, which encodes pigment epithelium-derived factor (PEDF), a ubiquitously expressed protein originally described for its neurotrophic and antiangiogenic properties. In this study, we characterized the skeletal phenotype of a mouse with targeted disruption ...
Akdeniz Cansu C Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, - - 2013
In the acute coronary syndrome setting, the interaction between epicardial coronary artery stenosis and microcirculation subtended by the culprit vessel is poorly understood. The purpose of the present study was to assess the immediate impact of percutaneous coronary intervention (PCI) on microvascular resistance (MR) in patients with non-ST-elevation myocardial infarction ...
Voskanian Natalie - - 2013
Female athletes are at 3.5 times risk of sustaining a non-contact ACL injury compared with males. Research has shown that this gender discrepancy results from differences in neuromuscular adaptations and biomechanics related to landing techniques. Studies have examined the preventative effect of ACL prevention programs, which have been designed to ...
Smith Ken R KR Department of Family and Consumer Studies, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84102, USA. - - 2013
To review recent publications examining BRCA1 and BRCA2 mutations and their relationship with female fertility. Eight relevant studies of female fertility, five of which were published since January 2010 and the remainder in the preceding decade. Several mechanisms suggest that reproduction will be adversely affected among BRCA1/2 mutation carriers, with ...
Veiga Lene H S LH Institute of Radiation Protection and Dosimetry, Brazilian Nuclear Energy Commission, Rio de Janeiro, Brazil. - - 2013
Thyroid cancer incidence has risen steadily over the last few decades in most of the developed world, but information on incidence trends in developing countries is limited. Sao Paulo, Brazil, has one of the highest rates of thyroid cancer worldwide, higher than in the United States. We examined thyroid cancer ...
Sonneveld Liza P - - 2013
A history of sexual abuse is to be found in approximately 40% of all adult patients with gastrointestinal complaints. Data on the prevalence of child sexual abuse (CSA) in children with chronic abdominal pain (CAP) are lacking. The objective of this systematic review is to determine the prevalence of CSA ...
Boscolo Annalisa A Department of Anesthesiology, University of Virginia Heath System, Charlottesville, VA, - - 2013
General anesthetics induce apoptotic neurodegeneration in the developing mammalian brain. General anesthesia (GA) also causes significant disturbances in mitochondrial morphogenesis during intense synaptogenesis. Mitochondria are dynamic organelles that undergo remodeling via fusion and fission. The fine balance between these two opposing processes determines mitochondrial morphometric properties, allowing for their regeneration ...
Rao-Bindal Krithi K Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, - - 2013
The purpose of this study was to determine the effects of the histone deacetylase inhibitor, MS-275, on the Fas signaling pathway and susceptibility of osteosarcoma (OS) to Fas ligand (FasL)-induced cell death. OS metastasizes almost exclusively to the lungs. We have shown that Fas expression in OS cells is inversely ...
Rockstroh Jürgen K JK Department of Medicine I, University of Bonn, Bonn, - - 2013
STARTMRK, a phase III noninferiority trial of raltegravir-based versus efavirenz-based therapy in treatment-naive patients, remained blinded until its conclusion at 5 years. We now report the final study results. Previously untreated patients without baseline resistance to efavirenz, tenofovir, or emtricitabine were eligible for a randomized study of tenofovir/emtricitabine plus either ...
DePetris Andrea Elizabeth AE Cambridge Health Alliance Center for Multicultural Mental Health Research, 120 Beacon St., Somerville, MA 02143, USA. - - 2013
OBJECTIVE Numerous articles have identified that medical technologies diffuse more rapidly among non-Latino whites compared with other racial-ethnic groups. However, whether health risk warnings also diffuse differentially across racial-ethnic minority groups is uncertain. This study assessed racial-ethnic variation in children's antidepressant use before and after the 2004 black-box warning concerning ...
Thompson Russell E RE Department of Biology, Harvey Mudd College, Claremont, CA 91711, - - 2013
Corneal disease is the fourth leading cause of blindness. According to the World Health Organization, roughly 1.6 million people globally are blind as a result of this disease. The only current treatment for corneal opacity is a corneal tissue transplant. Unfortunately, the demand for tissue exceeds supply, making a tissue-engineered ...
Phillips Craig L CL Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, St. Leonards, Australia. - - 2013
Continuous positive airway pressure (CPAP) and mandibular advancement device (MAD) therapy are commonly used to treat obstructive sleep apnea (OSA). Differences in efficacy and compliance of these treatments are likely to influence improvements in health outcomes. To compare health effects after 1 month of optimal CPAP and MAD therapy in ...
Anjamrooz Seyed Hadi - - 2013
The crucial facts underlying the low efficiency of cellular reprogramming are poorly understood. Cellular reprogramming occurs in nuclear transfer, induced pluripotent stem cell (iPSC) formation, cell fusion, and lineage-switching experiments. Despite these advances, there are three fundamental problems to be addressed: (1) the majority of cells cannot be reprogrammed, (2) ...
O'Rourke Michael F - - 2013
Current guidelines on isolated systolic hypertension (ISH) suggest the same treatment to patients of all ages. Application of these guidelines in youth with ISH may not be appropriate, as presently no data show adverse outcome or benefit of drug therapy in this group. Simple noninvasive tonometric techniques now enable physicians ...
Guharoy Roy R Ascension Health, St. Louis, MO 63146, USA. - - 2013
Compounding pharmacies serve a critical role in modern health care to meet special patient care needs. Although the US Food and Drug Administration (FDA) has clearly delineated jurisdiction over drug companies and products manufactured under Good Manufacturing Practice (GMP) regulations to ensure quality, potency, and purity, compounding pharmacies are regulated ...
Hoot Michelle R MR Torrey Pines Institute of Molecular Studies, Port St Lucie, Florida 34987, - - 2013
Inhibition of Gβγ-subunit signaling to phospholipase C β3 has been shown to potentiate morphine-mediated antinociception while attenuating the development of tolerance and dependence in mice. The objective of this study was to determine the effect of Gβγ-subunit inhibition on antinociception and other pharmacological effects, such as respiratory depression, constipation, and ...
Brand Lucas J LJ Graduate Program in Microbiology, Immunology, and Cancer Biology, University of Minnesota, Minneapolis, MN 55455, - - 2013
The androgen receptor (AR) is a master regulator transcription factor in normal and cancerous prostate cells. Canonical AR activation requires binding of androgen ligand to the AR ligand binding domain, translocation to the nucleus, and transcriptional activation of AR target genes. This regulatory axis is targeted for systemic therapy of ...
Coffin Allison B AB Virginia Merrill Bloedel Hearing Research Center, University of Washington, Box 357923, Seattle, WA 98195, USA. - - 2013
Programmed cell death (PCD) is an important process in development and disease, as it allows the body to rid itself of unwanted or damaged cells. However, PCD pathways can also be activated in otherwise healthy cells. One such case occurs in sensory hair cells of the inner ear following exposure ...
Ratliff Michelle M Department of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, - - 2013
Aged mice exhibit ~ 5-10-fold increases in an ordinarily minor CD21/35(-) CD23(-) mature B-cell subset termed age-associated B cells (ABCs). ABCs from old, but not young, mice induce apoptosis in pro-B cells directly through secretion of TNFα. In addition, aged ABCs, via TNFα, stimulate bone marrow cells to suppress pro-B-cell ...
White Nicole M NM Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, - - 2013
DNA damage and genetic rearrangements are hallmarks of cancer. However, gene fusions as driver mutations in cancer have classically been a distinction in leukemia and other rare instances until recently with the discovery of gene fusion events occurring in 50 to 75% of prostate cancer patients. The discovery of the ...
Zhang Wenyu W Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061, - - 2013
We report branched peptide boronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46 656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.
Schoenemann Spruce W - - 2013
The absence of an agreed-upon δ(17) O value for the primary reference water SLAP leads to significant discrepancies in the reported values of δ(17) O and the parameter (17) O(excess) . The accuracy of δ(17) O and (17) O(excess) values is significantly improved if the measurements are normalized using a ...
Ibrahim Hany - - 2013
Indolone-N-oxide derivatives possess interesting biological properties. The analysis of these compounds using mass spectrometry (MS) may lead to interference or under-estimation due to the tendency of the N-oxides to lose oxygen. All the previous works focused only on the temperature of the heated parts (vaporizer and ion-transfer tube) of the ...
Martínez-Jarquín Sandra - - 2013
The direct detection of organic molecules by mass spectrometry requires ionization methods which are compatible with ambient conditions. A relatively new strategy is the use of a free low-temperature plasma beam for ionization. The objective is to design a safe and adjustable plasma beam to enable optimal ionization and desorption ...
Bernasconi Stefano M - - 2013
The measurement of the abundances of minor isotopologues by mass spectrometry requires correction of subtle non-linearities in the mass spectrometer that cause deviations in the relationship between actual and measured isotope ratios. Here we show that negative backgrounds on the Faraday cups recording the minor ion beams are the cause ...
Leefmann Tim - - 2013
Over the last decade, the high lateral resolution and imaging capabilities of time-of-flight secondary ion mass spectrometry (ToF-SIMS) have increasingly stimulated interest in studying organic molecules in complex environmental materials. However, unlike with the established mass spectrometric techniques, the use of ToF-SIMS in the biogeosciences is still hampered by a ...
Cardenas-Valencia Andres M - - 2013
In situ analytical techniques that require the storage and delivery of reagents (e.g., acidic or basic solutions) have inherent durability limitations. The reagentless electrolytic technique for pH modification presented here was developed primarily to ease and to extend the longevity of dissolved inorganic carbon (DIC) determinations in seawater, but can ...
de la Iglesia P - - 2013
Gymnodimines (GYMs) are fast-acting toxins that belong to the cyclic imine group, a subclass of lipophilic marine toxins. GYMs are considered to be emerging toxins but have not yet been linked to incidents of human poisoning, Limited knowledge on the metabolism of GYMs means that a proper risk assessment has ...
Ren Xinxin - - 2013
With the rapid development of ambient mass spectrometry, the hybrid laser-based ambient ionization methods which can generate multiply charged ions of large biomolecules and also characterize small molecules with good signal-to-noise in both positive and negative ion modes are of particular interest. An ambient ionization method termed high-voltage-assisted laser desorption ...
Pellati Federica - - 2013
The essential oil of Rosa damascena Mill. is known for its fine perfumery application, use in cosmetic preparations and for several pharmacological activities. Due to its high value, it can be easily adulterated with flavors or cheaper oils. This study is aimed at a detailed phytochemical characterization of commercial samples ...
Jagtap Pratik P Minnesota Supercomputing Institute, Minneapolis, MN, USA. - - 2013
Large databases (>10(6) sequences) used in metaproteomic and proteogenomic studies present challenges in matching peptide sequences to MS/MS data using database-search programs. Most notably, strict filtering to avoid false-positive matches leads to more false negatives, thus constraining the number of peptide matches. To address this challenge, we developed a two-step ...
Lamichhane Rajan R Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, - - 2013
DNA polymerases replicate DNA by catalyzing the template-directed polymerization of deoxynucleoside triphosphate (dNTP) substrates onto the 3' end of a growing DNA primer strand. Many DNA polymerases also possess a separate 3'-5' exonuclease activity that is used to remove misincorporated nucleotides from the nascent DNA (proofreading). The polymerase (pol) and ...
Salles Marie-Josèphe - - 2013
D2/D3 dopamine receptors (D2R/D3R) agonists regulate Akt, but their effects display a complex time-course. In addition, the respective roles of D2R and D3R are not defined and downstream targets remain poorly characterized, especially in vivo. These issues were addressed here for D3R. Systemic administration of quinelorane, a D2R/D3R agonist, transiently ...
Candelario Kate M KM Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131-0001, - - 2013
Neural stem/progenitor cells (NSPCs) are multipotent cells within the embryonic and adult brain that give rise to both neuronal and glial cell lineages. Maintenance of NSPC multipotency is promoted by low oxygen tension, although the metabolic underpinnings of this trait have not been described. In this study, we investigated the ...
Barreca Maria Letizia ML Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Farmaceutica II, Università degli Studi di Perugia, Via del Liceo 1, 06123 Perugia, Italy. - - 2013
The NS5B RNA-dependent RNA polymerase is an attractive target for the development of novel and selective inhibitors of hepatitis C virus replication. To identify novel structural hits as anti-HCV agents, we performed structure-based virtual screening of our in-house library followed by rational drug design, organic synthesis, and biological testing. These ...
Guillebastre Bastien B Department of Physical Exercise, University of Savoie, Le Bourget-du-Lac, 73376 Le Bourget du Lac, - - 2013
The aim of this study was to examine the relationships between lower limb muscular deficiencies and postural and gait capacities. Observational study. A total of 26 patients with Charcot-Marie-Tooth disease and 19 health-matched healthy subjects. Barefoot gait and postural control were analysed using a walking mat and a force platform, ...
Lu Yu-Yu - - 2013
ABSTRACT: A 49-year-old man was brought to our hospital because of lethargy. His medical history was hydrocephalus with ventriculoperitoneal shunt initially. The ventriculoperitoneal shunt was replaced several times owing to malfunction, and it was later replaced with a right-sided ventriculopleural shunt. The chest radiograph revealed a mass at the right ...
Lee Pyng - - 2013
Pleuroscopy provides a window to the pleural space while enabling biopsy of the parietal pleura under direct visual guidance for effusions of unknown etiology, guided chest tube placement, and pleurodesis for recurrent pleural effusions or pneumothoraces in selected patients. The procedure enjoyed resurgence when thoracic surgeons introduced the technique for ...
Pacheva I - - 2013
The International Classification of Headache Disorders (ICHD-II) - 2004 recognises many migraine variants (different from migraine without aura and migraine with typical aura), but acute confusional migraine (ACM) remains unclassified and most clinicians are not well acquainted with it. The aim of this study was to illustrate ACM in the ...
Tenoever Benjamin R - - 2013
Gene silencing by small RNAs (sRNAs) occurs in all three domains of life. In recent years, our appreciation of the diverse functions of sRNAs has increased, and we have identified roles for these RNAs in cellular differentiation, fitness and pathogen defence. Interestingly, although plants, nematodes and arthropods use sRNAs to ...
Prado Vania F - - 2013
Acetylcholine, the first chemical to be identified as a neurotransmitter, is packed in synaptic vesicles by the activity of VAChT (vesicular acetylcholine transporter). A decrease in VAChT expression has been reported in a number of diseases, and this has consequences for the amount of acetylcholine loaded in synaptic vesicles as ...
Napoli Anthony M - - 2013
: Epidemiological studies have demonstrated racial disparities in the workup of emergency department patients with chest pain and the referral of admitted patients for intervention. However, little is known about possible disparities in stress test utilization in low-risk chest pain patients admitted to emergency department chest pain units. : A ...
- - 2013
A short-cut review was carried out to establish whether CT pulmonary angiography (CTPA) or ventilation-perfusion (VQ) scanning offer advantages in imaging the pregnant woman with a possible deep vein thrombosis. A total of 80 papers was found using the reported search, of which four represented the best evidence to answer ...
Erb Christopher T - - 2013
Primary pleural tumors other than mesothelioma account for fewer than 1% of all lung cancers, and consequently they pose diagnostic and management challenges. Their treatment must be targeted toward the specific tumor type and is often quite different from the treatment for mesothelioma or metastases. Despite the best efforts at ...
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