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Results 301 - 350 of 3474
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Sun Huiqing - - 2013
The members of high-temperature requirement (HtrA) family are evolutionarily conserved serine proteases that combine a trypsin-like protease domain with at least one PDZ interaction domain. HtrA2, a special one, is mainly located in mitochondria and required for maintaining homeostasis. Once released into cytoplasm, HtrA2 contributes to apoptosis via caspase-dependent and ...
Teramoto Koji - - 2013
PURPOSE: Simultaneous activation of T helper 1 (Th1) cell function has crucial roles in induction of potent cytotoxic T lymphocyte (CTL) responses in cancer immunotherapy. Here, we investigated whether dendritic cell (DC)-based vaccines loaded with both tumor-associated antigen (TAA)-derived MHC class I and pan-MHC class II peptides could elicit more ...
Borowiak Robert - - 2013
OBJECT: The design of a multinuclear low-field NMR unit with variable field strength <6 mT providing accurate spin manipulations and sufficient sensitivity for direct detection of samples in thermal equilibrium to aid parahydrogen-based hyperpolarization experiments. MATERIALS AND METHODS: An optimized, resistive magnet connected to a battery or wall-power driven current source ...
Di Bella Giuseppa - - 2013
Our study was carried out on two species of clams, Venerupis aurea laeta and Cerastoderma edule glaucum, from Ganzirri Lake considered as "environmental biomarkers" for their changes in physiology, morphology or distribution under the influence of substances in the environment. The aim of the present study was to conduct a ...
Yang Chongyin - - 2013
Nanostrcutured particles and polycrystalline thin films of Sn-doped chalcopyrite are synthesized by newly-developed methods. Surprisingly, Sn doping introduces a narrow partially filled intermediate band (IB) located ~1.7 eV (CuGaS(2)) and ~0.8 eV (CuInS(2)) above the valance band maximum in the forbidden band gap. Diffuse reflection spectra and photoluminescence spectra reveal extra absorption ...
Yunker W K - - 2013
PURPOSE: Our institution routinely utilizes needle core biopsy (NCB), instead of fine needle aspiration, in the evaluation of pediatric thyroid nodules. This practice initially arose from limited cytopathology services in our hospital. Given the lack of information regarding the utility of NCB in diagnosing pediatric thyroid neoplasms, we set out ...
Cannon C M - - 2013
We evaluated the effect of Aurora kinase inhibitors AZD1152 and VX680 on canine osteosarcoma cells. Cytotoxicity was seen in all four cell lines; however, half-maximal inhibitory concentrations were significantly higher than in human leukaemia and canine lymphoma cells. AZD1152 reduced Aurora kinase B phosphorylation, indicating resistance was not because of ...
Narang Jagriti - - 2013
A method is described for the construction of a highly sensitive amperometric sensor for the detection of tyrosine, employing a magnetic nanoparticles-zinc oxide/zinc hexacyanoferrate (Fe(3)O(4)NP-ZnO/ZnHCF) hybrid film electrodeposited on the surface of a Pt electrode as working electrode. The sensor is based on electrocatalytic mechanism initiated by electrochemical oxidation of ...
García-Perdomo Herney Andrés - - 2013
OBJECTIVE: To establish the efficacy of antibiotic prophylaxis prior to cystoscopy in outpatients in decreasing the incidence of post-procedure urinary tract infection. STUDY DESIGN AND SETTING: A randomized clinical trial in patients (men and women) older than 18 who underwent cystoscopy for any non-urgent indication. The intervention was Levofloxacin 500 mg ...
Blomberg Björn A - - 2013
INTRODUCTION: Advances in positron emission tomography (PET) imaging have provided opportunities to develop radiotracers specific for imaging insulin-producing pancreatic β-cells. However, a host of lingering questions should be addressed before these radiotracers are advocated for noninvasive quantification of β-cell mass (BCM) in vivo in the native pancreas. METHOD: We provide ...
Bahena I - - 2013
Summary In a previous study, we have identified a set of conserved spermatogenic genes whose expression is restricted to testis and ovary and that are developmentally regulated. One of these genes, the transcription factor Mael, has been reported to play an essential role in mouse spermatogenesis. Nevertheless, the role of ...
Kato Takashi - - 2013
Bone marrow cell infusion (BMI) has recently been suggested as an effective therapy for refractory liver disease; however, the efficiency of BMI using canine bone marrow cells (cBMCs) has not been reported. We evaluated the accumulation potential of cBMCs in a mouse model of acute liver failure. Acute hepatitis was ...
Tyler Frances - - 2013
ABSTRACT: BACKGROUND: Post-mating interactions between the reproductive traits and gametes of mating individuals and among their genes within zygotes are invariably complex, providing multiple opportunities for reproduction to go awry. These interactions have the potential to act as barriers to gene flow between species, and may be important in the ...
Kaye Alan David - - 2013
Electrophysiological abnormalities of the QT interval of the standard electrocardiogram are not uncommon. Congenital long QT syndrome is due to mutations of several possible genes (genotype) that result in prolongation of the corrected QT interval (phenotype). Abnormalities of the QT interval can be acquired and are often drug-induced. Torsades de ...
Botteri Edoardo - - 2013
The impact of breast surgery on survival of metastatic breast cancer (MBC) patients is controversial. We addressed the question in a mono-institutional series of MBC patients with synchronous bone metastases. We identified 187 consecutive women diagnosed between 2000 and 2008 with locally operable (T1-T3) MBC, synchronous bone metastases, with no ...
Van Nguyen Huy - - 2013
Risks for HIV infection remain unknown in male street laborers. This research investigates patterns of self-reported risk behaviors among these men in urban Vietnam. In a cross-sectional survey using a social mapping technique, 450 men, mostly low-skilled and unregistered migrant laborers across 13 districts in Hanoi were approached for interviews. ...
Broadhouse Kathryn M - - 2013
Patent ductus arteriosus (PDA) remains common in preterm newborns, but uncertainty over optimal management is perpetuated by clinicians' inability to quantify its true haemodynamic impact. Our aim was to develop a technique to quantify ductal shunt volume and the effect of PDA on systemic blood flow volume in neonates. Phase ...
Cehreli Cavit - - 2013
Chronic basophilic leukemia (CBL) is an extremely rare disorder. A female patient presented with recurrent attacks of chills, fever and abdominal pain was found to have simultaneous cyclic oscillation in leukocyte counts and C-reactive protein values. She was initially diagnosed with familial Mediterranean fever and treated with colchicine. Diagnosis of ...
Skare Thelma L - - 2013
Recently, it has been found that some lupus patients may have anti-cyclic citrullinated peptide antibodies (anti-CCP), although the clinical significance of such finding is not well established. Systemic lupus erythematosus (SLE) patients may have joint complaints that are very similar to those observed in rheumatoid arthritis (RA). In early stages ...
Vermeulen Nicolas - - 2013
In the present experiments, participants had to verify properties of concepts but, depending on the trial condition, concept-property pairs were presented via headphones or on the screen. The results showed that participants took longer and were less accurate at verifying conceptual properties when the channel used to present the CONCEPT-property ...
Triantos Christos - - 2013
Chronic hepatitis C (CHC) and iron overload are the main causes of liver disease in β-thalassemia major (βTM). There is limited data regarding the course of CHC in this population. All patients (n = 144) from the thalassemia centre of the University Hospital of Patras were evaluated (January 1981 to June 2012). ...
Childs Andrew M - - 2013
A quantum walk is a time-homogeneous quantum-mechanical process on a graph defined by analogy to classical random walk. The quantum walker is a particle that moves from a given vertex to adjacent vertices in quantum superposition. We consider a generalization to interacting systems with more than one walker, such as ...
Pelagio-Flores Ramón - - 2013
The control of cell division by growth regulators is critical to proper shoot and root development. Alkamides belong to a class of small lipid amides involved in plant morphogenetic processes, from which N-isobutyl decanamide is one of the most active compounds identified. This work describes the isolation and characterization of ...
Virmani Jitendra - - 2013
Characterization of hepatocellular carcinomas (HCCs) and metastatic carcinomas (METs) from B-mode ultrasound presents a daunting challenge for radiologists due to their highly overlapping appearances. The differential diagnosis between HCCs and METs is often carried out by observing the texture of regions inside the lesion and the texture of background liver ...
Tan Louisa - - 2013
Background: Well-being in persons with dementia (PWD) depends much on the quality and type of care received. The Dementia Management Strategies Scale (DMSS) is a useful instrument to appraise care styles of caregivers. The present study expanded on previous research by refining and establishing the scale's content validity and psychometric ...
Wada Keiko - - 2013
Abstract Osteopetrosis is a rare genetic disorder characterized by increased bone mineral density (BMD) due to osteoclast failure. T-cell immune regulator 1 (TCIRG1) plays crucial roles on osteoclast function, and its mutation causes autosomal recessive osteopetorosis. However, mutations in TCIRG1 have never been identified in autosomal dominant osteopetrosis (ADO). A ...
Cho Eunae - - 2013
Iron is an essential nutrient for nitrogen-fixing legume root nodules, and the chelation of ferrous iron plays an important role in the mobility and availability of iron to the legume. In the present study, we investigated the iron-binding properties of low-molecular weight succinoglycans isolated from the nitrogen-fixing bacterium, Sinorhizobium meliloti. ...
van de Waterbeemd Bas - - 2013
At present only vaccines containing outer membrane vesicles (OMV) have successfully stopped Neisseria meningitidis serogroup B epidemics. These vaccines however require detergent-extraction to remove endotoxin, which changes immunogenicity and causes production difficulties. To investigate this in more detail, the protein content of detergent-extracted OMV is compared with two detergent-free alternatives. ...
Yoshida Yusaku - - 2013
PURPOSE: To report the 2-year results of reduced-fluence photodynamic therapy (RF-PDT) combined with intravitreal ranibizumab (IVR) for typical age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV). METHODS: Twenty-four previously untreated eyes of 23 AMD patients with decimal best-corrected visual acuity (BCVA) of less than 0.7 received the combined therapy, ...
Xu Shuai - - 2013
An exquisitely structured CPP consisting of a self-supported POM-Zn(ii) coordination polymer as the shell and a Fe(3)O(4) cluster as the core was synthesized, which could be fabricated as a supercapacitive film electrode showing prominent electrochemical activities for enormous energy storage.
Karpman D - - 2013
The endothelium lining the vascular lumen is continuously exposed to complement from the circulation. When erroneously activated on host cells, complement may generate a deleterious effect on the vascular wall leading to endothelial injury, exposure of the subendothelial matrix and platelet activation.In this review the contribution of complement activation to ...
Bhalla Vandana - - 2013
The binding behavior of nanoaggregates of pentacenequinone derivative having thiophene groups has been investigated toward various cations (Fe(3+), Fe(2+), Pd(2+), Mg(2+), Cd(2+), Hg(2+), Ni(2+), Zn(2+), Cu(2+), Pb(2+), Co(2+), K(+), Na(+) and Li(+)) using UV-vis and fluorescence spectroscopy. Among the various cations tested, nanoaggregates of compound show a selective and sensitive ...
Schuh P - - 2013
In accidents resulting in severe injuries, a clinical forensic examination is generally abandoned in the initial phase due to high-priority clinical needs. However, in many cases, data from clinical computed tomography (CT) examinations are available. The goals of this prospective study were (a) to evaluate clinical CT data as a ...
Azuma Kentaro - - 2013
Regulatory convergence in safety reporting requirements for medical device clinical trials has not yet been achieved. The Global Harmonization Task Force (GHTF) issued new guidance, GHTF/SG5/N5, on this topic in August 2012. First, we compared current reporting requirements for drug and medical devices in Japan with the international guidelines International ...
Ruiz-Ibán Miguel A - - 2013
PURPOSE: Pectoralis major transfer is indicated for irreparable subscapularis tendon tears. One surgical option is transferring the sternal part of the pectoralis major to the humeral insertion of the subscapularis under the conjoined tendon of the coracobrachialis and biceps muscles. The purpose of this study is to define the anatomical ...
Stuart Lynda M LM Developmental Immunology/CCIB, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114, USA. - - 2013
A fundamental question regarding any immune system is how it can discriminate between pathogens and non-pathogens. Here, we discuss how this discrimination can be mediated by a surveillance system distinct from pattern-recognition receptors that recognize conserved microbial patterns. It can be based instead on the ability of the host to ...
Pooler Amy M - - 2013
Propagation of tau pathology is linked with progressive neurodegeneration, but the mechanism underlying trans-synaptic spread of tau is unknown. We show that stimulation of neuronal activity, or AMPA receptor activation, induces tau release from healthy, mature cortical neurons. Notably, phosphorylation of extracellular tau appears reduced in comparison with intracellular tau. ...
Coyle V J - - 2013
The purpose of this retrospective study was to describe the biological behaviour of canine mandibular osteosarcoma (OSA) and to examine factors for their impact on metastasis-free interval (MFI) and survival time (ST). Records from dogs treated with mandibulectomy for OSA (1999-2007) were reviewed. Archived tumour samples were evaluated for mitotic ...
Ogden Ruth S - - 2013
Previous research suggests that feelings of fear, dislike, shame and sadness affect our perception of duration (Droit-Volet et al., 2004; Gil et al., 2009). The current study sought to expand our understanding of the variables which moderate temporal perception by examining whether the attractiveness of a face influenced its perceived ...
Alves Cresio - - 2013
Abstract Pseudohypoparathyroidism type Ia (PHP Ia) is a rare disease characterized by an elevated parathyroid hormone due to the resistance to its action in target tissues. We report a new GNAS mutation causing PHP Ia and an atypical early-onset primary hypothyroidism. A 3-year-old boy was diagnosed with obesity, delayed pyschomotor ...
Melis M H M MH Targeted Therapy, Institute of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, - - 2013
Effective anticancer treatments often result in the induction of large amounts of tumour cell death. In vivo, such dying tumour cells are a potential source of antigens for T-cell stimulation. Although apoptosis is generally considered nonimmunogenic, recent evidence suggests that some anticancer therapies that induce apoptosis can elicit antitumour immune ...
Anwar-Mohamed Anwar - - 2013
Abstract 1. Arsenic (As(III)) toxicity has received increasing attention as human exposure to arsenic is associated with pulmonary, hepatic and renal toxicities. Therefore, in the present study, we investigated the effect of acute As(III) treatment on pulmonary, hepatic and renal cytochrome (CYP) P450-mediated arachidonic acid metabolism. 2. Our results demonstrated that acute ...
Kühn Tilman - - 2013
Recent meta-analyses have confirmed that fish consumption is related to decreased risks of ischaemic stroke and fatal CHD, while there seem to be no clear associations between fish consumption and the risks of haemorrhagic stroke and non-fatal CHD. As no studies in German populations have been reported to date, we ...
García-Pérez Miguel A - - 2013
Parallel tests are needed so that alternate forms can be applied to different groups or on different occasions, but also in the context of split-half reliability estimation for a given test. Statistically, parallelism holds beyond reasonable doubt when the null hypotheses of equality of observed means and variances across the ...
Tarasova Nadezhda - - 2013
A new type of plant-derived signal molecules that activate extracellular pectate lyase activity in phytopathogenic bacterium Pectobacterium atrosepticum SCRI1043 was revealed. These compounds were characterized and partially purified by means of several approaches including RT-PCR analysis, luminescence bioassay and HPLC fractionation. They were smaller than 1 kDa, thermoresistant, nonproteinaceous, hydrophilic, and ...
Zhou Li-Jun - - 2013
The objective of this study was to screen the occurrence of 50 antibiotics in a typical swine farm in southern China, which includes animal feeds, waste collection and treatment systems (lagoons and anaerobic digesters), and receiving environments (vegetable fields, streams, and private wells). Nine antibiotics were found in the feeds ...
Saxena Anita - - 2013
OBJECTIVE: To determine outcome of children receiving carvedilol in addition to other standard drug therapy for treatment of dilated cardiomyopathy. METHODS: Children receiving carvedilol for treatment of dilated cardiomyopathy with moderate to severe ventricular dysfunction were included into the study. Data on history, clinical examination and investigations were obtained and ...
Wu Yen-Hsun YH Department of Kinesiology, Rec.Hall-267, The Pennsylvania State University, University Park, PA 16802, - - 2013
We studied the effects of a single practice session of a variable task with subject-specific adjustments of task difficulty (instability) on indices of multi-finger coordination in young and elderly persons. The main hypothesis was that practicing such a task would lead to contrasting changes in the amounts of two components ...
Surdutovich Eugene - - 2013
Radiation damage following the ionising radiation of tissue has different scenarios and mechanisms depending on the projectiles or radiation modality. We investigate the radiation damage effects due to shock waves produced by ions. We analyse the strength of the shock wave capable of directly producing DNA strand breaks and, depending ...
Veurink Marieke - - 2013
PURPOSE: To investigate the mechanism behind the aggregation breaking properties of dexamethasone phosphate and related corticosteroids on the IgG1 antibody bevacizumab (Avastin®). METHODS: An in silico 3D dimer model is developed to identify the bevacizumab-bevacizumab interface, and different corticosteroids are docked onto the model to distinguish preferred binding sites. In ...
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