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Blomberg Björn A - - 2013
INTRODUCTION: Advances in positron emission tomography (PET) imaging have provided opportunities to develop radiotracers specific for imaging insulin-producing pancreatic β-cells. However, a host of lingering questions should be addressed before these radiotracers are advocated for noninvasive quantification of β-cell mass (BCM) in vivo in the native pancreas. METHOD: We provide ...
Bahena I - - 2013
Summary In a previous study, we have identified a set of conserved spermatogenic genes whose expression is restricted to testis and ovary and that are developmentally regulated. One of these genes, the transcription factor Mael, has been reported to play an essential role in mouse spermatogenesis. Nevertheless, the role of ...
Meyers Marc André - - 2013
Spider silk is extraordinarily strong, mollusk shells and bone are tough, and porcupine quills and feathers resist buckling. How are these notable properties achieved? The building blocks of the materials listed above are primarily minerals and biopolymers, mostly in combination; the first weak in tension and the second weak in ...
Wahle Elmar - - 2013
Abstract Asymmetric dimethylation of arginine side chains in proteins is a frequent post-translational modification, catalyzed by type I protein arginine methyltransferases (PRMTs). This article summarizes what is known about this modification in the nuclear poly(A) binding protein (PABPN1). PABPN1 contains thirteen dimethylated arginine residues in its C-terminal domain. Three enzymes, ...
Geybels Milan S - - 2013
PURPOSE: Tea and coffee contain bioactive compounds and both beverages have recently been associated with a reduced risk of prostate cancer (PCa). METHODS: We studied associations of tea and coffee consumption with PCa risk in a population-based case-control study from King County, Washington, USA. Prostate cancer cases were diagnosed in ...
Flechl Birgit - - 2013
Glioblastoma multiforme (GBM) still harbors a fatal prognosis. The involvement of the neurocognition and psyche poses unique challenges for care provision by relatives. We lack data about the caregivers' perspective on the end-of-life (EOL) phase of GBM patients to improve counseling and support. In this study we investigated the experiences ...
Oh Byong Sun - - 2013
ABSTRACT: BACKGROUND: Accumulating evidence indicates that components of the systemic inflammatory response, such as C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR), have been associated with prognosis of various cancers. We aimed to elucidate whether CRP and NLR could serve as potential surrogate markers for response and survival in patients with ...
Miyazaki Takuro - - 2013
A rare case of a patient with primary adenocarcinoma of the middle lobe bronchus that was successfully treated with rigid bronchoscopy followed by middle sleeve lobectomy is reported. The patient was a 75-year-old man who presented with low-grade fever and cough. Chest computed tomography showed obstructive pneumonia of the lower ...
Silva Sílvia A - - 2013
OBJECTIVES: The main goal of this study is to explore what is meant by "quality of care" (QoC) by both health professionals and patients. This research also intends to compare the perspectives of nurses, doctors and patients in order to understand whether these different actors share similar views on what ...
Ward-Ciesielski Erin F - - 2013
This open trial sought to develop and evaluate the preliminary feasibility and effectiveness of a brief, one-time, dialectical behavior therapy skills-based intervention with specific focus on ensuring acceptability to nontreatment-seekers. Treatment-seeking and nontreatment-seeking suicidal individuals were recruited successfully from the community. Both groups found the intervention valuable. Suicide ideation was ...
Farrow N - - 2013
Genetic therapies for cystic fibrosis (CF) must be assessed for safety and efficacy, so testing in a non-human primate (NHP) model is invaluable. In this pilot study we determined if the conducting airways of marmosets (n = 2) could be transduced using an airway pre-treatment followed by an intratracheal bolus ...
Garcia Sandra N - - 2013
Cytotoxicity measurements are often performed to evaluate the biocompatibility of medical device materials. Here, we describe the use of a real-time cell analyzer (RTCA) system for the investigation of biocompatibility of medical devices by comparing RTCA results to two distinct methods described in the International Organization for Standardization (ISO) guidelines. ...
Bosetti Michela - - 2013
The importance of the complex interrelated regulatory pathways involving IGF factors and pancreatic hormones can be observed in several metabolic diseases, where the deregulation of these factors has a wide impact on bone health. These findings have stimulated us to compare the effect of IGF-I, IGF-II, insulin and preptin on ...
Alekseyev Aleksey B - - 2013
The multireference spin-orbit (SO) configuration interaction (CI) method in its Λ-S contracted SO-CI version is employed to calculate two-dimensional potential energy surfaces for the ground and low-lying excited states of CF(3)I relevant to its photodissociation in the lowest absorption band (A band). The computed equilibrium geometry for the X[combining tilde]A(1) ...
Matar Hosam E - - 2013
PURPOSE: The purpose of this study was to assess the value of SPECT/CT imaging in patients with chronic spinal pain. METHODS: This was a retrospective consecutive study. Patients with chronic neck or back pain from outpatient spinal clinics with clinical features raising the possibility of a facetogenic pain generator and ...
Kudlicka Aleksandra - - 2013
Executive functioning is frequently impaired among people with Parkinson's disease (PD). Little is known about awareness of executive functioning, in the sense of being able to accurately appraise functioning or performance, in people with PD, or about whether awareness is particularly affected in those who have impaired executive functioning. This ...
Schaller Benoît - - 2013
The broad resonances underlying the entire (1) H NMR spectrum of the brain, ascribed to macromolecules, can influence metabolite quantification. At the intermediate field strength of 3 T, distinct approaches for the determination of the macromolecule signal, previously used at either 1.5 or 7 T and higher, may become equivalent. The aim ...
Oró-Solé Judith - - 2013
The correlated anion order in the oxynitride perovskite NdVO(2)N, where disordered zig-zag VN chains segregate into planes within a pseudo-cubic lattice, is similar to that in materials such as SrTaO(2)N containing d(0) transition metal cations. However, NdVO(2)N has 3d(1) V(4+) cations and the 3d-electrons are itinerant, showing that the anion ...
Ghasemipour Yadollah - - 2013
This study examined how mindfulness and integrative self-knowledge were related to health-related issues. Men in general population (n = 103) and coronary heart disease samples (n = 101) completed the Mindful Attention Awareness Scale, the Integrative Self-knowledge Scale, the Type 2 subscale of the Interpersonal Reactions Inventory, the Perceived Stress Scale, and the Anxiety ...
Igari Kimihiro - - 2013
Purpose: To determine the influence of the abdominal aortic aneurysm (AAA) anatomy on the clinical outcomes after endovascular AAA repair (EVAR). Methods: Between January 2008 and December 2010, 53 patients underwent EVAR. The parameters outside of the device instructions for use (IFU) were: short neck length (<15 mm), proximal neck ...
Pfandler Edina - - 2013
This study explored children's development in comprehending four types of pointing gestures with different familiarity. Our aim was to highlight human infants' pointing comprehension abilities under the same conditions used for various animal species. Sixteen children were tested longitudinally in a two-choice task from 1 year of age. At the age ...
Licina Derek - - 2013
BACKGROUND: United States foreign policy is tied extensively to health initiatives, many related to the use of military assets. Despite substantial resource investment by the US Department of Defense (DoD) in hospital ship humanitarian assistance and disaster response missions, the impact of this investment is unclear. METHODS: A systematic literature ...
Purdy T P - - 2013
The quantum mechanics of position measurement of a macroscopic object is typically inaccessible because of strong coupling to the environment and classical noise. In this work, we monitor a mechanical resonator subject to an increasingly strong continuous position measurement and observe a quantum mechanical back-action force that rises in accordance ...
Golbar Hossain M - - 2013
Histopathologically, fibrosis in Fasciola-infected cattle livers was characterized by inflammatory cell infiltration such as eosinophils and macrophages, pseudo-lobule, pseudo-bile ducts and fibrotic bridges separating pseudo-lobules; the fibrotic lesions were developed in the Glisson's sheath. Pseudo-bile ducts consisting of epithelial cells reacted clearly to cytokeratin (CK) 19, indicating cholangiocyte origin. Immunophenotypes ...
Zarei Mina - - 2013
The H-NS chromosome-organizing protein in E. coli can stabilize genomic DNA loops, and form oligomeric structures connected to repression of gene expression. Motivated by the link between chromosome organization, protein binding and gene expression, we analyzed publicly available genomic data sets of various origins, from genome-wide protein binding profiles to ...
Thurtell Matthew J - - 2013
Patients with idiopathic intracranial hypertension (IIH) frequently have coexisting obstructive sleep apnea (OSA). We aimed to determine if the prevalence and severity of OSA is greater in patients with IIH than would be expected, given their other risk factors for OSA. We included 24 patients (20 women, four men) with ...
Silva Rodrigo - - 2013
Several studies have sought to understand the health effects of occupational exposure to cosmic radiation. However, only few biologic markers or associations with disease outcomes have so far been identified. In the present study, 22 long- and 26 medium-haul male Portuguese airline pilots and 36 factory workers who did not ...
Karihtala Peeter - - 2013
In epithelial-to-mesenchymal transition (EMT) epithelial cancer cells achieve mesenchymal features, essentially helping them to metastasize. There is some evidence that EMT could be increased in triple-negative (TNBC) or basal-like breast cancers, although more precise mechanisms considering e.g. EMT-regulating transcription factors are largely unknown. We assessed immunohistochemically vimentin (separately in in ...
Choo Wai Kah - - 2013
We present a case of cardiac sarcoidosis of insidious onset mimicking arrhythmogenic right ventricular cardiomyopathy. Our patient initially presented with systemic sarcoidosis but later developed palpitations. The similarity in clinical presentation and cardiac magnetic resonance findings in both conditions posed a challenge in differentiating between the two in the absence ...
Putman S - - 2013
We report a case of a 21-year-old male with massive hypertrophic ischial tuberosity non-union. Among multiple other lesions, the patient suffered an open avulsion of the ischial tuberosity in a severe traffic accident in adolescence. A conservative treatment was decided for the avulsion. Because of sciatic pain and difficulties while ...
Wood Frances O - - 2013
There is no consensus on the best management of coronary artery aneurysms (CAA) in adults. We describe two patients with CAA and review transcatheter approaches to exclude them from the circulation. © 2013 Wiley Periodicals, Inc.
Karlsson Oskar - - 2013
The cyanobacterial toxin β-N-methylamino-L-alanine (BMAA) is suggested to play a role in neurodegenerative disease. We have previously shown that although the selective uptake of BMAA in the rodent neonatal striatum does not cause neuronal cell death, exposure during the neonatal development leads to cognitive impairments in adult rats. The aim ...
Wang Hui - - 2013
Ubiquitin-specific protease 22 (USP22), a novel deubiquitinating enzyme, has been associated with metastasis, therapy resistance, and cell cycle progression. The purpose of this study was to investigate the expression level of USP22 in papillary thyroid carcinoma (PTC) samples and to evaluate its clinical significance in PTC patients. USP22 expression was ...
Smith Gregory N - - 2013
Concentration dependent aggregation of two surfactants, anionic sodium dioctylsulfosuccinate (Aerosol OT or AOT) and nonionic pentaethylene glycol monododecyl ether (C12E5), has been studied in cyclohexane-D12 using small-angle neutron scattering (SANS). A clear monomer to aggregate transition has been observed for both surfactants, spherical inverse micelles for AOT and hank-like micelles ...
Nguyen Kong Thong - - 2013
Protein methyltransferases (PMTs) are a novel gene family of therapeutic relevance involved in chromatin-mediated signaling and other biological mechanisms. Most PMTs are organized around the structurally conserved SET domain that catalyzes the methylation of a substrate lysine. A few potent chemical inhibitors compete with the protein substrate, and all are ...
Sezai Akira - - 2013
Purpose: Recently, coronary atrial bypass grafting (CABG) for dialysis patients increase, but the mortality is still high. Additionally, many patients show major adverse cardiovascular and cerebrovascular event (MACCE) after discharge and long-term results are not satisfactory. Methods: Ninety patients underwent CABG for dialysis patients. Logistic regression analysis was conducted using ...
Crowther Mark A - - 2013
Medical thromboprophylaxis reduces venous thromboembolism (VTE), while causing bleeding. Routine application of pharmacological VTE prophylaxis to low risk medical patients is likely to cause net harm; as a result only moderate or high risk patients should be exposed to VTE prophylaxis. To avoid unneeded exposure to VTE prophylaxis health care ...
Knight Kelly R - - 2013
Episodic (less than weekly) drug use and binge drinking increase HIV-related sexual risk behaviors among men who have sex with men (MSM), yet no evidence-based interventions exist for these men. We describe an adaptation process of the Personalized Cognitive Counseling (PCC) intervention for utilization with high-risk, HIV-negative episodic, substance-using MSM. ...
Moret Séverine - - 2013
In water, spin-lattice relaxation times (T(1)) and calibration curves for chemical shifts have been determined for the (13)C and the (1)H(C) atoms in HCOOH, HCOONa, CO(2), Na(2)CO(3) and NaHCO(3) by NMR spectroscopy. These data facilitate kinetic and mechanistic studies for H(2) storage/delivery in the carbon dioxide-formic acid systems under H(2) ...
Wu Lili - - 2013
Abstract Aims and objectives. The aim is to determine the efficacy of internal and external biliary drainage (ED) with special reference to the effect of bile acid on intestinal epithelium during experimental biliary obstruction. Methods. A total of 59 male Sprague Dawley rats were randomly assigned to four groups: (I) ...
Powell Philip A - - 2013
Research has shown that feelings of self-disgust may have a functional role in the genesis of depression by partially mediating the cross-sectional relationship between dysfunctional thoughts and depressive symptoms. However, there are many outstanding issues regarding these hypothesised associations. First, it is not yet clear whether self-disgust is a temporal ...
Sunde Jadranka - - 2013
Summary A detailed database on the genealogy of the Makarska region in Croatia has been created. The twinning rate for three villages in the region (Podgora, Tučepi and Brela) were analysed over the period 1870 to 1940 and factors such as mother's age and birth order are discussed. Of the ...
Hines Mary - - 2013
Intramuscular 17 α-hydroxyprogesterone caproate (Makena(®)), a synthetic progestin, is indicated to reduce the risk of preterm birth in women with a singleton pregnancy who have a history of a singleton spontaneous preterm birth. Makena(®) reduces the risk of preterm birth in this patient population, and is associated with improvements in ...
Wu Fen - - 2013
Objective: To explore the association of the methylation status of MGMT and hMLH1 with chromosome damage induced by vinyl chloride monomer (VCM). Materials and Methods: Methylation of MGMT and hMLH1 was measured in 101 VCM-exposed workers by methylation-specific PCR. Chromosome damage in peripheral blood lymphocytes was measured by the cytokinesis-block ...
Veldre K - - 2013
Abstract Flecainide base is pharmaceutically active substance used for production of flecainide acetate which is known in market as Tambacor, Almarytm, Apocard, Ecrinal or Flecaine. It is determined that flecainide base forms four polymorphic forms abbreviated as I(b), II(b), III(b) and IV(b). Flecainide base form I(b) is thermodynamically stable form ...
Li Endan - - 2013
Adult hippocampal neurogenesis is important in mediating hippocampal-dependent learning and memory. Exogenous ghrelin is known to stimulate progenitor cell proliferation in the dentate gyrus of adult hippocampus. The aim of this study was to investigate the role of endogenous ghrelin in regulating the in vivo proliferation and differentiation of the ...
Kasapkara Ciğdem Seher - - 2013
Abstract Patients with glycogen storage disease type I (GSD-I) often have marked hyperlipidemia with abnormal lipoprotein profiles. This metabolic abnormality improves, but is not fully corrected, with dietary therapy; therefore, these patients may be at high risk for the development of atherosclerosis. A recently discussed cardiovascular risk factor, asymmetric dimethylarginine ...
Di Nardo W - - 2013
The purpose of this study was to evaluate the benefits of unilateral cochlear implant (CI) in patients over 60 on speech perception and quality of life, comparing the results obtained with a control group of younger CI recipients. Twenty CI users (mean age 72 years), postlingually deafened, were included in this ...
Sautner Judith - - 2013
Osteoarthritis (OA) is one of the most frequent indications in musculoskeletal imaging because OA is the most prevalent musculoskeletal disease in developed countries. As the population becomes older and older, the need for adequate imaging techniques also increases. The various forms of osteoarthritis are associated with a high degree of ...
Song Jiankang - - 2013
C6-carboxy-cellulose with a carboxylate content of 0.8 mmol g(-1) was obtained by oxidation of once-dried cellulose, using the 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)/NaClO/NaClO(2) system at pH 6.8 and 60 °C for 16 h. This method, with the addition of reagents in the order TEMPO, NaClO and NaClO(2), was 38 h faster than a ...
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