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Karmon Sharon L - - 2013
The integrase enzyme facilitates the incorporation of HIV-1 proviral DNA into the host cell genome and catalyses a function vital to viral replication. Inhibitors of this enzyme represent the newest class of antiretroviral drugs in our armamentarium to treat HIV-1 infection. Raltegravir, an integrase strand transfer inhibitor, was the first ...
Gupta Santosh Kumar - - 2013
The aim of this work was to calculate the radiation absorbed dose to kidneys, liver, spleen, pituitary gland, and neuroendocrine tumors (NETs) of patients treated with (177)Lu-DOTATATE. We enrolled 61 patients (male/female patients, 40/21) with mean age of 48.1 ± 15.3 years affected by different types of NETs diagnosed with ...
Yuan Yong - - 2013
Transforming growth factor-alpha (TGF-α) transduces its signal through the epidermal growth factor receptor and is essential for corneal epithelial homeostasis. Previous studies have demonstrated that overexpression of TGF-α in the developing eye leads to anterior segment dysgenesis. However, the underlying mechanisms remain unclear. Here we examined the effects of TGF-α ...
Kang Jae H - - 2013
To evaluate prediagnostic markers of endothelial dysfunction and inflammatory processes in primary open-angle glaucoma (POAG). Blood samples were collected from 1989 to 1990 in the nurses' health study (women) and from 1993 to 1995 in the health professionals follow-up study (men), and medical-record confirmed incident poag cases were identified (women: ...
Morgan Jessica I W - - 2013
We measured the bleaching and regeneration kinetics of rhodopsin in the living human eye with two-wavelength, wide-field scanning laser ophthalmoscopy (SLO), and investigated the effect of rhodopsin bleaching on autofluorescence intensity. The retina was imaged with an Optos P200C SLO by its reflectance of 532 and 633 nm light, and ...
Banitt Michael R - - 2013
We determined the time lag between loss of retinal ganglion cell function and retinal nerve fiber layer (RNFL) thickness. Glaucoma suspects were followed for at least four years. Patients underwent pattern electroretinography (PERG), optical coherence tomography (OCT) of the RNFL, and standard automated perimetry testing at 6-month intervals. Comparisons were ...
- - 2013
Biliary and pancreatic stents are used in a variety of benign and malignant conditions including strictures and leaks and in the prevention of post-ERCP pancreatitis.Both plastic and metal stents are safe, effective, and easy to use. SEMSs have traditionally been used for inoperable malignant disease. Covered SEMSs are now being ...
Luo Jiing-Chyuan - - 2013
Hemodialysis patients carry a higher risk of peptic ulcer bleeding. Whether hemodialysis patients also have a higher occurrence of nonpeptic ulcer, nonvariceal gastrointestinal bleeding needs further evaluation. Using Taiwan's National Health Insurance research database, the occurrence of nonpeptic ulcer, nonvariceal gastrointestinal bleeding was compared among the hemodialysis patients, chronic kidney ...
Misra Devyani D Boston University School of Medicine, Mass, USA. - - 2013
Osteoarthritis is the most common form of arthritis, with knee osteoarthritis being the leading cause of lower extremity disability among older adults in the US. There are no treatments available to prevent the structural pathology of osteoarthritis. Because of vitamin K's role in regulating skeletal mineralization, it has potential to ...
Cottler Linda B LB Department of Epidemiology, Colleges of Medicine and Public Health and Health Professions, University of Florida, Gainesville, Florida 32611, - - 2013
The prevalence of substance abuse and other psychiatric disorders among physicians is not well-established. We determined differences in lifetime substance use, and abuse/dependence as well as other psychiatric disorders, comparing physicians undergoing monitoring with a general population that had sought treatment for substance use. Participants were 99 physicians referred to ...
Benichou Gilles G Transplantation Research Center, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. - - 2013
After transplantation, recipient T cells can recognize donor antigens either by interacting with MHC class II on donor bone marrow-derived cells (direct allorecognition), or by recognizing allogeneic peptides bound to self-MHC class II molecules on recipient antigen presenting cells (indirect allorecognition). The activation of pro-inflammatory T cells via either of ...
Winter Anke C AC Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass, - - 2013
Previous studies evaluating the association of cardiovascular disease and vascular risk factors with restless legs syndrome showed inconsistent results, especially for the potential relation between various vascular risk factors and restless legs syndrome. We therefore aimed to analyze the relationships between vascular risk factors, prevalent cardiovascular disease, and restless legs ...
Grebe Alena A Institute of Innate Immunity, University Hospitals Bonn, Bonn, Germany. - - 2013
Chronic vascular inflammation is regarded as a crucial aspect of cardiovascular disease. However, the elicitors of this inflammatory response in the vessel wall are currently not well understood. Excessive amounts of cholesterol, an abundant and fundamental lipid molecule in mammalian cells, can initiate the development and progression of atherosclerosis. Accumulation ...
Enestvedt Brintha K BK Division of Gastroenterology and Hepatology, Temple University, Philadelphia, PA, - - 2013
The American Society of Anesthesiologists (ASA) physical status classification is a measurement of comorbidity and a predictor of perioperative morbidity and mortality. To assess the predictive ability of the ASA class for periendoscopic adverse events. Retrospective cohort analysis. A total of 74 sites in the United States comprising academic, community/health ...
Winter Anke C AC Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass, - - 2013
The prevalence of vascular risk factors, cardiovascular disease, and restless legs syndrome increases with age. Prior studies analyzing the associations between vascular risk factors, cardiovascular disease, and restless legs syndrome found controversial results. We therefore aim to evaluate the associations between prevalent vascular risk factors, prevalent cardiovascular disease, and restless ...
Unick Jessica L JL Weight Control and Diabetes Research Center, The Miriam Hospital and Warren Alpert Medical School at Brown University, Providence, RI 02903, USA. - - 2013
Severe obesity (body mass index [BMI] ≥40 kg/m(2)) is a serious public health concern. Although bariatric surgery is an efficacious treatment approach, it is limited in reach; thus, nonsurgical treatment alternatives are needed. We examined the 4-year effects of an intensive lifestyle intervention on body weight and cardiovascular disease risk ...
Kelly Matthew S MS Department of Medicine, Dana-Farber Cancer Institute, Boston, MA, USA. - - 2013
Risk factors for central line-associated bloodstream infections (CLABSI) among children with cancer in the outpatient setting remain poorly defined, and the microbiology may differ from hospital-onset CLABSI. We conducted a matched case-control study of oncology patients followed at the Dana Farber/Children's Hospital Cancer Center. Cases (N=41) were patients with CLABSI ...
Nicholson Benjamin B National Eye Institute, National Institutes of Health, Bethesda, MD 20814, - - 2013
Recent technological advances--new pathophysiological insights, new imaging techniques for diagnosis and management, and new treatments--have led to an improved understanding of central serous chorioretinopathy (CSC). The primary role of the choroid has become more widely accepted with widespread use of indocyanine green angiography. Optical coherence tomography (OCT), and particularly enhanced ...
Jansen Chimed C Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute of Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The - - 2013
Trypanosoma brucei cyclic nucleotide phosphodiesterase B1 (TbrPDEB1) and TbrPDEB2 have recently been validated as new therapeutic targets for human African trypanosomiasis by both genetic and pharmacological means. In this study we report the crystal structure of the catalytic domain of the unliganded TbrPDEB1 and its use for the in silico ...
Ruhnke Gregory W GW Department of Medicine, University of Chicago, Ill 60637, USA. - - 2013
Accounting for changes in coding practices may be important in analyzing trends based on administrative data. Several studies have demonstrated large reductions in mortality over time among pneumonia patients. However, a recent study suggested that this reduction may have been an artifact of case definition because more of the highest-risk ...
Morris Rachel L RL Department of Microbiology and Molecular Genetics, 6180 Biomedical Physical Sciences, Michigan State University, East Lansing, Michigan 48824, - - 2013
Competition for molecular oxygen (O(2)) among respiratory microorganisms is intense because O(2) is a potent electron acceptor. This competition leads to the formation of microoxic environments wherever microorganisms congregate in aquatic, terrestrial and host-associated communities. Bacteria can harvest O(2) present at low, even nanomolar, concentrations using high-affinity terminal oxidases. Here, ...
Nutescu Edith A EA Department of Pharmacy Practice and Center for Pharmacoeconomic Research, College of Pharmacy, University of Illinois at Chicago, Chicago , IL 60612, USA. - - 2013
Clinical and resource-utilization outcomes associated with warfarin anticoagulation after major orthopedic surgery were evaluated. Consecutive patients who received postsurgical prophylaxis with warfarin within 24 hours of total knee replacement (TKR) or total hip replacement (THR) surgery and who were referred to and had outpatient follow-up for anticoagulation management in a ...
Zhang Yang Y Division of Pharmacy Practice, School of Pharmacy, University of Wisconsin (UW)- Madison, 53705, - - 2013
The stability of two rituximab preparations stored in polyvinyl chloride (PVC) bags at 4 °C for up to 14 days was investigated. Two types of test samples were prepared: (1) 10 mL of rituximab solution (10 mg/mL) drawn directly from the original manufacturer's vial and injected into sterile glass vials ...
Sumbria Rachita K RK Department of Medicine, UCLA, Los Angeles, California 90024, - - 2013
Tumor necrosis factor (TNF)-α is a proinflammatory cytokine active in the brain. Etanercept, the TNF decoy receptor (TNFR), does not cross the blood-brain barrier (BBB). The TNFR was re-engineered for BBB penetration as a fusion protein with a chimeric monoclonal antibody (mAb) against the mouse transferrin receptor (TfR), and this ...
Quartararo Christine E CE Department of Biochemistry, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, New York 10461, United - - 2013
Mycobacterium tuberculosis (Mtb) is the leading cause of death due to a bacterial infection. The success of the Mtb pathogen has largely been attributed to the nonreplicating, persistence phase of the life cycle, for which the glyoxylate shunt is required. In Escherichia coli, flux through the shunt is controlled by ...
Campbell Scott B SB Department of Chemical Engineering, McMaster University , 1280 Main Street West, Hamilton, Ontario, Canada L8S - - 2013
Injectable, in situ-gelling magnetic composite materials have been fabricated by using aldehyde-functionalized dextran to cross-link superparamagnetic nanoparticles surface-functionalized with hydrazide-functionalized poly(N-isopropylacrylamide) (pNIPAM). The resulting composites exhibit high water contents (82-88 wt.%) while also displaying significantly higher elasticities (G' >60 kPa) than other injectable hydrogels previously reported. The composites hydrolytically degrade ...
Anilkumar Parambath - - 2013
Carbon dots (surface-passivated small carbon nanoparticles) are crosslinked to result in fluorescence probes containing one or multiple dots. For the single-dot probes, the crosslinking further stabilizes the dot structure, while for those packed with multiple dots, the individual probe imaging results demonstrate that the fluorescence properties are additive, with more ...
Goldman Darin R - - 2013
Late-stage Takayasu's arteritis can result in significant ocular ischemic disease from global retinal hypoperfusion. The authors report the case of a 32-year-old woman with known Takayasu's arteritis who presented with severe, late-stage Takayasu's arteritis and prominent retinal findings. The systemic burden of the disease is illustrated using computed tomography angiography ...
Martin Seth S - - 2013
The purpose of this study was to quantitatively examine the association of patient- and trial-specific factors with participation in cardiovascular randomized clinical trials. Randomized clinical trials are central to evidenced-based medicine, but low patient participation rates and potentially modifiable barriers are not well understood. At a large U.S. academic health ...
Mahjoub Haïfa - - 2013
This study sought to identify the clinical and metabolic determinants of bioprosthetic valve degeneration. Structural valve degeneration (SVD) is the major cause of bioprosthetic valve failure. Recent retrospective studies have reported an association between atherosclerotic risk factors and development of SVD. A total of 203 consecutive patients with aortic bioprosthetic ...
Groenveld Hessel F HF Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the - - 2013
This study sought to investigate differences in outcome between patients treated with successful strict, failed strict, and lenient rate control. The RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation) study showed no difference in outcome between lenient and strict rate control in patients with permanent atrial fibrillation (AF). However, ...
Dagenais Gilles R GR Quebec Heart and Lung University Institute, Quebec City, Quebec, Canada. - - 2013
The purpose of this analysis was to assess in patients with type 2 diabetes and stable coronary artery disease (CAD) whether the risk of all-cause mortality and cardiovascular events varied according to the presence or absence of angina and angina equivalent symptoms. Data on the prognostic value of symptoms in ...
Jiang Wei W Department of Psychiatry & Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA. - - 2013
The goal of this study was to evaluate the prevalence and clinical characteristics of mental stress-induced myocardial ischemia. Mental stress-induced myocardial ischemia is prevalent and a risk factor for poor prognosis in patients with coronary heart disease, but past studies mainly studied patients with exercise-induced myocardial ischemia. Eligible patients with ...
Li Jian - - 2013
To investigate design methods of dual insertion paths and observe a short-term clinic overview of rotational path removable partial dentures (RPDs). In the study, 40 patients with partial edentulous arches were included and divided into two groups. The patients in group one were restored with rotational path RPDs (10 Kennedy ...
Oh Jina - - 2013
The use of film in nursing and medical education has been supported as an effective instructional method. The purpose of this article is to identify and synthesize the available studies on teaching-learning strategies to be used with film for prelicensure students. Electronic databases were searched to identify studies published in ...
Zhu Feng - - 2013
To assess the effects of length of continuous femoral catheter on blockade of femoral nerve, lateral femoral cutaneous nerve and obturator nerve. In the study, 70 patients with American Association of Anesthesiologist grades I-II undergoing total knee arthroplasty were randomly divided into three groups, femoral nerve catheters were inserted 5 ...
Lu Rui Fang - - 2013
Short chain fatty acids (SCFAs), such as succinic acid, acetic acid, propionic acid, butyric acid, etc. are metabolic product of putative periodontal pathogens, which play significant roles in periodontitis. The aim of this study was to analyze the relationship between Porphyromonas gingivalis (P. gingivalis), Treponema denticola (T. denticola), and the ...
Liu Shi Ming - - 2013
To investigate the stress distribution of post and core restored maxillary premolar with reduced alveolar bone support. Cone-beam CT based 3D finite element models of post and core restored maxillary premolar were established, with 3 different alveolar bone support. Group I (control) simulated a clinical situation without horizontal bone loss. ...
Xu Jing Ling - - 2013
To investigate the effect of periodontal therapy on periodontal clinical index, metabolic control and serum biochemical markers in subjects with type 2 diabetes and chronic periodontitis comprehensively. Forty patients with type 2 diabetes and chronic periodontitis were enrolled, and periodontal clinical parameters, HbA1c, fasting blood glucose (FBG) and serum biochemical ...
Liang Ling Yun - - 2013
To investigate the prevalence of human papilloma virus (HPV) infection and cervical intraepithelial neoplasia (CIN) and pathogenecity of the HPV subtyping and virus loads in Shenzhen district. In the study, 10 000 sexually active women from Shenzhen city and rural areas around were screened for cervical cancer, and all the ...
Li Zhi - - 2013
To evaluate the fatigue and fracture resistance of the flared roots restored with computer aided design (CAD) and computer aided manufacturing (CAM) glass fiber posts. In the study, 32 maxillary central incisors with roots longer than 13 mm were selected and their canals were flared, and the roots were allocated ...
Wei Song - - 2013
To observe the self-adjustment of the mandibular dental arch after extraction of the second mandibular premolars. Mandibular dental casts of 20 Angle class II patients treated with extraction of lower second premolars and upper first premolars, bonded with Alexander appliance,were taken before (T1) and after self-adjustment (T2). All the casts ...
Xia Bin - - 2013
To assess dental treatment needs and oral health status among children under 18-year-old in Beijing and to examine how these are affected by age, gender. In the retrospective study, 3 148 children aged 0.8-18.0 years were selected from patients who first visit the Department of Paediatric Dentistry, Peking University School ...
Li Fang Fang - - 2013
To evaluate the protection of calcium alginate hydrogel beads for mouse preosteoblastic cell line (MC3T3-E1) during the setting reaction of calcium phosphate cement (CPC) pastes and to analyze related influencing factors. The MC3T3-E1 cells encapsulated in alginate hydrogel beads were cultured in vitro with β-tricalcium phosphate/calcium phosphate cement (β-TCP/CPC) pastes ...
Zhang Xiao Yun - - 2013
Cone-beam CT (CBCT) was developed for the three-dimensional (3D) imaging of the maxillofacial area and has become popular in dentistry, orthodontics, and maxillofacial surgery. The advantages of CBCT include less radiation exposure (than conventional CT), less artifacts, and submillimeter spatial resolution. CBCT has been shown to produce accurate 3D images ...
Ding Ning - - 2013
To compare the quantity of the main important Candida species in the oral cavity between the patients with primary Sjogren's syndrome (pSS) and no dry mouth healthy controls,and to explore the discriminative species of fungi between the two groups. In this study, 25 pSS patients from Department of Oral Medicine ...
Ouyang Xiang Ying - - 2013
Translational Medicine is an evolutional concept that encompasses the rapid translation of basic research for use in clinical disease diagnosis, prevention, treatment and finally in public health promotion. It follows the idea "from bench to bedside and back", and hence relies on cooperation between laboratory research and clinical care. Translation ...
Xue Shi Hua - - 2013
To explore the three dimensional(3D)bioprinting technology, using human dental pulp cells (hDPCs) mixture as bioink and to lay initial foundations for the application of the 3D bioprinting technology in tooth regeneration. Imageware 11.0 computer software was used to aid the design of the 3D biological printing blueprint. Sodium alginate-gelatin hydrosol ...
Williams Susan C - - 2013
This article provides an overview of one nursing department's experience with implementation of a formalized civility code to address increasing incidents of incivility within the classroom and educational environment. The plan-do-study-act improvement model is used as a framework to describe the process. Discussion of next steps in the improvement process ...
Li Peng - - 2013
To evaluate the periodontal status of post-acute myocardial infarction patients, to identify whether periodontitis is associated with post-acute myocardial infarction in Chinese community population. Case and control subjects were enrolled from a community population, the diagnose of post-acute myocardial infarction and systemic health were based on blood, electrocardiogram and ultrasound ...
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