Background:  The complex relationship between bladder and bowel function has implications for treating pelvic disorders. In this systematic review, we discuss the relationship between bladder and bowel function and its implications for managing coexisting constipation and overactive bladder (OAB) symptoms. Methods:  Multiple PubMed searches of articles published in English from ...

The purpose of this study was to examine whether gender differences on the Minnesota Multiphasic Personality Inventory-2 (MMPI-2; Butcher, Dahlstrom, Graham, Tellegen, & Kaemmer, 1989) and Minnesota Multiphasic Personality Inventory-Adolescent (MMPI-A; Butcher et al., 1992) items are comparable across 2 distinctive cultural samples: Americans and Koreans. Using large, representative adult and ...

The prevalence of vascular risk factors, cardiovascular disease, and restless legs syndrome increases with age. Prior studies analyzing the associations between vascular risk factors, cardiovascular disease, and restless legs syndrome found controversial results. We therefore aim to evaluate the associations between prevalent vascular risk factors, prevalent cardiovascular disease, and restless ...

The metalloproteases meprin α and meprin β exhibit structural and functional features that are unique among all extracellular proteases. Although meprins were discovered more than 30 years ago, their precise substrates and physiological roles have been elusive. Both enzymes were originally found to be highly expressed in kidney and intestine, which ...

Pregnancy-associated retinal diseases are conditions that may occur uniquely in pregnancy or, more commonly, general conditions that may worsen or alter during pregnancy as a result of hematologic, hormonal, metabolic, cardiovascular, and immunologic changes. Diabetic retinopathy (DR) is by far the most common retinal condition that is altered by pregnancy. ...

: To study the reperfusion strategies currently being used in the treatment of ST-elevation myocardial infarction (STEMI) at an academic medical center in a developing country and to analyze the door-to-balloon time (DBT) in those patients undergoing primary percutaneous coronary intervention (PCI). : The study included all patients presenting with ...

The aim of this study was to investigate the hepatotoxicity induced by arsenic trioxide (As2O3) at a therapeutic dose for pediatric acute promyelocytic leukemia (APL). A total of APL patients received As2O3 treatment by IV drip. Hepatotoxicity was monitored based on the observations of the dynamic changes in liver function ...

Background The purpose of the current study was to examine the characteristics of those who report fulfilment of sexual desires as a result of internet use for sexual purposes and which sexually related online activities contribute to the fulfilment of sexual desires. Methods: Data were collected through a questionnaire posted ...

: Telemetry monitoring is often overused in the inpatient setting. This has led to overcrowding of telemetry beds, increased wait times in the emergency department, and inefficient allocation of hospital resources. The American College of Cardiology/American Heart Association (ACC/AHA) guidelines exist to guide appropriate utilization of cardiac monitoring. We sought ...

A short-cut review was carried out to establish whether adrenaline use during cardiac arrest improves long-term survival. A total of 209 papers was found using the reported search, of which seven represented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, ...

The processes used by institutions to manage and coordinate multiple pharmacy residency programs were evaluated. An 18-question survey was developed. The survey was distributed via e-mail to all University HealthSystem Consortium (UHC) member institutions. The survey request was e-mailed to the pharmacy director of each hospital. Respondents submitted their information ...

Pleural disease is commonly encountered by the chest physician. Evaluation of pleural disease typically begins with thoracentesis and pleural fluid analysis. With improvements in minimally invasive procedures, imaging, and the use of pleural manometry, a more complete understanding of lung, pleural, and chest wall physiology is possible. The improved knowledge ...

Although colonoscopy is the criterion standard for detecting colorectal adenomas and cancers, a significant percentage of adenomas are missed. To compare forward-viewing with ultrawide-viewing colonoscopy in the detection of simulated colon polyps in an in vitro colon model. Prospective, multicenter. Six endoscopy units (3 in the United States and 3 ...

Important developments in chemotherapy for advanced colorectal cancer over the past 15 years are reviewed, with an emphasis on the most recently published data from clinical trials of newer multidrug regimens, administration techniques, and dosing schedules. Eight agents are approved by the Food and Drug Administration (FDA) for use in ...

ABSTRACT: After a total or near total thyroidectomy and radioiodine ablation therapy for differential thyroid cancer (DTC), routine follow-up methods are I or I whole-body scanning (WBS) as well as serum thyroglobulin (Tg) and anti-thyroglobulin (anti-Tg) levels. We describe a case of a 41-year-old woman with follicular thyroid cancer. Although ...

Risk factors for central line-associated bloodstream infections (CLABSI) among children with cancer in the outpatient setting remain poorly defined, and the microbiology may differ from hospital-onset CLABSI. We conducted a matched case-control study of oncology patients followed at the Dana Farber/Children's Hospital Cancer Center. Cases (N=41) were patients with CLABSI ...

Background:  Plasminogen Activator Inhibitor 1 (PAI-1) is a prothrombotic adipokine involved in the coagulation cascade and fibrinolysis that associated with proinflammatory adipokines may increase the risk related to obesity. Anthropometric measures are commonly used in clinical practice and, currently, neck circumference (NC) has been used as a marker of cardiovascular ...

Accounting for changes in coding practices may be important in analyzing trends based on administrative data. Several studies have demonstrated large reductions in mortality over time among pneumonia patients. However, a recent study suggested that this reduction may have been an artifact of case definition because more of the highest-risk ...

The Society for Research on Nicotine and Tobacco (SRNT) Trainee Network was formed to facilitate the development of the emerging generation of tobacco scientists. The advisory board of the Trainee Network conducted an online survey to collect data on trainees' areas of tobacco-related interest, demographics, and interest in potential events, ...

Osteoarthritis is the most common form of arthritis, with knee osteoarthritis being the leading cause of lower extremity disability among older adults in the US. There are no treatments available to prevent the structural pathology of osteoarthritis. Because of vitamin K's role in regulating skeletal mineralization, it has potential to ...

Abstract Objective: The aim of this study is to reveal the correlation of shedding and expression of c-Met in non-small cell lung cancer (NSCLC) patient. Materials and methods: We measured soluble c-Met and c-Met level in a panel of pre-clinical models and 197 advanced Chinese NSCLC patients by enzyme-linked immunosorbent ...

Improving cancer survival rates is a UK priority and equity of access to high quality cancer irrespective of geography is a key principle. Surgery, radiation therapy and systemic therapy remain the cornerstone of the multidisciplinary management of cancer. However, costs of cancer care continue to escalate. A recent review (1) ...

Intra-abdominal fluid may migrate readily into the pleural space through naturally occurring holes in the diaphragm or intradiaphragmatic lymphatics. Although any type of fluid in the abdomen may migrate, additional pathologic mechanisms are involved in the development of chylous ascites/chylothorax, yellow nail syndrome, urinothorax, pancreaticopleural fistulas, or other connections. In ...

Chronic vascular inflammation is regarded as a crucial aspect of cardiovascular disease. However, the elicitors of this inflammatory response in the vessel wall are currently not well understood. Excessive amounts of cholesterol, an abundant and fundamental lipid molecule in mammalian cells, can initiate the development and progression of atherosclerosis. Accumulation ...

Aim:  This Belgian epidemiological study aimed to assess the prevalence of overactive bladder (OAB) and stress urinary incontinence (SUI) and associated bother in a female primary care population. Methods:  Data on OAB and SUI were prospectively collected among women ≥ 40 years by general practitioners (GP) during a regular visit for any ...

The aim of the study was to investigate the validity of the Rorschach Perceptual Thinking Index (PTI) to detect psychotic perceptual and thought disturbance in a sample of Slovene psychiatric inpatients. Using a sample of 275 adult psychiatric inpatients of both sexes, we examined the differences between patients with psychosis ...

Hospital readmission rates for patients with nonvalvular atrial fibrillation (NVAF), as well as reasons and risk factors for rehospitalization, were investigated. Demographic, clinical, and prescription claims data on patients hospitalized for atrial fibrillation (AF) over a five-year period were extracted from insurance claims databases; from that data set, a subset ...

ABSTRACT: The lymphatic drainage of cutaneous melanomas located on the upper trunk is often complex and sometimes follows an unexpected pattern. Occasionally, even direct drainage to cervical lymph nodes is seen. In this case series, 3 patients with lymphatic drainage to the neck derived from melanomas located over the manubrium ...

Patients presenting with microangiopathic hemolysis and thrombocytopenia are often given the diagnosis of thrombotic thrombocytopenic purpura and treated with plasma exchange until the acute episode is over. Recent findings have shown that acquired thrombotic thrombocytopenic purpura is a chronic autoimmune disease with inhibitory antibodies of a disintegrin and metalloprotease with ...

Although the synthesis of ventilation-perfusion (V/Q) scan result and clinical pretest probability is vital to the diagnostic accuracy of V/Q scanning, there is no updated pretest/posttest tabular decision tool since that presented in the Prospective Investigation of Pulmonary Embolism Diagnosis I data. Because this verbal communication between the nuclear medicine ...

Vector-borne disease is one of the greatest contributors to human mortality and morbidity throughout the tropics. Mosquito-transmitted diseases such as malaria, dengue, yellow fever and filariasis are the main contributors to this burden. Although insecticides have historically been used to try to control vector populations, over the past 15 years, ...

ABSTRACT: Earlier studies indicate that abnormal liver and spleen uptake on bone scan has been observed in association with intravenous injection of Gd-DTPA contrast for MRI. All of these patients, however, received Gd-DTPA injection prior to Tc MDP administration. We report herein 3 patients with hepatic and splenic uptake on ...

The number of cases of out-of-hospital cardiac arrest is estimated to be 300,000/year in the United States. Two landmark studies published in 2002 demonstrated that therapeutic hypothermia decreased mortality and improved neurological outcome after out-of-hospital cardiac arrest. Our institutional pathway for the management of survivors of cardiac arrest stresses teamwork ...

: Prognostication beyond troponin levels in patients with acute atrial fibrillation (AF) is still unclear. : One-month and 1-year outcomes in 1091 patients with acute AF were analyzed. Primary endpoints were stroke or the composite of acute coronary syndrome, revascularization, and death. : In the short term, troponin (odds ratio ...

A short-cut review was carried out to establish whether the addition of a non-steroidal anti-inflammatory drug (NSAID) to antibiotics is of benefit to patients with uncomplicated urinary tract infections (UTI). A total of 80 papers was found using the reported search, of which four represented the best evidence to answer ...

The stability of two rituximab preparations stored in polyvinyl chloride (PVC) bags at 4 °C for up to 14 days was investigated. Two types of test samples were prepared: (1) 10 mL of rituximab solution (10 mg/mL) drawn directly from the original manufacturer's vial and injected into sterile glass vials ...

The treatment of reperfusion injury requires measures beyond timely reperfusion. Conventional postconditioning (PostC) of ischemic tissues offers a strategy to reduce reperfusion injury, but its adoption is challenged by requiring access and imposing additional ischemia to the ischemic organ. Generating protective signals by PostC in a tissue remote from the ...

: To examine the ability of working direct care nurses to trust nurses in recovery from substance use (or abuse) disorders (SUDs) reentering the workplace. : A researcher-designed quantitative survey was used to gather data. : Nurses said that they've worked with a nurse with SUD at some time in ...

Super-short carbon nanotubes with uniform and molecular scale length, which can be regarded as carbon nanorings (CNRs), are difficult to obtain from long carbon nanotubes. Wensheng Yang and co-workers report on page 1125 a strategy for fabricating CNRs with ∼1 nm length in the confined interlayer galleries of a layered ...

Carbon dots (surface-passivated small carbon nanoparticles) are crosslinked to result in fluorescence probes containing one or multiple dots. For the single-dot probes, the crosslinking further stabilizes the dot structure, while for those packed with multiple dots, the individual probe imaging results demonstrate that the fluorescence properties are additive, with more ...

A sponge-like cotton fabric autonomously collects and releases water from fogs, triggered by day- and night temperature variations, typically encountered in dry areas. The reversible switching between absorbing-superhydrophilic/releasing-superhydrophobic states results from structural changes of a temperature-responsive polymer grafted on the highly rough fabric-surface, as reported by John H. Xin, A. ...

Large area two dimensional gold nanorod arrays are fabricated on block copolymer templates after a facile plasma etching process. Either side-by-side or end-to-end assemblies could be obtained simply because of dimensional commensurability. The sub-50 nm nanorod array with excellent position selectivity has many potential applications in optoelectronic, catalytic, SERS and ...

On page 1017, Martin Möller, Xiaomin Zhu, and co-workers report a facile and universal approach for the preparation of silica particles of various mesostructures based on the self-assembly of amphiphilic precursor polymers in water and subsequent condensation. Depending on the hydrophilization degree of hyperbranched polyethoxysiloxane, various silica morphologies including mesoporous ...

Interconnected mesoporous NiCo(2) O(4) nanosheets can be directly grown on various conductive substrates including Ni foam, stainless steel, Ti foil, and flexible graphite paper through a simple solution method. The NiCo(2) O(4) nanosheets-Ni foam structure exhibits superior pseudocapacitive performance with a high capacitance of 1743 F g(-1) under a constant ...

Late-stage Takayasu's arteritis can result in significant ocular ischemic disease from global retinal hypoperfusion. The authors report the case of a 32-year-old woman with known Takayasu's arteritis who presented with severe, late-stage Takayasu's arteritis and prominent retinal findings. The systemic burden of the disease is illustrated using computed tomography angiography ...

The purpose of this study was to quantitatively examine the association of patient- and trial-specific factors with participation in cardiovascular randomized clinical trials. Randomized clinical trials are central to evidenced-based medicine, but low patient participation rates and potentially modifiable barriers are not well understood. At a large U.S. academic health ...

This study sought to identify the clinical and metabolic determinants of bioprosthetic valve degeneration. Structural valve degeneration (SVD) is the major cause of bioprosthetic valve failure. Recent retrospective studies have reported an association between atherosclerotic risk factors and development of SVD. A total of 203 consecutive patients with aortic bioprosthetic ...

The goal of this study was to evaluate the prevalence and clinical characteristics of mental stress-induced myocardial ischemia. Mental stress-induced myocardial ischemia is prevalent and a risk factor for poor prognosis in patients with coronary heart disease, but past studies mainly studied patients with exercise-induced myocardial ischemia. Eligible patients with ...

The purpose of this analysis was to assess in patients with type 2 diabetes and stable coronary artery disease (CAD) whether the risk of all-cause mortality and cardiovascular events varied according to the presence or absence of angina and angina equivalent symptoms. Data on the prognostic value of symptoms in ...

This study sought to investigate differences in outcome between patients treated with successful strict, failed strict, and lenient rate control. The RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation) study showed no difference in outcome between lenient and strict rate control in patients with permanent atrial fibrillation (AF). However, ...