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Lipman Timothy O - - 2013
The volume of medical literature grows exponentially. Yet we are faced with the necessity to make clinical decisions based on the availability and quality of scientific information. The general strength (reliability, robustness) of any interpretation that guides us in clinical decision making is dependent on how information was obtained. All ...
Teuschl Yvonne - - 2013
BACKGROUND AND PURPOSE: Demographic changes, increased awareness of vascular risk factors, better diagnostic, progress in medical care, and increasing primary stroke prevention influence the profile of patients admitted to stroke-units. Changes in patient population and stroke type have important consequences on outcome and management at stroke-units. METHODS: Data from the ...
Nishimura Toshiya - - 2013
Thrombocytopenia (TTP) is a blood disease common to canines and human beings. Currently there is no valid therapy for this disease except blood transfusion. In this study, we report the generation of canine induced pluripotent stem cells (ciPSCs) from canine embryonic fibroblasts, and a novel protocol for creating mature megakaryocytes ...
Scheirer Mary Ann - - 2013
Researchers, funders, and managers of health programs and interventions have become concerned about their long-term sustainability. However, most research about sustainability has not considered the nature of the program to be sustained. Health-related interventions may differ in their likelihood of sustainability and in the factors likely to influence continuation. I ...
Liyasova Mariya S - - 2013
The plant growth regulator ethephon (2-chloroethylphosphonic acid) inhibits human butyrylcholinesterase (BChE) by making a covalent adduct on the active site serine 198. Our goal was to extend earlier studies on ethephon inhibition. Addition of freshly prepared ethephon to BChE in buffered medium, at pH 7.0 and 22°C, resulted in no ...
Stingl Katarina - - 2013
Abstract Purpose: One approach for restoring vision in end-stage hereditary retinal diseases is implantation of a subretinal microphotodiode array. We analyzed retinal fluorescein angiography findings of the implant area. Methods: In this pilot study, patients (n = 11; 10 men, one woman; ages 45.2 ± 8.7 years), with visual acuity of light perception or ...
Santana L N S - - 2013
The aim of this study was to describe the dentine morphology of sloths (Bradypus tridactylus). The sloth teeth were removed and prepared for light microscopy (LM) and scanning electron microscopy analyses (SEM). LM revealed two patterns of tubular dentins: an outer with dentinary tubules over the all tooth length and ...
Ferrara Pietro - - 2013
This population-based study evaluates the prevalence of factitious disorders, Münchausen syndrome, and Münchausen syndrome by proxy in a clinical setting. All children referred to the Pediatric Unit of the Department of Pediatrics of the Catholic University Medical School (Agostino Gemelli Hospital) in Rome were recruited between November 2007 and March ...
Wilson Mary - - 2013
This paper reports on a descriptive qualitative five-year follow-up to an initial UK-based grounded theory study entitled 'Living with Faecal Incontinence.' Both studies collected data using in-depth guided interviews. The aim of the follow-up study was to identify any changes including adaptation and establish determining factors for people with faecal ...
Westgard Bjorn C - - 2013
Abstract Objectives. The primary aims of this study were to determine whether the frequency of placement, type of advanced airway, and settings of advanced airway placement (clinical vs. field) have changed for paramedic students over the last 11 years, and to describe regional differences regarding the same set of variables. Methods. ...
Li Shengkun - - 2013
A novel rhodium catalytic system with Naphos as ligand was developed for an efficient hydroaminomethylation of 1,1-diphenylethene under relatively mild conditions. This will allow for an atom-economic and environmentally benign synthesis of fenpiprane and related pharmaceuticals.
Li Mingqiang - - 2013
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Herein, we develop a polypeptide-based block ionomer complex formed by anionic methoxy poly(ethylene glycol)-b-poly(L-glutamic acid) (mPEG-b-PLG) and cationic anticancer drug doxorubicin hydrochloride (DOX•HCl) for NSCLC treatment. This complex spontaneously self-assembled into spherical nanoparticles (NPs) in aqueous solutions ...
Riffe Matthew J - - 2013
PURPOSE: Single sideband amplitude modulation (SSB) is an appealing platform for highly parallel wireless MRI detector arrays because the spacing between channels is ideally limited only by the MRI signal bandwidth. However this assumes that no other sources of interference are present outside that bandwidth. This work investigates the practical ...
Cowcher David - - 2013
Portable rapid detection of pathogenic bacteria such as Bacillus is highly desirable for safety in food manufacture and under the current heightened risk of biological terrorism. Surface enhanced Raman scattering (SERS) is becoming the preferred analytical technique for bacterial detection, due to its speed of analysis and high sensitivity. However ...
Jones Heather A - - 2013
Objective: The primary aim of this study was to examine relationships among parenting style, symptoms of ADHD, and academic adjustment in college students. Specifically, we investigated whether parenting style may act as a buffer in the negative relationship between ADHD symptoms and academic adjustment. Method: Participants were 200 undergraduate students ...
Mazhab-Jafari Mohammad T - - 2013
Like most Ras superfamily proteins, the GTPase domain of Ras homolog enriched in brain (Rheb) is tethered to cellular membranes through a prenylated cysteine in a flexible C-terminal region, however little is known about how Rheb or other GTPases interact with the membrane or how this environment may affect their ...
Guan Buyuan - - 2013
A very simple cooperative template-directed coating method is developed for the preparation of core-shell, hollow, and yolk-shell microporous carbon nanocomposites. Particularly, the cationic surfactant C(16)TMA(+)·Br(-) used in the coating procedure improves the core dispersion in the reaction media and serves as the soft template for mesostructured resorcinol-formaldehyde resin formation, which ...
Rodríguez-Chueca J - - 2013
The purpose of the current study is to evaluate the inactivation of three different kinds of bacteria usually present in municipal wastewater treatment effluents (Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli) using a coagulation-flocculation-decantation (CFD) process combined with photo-Fenton treatment at pH 5. Different concentrations of Fe(3+)-H(2)O(2) (0.4/25, 5/25 and ...
Ta┼čtan Eren - - 2013
IMPORTANCE Autogenous rib cartilage is widely used in the septorhinoplasty cases with major structural grafting requirements. However, there is a risk of warping over time. OBJECTIVE To introduce a novel method for carving costal cartilage grafts to obtain straight grafts of varying thicknesses and to eliminate the risk of warping. ...
Ma Chao - - 2013
Using electron energy loss spectroscopy (EELS) measurements and first-principles electronic structure calculations, the significant interlayer hybridization between the insulating layers (ReO or Ba) and the conducting FeAs layers was investigated in the layered iron pnictides, which is quite different from the case in the cuprate superconductors. This interlayer hybridization would ...
Ghesquières Hervé - - 2013
ABSTRACT Limited data support the use of bendamustine in Hodgkin lymphoma (HL). This retrospective study evaluated the efficacy and toxicity of bendamustine in 28 patients with refractory HL or relapsed HL after autologous stem cell transplantation (ASCT) used as part of a compassionate use program. The median number of therapies ...
Lenis Gustavo - - 2013
Abstract Ventricular ectopic beats (VEBs) trigger a characteristic response of the heart called heart rate turbulence (HRT). The HRT can be used to predict sudden cardiac death in patients with a history of myocardial infarction. In this work, we present a reliable algorithm to detect and classify ectopic beats. Every ...
Carrero-González L - - 2013
PURPOSE: MRI with perfluorinated gases has been shown as an alternative to hyperpolarized gases to image both microstructure and gas diffusivity in the lung. The aim of this study was to measure diffusion restriction of C(2) F(6) in rat lungs and to compare the different levels of restriction between healthy ...
Hirsch Sebastian - - 2013
PURPOSE: Viscoelastic properties of the liver are sensitive to fibrosis. This study proposes several modifications to existing magnetic resonance elastography (MRE) techniques to improve the accuracy of abdominal MRE. METHODS: The proposed method comprises the following steps: (i) wave generation by a nonmagnetic, piezoelectric driver suitable for integration into the ...
McQuarrie Emily P - - 2013
BackgroundBlockade of the mineralocorticoid receptor (MR) in patients with chronic kidney disease (CKD) improves surrogate cardiovascular outcomes, such as left ventricular mass. Animal models of renal disease support a pathological role of mineralocorticoids, in the context of a high sodium intake. We aimed to assess the regulation of mineralocorticoid biosynthesis ...
Maegawa Tomohiro - - 2013
A mild and efficient method for formation of methylene acetals from 1,2- and 1,3-diols using methoxymethylphenylsulfide, 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) and tert-butylhydroxytoluene (BHT) is described. The use of BHT in this process suppresses side reactions and enables high yielding formation of methylene acetals of various diols, including carbohydrate-type substrates.
Stintzing Sebastian - - 2013
Background. Stereotactic radiation therapy is an evolving modality to treat otherwise unresectable liver metastases. In this analysis, two local therapies: 1) single session robotic radiosurgery (RRS) and 2) percutaneous radiofrequency ablation (RFA) were compared in a total of 60 heavily pretreated colorectal cancer patients. Methods. Thirty patients with a total ...
Chen X - - 2013
Modern medicinal chemistry has come to its bottleneck and is full of challenges, especially when facing with long-term central nervous system (CNS) disorders induced by several factors, such as Alzheimer's disease (AD) or Parkinson's disease (PD). In order to probe these challenges, multi-target directed ligands (MTDLs) design has been applied ...
Meredith P - - 2013
Inorganic semiconductors permeate virtually every sphere of modern human existence. Micro-fabricated memory elements, processors, sensors, circuit elements, lasers, displays, detectors, etc are ubiquitous. However, the dawn of the 21st century has brought with it immense new challenges, and indeed opportunities-some of which require a paradigm shift in the way we ...
Liang Xuyang - - 2013
A QuEChERS procedure for the simultaneous determination of pyrimethanil, cyprodinil, mepanipyrim and its metabolite (M31) in fresh and processed fruit and vegetables was developed using ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS). The determination of the four target compounds was achieved in less than 6.0 min using an electrospray ionisation source in ...
Mahon Bradford Z - - 2013
It is widely argued that the ability to recognize and identify manipulable objects depends on the retrieval and simulation of action-based information associated with using those objects. Evidence for that view comes from fMRI studies that have reported differential BOLD contrast in dorsal visual stream regions when participants view manipulable ...
Scheers Tineke - - 2013
ABSTRACT: BACKGROUND: In the past decades, several public health guidelines concerning physical activity have been published. This study evaluated compliance with various physical activity guidelines and examined the associations between meeting the guidelines and socio-demographic characteristics. METHODS: Data were obtained from 357 Flemish men and women (41.9 +/- 9.6 years). ...
Uhl Sarah A - - 2013
BACKGROUND: Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are persistent, synthetic industrial chemicals. Perfluorinated compounds are linked to health impacts that may be relevant to osteoarthritis, cartilage repair, and inflammatory responses. OBJECTIVES: We investigated whether PFOA and PFOS exposures are associated with prevalence of osteoarthritis, and whether associations differ between men ...
Briones-Chávez Carlo - - 2013
OBJECTIVE: To compare prevalences of intestinal helminths and waterborne protozoa in indigenous and settler populations in a remote area of Peru. These populations live in adjacent but segregated small urban villages. METHODS: Stool samples were collected from representative members of these two populations and analysed for geohelminths and protozoa. RESULTS: ...
Hackert Thilo - - 2013
ABSTRACT: BACKGROUND: Partial pancreatico-duodenectomy (PD) is the standard treatment for tumors of the pancreatic head. Today, preservation of the pylorus has been widely accepted as the surgical standard in this procedure. A common postoperative complication is the occurrence of delayed gastric emptying (DGE), which causes impairment of oral intake andpatients' ...
Brinkerhoff Derick W - - 2013
Governance is increasingly recognized as an important factor in health system performance, yet conceptually and practically it remains poorly understood and subject to often vague and competing notions of both what its role is and how to address its weaknesses. This overview article for the symposium on health governance presents ...
Purusottam Rudra N - - 2013
Water plays a major structural and functional role around proteins. In an attempt to explore this mechanistic structural aspect of proteins, we present site-specific interaction of hydration water with major coat protein subunit of filamentous virus Pf1 by magic angle spinning (MAS) solid-state NMR. The interaction of surrounding water with ...
Matje Douglas M - - 2013
One of the most dramatic illustrations of enzymatic promotion of a high energy intermediate is observed in DNA modification and repair enzymes where an individual base is rotated (flipped) 180O around the deoxyribose-phosphate backbone and into the active site. While the end states are extensively characterized, experimental techniques have yet ...
Kim In Hye - - 2013
We investigated effects of caffeic acid, syringic acid, and their synthesis on transient cerebral ischemic damage in the gerbil hippocampal CA1 region. In the 10 mg/kg caffeic acid-, syringic acid-, and 20 mg/kg syringic-treated ischemia groups, we did not find any significant neuroprotection in the ischemic hippocampal CA region. In ...
Fernández de Luis Roberto - - 2013
Four isomorphic compounds with formula [{Co(2)(H(2)O)(2)(Bpe)(2)}(V(4)O(12))]·4H(2)O·Bpe, CoBpe 1; [{CoNi(H(2)O)(2)(Bpe)(2)}(V(4)O(12))]·4H(2)O·Bpe, CoNiBpe 2; [{Co(0.6)Ni(1.4)(H(2)O)(2)(Bpe)(2)}(V(4)O(12))]·4H(2)O·Bpe, NiCoBpe 3; and [{Ni(2)(H(2)O)(2)(Bpe)(2)}(V(4)O(12))]·4H(2)O·Bpe, NiBpe 4, have been obtained by hydrothermal synthesis. The crystal structures of CoBpe 1 and NiBpe 4 were determined by single-crystal X-ray diffraction (XRD). The Rietveld refinement of CoNiBpe 2 and NiCoBpe 3 XRD ...
Pautler Michael - - 2013
The vegetative and reproductive shoot architectures displayed by members of the grass family are critical to reproductive success, and thus agronomic yield. Variation in shoot architecture is explained by the maintenance, activity, and determinacy of meristems, pools of pluripotent stem cells responsible for post-embryonic plant growth. This review summarizes recent ...
Fritz Lars - - 2013
This article summarizes our understanding of the Kondo effect in graphene, primarily from a theoretical perspective. We shall describe different ways to create magnetic moments in graphene, either by adatom deposition or via defects. For dilute moments, the theoretical description is in terms of effective Anderson or Kondo impurity models ...
Yu Quanyao - - 2013
Patterned micro/nano structural hydrophobic Ni-P films were designed by the combination of electrochemical and chemical deposition. The formation mechanism is illustrated by the gradually changed morphology of the film. This work shows a new method for fabricating a patterned surface morphology with tailored hydrophobicity.
Gao Yan - - 2013
We present a study of static and dynamic interfacial properties of self-assembled polyelectrolyte complex nanoparticles (size 110-120 nm) containing entrapped surfactant molecules at a fluid-fluid interface. Surface tension vs. time measurements of an aqueous solution of these polyelectrolyte complex nanoparticles (PCNs) show a concentration dependent biphasic adsorption to the air/water ...
Zobel T - - 2013
The development of multicellular organisms involves a series of morphogenetic processes coordinating a highly dynamic and organized interplay between cells and their environment. Thus, the generation of forces that drive cellular and intracellular movements is prerequisite to shape single cells into tissues and organs. The actin cytoskeleton represents a highly ...
Brodsky Michael C - - 2013
IMPORTANCE We devised the optokinetic uncover test to examine the role of peripheral retinal motion input in generating horizontal optokinetic responses in patients with infantile strabismus. OBJECTIVE To ascertain whether subcortical visual input contributes to the asymmetrical monocular optokinetic responses that characterize infantile esotropia. DESIGN AND SETTING Observational study in ...
Moorhouse Rhiannon S - - 2013
The solid state structures of alkali metal complexes of the 1,3,6,8-tetra-tert-butylcarbazol-9-yl ((t)Bu(4)carb(-)) ligand are compared. Lithium complex [(t)Bu(4)carbLi](2) ([1](2)) is a dimer in the solid state featuring a planar LiNLiN rhomboid ring, with the differing Li-N distances within the ring due to the effects of σ- and π-interactions. Recrystallization of ...
Doody Owen - - 2013
Focus group interviews are widely used in health research to explore phenomena and are accepted as a legitimate qualitative methodology. They are used to draw out interaction data from discussions among participants; researchers running these groups need to be skilled in interviewing and in managing groups, group dynamics and group ...
Legut Dominik - - 2013
We report theoretical investigations of the lattice dynamics of KCuF(3). Our calculations are based on the generalized gradient approximation and parametrization of Perdew-Burke-Ernzerhof to the density functional theory corrected for on-site Coulomb interaction (GGA + U). Vibrations of the KCuF(3) lattice are studied within the harmonic approximation. Energetic stability of tetragonal and ...
Balaji S N - - 2013
Abstract Background: Primaquine (Pq) metabolic products are responsible for drug-associated hemotoxicity and limit primaquine usage. Methods: Methemoglobin (MetHb)-Pq molecular modeling was used to identify the Pq binding pocket. UPLC, mass spectrometry, and other indirect analytical methods were used to predict the metabolite. MetHb generation, development of oxidative stress, inhibition of ...
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