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Moroz Jennifer - - 2013
PURPOSE: To measure the arterial input function (AIF) in a mouse tail at high temporal resolution with signal phase of MR projections. METHODS: The technique involves the acquisition of one 2D image before injection, followed by a series of projections before, during, and after contrast injection. Differences in the signal ...
Rushworth Alastair M - - 2013
Summary The distributed lag model (DLM), used most prominently in air pollution studies, finds application wherever the effect of a covariate is delayed and distributed through time. We specify modified formulations of DLMs to provide computationally attractive, flexible varying-coefficient models that are applicable in any setting in which lagged covariates ...
Woo Seung Hoon - - 2013
Background. Ectopic thyroid tissue is relatively rare condition and a developmental anomaly characterized by an aggregated of thyroid tissue. Usually it occurs along the path of descent of the developing thyroid primodium from the foramen cecum, the commonest being in the anterior midline of neck at, or below, the level ...
Zeitani J - - 2013
Hemostasis is impaired during CABG and coagulation abnormalities often result in clinically relevant organ dysfunctions, eventually increasing morbidity and mortality rates. Fifteen consecutive patients with coronary artery disease submitted to conventional extracorporeal circulation (cECC) have been compared with 15 matched patients, using mini-ECC (MECC). Postoperative lung function was evaluated according ...
Zygmuntowicz Monika - - 2013
OBJECTIVE:: The optimal blood pressure (BP) in terms of health-related quality of life (HRQoL) in patients treated for hypertension remains unknown. This study aimed to determine BP values associated with optimal HRQoL among younger (<65 years old) and older patients (≥65 years old) treated for hypertension. METHODS:: HRQoL was assessed ...
Simmons Warren L WL Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA. - - 2013
Several mycoplasma species have been shown to form biofilms that confer resistance to antimicrobials and which may affect the host immune system, thus making treatment and eradication of the pathogens difficult. The present study shows that the biofilms formed by two strains of the human pathogen Mycoplasma pneumoniae differ quantitatively ...
Ou Shuching - - 2013
We discuss molecular dynamics simulations using polarizable charge equilibration force fields to study the energetics of an arginine side-chain analog, methyl guanidinium, as it crosses a DPPC lipid bilayer. Combining umbrella sampling MD simulations with the Weighted Histogram Analysis Method (WHAM) for unbiasing probabilities, we compute a potential of mean ...
Brittain Joan - - 2013
Approximately 90 000 inmates are admitted annually to the New York City jail system, many of whom require a high level of medical or mental health services. According to our analysis of deaths in custody from 2001 to 2009, crude death rates have dropped significantly despite the increasing age of the ...
Nyarko Kwame A KA Department of Health Management and Policy, University of Iowa, Iowa City, IA 52242, - - 2013
We sought to quantify how socioeconomic, health care, demographic, and geographic effects explain racial disparities in low birth weight (LBW) and preterm birth (PTB) rates in Brazil. We employed a sample of 8949 infants born between 1995 and 2009 in 15 cities and 7 provinces in Brazil. We focused on ...
Sand Rheanna R Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, - - 2013
Many proteins function by changing conformation in response to ligand binding or changes in other factors in their environment. Any change in the sequence of a protein, for example during evolution, which alters the relative free energies of the different functional conformations changes the conditions under which the protein will ...
Iyi Nobuo - - 2013
ClO(4)(-)MgAl-LDH3, a MgAl (Mg/Al = 3) layered double hydroxide (LDH) containing perchlorate, swells and forms colloidal suspensions (sols) via the gel state in concentrated aqueous solutions of zwitterionic compounds related to amino acids. In total, 36 zwitterionic compounds with different molecular structures and additional functional groups were examined at various ...
McGovern Margaret M - - 2013
Purpose:The purpose of this study was to perform a systematic evaluation of morbidity and mortality in type B Niemann-Pick -disease.Methods:A total of 103 patients with Niemann-Pick disease (49 males, 54 females, age range: 1-72 years) participated in natural history studies through Mount Sinai's International Center for Types A and B ...
Jaremka Lisa M LM Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH 43210, USA. - - 2013
Stress and depression consistently elevate inflammation and are often experienced simultaneously, which is exemplified by people in troubled relationships. Troubled relationships also elevate inflammation, which may be partially explained by their ability to engender high levels of stress and depression. People who are stressed, depressed, or in troubled relationships are ...
Peate Ian - - 2013
There has been a bit of a to do in some quarters concerning a call by the Academy of Medical Royal Colleges (AMRC) (2012) for a seven-day consultant presence. Nurses have always been seen as being with the patient 24 hours a day, 365 days a year, so for nursing ...
Castello Alfredo - - 2013
Owing to their preeminent biological functions, the repertoire of expressed RNA-binding proteins (RBPs) and their activity states are highly informative about cellular systems. We have developed a novel and unbiased technique, called interactome capture, for identifying the active RBPs of cultured cells. By making use of in vivo UV cross-linking ...
Liang Chao-Fan - - 2013
To analyze the role of toll-like receptor 4 in modulating metabolism and endothelial function. Type 2 diabetic mice with mutated toll-like receptor 4 (DWM) were protected from hyperglycemia and hypertension, despite an increased body weight. Isometric tension was measured in arterial rings with endothelium. Relaxations to acetylcholine were blunted in ...
Donati Marcello - - 2013
Abstract The authors describe the theoretical basis and development of simulation systems that led to the birth of "navigation in liver surgery." Navigation is a new technological application in the surgical field that has already been successfully used in neurosurgery and orthopedic surgery. A precondition to navigate a liver resection ...
Swisher Christine Leon - - 2013
PURPOSE: Magnetic resonance spectroscopy of hyperpolarized substrates allows for the observation of label exchange catalyzed by enzymes providing a powerful tool to investigate tissue metabolism and potentially kinetics in vivo. However, the accuracy of current methods to calculate kinetic parameters has been limited by T(1) relaxation effects, extracellular signal contributions, ...
Kinsey Steven G SG Department of Psychology, West Virginia University, Morgantown, West Virginia, - - 2013
The monoacylglycerol lipase (MAGL) inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) produces antinociceptive and anti-inflammatory effects. However, repeated administration of high-dose JZL184 (40 mg/kg) causes dependence, antinociceptive tolerance, cross-tolerance to the pharmacological effects of cannabinoid receptor agonists, and cannabinoid receptor type 1 (CB1) downregulation and desensitization. This functional CB1 receptor tolerance poses a ...
Hoffmann Luísa - - 2013
ABSTRACT: : About sixty thousand new cases of Hepatitis C virus (HCV) infection are recorded in Brazil each year. These cases are currently treated with pegylated interferon (PEG-IFN) and ribavirin (RBV) with an overall success rate of 50%. New compounds for anti-HCV therapy targeted to the HCV NS3 protease are ...
Fowell Christopher John - - 2013
Despite bone healing and the management options of facial fractures being reported at length, there is a lack of evidence-based return-to-play criteria for sportspeople who have sustained these fractures. This shortage of evidence has resulted in a lack of consensus among health professionals. A prospective study of 20 cases of ...
Weckhuysen Sarah - - 2013
Mutations in STXBP1 have been identified in a subset of patients with early onset epileptic encephalopathy (EE), but the full phenotypic spectrum remains to be delineated. Therefore, we screened a cohort of 160 patients with an unexplained EE, including patients with early myoclonic encephalopathy (EME), Ohtahara syndrome, West syndrome, nonsyndromic ...
Meurling Lisbet - - 2013
BACKGROUND: Teamwork-that is, collaboration and communication-is an important factor for safe healthcare, but professions perceive the quality of teamwork differently. OBJECTIVE: To examine the relationship between simulation-based team training (SBTT) and different professions' self-efficacy, experienced quality of collaboration and communication, perceptions of teamwork and safety, together with staff turnover. METHODS: ...
Ozen A - - 2013
This study was aimed to determine staining intensity, cellular localization and distribution of the nitric oxide synthase (NOS) enzymes during the sexual cycle in the cow oviduct. Oviduct samples belonging to 20 cows, 10 of which were in the estrual phase and 10 in the luteal phase of the sexual ...
Wang Wei - - 2013
Halobenzoquinones (HBQs) are a class of disinfection byproducts (DBPs) of health relevance. In this study, we aimed to uncover which HBQs were present in swimming pools. To achieve this goal, we developed a new method capable of determining eight HBQs while overcoming matrix effects to achieve reliable quantification. The method ...
Schäfer Philip - - 2013
Anaerobic conditions are often required in solution-based bionanotechnological applications. Efficient oxygen depletion is essential for increasing photostability, optimizing fluorescence signals, and adjusting kinetics of fluorescence intermittency in single-molecule fluorescence spectroscopy/microscopy, particularly for super-resolution imaging techniques. We characterized methylene blue (MB)- and thiol-based redox reactions aiming at designing an oxygen scavenger ...
Malhotra Ankit A Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22903, - - 2013
Tumor genomes are generally thought to evolve through a gradual accumulation of mutations, but the observation that extraordinarily complex rearrangements can arise through single mutational events suggests that evolution may be accelerated by punctuated changes in genome architecture. To assess the prevalence and origins of complex genomic rearrangements (CGRs), we ...
Scott Jason - - 2013
AIMS: Ambulance services in England receive around 8 million calls a year, and no known studies have explored characteristics of frequent callers. This study aimed to identify the characteristics of the most frequent callers to Yorkshire Ambulance Service (YAS) between April 2010 and March 2011. METHODS: Top 100 frequent callers ...
Hernández Diana - - 2013
The recent occurrence of Hurricane Sandy and other climate change-related calamities prompt us to consider the significance of public health in the aftermath of disaster. However, the field of public health also has a role to play in the awareness, preparedness, and deterrence of environmental factors that affect vulnerable populations ...
Gottschalk Catherine C Institutes of Molecular Medicine and Experimental Immunology, Rheinische Friedrich-Wilhelms-Universität, Sigmund Freud Strasse 25, 53105 Bonn, - - 2013
Although the spleen is a major site where immune tolerance to circulating innocuous antigens occurs, the kidney also contributes. Circulating antigens smaller than albumin are constitutively filtered and concentrated in the kidney and reach the renal lymph node by lymphatic drainage, where resident dendritic cells (DCs) capture them and induce ...
Kuentz P - - 2013
Does DPY19L2 status influence intracytoplasmic sperm injection (ICSI) outcomes with or without assisted oocyte activation (AOA)? DPY19L2 mutations have no major impact on ICSI outcomes in globozoospermic patients. Globozoospermia is a rare and severe teratozoospermia characterized by round-headed spermatozoa lacking an acrosome. Recently, it has been shown that DPY19L2 mutations ...
Patoine Dany - - 2013
Background: In humans, cytochrome P450 3A drug-metabolizing enzyme subfamily is the most important. Numerous pathophysiological factors, such as diabetes and obesity were shown to affect CYP3A activity. Often considered a precursor state for Type II diabetes, we hypothesized that metabolic syndrome exerts a modulating role on CYP3A. Objective: To evaluate ...
Ding Mingming - - 2013
Specific accumulation of therapeutics at tumor sites to improve in vivo biodistribution and therapeutic efficacy of anticancer drugs is a major challenge for cancer therapy. Herein, we demonstrate a new generation of intelligent nanosystem integrating multiple functionalities in a single carrier based on multifunctional multiblock polyurethane (MMPU). The smart nanocarriers ...
Lincoln Andrew E - - 2013
BACKGROUND:Boys' lacrosse has one of the highest rates of concussion among boys' high school sports. A thorough understanding of injury mechanisms and game situations associated with concussions in boys' high school lacrosse is necessary to target injury prevention efforts. PURPOSE:To characterize common game-play scenarios and mechanisms of injury associated with ...
Wahab Izyan A - - 2013
PURPOSE: To determine the validity of sequence symmetry analysis (SSA) method to detect adverse drug reactions from an administrative claims database. METHODS: Published randomised controlled trials (RCTs) of 19 medicines were identified through search databases, product information (PI) or the US Food and Drug Administration Web site. All adverse events ...
Sheats Kameron - - 2013
I applaud Florsheim et al.(1) for bridging the research to practice gap by developing and implementing the Young Parenthood Program (YPP) for expectant adolescent parents. The influence of intimate relationship factors upon the psychological adjustment and health of parents and children is a critical linkage that warrants more attention in ...
Van Look Paul F A - - 2013
We discuss the history of the World Health Organization's (WHO's) development of guidelines for governments on providing safe abortion services, which WHO published as Safe Abortion: Technical and Policy Guidance for Health Systems in 2003 and updated in 2012. We show how the recognition of the devastating impact of unsafe ...
Aizawa J - - 2013
Morphological studies of the gastrointestinal tract (GIT) of blue and yellow macaws (Ara ararauna) are scarce. Therefore, this study aims to describe the macaw's oropharyngeal cavity in order to supply the deficiency of anatomical data and as part of a broad study of the GIT of these birds. Two male ...
Tu Shikui S Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, - - 2013
Eric Davidson at Caltech has spent several decades investigating the molecular basis of animal development using the sea urchin embryo as an experimental system although his scholarship extends to all of embryology as embodied in several editions of his landmark book. In recent years his laboratory has become a leading ...
White William B - - 2013
ABSTRACT BACKGROUND Evaluation of CV safety for new therapies for COPD is important as there is a high prevalence of cardiac comorbidities in the COPD population. Hence, we evaluated the effects of roflumilast, a novel oral phosphodiesterase 4 (PDE-4) inhibitor developed for the treatment of prevention of COPD exacerbations on ...
Tong Lianpeng - - 2013
Mononuclear Ru-based water oxidation catalysts containing anionic ancillary ligands have shown promising catalytic efficiency and intriguing properties. However, their insolubility in water restricts a detailed mechanism investigation. In order to overcome this disadvantage, complexes [Ru(II)(bpc)(bpy)OH(2)](+) (1(+), bpc = 2,2'-bipyridine-6-carboxylate, bpy = 2,2'-bipyridine) and [Ru(II)(bpc)(pic)(3)](+) (2(+), pic = 4-picoline) were prepared ...
Rosati Anna A Neurology Clinic, Spedali Civili, Universityof Brescia, Brescia, Italy. - - 2013
Glutamine synthetase (GS) is an astrocytic enzyme catalyzing the conversion of glutamate and ammonia to glutamine. Its up-regulation has been related to higher tumor proliferation and poor prognosis in extra-cerebral tumors. We have previously reported a GS deficiency in patients with glioblastoma multiforme (GBM) who also developed epilepsy, which is ...
K Carroll Jennifer - - 2013
Transient perioperative hypothermia occurs as a consequence of surgery and general anaesthesia and is associated with increased blood loss (Schmied et al, 1996), increased transfusion rates, poor wound healing (MacFie et al, 2005), increased duration of inpatient stay and higher rates of surgical site infection (Kurz et al, 1996). It ...
Hayes Gemma E - - 2013
PURPOSE OF REVIEW: This review highlights key recent advances in fungal respiratory infections, encompassing developments in epidemiology, diagnostics and management, focussing on Aspergillus, Pneumocystis and Cryptococcus as key pathogens. RECENT FINDINGS: Chronic pulmonary aspergillosis complicates existing lung diseases, particularly those associated with cavities or bullae, with a high global disease ...
Mathieu Didier André - - 2013
Among the subsequent steps leading from impact to explosive decomposition in nitro compounds, the ability of early exothermic reactions to trigger the decomposition of neighboring molecules before the released energy has dissipated away is assumed to be critical. The rate of this process is roughly estimated using as only input ...
Azevedo Pedro - - 2013
Asthma frequently occurs in association with allergic rhinitis and a combined management approach has been suggested. The Control of Allergic Rhinitis and Asthma Test (CARAT) is the first questionnaire to assess control of both diseases concurrently. However, to have an impact on healthcare it needs to be disseminated and adopted. ...
Grubb Tamara L - - 2013
The cardiovascular and respiratory effects, and the quality of anesthesia of alfaxalone administered intramuscularly (IM) to cats sedated with dexmedetomidine and hydromorphone were evaluated. Twelve healthy adult cats were anesthetized, with six cats receiving dexmedetomidine (0.01 mg/kg IM) followed by alfaxalone (5 mg/kg IM; group DA) and six receiving dexmedetomidine ...
Cecchetti Valentina - - 2013
We have suggested that, in Arabidopsis, auxin controls the timing of anther dehiscence, possibly by preventing premature endothecium lignification. We show here that auxin content in anthers peaks before the beginning of dehiscence and declines when endothecium lignification occurs. We show that in the auxin-perception mutants afb1-3 and tir1afb2afb3 endothecium ...
Wang Eric - - 2013
Mixed-lineage leukemia (MLL) fusions are potent oncogenes that initiate aggressive forms of acute leukemia. As aberrant transcriptional regulators, MLL-fusion proteins alter gene expression in hematopoietic cells through interactions with the histone H3 lysine 79 (H3K79) methyltransferase DOT1L. Notably, interference with MLL-fusion cofactors like DOT1L is an emerging therapeutic strategy in ...
Bloch Yuval - - 2013
Objective: We hypothesized that patients with ADHD were typified by distress more than by functional difficulties. Thus, a decline in state anxiety while performing a cognitive task when taking methylphenidate would discriminate between ADHD patients and controls. Method: State anxiety and cognitive performance on a continuous performance test were assessed ...
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