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Boissière Louis L Unité chirurgie rachis1, Université Bordeaux CHU, 33076, Bordeaux, France. - - 2013
Sagittal malalignment is frequently observed in adult scoliosis. C7 plumb line, lumbar lordosis and pelvic tilt are the main factors to evaluate sagittal balance and the need of a vertebral osteotomy to correct it. We described a ratio: the lumbar lordosis index (ratio lumbar lordosis/pelvic incidence) (LLI) and analyzed its ...
Verity D H DH Orbital Unit, Moorfields Eye Hospital, London, UK. - - 2013
The active inflammatory phase of thyroid eye disease (TED) is mediated by the innate immune system, and management is aimed at aborting this self-limited period of autoimmune activity. In most patients with TED, ocular and adnexal changes are mild and management involves controlling thyroid dysfunction, cessation of smoking, and addressing ...
Fahed Akl C AC Department of Genetics, Harvard Medical School, Boston, MA 02115, - - 2013
Congenital heart disease (CHD) is the most common congenital anomaly in newborn babies. Cardiac malformations have been produced in multiple experimental animal models, by perturbing selected molecules that function in the developmental pathways involved in myocyte specification, differentiation, or cardiac morphogenesis. In contrast, the precise genetic, epigenetic, or environmental basis ...
Leunig Michael M Department of Orthopaedic Surgery, Schulthess Clinic, Zurich, Switzerland. - - 2013
The direct anterior approach for THA allows implantation through an internervous plane without muscle detachment from bone. However, the classic longitudinal skin incision does not follow the anatomic skin creases and can result in scar widening. We therefore modified our incision technique to a short oblique skin incision following the ...
Laborie Lene B LB Department of Surgical Sciences, University of Bergen, Bergen, Norway. - - 2013
Femoroacetabular impingement (FAI) is an incompletely understood clinical concept that implies pathomechanical changes in the hip as a cause for hip-related pain in young adults. While a positive anterior impingement test is suggestive of FAI, its association with clinical and radiographic findings remain unconfirmed in healthy young adults. We determined ...
Yu Raymond R Orthopaedic & Trauma Service, Department of Orthopaedic & Trauma, Royal Adelaide Hospital, Adelaide, SA, - - 2013
The Paprosky acetabular defect classification is widely used but has not been appropriately validated. Reliability of the Paprosky system has not been evaluated in combination with standardized techniques of measurement and scoring. This study evaluated the reliability, teachability, and validity of the Paprosky acetabular defect classification. Preoperative radiographs from a ...
Farshad M M Department of Orthopaedics, Balgrist University Hospital, University of Zürich, Forchstrasse 340, 8008 Zürich, Switzerland. - - 2013
While the Lasègue straight leg raising test is an established test for lumbar nerve root compression, an established equivalent for cervical nerve root compression is missing. The aim of this bi-modal study was to find the most effective way to stretch the cervical nerve roots anatomically in cadavers and to ...
Callahan S Todd ST Division of Adolescent and Young Adult Health, Department of Pediatrics, Vanderbilt School of Medicine, Nashville, Tennessee, USA. - - 2013
To assess the safety of psychotropic medication use in children and adolescents, it is critical to be able to identify suicidal behaviors from medical claims data and distinguish them from other injuries. The purpose of this study was to develop an algorithm using administrative claims data to identify medically treated ...
Thurtell Matthew J MJ Department of Ophthalmology, Emory University, Atlanta, GA, USA. - - 2013
Patients with idiopathic intracranial hypertension (IIH) frequently have coexisting obstructive sleep apnea (OSA). We aimed to determine if the prevalence and severity of OSA is greater in patients with IIH than would be expected, given their other risk factors for OSA. We included 24 patients (20 women, four men) with ...
Bates Marsha E ME Center of Alcohol Studies, Rutgers, The State University of New Jersey, 607 Allison Road, Piscataway, NJ 08854-8001, USA. - - 2013
Neurocognitive impairments are prevalent in persons seeking treatment for alcohol use disorders (AUDs). These impairments and their physical, social, psychological and occupational consequences vary in severity across persons, much like those resulting from traumatic brain injury; however, due to their slower course of onset, alcohol-related cognitive impairments are often overlooked ...
Alshaer Hisham H Sleep and Upper Airway Team & Technology Team, Toronto Rehabilitation Institute, University Health Network, 550 University Avenue, Toronto, ON M5G 2A2, Canada. - - 2013
Sleep apnea (SA) is a very common disease with serious health consequences, yet is very under-diagnosed, partially because of the high cost and limited accessibility of in-laboratory polysomnography (PSG). The purpose of this work is to introduce a newly developed portable system for the diagnosis of SA at home that ...
Henriques Ana A Centro do Sangue e da Transplantação de Coimbra, Instituto Português do Sangue e da Transplantação, Edifício São Jerónimo, 4º Piso Praceta Mota Pinto, 3001-301 Coimbra, - - 2013
With the discovery of Th17 cells, it became unclear whether rheumatoid arthritis (RA) is a Th1-mediated and/or a Th17-mediated disease. The aim of this study was to identify and characterize the pro-inflammatory function of IL-17-producing T cell subsets (Th(c)17) in RA. Flow cytometry analysis was performed on peripheral blood from ...
Zhu Rui R Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, CA, - - 2013
Omalizumab, a recombinant humanized monoclonal antibody, is the first approved anti-immunoglobulin E (IgE) agent for the treatment of subjects with moderate to severe persistent allergic asthma that are inadequately controlled by the standard of care. The objective of this study was to quantitatively characterize relationships between serum free IgE and ...
Stuart Lynda M LM Developmental Immunology/CCIB, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114, USA. - - 2013
A fundamental question regarding any immune system is how it can discriminate between pathogens and non-pathogens. Here, we discuss how this discrimination can be mediated by a surveillance system distinct from pattern-recognition receptors that recognize conserved microbial patterns. It can be based instead on the ability of the host to ...
Kumar Ankur N AN Department of Electrical Engineering, 367 Jacobs Hall, Vanderbilt University, Nashville, TN 37212, - - 2013
With the advent of in vivo laser scanning fluorescence microscopy techniques, time-series and three-dimensional volumes of living tissue and vessels at micron scales can be acquired to firmly analyze vessel architecture and blood flow. Analysis of a large number of image stacks to extract architecture and track blood flow manually ...
Piegari Elena E Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Naples, Italy. - - 2013
The increasing population of cancer survivors faces considerable morbidity and mortality due to late effects of the antineoplastic therapy. Cardiotoxicity is a major limiting factor of therapy with doxorubicin (DOXO), the most effective anthracycline, and is characterized by a dilated cardiomyopathy that can develop even years after treatment. Studies in ...
Swindle Jamala D JD Farquhar College of Arts and Sciences, Nova Southeastern University, Fort Lauderdale, FL, 33314, - - 2013
The discovery of a novel non-AT1, non-AT2 binding site for angiotensins in the rodent brain and testis that is unmasked by the organomercurial compound para-chloromercuribenzoic acid (PCMB) has catalyzed efforts to purify and characterize this protein. We recently reported that this protein is neurolysin and now report upon the specificity ...
Hoffmann U U Institute of Physiology and Anatomy, German Sport University, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany. - - 2013
During non-steady-state exercise, dynamic changes in pulmonary oxygen uptake (VO₂pulm) are dissociated from skeletal muscle VO₂ (VO₂musc) by changes in lung and venous O₂ concentrations (CvO₂), and the dynamics and distribution of cardiac output (CO) between active muscle and remaining tissues (Qrem). Algorithms can compensate for fluctuations in lung O₂ ...
Vandewauw Ine - - 2013
ABSTRACT: BACKGROUND: Somatosensory nerve fibres arising from cell bodies within the trigeminal ganglia (TG) in the head and from a string of dorsal root ganglia (DRG) located lateral to the spinal cord convey endogenous and environmental stimuli to the central nervous system. Although several members of the transient receptor potential ...
Tyan Chung Chun - - 2013
BACKGROUND: -Ischemia and tissue injury are common in patients with hypertrophic cardiomyopathy (HCM). Cardiovascular magnetic resonance (CMR) imaging offers combined evaluations of each phenomenon at sufficiently high resolution to examine transmural spatial distribution. In this prospective cohort study we examine the spatial distribution of stress perfusion abnormalities and tissue injury ...
Albright Karen C - - 2013
Background-The creation of The Joint Commission primary stroke centers (PSCs) has increased access to acute stroke care in metropolitan areas. We hypothesized that the rise in PSCs in the Houston area was associated with demographic changes and decreased trial enrollment at our comprehensive stroke center. METHODS: Consecutive admissions to the ...
Taioli Emanuela - - 2013
Video-assisted thoracic surgery (VATS) lobectomy is an appealing alternative to open lobectomy via thoracotomy for non-small-cell lung cancer. However, there is no clear consensus in regard to the superior approach for long-term outcomes. The data are limited to small series, which precludes further clarification. Meta-analysis of these studies was performed ...
Carraro Silvia - - 2013
ABSTRACT BACKGROUND. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor and uncoupler of nitric oxide synthase. By promoting the formation of peroxynitrite, ADMA is believed to contribute to several aspects of asthma pathogenesis, i.e. airway inflammation, oxidative stress, bronchial hyperresponsiveness and collagen deposition. The aim of the present study was to ...
Bolognesi M L - - 2013
Polypharmacology offers a model for the way drug discovery must evolve to develop therapies most suited to treating currently incurable diseases. It is driven by a worldwide demand for safer, more effective, and affordable medicines against the most complex diseases, and by the failures of modern drug discovery to provide ...
Piir G - - 2013
Quantitative structure-activity relationships (QSARs) are broadly classified as global or local, depending on their molecular constitution. Global models use large and diverse training sets covering a wide range of chemical space. Local models focus on smaller structurally or chemically similar subsets that are conventionally selected by human experts or alternatively ...
Ragno Michele - - 2013
BACKGROUND AND PURPOSE: To describe parkinsonism as a clinical manifestation of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. METHODS: We report 5 patients carrying the R1006C mutation in the exon 19 of NOTCH3 gene. All cases presented late onset, slowly progressive parkinsonism, not responsive to l-dopa. We performed ...
Wittkop Tobias - - 2013
ABSTRACT: BACKGROUND: Gene Ontology (GO) enrichment analysis remains one of the most common methods for hypothesis generation from high throughput datasets. However, we believe that researchers strive to test other hypotheses that fall outside of GO. Here, we developed and evaluated a tool for hypothesis generation from gene or protein ...
Koike Anna - - 2013
Isolates of the yeast Malassezia pachydermatis obtained from skin samples of healthy dogs and of dogs with atopic dermatitis in Japan, Taiwan and Korea were molecularly characterized using intergenic pacer 1 (IGS1) region analysis. The percentage of IGS1 subtype isolates detected in healthy skin was as follows: 1A (6%), 1B ...
Ballent M - - 2013
The role of the transporter P-glycoprotein (P-gp) in the disposition kinetics of different drugs therapeutically used in veterinary medicine has been demonstrated. Considering the anatomo-physiological features of the ruminant species, the constitutive expression of P-gp (ABCB1) along the sheep gastrointestinal tract was studied. Additionally, the effect of repeated dexamethasone (DEX) ...
Neumann Ignacio - - 2013
ABSTRACT BACKGROUND: The executive committee of the American College of Chest Physicians 9th edition of the Antithrombotic Guidelines (AT9) developed a novel policy for managing conflicts of interest (COI): methodologists bore primary responsibility for each chapter; there was equal emphasis on intellectual and financial COI; and content experts with COI ...
Williams Ellen P - - 2013
Obesity continues to affect African Americans in epidemic proportions, particularly among women and adolescent females. Perceptions, beliefs, behaviors, and body sizes of adolescents are associated with those of their mothers, yet little is known about the transgenerational meanings and experiences of obese African American adolescent girls and their mothers. An ...
Meckelmann Sven Werner - - 2013
The national Capsicum germplasm bank of Peru at INIA holds a unique collection of more than 700 Capsicum accessions, including many landraces. These conserved accessions have never been thoroughly characterized or evaluated. Another smaller collection exists at UNALM, and CIDRA provided taxonomically characterized fruits from the Amazon region of Ucayali. ...
Disanto Giulio - - 2013
Gene-environment interactions may shed light on the mechanisms underlying multiple sclerosis (MS). We pooled data from two case-control studies on incident demyelination and used different methods to assess interaction between HLA-DRB1*15 (DRB1-15) and history of infectious mononucleosis (IM). Individuals exposed to both factors were at substantially increased risk of disease ...
Laetz Cathy Ann - - 2013
In western North America, mixtures of current use pesticides have been widely detected in streams and other aquatic habitats for threatened and endangered Pacific salmon and steelhead (Oncorhynchus sp.). These include organophosphate insecticides that inhibit acetylcholinesterase (AChE) enzyme activity in the salmon nervous system, thereby disrupting swimming and feeding behaviors. ...
Syrmis Melanie W - - 2013
Shared strains of Pseudomonas aeruginosa are now well recognised in people with cystic fibrosis (CF) and suitable P. aeruginosa laboratory typing tools are pivotal to understanding their clinical significance and guiding infection control policies in CF clinics. We therefore compared a single nucleotide polymorphism (SNP)-based typing method using Sequenom iPLEX ...
Zheng Ze-Bao - - 2013
The anion-interaction properties of a Ru(II) complex of [Ru(bpy)(2)(Htppip)](ClO(4))(2)·H(2)O·DMF (RuL) {bpy =2,2'-bipyridine and Htppip =2-(4-(2,6-di(pyridin-2-yl)pyridin-4-yl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline} were thoroughly investigated in CH(3)CN and CH(3)CN/H(2)O (50:1, v/v) solutions by UV-visible absorption, emission, and (1)H NMR spectra. These analyses revealed that RuL acts as an efficient "turn on" emission sensor for H(2)PO(4)(-), and a ...
Bohinc Brittany - - 2013
Background: Locally or widely metastatic medullary thyroid carcinoma (MTC) is difficult to treat and therapeutic options are limited. Recently, kinase inhibitors have shown partial efficacy in this cancer, but there is a continued need for the development of novel therapeutics. Within this context, the Hedgehog (Hh) pathway has been implicated ...
Marsh Pamela - - 2013
OBJECTIVE: Social cognition is profoundly impaired in patients with schizophrenia. This study describes 'Mental-State Reasoning Training for Social Cognitive Impairment' (SoCog-MSRT), a 5-week program developed to improve social cognition in patients with schizophrenia. We aimed to investigate the feasibility of implementing SoCog-MSRT in a rehabilitation setting and to evaluate whether ...
Conde Ana - - 2013
The dehydrogenation of n-hexane and cycloalkanes giving n-hexene and cycloalkenes has been observed in the reaction of such hydrocarbons with hydrogen peroxide, in the presence of copper complexes bearing trispyrazolylborate ligands. This catalytic transformation provides the typical oxidation products (alcohol and ketones) with small amounts of the alkenes, a novel ...
Stanciuc Nicoleta - - 2013
Bovine lactoferrin (LF) is subjected to thermal processing during isolation for commercial use and while preparing milk products intended for infant nutrition. The present study is focused on the heat-induced structural changes of LF in buffer solution. Fluorescence spectroscopy, molecular modeling and enzymatic hydrolysis studies were combined to extensively characterize ...
den Adel Brigit - - 2013
Recent advances in molecular resonance imaging of atherosclerosis enable to visualize atherosclerotic plaques in vivo using molecular targeted contrast agents. This offers opportunities to study atherosclerosis development and plaque vulnerability noninvasively. In this review, we discuss MRI contrast agents targeted toward atherosclerotic plaques and illustrate how these new imaging platforms ...
Paneni Francesco - - 2013
BACKGROUND: Reactive oxygen species (ROS) are major determinants of vascular aging. JunD, a member of the activated protein 1 (AP-1) family of transcription factors, is emerging as a major gatekeeper against oxidative stress. However, its contribution to ROS homeostasis in the vasculature remains unknown. METHODS AND RESULTS: Endothelium-dependent vasorelaxation was ...
Degnan A J - - 2013
SUMMARY:Most dementias begin insidiously, developing slowly and generally occurring in the elderly age group. The so-called rapidly progressive dementias constitute a different, diverse collection of conditions, many of which are reversible or treatable. For this reason, accurate identification and assessment of acute and subacute forms of dementia are critical to ...
Panigrahi Rajesh - - 2013
ABSTRACT: BACKGROUND: Antiviral therapy using nucleos(t)ide analogues (NAs) is an effective control measure of chronic hepatitis B virus (HBV) infection; however they need long term treatment. Presence of drug-resistance mutations may get in the way of the efficacy of antiviral therapy. Our study was aimed at defining the prevalence of ...
Hayes Mark - - 2013
PURPOSE: This study examined the effect of a hot humid (HH) compared to a hot dry (HD) environment, matched for heat stress, on intermittent sprint performance. In comparison to HD, HH environments compromise evaporative heat loss and decrease exercise tolerance.6 It was hypothesized HH would produce greater physiological strain and ...
Park Mi-Young - - 2013
BACKGROUND: Many approaches have been suggested as anti-tumor therapy targeting IGF-1R, such as monoclonal antibodies and tyrosine kinase inhibitor (TKI). We introduced recombinant adenoviruses expressing antisense, dominant negative, or short hairpin RNA to IGF-1R. Moreover, we demonstrated that HDAC inhibitor (vorinostat) can increase the transduction efficiency of adenoviruses by increasing ...
Kessels Roy P C - - 2013
The ability to recognize and label emotional facial expressions is an important aspect of social cognition. However, existing paradigms to examine this ability present only static facial expressions, suffer from ceiling effects or have limited or no norms. A computerized test, the Emotion Recognition Task (ERT), was developed to overcome ...
Gervain Judit - - 2013
A central problem in language acquisition is how children effortlessly acquire the grammar of their native language even though speech provides no direct information about underlying structure. This learning problem is even more challenging for dual language learners, yet bilingual infants master their mother tongues as efficiently as monolinguals do. ...
Kung Annie W - - 2013
ABSTRACT: BACKGROUND: A vast amount of literature describes the incidence of fracture as a risk for recurrent osteoporotic fractures in western and Asian countries. Osteoporosis evaluation and treatment after a low-trauma fracture, however, has not been well characterized in postmenopausal women in Asia. The purpose of this study was to ...
Lipman Timothy O - - 2013
The volume of medical literature grows exponentially. Yet we are faced with the necessity to make clinical decisions based on the availability and quality of scientific information. The general strength (reliability, robustness) of any interpretation that guides us in clinical decision making is dependent on how information was obtained. All ...
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