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Results 601 - 650 of 3474
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Cipriani Paola - - 2013
INTRODUCTION: Vascular involvement is a key feature of Systemic sclerosis (SSc). Although the pericytes/endothelial cells (ECs) cross-talk regulates vessels formation, no evidences about the pericytes contribution to ineffective angiogenesis in SSc are available. Recent findings showed similarities between pericytes and Bone Marrow Mesenchymal Stem Cells (BM-MSCs). Due to difficulties in ...
Fathallah Salem - - 2013
This study assessed sediment pollution along the Tunisian coast using the sediment contact assay with embryo and larval life-stages of the clam Ruditapes decussatus. Sediment was collected from four sites for testing: Mahres, Monastir lagoon, Zarat and Chebba. Embryo development was significantly (p < 0.05) inhibited in sediment at concentrations ≥5 g L(-1) from ...
Morita Hideki - - 2013
Hereditary hemorrhagic telangiectasia (HHT; Osler-Weber-Rendu syndrome) is an uncommon disease characterized by abnormal telangiectasias and arteriovenous malformations that cause recurrent bleeding. Here, we present the case of a patient with HHT, who had a history of pulmonary and hepatic arteriovenous malformations and endocarditis of a prosthetic aortic valve that was ...
Kim Beom-Su - - 2013
Collagen sponges (COL-S) are used as scaffolds to support osteoblasts and stimulate bone repair because of their flexibility, biocompatibility, and biodegradability. In this study, we added fibrin networks to COL-S scaffolds by using a fibrinogen (FNG) cross-linking reaction and evaluated the proliferation, differentiation, and adhesion of MG-63 cells on these ...
Dhanani Akhilesh S - - 2013
The aim of the present study was to evaluate the potential of Lactobacillus plantarum CS24.2 to antagonize Escherichia coli adhesion and modulate the expression of inflammatory molecules by HT-29 cells response to the E. coli adhesion. This was carried out under different adhesion conditions and compared with the response seen ...
Liu Zhenzhen - - 2013
PURPOSE: Larotaxel is a new taxane compound with poor solubility. The aim of this study is to develop a new formulation to locate the poorly soluble drug and compare the pharmacokinetics and tissue distribution of larotaxel-loaded microsphere (LTX-LM) with the solution form larotaxel-solution (LTX-solution). METHODS: A sensitive and efficient UPLC-MS/MS ...
Switzer William - - 2013
Thalassemia is an inherited genetic disorder requiring multiple transfusions to treat anemia caused by low hemoglobin levels. Thus, thalassemia patients are at risk for infection with blood-borne pathogens, including human T-cell lymphotropic viruses (HTLV) that are transmitted by transfusion of cellular blood products. Here, we examined the prevalence of HTLV ...
Har R - - 2013
AIMS/HYPOTHESIS: High intraglomerular pressure causes renal inflammation in experimental models of diabetes. Our objective was to determine whether renal hyperfiltration, a surrogate for intraglomerular hypertension, is associated with increased excretion of urinary cytokines/chemokines in patients with type 1 diabetes mellitus. METHODS: Blood pressure, renal haemodynamic function (inulin and para-aminohippurate clearances ...
Verity D H DH Orbital Unit, Moorfields Eye Hospital, London, UK. - - 2013
The active inflammatory phase of thyroid eye disease (TED) is mediated by the innate immune system, and management is aimed at aborting this self-limited period of autoimmune activity. In most patients with TED, ocular and adnexal changes are mild and management involves controlling thyroid dysfunction, cessation of smoking, and addressing ...
García-Medina J - - 2013
PURPOSE: To evaluate the value of duplex ultrasound assistance during thromboaspiration of thrombosed arteriovenous fistulae for haemodialysis. MATERIALS AND METHODS: We prospectively studied 54 thrombosed native fistulae (23 with total thrombosis and 31 with partial thrombosis), in which we performed manual thromboaspiration guided by ultrasonography associated with fluoroscopy. RESULTS: The ...
Fahed Akl C AC Department of Genetics, Harvard Medical School, Boston, MA 02115, - - 2013
Congenital heart disease (CHD) is the most common congenital anomaly in newborn babies. Cardiac malformations have been produced in multiple experimental animal models, by perturbing selected molecules that function in the developmental pathways involved in myocyte specification, differentiation, or cardiac morphogenesis. In contrast, the precise genetic, epigenetic, or environmental basis ...
Wu Jihuai - - 2013
Here we present an ultraviolet responsive inorganic-organic hybrid solar cell based on titania/poly(3-hexylthiophene) (TiO(2)/P3HT) heterojuction. In this solar cell, TiO(2) is an ultraviolet light absorber and electronic conductor, P3HT is a hole conductor, the light-to-electrical conversion is realized by the cooperation for these two components. Doping ionic salt in P3HT ...
Carman Kursat Bora - - 2013
Elemental mercury exposure occurs frequently and is potentially a toxic, particularly in children. Children are often attracted to elemental mercury because of its color, density, and tendency to form beads. Clinical manifestations of elemental mercury intoxication vary depending on its form, concentration, route of ingestion, and the duration of exposure. ...
Ghosh Debashis - - 2013
A phenylalanine derived chiral amide is developed that serves as an effective organocatalyst for the reaction of allyltrichlorosilane with aryl, hetero-aryl and α,β-unsaturated aldehydes to afford the desired homoallylic alcohols in good yield (up to 90%) and high enantioselectivity (up to 99%). The experimental results and DFT calculations suggest that ...
Nandre R - - 2013
To evaluate the efficacy of a novel attenuated Salmonella Enteritidis (△lon△cpxR) vaccine candidate (JOL919), chickens were immunized through oral and intramuscular routes to reduce egg contamination against S. Enteritidis challenge. Birds were orally immunized with JOL919 on the first day of life and were subsequently boosted in the 6th and 16th ...
Antoneli Fernando - - 2013
In this paper, we revisit and adapt to viral evolution an approach based on the theory of branching process advanced by Demetrius et al. (Bull. Math. Biol. 46:239-262, 1985), in their study of polynucleotide evolution. By taking into account beneficial effects, we obtain a non-trivial multivariate generalization of their single-type ...
Ladwani Kiran D - - 2013
This study was carried out to generate data pertaining to spatial distribution of PAHs immediately after an oil spill event in a near shore environment. The physico-chemical characteristics of the sea water after the oil spill event indicated pH variation between 7.69 and 8.06, temperature varied between 27.0 and 29.5°C, ...
Terai Takuya - - 2013
Fluorescent compounds based on synthetic small molecules are powerful tools to visualize biological events in living cells and organisms. Ever since the discovery of organic fluorescent compounds in the late nineteenth century, efforts have been made to "see" the behaviors of specific biomolecules in living systems by using these dyes ...
Combres Laurent - - 2013
With respect to our psychoanalytic frame of reference allowing us to study the extent of the hypotheses concerning the religious phenomenon as formulated by Sigmund Freud and Jacques Lacan, in the context of a cross approach between the accuracy of the concept of conversion and of psychic mechanisms or phenomena ...
Lemaitre Guillaume - - 2013
We searched for evidence that the auditory organization of categories of sounds produced by actions includes a privileged or "basic" level of description. The sound events consisted of single objects (or substances) undergoing simple actions. Performance on sound events was measured in two ways: sounds were directly verified as belonging ...
Hoffmann U U Institute of Physiology and Anatomy, German Sport University, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany. - - 2013
During non-steady-state exercise, dynamic changes in pulmonary oxygen uptake (VO₂pulm) are dissociated from skeletal muscle VO₂ (VO₂musc) by changes in lung and venous O₂ concentrations (CvO₂), and the dynamics and distribution of cardiac output (CO) between active muscle and remaining tissues (Qrem). Algorithms can compensate for fluctuations in lung O₂ ...
Kumar Ambuj - - 2013
Centrosomes are the key-regulating element of cell cycle progression. Aberrations in their functional mechanism lead to several cancer-related disorders. Aurora A protein is a centrosome-associated protein that regulates the centriole duplication and its abberations are associated with multiple cases of aneuploidy and cancer-related disorders. S155R mutation in Aurora A is ...
Cento Valeria - - 2013
A patient classified as HCV-1a positive by both LiPA Siemens 2.0 and Abbott RealTime HCV-Genotype II, was instead infected with HCV-1g, as determined by phylogenetic-analysis of NS3-sequences. HCV-1g NS3-sequences to date available naturally harbor the resistance-substitution T54S, plus P131S and L135F changes, located in the highly conserved NS3-positions within boceprevir-binding ...
Liu Bin - - 2013
A new hydrogen sensor was fabricated by coating a Pd-decorated In(2)O(3) film on Au electrodes. In response to 1 vol% H(2) at room temperature, an ultra high sensitivity of 4.6 × 10(7) was achieved. But after an annealing treatment in vacuum, its sensitivity degenerated by 4 orders of magnitude. In ...
Shetty Prakash - - 2013
Advances in agriculture and food systems, consequent increases in food availability, and a shift in dietary consumption patterns with economic development and urbanization of developing societies leads to adverse health outcomes. The structure of the habitual diet is altered and is characterized by increasing consumption of fats, saturated fats largely ...
Quesseveur G - - 2013
Evidence suggests that the serotonin 2A receptor (5-HT(2A)R) modulates the therapeutic activity of selective serotonin reuptake inhibitors (SSRIs). Indeed, among the genetic factors known to influence the individual response to antidepressants, the HTR2A gene has been associated with SSRIs response in depressed patients. However, in these pharmacogenetic studies, the consequences ...
Fowler John - - 2013
This series of articles is designed to help you advance your nursing practice. Parts one and two explored the motivation to advance practice, the differences between specialist and advanced practice and the importance of setting objectives.
Sifre L - - 2013
Optical microscopy offers the simplest way to obtain magnified images of biological tissues. The assessment of the muscle destructuration level can be performed by a method called Meat Destruction Indicator (MDI), which combines optical microscopy and image analysis. MDI can be used for evaluation of food quality and for considering ...
Scholz Judith - - 2013
ABSTRACT: BACKGROUND: Expression and purification of correctly folded proteins typically require screening of different parameters such as protein variants, solubility enhancing tags or expression hosts. Parallel vector series that cover all variations are available, but not without compromise. We have established a fast, efficient and absolutely background free cloning approach ...
Naing A A Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. - - 2013
Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy without an available effective systemic chemotherapy. Insulin growth factor 2 (IGF-2) overexpression leading to the activation of the IGF-1 receptor (IGF-1R)/mammalian target of rapamycin (mTOR) pathway is well described in ACC. Cixutumumab, a fully human IgG1 monoclonal antibody directed at ...
Maoz Ben M - - 2013
Chiral molecules are shown to induce circular dichroism (CD) at surface plasmon resonances of gold nanostructures when in proximity to the metal surface without direct bonding to the metal. By changing the molecule-Au separation, we were able to learn about the mechanism of plasmonic CD induction for such nanostructures. It ...
Westphal Anne - - 2013
The manganese(III) Schiff base complexes [Mn(acen)X] (H(2)acen: N,N'-ethylenebis(acetylacetone)imine, X: I(-), Br(-), Cl(-), NCS(-)) are considered as model systems for a combined study of the electronic structure using vibrational, UV/vis absorption, parallel-mode electron paramagnetic resonance (EPR) and low-temperature magnetic circular dichroism (MCD) spectroscopy. By variation of the co-ligand X, the influence ...
Rossow Lindy M - - 2013
Bodybuilding is a sport in which competitors are judged on muscular appearance. This case study tracked a drug-free male (aged 26-27) bodybuilder for the six months prior to and following a competition. PURPOSE: The aim of this study was to provide the most comprehensive physiological profile of bodybuilding competition preparation ...
Song Daisheng D Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, - - 2013
Prolyl hydroxylase domain protein 2 (PHD2, also known as Egg Laying Defective Nine homolog 1) is a key oxygen-sensing protein in metazoans. In an oxygen-dependent manner, PHD2 site-specifically prolyl hydroxylates the master transcription factor of the hypoxic response, hypoxia-inducible factor-α (HIF-α), thereby targeting HIF-α for degradation. In this report we ...
Hermann D - - 2013
Several metal-organic framework compounds (MOF-5, MIL-68(Ga), MIL-68(In), MIL-53(Al)) were loaded with azobenzene (AZB), as confirmed by XRPD measurements and elemental analysis. By IR spectroscopy, it was shown that the light-induced trans/cis isomerization of AZB in these hybrid host-guest compounds is improved compared to that of solid AZB. A population of ...
Li Hai - - 2013
ABSTRACT: BACKGROUND: Critical illness polyneuropathy (CIP) and critical illness myopathy (CIM) are complications causing weakness of respiratory and limb muscles in critically ill patients. As an important differential diagnosis of Guillain-Barre syndrome (GBS), CIP and CIM should be diagnosed with caution, after a complete clinical and laboratory examination. Although not ...
Shrestha Anish Man Singh - - 2013
Many high-throughput sequencing experiments produce paired DNA reads. Paired-end DNA reads provide extra positional information that is useful in reliable mapping of short reads to a reference genome as well as in downstream analyses of structural variations. Given the importance of paired-end alignments, it is surprising that there have been ...
Xin Hong-Wu - - 2013
OBJECTIVE: The standard therapy for advanced hepatocellular carcinoma (HCC) is sorafenib, with most patients experiencing disease progression within 6 months. Label-retaining cancer cells (LRCC) represent a novel subpopulation of cancer stem cells (CSC). The objective was to test whether LRCC are resistant to sorafenib. METHODS: We tested human HCC derived ...
Cruz-Silva Eduardo - - 2013
High-resolution transmission electron microscopy (HRTEM) studies show the dynamics of small graphene platelets on larger graphene layers. The platelets move nearly freely to eventually lock in at well-defined positions close to the edges of the larger underlying graphene sheet. While such movement is driven by a shallow potential energy surface ...
Morís de la Tassa Joaquín - - 2013
To improve patient safety, it is essential to have knowledge of the attitudes of all those involved in health care. The Thomas Jefferson Survey on Inpatient Adverse Events was translated and validated; all residents in Asturias, Spain, were invited to complete the survey. A total of 359 residents (60%) completed ...
Ribeiro Fernanda - - 2013
Exercise training is one of the most powerful interventions to provide symptomatic relief in patients with COPD. The purpose of this mini-review is to discuss how exercise training can improve limb muscle dysfunction in this disease. Various exercise training strategies will be outlined, along with their beneficial effects and potential ...
Ganaden Rachel E - - 2013
Traditionally, it has been theorized that the human visual system identifies and classifies scenes in an object-centered approach, such that scene recognition can only occur once key objects within a scene are identified. Recent research points toward an alternative approach, suggesting that the global image features of a scene are ...
Close Graeme L - - 2013
BACKGROUND: Vitamin D deficiency is common in the general public and athletic populations and may impair skeletal muscle function. We therefore assessed the effects of vitamin D(3) supplementation on serum 25[OH]D concentrations and physical performance. METHODS: 30 club-level athletes were block randomised (using baseline 25[OH]D concentrations) into one of three ...
Lin Ke - - 2013
Background: Doubly committed Subarterial ventricular septal defect (VSD) is a specific anatomic type of VSD located just beneath the aortic valve. The purpose of this study was to evaluate the safety and feasibility of using minimal invasive perventricular device closure in managing this type of VSD. Methods: During Dec 2008 ...
Paradis Jean-Michel - - 2013
We report the case of an 81 year-old woman with symptomatic severe aortic stenosis, extremely significant peripheral arterial disease and obstructive coronary artery disease who underwent percutaneous coronary intervention via a transaxillary conduit immediately before a trans-apical transcatheter aortic valve replacement performed with a transfemoral device. After deployment of the ...
Chang Yi-Chih - - 2013
The "Guideliner", a child catheter, aims to deliver stents in tortuous coronary lesions by deep engagement and providing better support. Coronary artery spiral dissection which may be caused by deep-seated coronary catheters or non-coaxial engagement is one of the most seen percutaneous coronary intervention-related complications. In this case, Guideliner-related left ...
Smith Elizabeth A EA Department of Social and Behavioral Sciences, University of California, San Francisco, USA. - - 2013
Smoking impairs the readiness and performance of military personnel, yet congressional opposition has thwarted military tobacco control initiatives. Involvement of civilian organizations might alter this political dynamic. We interviewed 13 leaders of national civilian public health and tobacco control organizations to explore their perspectives on military tobacco control, inductively analyzing ...
Rumball-Smith Juliet - - 2013
OBJECTIVE: /st>To compare the quality of hospital care for New Zealand (NZ) Māori and NZ European adult patients, using the rate of unplanned readmission or death within 30 days of discharge as an indicator of quality. DESIGN: /st>Retrospective cohort study. SETTING: /st>NZ public hospitals. PARTICIPANTS: /st>Data from 89 658 patients ...
McDowell J J - - 2013
A complex system is one that generates emergent structures, usually by the repeated application of relatively simple rules. The structures are emergent in the sense that they are not specified in, and cannot be predicted from, the rules that produce them. Mitchell argues for a unified science of complexity but ...
Cebula Marcus M Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, - - 2013
The human selenoprotein thioredoxin reductase 1 (TrxR1), encoded by the TXNRD1 gene, is a key player in redox regulation. Alternative splicing generates several TrxR1 variants, one of which is v3 that carries an atypical N-terminal glutaredoxin domain. When overexpressed, v3 associates with membranes and triggers formation of filopodia. Here we ...
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