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Molloy Lauren E LE The Pennsylvania State University, University Park, PA, USA, - - 2013
Programs delivered in the "real world" often look substantially different from what was originally intended by program developers. Depending on which components of a program are being trimmed or altered, such modifications may seriously undermine the effectiveness of a program. In the present study, these issues are explored within a ...
Salabei Joshua K JK Department of Medicine, Diabetes and Obesity Center, University of Louisville, 580 S. Preston Street, Delia Baxter Building, Rm. 404E, Louisville, KY, 40292, - - 2013
Cardiovascular disease (CVD) remains the leading cause of death worldwide, despite the significant advances in medicine. Autophagy, a process of self-cannibalization employed by mammalian cells for the recycling of cellular contents, is altered not only in a number of CVDs, but in other diseases, as well. Many FDA-approved drugs are ...
Holstein Joerg H JH Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Kirrberger Strasse 1, 66421, Homburg, Germany. - - 2013
Data from literature on predictors for patients' quality of life after pelvic ring fractures are conflicting and based on small study populations. We therefore evaluated predictors for health-related quality of life in patients with pelvic ring injuries at a minimum of 1 year postfracture. We surveyed 172 patients of the ...
Sitnik Alexandre A AA Belarus Republic Scientific and Practical Center for Traumatology and Orthopedics, Kizhevatova 60-4, 220004, Minsk, Belarus. - - 2013
Minimally invasive percutaneous plate fixation (MIPPF) has gained wide acceptance for treating periarticular fractures of the tibia. Despite the theoretical biological advantages of MIPPF, it is unclear whether these are offset by wound complications, union rate, and malalignment. We therefore estimated the rate of union in tibial fractures treated by ...
Unuane David D Department of Endocrinology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, - - 2013
Thyroid autoimmunity (TAI) is frequent in infertile women, but to what extent thyroglobulin autoantibodies (Tg-Abs) contribute to TAI is unclear in the literature. The aims of the present study were to determine the prevalence of TAI in women consulting for fertility problems and to investigate the impact of isolated Tg-Abs, ...
Gedmintas Lydia L Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA. - - 2013
Although there is strong evidence that bisphosphonates prevent certain types of osteoporotic fractures, there are concerns that these medications may be associated with rare atypical femoral fractures (AFF). Recent published studies examining this potential association are conflicting regarding the existence and strength of this association. We conducted a systematic review ...
Wardlow Liane L Department of Psychology 0109, University of California, San Diego, La Jolla, CA 92093-0109, USA. - - 2013
Both speaking and listening require taking into account the perspective of one's communicative partner. Is perspective taking a domain-specific process internal to the language production and comprehension systems? Or is it a domain-general process regulated by the same mechanisms that are used to regulate other forms of behavior? Past research ...
Gletsu-Miller Nana N Department of Nutrition Sciences, Purdue University, 700 W. State Street, Stone Hall, West Lafayette, IN 47907, USA. - - 2013
In the context of increasing obesity prevalence, the relationship between large visceral adipose tissue (VAT) volumes and type 2 diabetes mellitus (T2DM) is unclear. In a clinical sample of severely obese women (mean body mass index [BMI], 46 kg/m(2)) with fasting normoglycemia (n = 40) or dysglycemia (impaired fasting glucose ...
Shapiro Jay R JR Department of Bone and Osteogenesis Imperfecta, Kennedy Krieger Institution, Johns Hopkins University, Baltimore, MD, - - 2013
In a large cohort of osteogenesis imperfecta type V (OI type V) patients (17 individuals from 12 families), we identified the same mutation in the 5' untranslated region (5'UTR) of the interferon-induced transmembrane protein 5 (IFITM5) gene by whole exome and Sanger sequencing (IFITM5 c.-14C > T) and provide a detailed description ...
Freddolino Peter L PL Joint Centers for Systems Biology, Columbia University, New York, NY, - - 2013
Phototropins are one of several classes of photoreceptors used by plants and algae to respond to light. These proteins contain flavin-binding LOV (Light-Oxygen-Voltage) domains that form covalent cysteine-flavin adducts upon exposure to blue light, leading to the enhancement of phototropin kinase activity. Several lines of evidence suggest that adduct formation ...
Weihl Conrad C CC Department of Neurology, Washington University School of Medicine, PO Box 8111, 660 South Euclid Avenue, St Louis, MO 63110, USA. - - 2013
Neurodegenerative diseases such as Huntington disease, Parkinson's disease, and Alzheimer's disease are caused by the accumulation of aggregate prone proteins. Pathogenic proteins misfold, aggregate, and escape the cell's normal degradative pathways. Protein aggregates subsequently lead to the toxic disruption of normal cellular processes leading, ultimately, to disease. Several lines of ...
Ferrari Giulio G G.B. Bietti Eye Foundation-IRCCS, Rome, Italy. - - 2013
To examine the effect of topical ranibizumab on clinically stable corneal neovascularization (NV). This was a prospective, open-label, monocentric, uncontrolled noncomparative study. Ten eyes of 9 patients with corneal NV received topical ranibizumab (1%) 4 times a day for 3 weeks with a follow-up period of 16 weeks. The main ...
Kerr David C R DC School of Psychological Science, Oregon State University, Reed Lodge, Corvallis, OR 97331, USA. - - 2013
Research clearly demonstrates that parents pass risk for depression and antisocial behavior on to their children. However, most research confounds genetic and environmental mechanisms by studying genetically related individuals. Furthermore, most studies focus on either depression or antisocial behavior in parents or children, despite evidence of co-occurrence and shared etiology, ...
Bunya Vatinee Y VY Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. - - 2013
The Schirmer test is one of the 2 ocular surface tests included in the current classification criteria for Sjögren syndrome (SS). Tear osmolarity may also be a useful test for the diagnosis of dry eye disease. The purpose of this study was to examine the relationship between tear osmolarity, the ...
O'Brien Meagan M Division of Infectious Diseases and Immunology, Cancer Institute, New York University, School of Medicine, New York, NY, USA. - - 2013
Mechanisms for increased cardiovascular risk in HIV-1-infected adults are incompletely understood, but platelet activation and immune activation leading to a prothrombotic state have been proposed as significant contributors. Aspirin has antiplatelet and immunomodulatory properties. We explored whether 1 week of low-dose aspirin attenuates platelet activation and immune activation in HIV-1-infected ...
Cary Rachel L RL James Graham Brown Cancer Center and Owensboro Cancer Research Program, University of Louisville, Louisville, KY, - - 2013
Bone remodeling, a physiological process characterized by bone formation by osteoblasts (OBs) and resorption of preexisting bone matrix by osteoclasts (OCs), is vital for the maintenance of healthy bone tissue in adult humans. Imbalances in this vital process result in pathological conditions including osteoporosis. Owing to its initial asymptomatic nature, ...
Mitchell Jonathan A JA Center for Genetics and Complex Traits, Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, USA. - - 2013
To determine whether previously identified adult obesity susceptibility loci were associated uniformly with childhood BMI across the BMI distribution. Children were recruited through the Children's Hospital of Philadelphia (n = 7,225). Associations between the following loci and BMI were assessed using quantile regression: FTO (rs3751812), MC4R (rs12970134), TMEM18 (rs2867125), BDNF ...
Li Ping P Department of Anesthesiology and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri, - - 2013
The γ-aminobutyric acid (GABA) type A receptor is a target for several anesthetics, anticonvulsants, anxiolytics, and sedatives. Neurosteroids, barbiturates, and etomidate both potentiate responses to GABA and allosterically activate the receptor. We examined the ability of a benzodiazepine, diazepam, to potentiate responses to allosteric agonists. The GABA type A receptors ...
Miljkovic Iva I Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, - - 2013
Skeletal muscle adipose tissue (AT) infiltration (myosteatosis) increases with aging and may contribute to the development of Type 2 diabetes mellitus (T2DM). It remains unclear if myosteatosis is associated to glucose and insulin homeostasis independent of total and central adiposity. The association between intermuscular AT (IMAT) in the abdominal skeletal ...
Schueler Jessica J Department of Family and Consumer Sciences, University of Wyoming, Laramie, WY, - - 2013
The presence of appetite hormones, namely glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and leptin in breast milk may be important in infant feeding regulation and infant growth. This study evaluated whether concentrations of GLP-1, PYY, and leptin change across a single feeding (from fore- to hindmilk), and are associated with ...
Hartmann Phillipp P Department of Medicine, University of California San Diego, La Jolla, CA, - - 2013
The intestinal mucus layer protects the epithelium from noxious agents, viruses, and pathogenic bacteria present in the gastrointestinal tract. It is composed of mucins, predominantly mucin (Muc) 2, secreted by goblet cells of the intestine. Experimental alcoholic liver disease requires translocation of bacterial products across the intestinal barrier into the ...
Zhang Li-Na LN Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, - - 2013
The biochemical response to ursodeoxycholic acid (UDCA) in primary biliary cirrhosis is a strong predictor of long-term outcome and thus facilitates the rapid identification of patients needing new therapeutic approaches. Numerous criteria for predicting outcome of treatment have been studied based on biochemical response to UDCA at 1 year. We ...
Malhotra Rahul R Health Services and Systems Research, Duke-NUS Graduate Medical School Singapore, - - 2013
To estimate the expected weight gain through midlife for those in a given BMI category in young adulthood. Group-based trajectory modeling and National Longitudinal Survey of Youth 1979 data from 1990 to 2008 were used to quantify weight trajectories through midlife for 10,038 young adult men and women stratified by ...
Kamo Naoko N Division of Liver and Pancreas Transplantation, Dumont-UCLA Transplantation Center, Department of Surgery, University of California Los Angeles, Los Angeles, CA, - - 2013
Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), an adaptor protein for inflammasome receptors, is essential for inducing caspase-1 activation and the consequent secretion of interleukin-1β (IL-1β), which is associated with local inflammation during liver ischemia/reperfusion injury (IRI). However, little is known about the mechanisms by which the ASC/caspase-1/IL-1β ...
Madhu Tiruveedhula S - - 2013
Avascular necrosis (AVN) of the femoral head is a serious complication in the management of developmental dislocation of the hip. Increasing the abduction angle increases its stability but compromises the vascularity of the femoral head. From our database of 240 children treated for developmental dislocation of hip by the two ...
Medina Carlos A CA Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, - - 2013
To test the therapeutic efficacy of azithromycin (AZM), a macrolide antibiotic for prolonging murine "high-risk" corneal allograft survival. Fully major histocompatibility complex-mismatched corneas were transplanted from C57BL/6 donors to BALB/c recipients with suture-induced vascularized high-risk corneal beds. Recipient mice were either not treated or treated with topical AZM, oral AZM, ...
Hahn Paul P Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, - - 2013
To compare the longitudinal incidence over 10 years of dry and wet age-related macular degeneration (AMD) in a U.S. sample of Medicare beneficiaries with no diabetes mellitus, diabetes mellitus without retinopathy, nonproliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR). Using Medicare claims data, the 10-year incidence of dry and ...
Christoforidis John B JB Department of Ophthalmology and Vision Science, The University of Arizona Medical Center, Tucson, Arizona 85711, USA. - - 2013
To determine the anatomic characteristics and pharmacokinetic properties of intravitreally placed bevacizumab and ranibizumab after pars plana lensectomy or pars plana vitrectomy and to compare these with nonoperated control eyes in a rabbit model. Three groups of six Dutch-belted rabbits each underwent pars plana vitrectomy, pars plana lensectomy, or served ...
Bhat Mamatha M Division of Gastroenterology, McGill University Health Centre, Montreal, - - 2013
The mechanistic/mammalian target of rapamycin (mTOR) pathway plays a critical role in cellular metabolism, growth, and proliferation and has been evaluated as a target for therapy in various malignancies. The mTOR pathway is a major tumor-initiating pathway in hepatocellular carcinoma, with up-regulation seen in up to 50% of tumors. Metformin, ...
Bayrak Alexandra A Institute of Medical Immunology, Charité Universitätsmedizin Berlin, Berlin, - - 2013
Novel tissue-engineering approaches for cardiovascular matrices based on xenogeneic extracellular matrix protein (ECMp) constituents require a detailed evaluation of their interaction with essential immune cell subsets playing a role in innate or adaptive immunity. Therefore, in this study, the effects of xenogeneic (porcine, bovine) collagen type I and elastin as ...
Askarinam Asal A Dental and Craniofacial Research Institute and Section of Orthodontics, School of Dentistry, UCLA, Los Angeles, California, - - 2013
An ideal mesenchymal stem cell (MSC) source for bone tissue engineering has yet to be identified. Such an MSC population would be easily harvested in abundance, with minimal morbidity and with high purity. Our laboratories have identified perivascular stem cells (PSCs) as a candidate cell source. PSCs are readily isolatable ...
Wald Ilan I School of Psychological Sciences and School of Neuroscience, Tel Aviv University, Tel Aviv, - - 2013
Combat places soldiers at risk for posttraumatic stress disorder (PTSD). The excessive rates of PTSD and other adjustment disorders in soldiers returning home make it imperative to identify risk and resilience factors that could be targeted by novel therapeutic treatments. To investigate the interplay among attention to threat, combat exposure, ...
Simonato Michele M Section of Pharmacology, Department of Medical Sciences, Neuroscience Center, University of Ferrara, Via Fossato di Mortara 17–19,Ferrara, Italy. - - 2013
Preclinical research in epileptology has been very successful in producing effective drugs. Unfortunately, however, seizures are still not adequately controlled in a third of the affected individuals, and comorbidities still impose a major burden on the quality of life. New preclinical and clinical drug development strategies are needed to identify ...
Appell Malin L ML Department of Medical and Health Sciences, Division of Drug Research, Faculty of Health Sciences, Linköping University, Linköping, Sweden. - - 2013
The drug-metabolizing enzyme thiopurine methyltransferase (TPMT) has become one of the best examples of pharmacogenomics to be translated into routine clinical practice. TPMT metabolizes the thiopurines 6-mercaptopurine, 6-thioguanine, and azathioprine, drugs that are widely used for treatment of acute leukemias, inflammatory bowel diseases, and other disorders of immune regulation. Since ...
Cotten C Michael CM Division of Neonatology, Department of Pediatrics, Duke University, Durham, North Carolina 27710, USA. - - 2013
Clinicians' adherence to the Centers for Disease Control guidelines to prevent group B Streptococcus (GBS) early-onset sepsis (EOS) has reduced GBS EOS. Although evidence-based testing and empirical antibiotic initiation are likely saving lives, clinicians have less compelling data to guide duration of empirically initiated antibiotics when cultures remain sterile and ...
Fani Negar N Departments of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, - - 2013
The FKBP5 gene product regulates glucocorticoid receptor (GR) sensitivity and hypothalamic-pituitary-adrenal axis functioning and has been associated with many stress-related psychiatric disorders. The study of intermediate phenotypes, such as emotion-processing biases and their neural substrates, provides a way to clarify the mechanisms by which FKBP5 dysregulation mediates risk for psychiatric ...
Lee Ping-Chang PC Industrial Technology Research Institute, Hsin Chu, - - 2013
The rapid development of microscopic imaging techniques has greatly facilitated time-lapse imaging of neuronal morphology. However, analysis of structural dynamics in the vast amount of 4-Dimensional data generated by in vivo or ex vivo time-lapse imaging still relies heavily on manual comparison, which is not only laborious, but also introduces ...
Weingarten Toby N TN Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, - - 2013
Our objective is to describe prediction models for surgical patients who have suspected obstructive sleep apnea (OSA) at risk for postoperative respiratory complications and for surgical patients at risk for postoperative acute respiratory distress syndrome (ARDS). Because of the increased rate of severe perioperative respiratory complications in patients with OSA, ...
Engel Jerome J Jr Department of Neurology, The Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. - - 2013
Tremendous advances have occurred in recent years in elucidating basic mechanisms of epilepsy at the level of ion channels and neurotransmitters. Epilepsy, however, is ultimately a disease of functionally and/or structurally aberrant connections between neurons and groups of neurons at the systems level. Recent advances in neuroimaging and electrophysiology now ...
Scott Sasha M SM School of Health Science, Queen Margaret University, EH21 6UU Edinburgh, - - 2013
To assess whether the application of Functional Electrical Stimulation improves gait kinematics and walking ability in people with multiple sclerosis who experience foot drop. Acute open labelled comparative observation trial. Twelve people (3 females, 9 males, EDSS 2-4) with relapsing remitting multiple sclerosis (47.8 years (standard deviation 6.6)) who were ...
Werling Donna M DM Neuroscience Interdepartmental Program, Brain Research Institute, Los Angeles, California, - - 2013
A strong male bias in autism spectrum disorder (ASD) prevalence has been observed with striking consistency, but no mechanism has yet to definitively account for this sex difference. This review explores the current status of epidemiological, genetic, and neuroendocrinological work addressing ASD prevalence and liability in males and females, so ...
Joshi Deepak D Institute of Liver Studies, King's College Hospital, London, - - 2013
Recurrent hepatitis C virus (HCV) infection is associated with accelerated fibrosis rates after liver transplantation (LT) and is the leading cause of graft failure. Furthermore, distinguishing recurrent HCV from acute cellular rejection (ACR) can be problematic, and this can lead to inappropriate treatments and adverse outcomes. We hypothesized that intragraft ...
Ankeny Randall F RF Parker H. Petit Institute for Bioengineering and Bioscience and Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA. - - 2013
Endothelial outgrowth cells (EOCs) have garnered much attention as a potential autologous endothelial source for vascular implants or in tissue engineering applications due to their ease of isolation and proliferative ability; however, how these cells respond to different hemodynamic cues is ill-defined. This study investigates the inflammatory and thrombotic response ...
Lai Fangfang F Department of Cell Biology, University of Miami Miller School of Medicine, Miami, Florida 33136, - - 2013
The earliest stages of embryonic development in many animals proceed without zygotic transcription. Genetic control is executed by maternally inherited mRNAs that are under translational control. To set aside the future germ cell lineage, it is pivotal to both exert translational regulation of maternal germline mRNAs and to repress maternal ...
Wan Qiaoqiao Q Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, 723 West Michigan Street, Indianapolis, IN 46202, - - 2013
Physical force environment is a major factor that influences cellular homeostasis and remodelling. It is not well understood, however, as a potential role of force intensities in the induction of cellular mechanotransduction. Using a fluorescence resonance energy transfer-based approach, we asked whether activities of GTPase RhoA in chondrocytes are dependent ...
Gu Lei L Department of Neurology, Brain Research Institute, Molecular Biology Institute, University of California, Los Angeles, California 90095, - - 2013
Deposition of amyloid β (Aβ) in the brain is a pathological hallmark of Alzheimer's disease. There are two major isoforms of Aβ: the 42-residue Aβ42 and the 40-residue Aβ40. The only difference between Aβ42 and Aβ40 is that Aβ42 has two extra residues at the C-terminus. The amyloid plaques in ...
Avelar Alicia J AJ Cell Biology, Physiology & Development Section, School of Biological Sciences, Illinois State University, Normal, IL 61790-4120, - - 2013
Amphetamine has well-established actions on pre-synaptic dopamine signaling, such as inhibiting uptake and degradation, activating synthesis, depleting vesicular stores, and promoting dopamine-transporter reversal and non-exocytotic release. Recent in vivo studies have identified an additional mechanism: augmenting vesicular release. In this study, we investigated how amphetamine elicits this effect. Our hypothesis ...
Wasenius Niko N Department of General Practice and Primary Health Care, Institute of Clinical Medicine, Faculty of Medicine, University of Helsinki, Helsinki, Finland. - - 2013
To determine the intensity and volume of therapeutic exercises during a standard 13-day inpatient neck rehabilitation course in relation to overall physical activity in rehabilitation and everyday life. Cross-sectional study. Subjects (n = 19; 16 women and 3 men; mean age 48.6 years, standard deviation (SD) 6.6) with chronic non-specific neck pain ...
Dhandhukia Jugal J Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90033-9121, - - 2013
Elastin-like polypeptides (ELPs) are protein polymers that reversibly phase separate in response to increased temperature, pressure, concentration, ionic strength, and molecular weight. If it were possible to engineer their phase separation to respond to specific molecular substrates, ELP fusion proteins might be engineered as biosensors, smart biomaterials, diagnostic imaging agents, ...
Shi Julie J Department of Bioengineering and Molecular Engineering & Sciences Institute, University of Washington, Seattle, WA 98195, - - 2013
Quantitative analysis of the intracellular trafficking of nonviral vectors provides critical information that can guide the rational design of improved cationic systems for gene delivery. Subcellular fractionation methods, combined with radiolabeling, produce quantitative measurements of the intracellular trafficking of nonviral vectors and the therapeutic payload. In this work, differential and ...
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