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Shi Julie J Department of Bioengineering and Molecular Engineering & Sciences Institute, University of Washington, Seattle, WA 98195, - - 2013
Quantitative analysis of the intracellular trafficking of nonviral vectors provides critical information that can guide the rational design of improved cationic systems for gene delivery. Subcellular fractionation methods, combined with radiolabeling, produce quantitative measurements of the intracellular trafficking of nonviral vectors and the therapeutic payload. In this work, differential and ...
Liu Zhongmin - - 2013
The identification of T-helper 9 (Th9), Th17, Th22 cells as distinct subsets of CD4(+) T cells has extended the Th1/Th2 paradigm in the adaptive immunity. In the past decade, many studies in animal models and clinical transplantation have demonstrated that interleukin-17 (IL-17) is involved in allograft rejection. It appears that ...
Li Chih-Ping - - 2013
: Although numerous predictors of mortality hazard in later life have been identified, the precise relationship between life satisfaction and mortality hazards among elderly people remains unclear. : The purpose of this study was to examine and compare the relationship between life satisfaction and mortality hazards among elderly people in ...
Jansen Karine Aasgaard - - 2013
From March 2005 to April 2007 the French overseas department and Indian Ocean island of Réunion was significantly affected by an epidemic of chikungunya. Chikungunya is a vector-spread disease (by the aedes albopictus mosquito) that leads to painful rheumatic symptoms. The disease infected approximately one third of the island's total ...
Emory Jan - - 2013
Nurse educators need predictors of failure for early intervention. This study investigated the predictability of fundamentals, mental health, and pharmacology standardized assessment scores to identify the risk of baccalaureate students' failure on the NCLEX-RN. Using logistic regression the pharmacology assessment score was predictive with 73.7% accuracy. Use of the pharmacology ...
Sulley Anna - - 2013
To evaluate the ease with which astigmats from three groups of current non-wearers of toric contact lenses can be fitted with current toric soft lenses, and to determine toric lens-wearing success. This was a 1-month, randomized, bilateral, open-label, daily wear study involving 200 subjects and 16 investigational sites in the ...
Guo Shuguang - - 2013
The aim of this study was to observe the clinical effects of bilateral decompression via vertebral lamina fenestration for lumbar interbody fusion in the treatment of lower lumbar instability. The 48 patients comprised 27 males and 21 females, aged 47-72 years. Three cases had first and second degree lumbar spondylolisthesis ...
Luzze H - - 2013
To determine the proportion of recurrent tuberculosis (TB) due to relapse with the patient's initial strain or reinfection with a new strain of Mycobacterium tuberculosis 1-2 years after anti-tuberculosis treatment in Uganda, a sub-Saharan TB-endemic country. Records of patients with culture-confirmed TB who completed treatment at an urban Ugandan clinic ...
Ross Colin A - - 2013
The aim of this study was to determine whether classical culture-bound syndromes occur among psychiatric inpatients with dissociative disorders in North America. The Dissociative Trance Disorder Interview Schedule, the Dissociative Experiences Scale, and the Dissociative Disorders Interview Schedule were administered to 100 predominantly Caucasian, American, English-speaking trauma program inpatients at ...
Jatapai Anchalee - - 2013
Asymptomatic Chlamydia trachomatis (CT) infection and other sexually transmitted infections in men potentially contribute significantly in sustaining the spread of the infection. To describe the distribution and related sexual behaviors, we conducted a cross-sectional study among young Thai men using a (1:30) systematic sampling of all newly inducted military conscripts ...
Bernink Jochem - - 2013
Innate lymphoid cells (ILCs) constitute a family of effectors in innate immunity and regulators of tissue remodeling that have a cytokine and transcription factor expression pattern that parallels that of the T-helper (Th) cell family. Here, we discuss how ILCs can be categorized and summarize the current knowledge of Th1- ...
Hsieh Yueh-Tzu - - 2013
: Prenatal detection of cleft lip and/or palate (CL/P) leads to high rates of induced termination of pregnancy. There has been little research in Taiwan done on the psychosocial factors affecting those who decide to continue their CL/P pregnancy. : This study identified the principal psychosocial factors that affect expecting ...
Duckett Kathryn - - 2013
Despite the role of the pharmacist in the delivery of community health care, anthropological research placing them at the center of enquiry has been limited. In this article, I explore the experience of independent community pharmacists in hyperdiverse, urban communities. Research was conducted in East and South-East London, combining participant ...
Jenkins H E - - 2013
The Republic of Moldova, in Eastern Europe, has among the highest reported nationwide proportions of tuberculosis (TB) patients with multidrug-resistant tuberculosis (MDR-TB) worldwide. Default has been associated with increased mortality and amplification of drug resistance, and may contribute to the high MDR-TB rates in Moldova. To assess risk factors and ...
Stephens Sally C - - 2013
Current data on sexual health in the United States is limited, in part, because of a lack of measurement tools. It is difficult for programs to develop a holistic approach to improving sexual health that is data-driven and evaluable without a tool that encompasses sexual health beyond the absence of ...
Zhao Qinghua - - 2013
Homo sapiens longevity assurance homolog 2 of yeast LAG1 (LASS2), a metastasis suppressor gene of human cancer, is the most abundantly expressed member of the ceramide synthase gene family. Expression of LASS2 has been reported in carcinomas of the prostate, liver and breast. However, there has been no report on ...
Seebacher F - - 2013
Aggressive behaviour is linked to fitness, but it is metabolically costly. Changes in metabolic demand during the reproductive cycle could constrain activity and thereby modulate behavioural phenotypes. We predicted that increased metabolic demands in late pregnancy would lead to reduced aggression and a lower metabolic cost of behaviour in the ...
Wu Zhenhua - - 2013
Radiation-induced lung injury is a well-described complication of nuclear accidents, marrow-transplant pretreatment and thoracic radiotherapy. The mechanism is complex and no special therapy for it is available at present. To study radiation pulmonary injury following heavy ion radiotherapy for thoracic tumors, Kunming mice were randomly divided into 4 groups: normal ...
Borges Rosivaldo S - - 2013
This theoretical and experimental study describes the design and evaluation of the free-radical scavenging effect for the molecular association of 4-aminophenol and salicylate derivatives. For this purpose, we employed theoretical methods for the selection of antioxidant drugs and the rapid methods of evaluation: the 1,1-diphenyl-2-picrylhydrazyl radical and the thiobarbituric acid ...
Jiménez-Fuentes M A - - 2013
To compare the tolerance, adherence and effectiveness of two approaches for the treatment of latent tuberculosis infection (LTBI): 6 months of isoniazid (6H) vs. 3 months of isoniazid plus rifampicin (3RH). Immigrants with LTBI. Participants were enrolled in a controlled, randomised clinical trial in Barcelona, Spain, from April 2001 to ...
Torrone Elizabeth A - - 2013
Prevalence estimates from population-based surveys do not suffer from the same biases as case-report and clinic positivity data and may be better to monitor sexually transmitted disease morbidity over time. We estimated the prevalence of Neisseria gonorrhoeae in a nationally representative sample of persons aged 14 to 39 years participating ...
Wang Hong-Yan - - 2013
The intermingling of two malignant neoplasms within the same cutaneous tumor is rare. No consensus has been reached for a clear definition and categorization. In the current study, we describe a cutaneous neoplasm; a squamomelanocytic tumor (SMT) with histological features combining those of a squamous cell carcinoma (SCC) and a ...
Vinauger Clément - - 2013
It has been largely accepted that the cognitive abilities of disease vector insects may have drastic consequences on parasite transmission. However, despite the research effort that has been invested in the study of learning and memory in haematophagous insects, hitherto few conclusive results have been obtained. Adapting procedures largely validated ...
Mahjabeen Ishrat - - 2013
The aetiology of head and neck cancer (HNC) has been shown to be associated with genetic and certain environmental factors that produce DNA damage. Base excision repair (BER) genes are responsible for repair of DNA damage caused by reactive oxygen species and other electrophiles and therefore are good candidate susceptibility ...
Sandole Denise H - - 2013
This qualitative research study deals with female survivors of the 1994 genocide against the Tutsi in Rwanda. It examines dissociation and identity change in these women before, during, and after the genocide. Three theories were used to frame the findings. The 1st was assumptive world theory ( R. Janoff-Bulman, 1992 ...
Armario Pedro - - 2013
Blood pressure is poorly controlled in most European countries and the control rate is even lower in high-risk patients such as patients with chronic kidney disease, diabetic patients or previous coronary heart disease. Several factors have been associated with poor control, some of which involve the characteristic of the patients ...
Azuero Andres - - 2013
Doctoral nursing students and researchers are expected to understand, critique, and conduct research that uses advanced quantitative methodology. The authors describe the design and contents of a distance-based course in multivariate statistics for PhD students in nursing and health administration, compare the design to recommendations found in the literature for ...
Sacher Adrian G - - 2013
: Elderly patients constitute the majority of patients with advanced non-small-cell lung cancer (NSCLC). The median age of newly diagnosed patients with lung cancer in the United States is approximately 70 years. Despite this, the elderly are significantly underrepresented in clinical trials. This has led to increasing uncertainty as to ...
Pontén Ingrid - - 2013
AZD9708 is a new chemical entity with selective and long-acting β2-agonistic properties currently being evaluated by AstraZeneca for potential use in treatment of respiratory diseases by the inhaled route. As part of the toxicological characterisation of this compound, an increased incidence of micronucleated immature erythrocytes (MIEs) was seen in the ...
Putnam Frank W - - 2013
Interrogation, the questioning of persons detained by police, military, or intelligence organizations, is designed to extract information that a subject may resist disclosing. Interrogation techniques are frequently predicated on inducing mental states of despair, dread, dependency, and debility that weaken an individual's resistance. Descriptions of techniques from 2 Central Intelligence ...
Golebiowski Blanka - - 2013
Assessment of corneal sensory function is more frequently being carried out using novel non-contact methods, which promise better stimulus control and a greater intensity range than more traditional techniques. An examination of the characteristics of the air-jet stimulus of these 'non-contact' aesthesiometers is important to enable an understanding of how ...
Zúñiga Luis A - - 2013
T cells surviving the clonal selection process emigrate from the thymus to the periphery as immature naive T cells. In the periphery, upon activation under specific cytokine milieus, naive T cells adopt specific effector phenotypes, e.g. T-helper 1 (Th1), Th2, or Th17, and acquire diverse functions to control a myriad ...
Kang Y R - - 2013
Patients with new pulmonary infiltrates on chest computed tomography (CT) scans at a tertiary centre in South Korea. To demonstrate associations among radiological changes, blood eosinophilia (E) and Toxocara (T) seropositivity. We retrospectively reviewed blood eosinophilia, Toxocara seropositivity, history of raw meat intake and radiological features, and divided study patients ...
Tanner Sharon J - - 2013
This column provides information on accreditation for nursing programs of all types. Readers may submit questions to the National League for Nursing Accrediting Commission. General questions of interest to a wide audience will be addressed in this column, whereas more specific questions or those requiring confidentiality will be answered directly.
Sachs Adah - - 2013
This article examines the prevalence and types of modifications to professional boundaries that occur in the treatment of people with dissociative disorders (DDs) and considers some of the implications of the findings. The study is based on the replies of 163 professionals to a 20-question survey. The survey compared the ...
St Onge Judith - - 2013
There is a growing call to include quality and safety content into nursing curricula that are already overburdened with content. Yet evidence suggests that many nursing schools have not yet done so. The authors describe 1 innovative, experiential approach to teaching quality and safety in the clinical environment. This approach, ...
Makhmoor Talat - - 2013
Context: In the course of searching hepatoprotective agents from natural sources, the protective effect of chemical constituents of the marine brown alga Spatoglossum variabile Figaro et DE Notar (Dictyoaceae) against CCl(4)-induced liver damage in Wistar rats was investigated. The compounds were first investigated for in vitro radical scavenging potential and ...
Hao Guangtao - - 2013
A rapid, sensitive and specific HPLC-MS/MS method was developed and validated for the quantification of potassium oxonate (Oxo) in human plasma using [(13)C(2),(15)N(3)]-Oxo as an internal standard (IS). The target substance was separated from human plasma using the solid-phase extraction method. Chromatography separation was performed on a Waters:Atlantis dC(18) column ...
Ramiscal Roybel R - - 2013
T cells are known to migrate to B-cell-enriched follicles and germinal centers within secondary lymphoid organs to provide help to B cells. Cognate T:B interactions that take place at the T:B border and subsequently within germinal centers are essential for B-cell priming, differentiation into germinal center B cells, and selection ...
McGuire Liam P - - 2013
Many species of bats migrate long distances, but the physiological challenges of migration are poorly understood. We tested the hypothesis that migration is physiologically demanding for bats by examining migration-related phenotypic flexibility. Both bats and birds are endothermic, flying vertebrates; therefore, we predicted that migration would result in similar physiological ...
Raffaetà Roberta - - 2013
Based on an ethnographic study conducted in both biomedical and complementary and alternative medicine settings in north Italy, I explore how people and practitioners make sense of allergy and how patients utilize plural healing options. Despite a wide range of medical modalities, people categorize and use medicine according to whether ...
Aycock Dawn M - - 2013
Nursing students are a viable population for inclusion in research; however, the ease of recruiting students also places them at risk for harm. Students are subject to the formal authority of others, which can limit their autonomy. When designing research involving students, nurse educators must implement additional strategies to protect ...
Huang Qishun - - 2013
The aim of this study was to investigate the feasibility of establishing dog models of lunatomalacia through liquid nitrogen freezing. Twelve adult crossbred dogs were divided into three groups. Unilateral lunates were peeled off the parenchyma and frozen to result in avascular necrosis. They were observed dynamically through X-ray, computed ...
Mori Yasuhisa - - 2013
The aim of this study was to establish a minimally invasive and simple screening test for detection of pancreatic ductal adenocarcinoma (PDAC) using duodenal juice (DJ). Duodenal juice was collected prospectively before endoscopic retrograde cholangiopancreatography in 46 patients. A protease inhibitor was not added to the samples collected during the ...
Van Der Pol Barbara - - 2013
ABSTRACT: Performance characteristics of the Cobas 4800 CT/NG assay were estimated for vaginal swab samples from more than 4000 women. Vaginal samples identified 92.9% and 98.5% of Chlamydia and Gonorrhea infections, respectively, which was more than any other single specimen type (endocervical swabs or urine) regardless of collection method (clinician ...
Baglar Rosslyn - - 2013
This article explores diabetes mellitus in the United Arab Emirates (UAE), with an analysis of gift exchange and hospitality revealing how rapid environmental and economic transformations have led to chronicities of physical activity, food, and stress; uniting at a critical point in time to produce chronicities of modernity that precipitate ...
Oliveras Anna - - 2013
There is no doubt that patients with high blood pressure (BP) are at higher cardiovascular and death risk than those subjects whose BP levels are below the admitted normal threshold. However, most of the epidemiological surveys show that BP is uncontrolled in more than fifty percent of hypertensive subjects. There ...
He Yue-Jun - - 2013
Estrogen receptor-α (ERα) is essential for estrogen-dependent growth and its level of expression is a crucial determinant of response to endocrine therapy and prognosis in ERα-positive breast cancer. Breast cancer patients show a wide range of ERα expression levels which change in individual patients during disease progression and in response ...
Huang Tsuey-Yuan - - 2013
BACKGROUND:: Dyspnea is the most common and distressing symptom of heart failure (HF). Evidence from empirical studies has shown that multiple factors apart from pathophysiological changes may influence this symptom. PURPOSE:: This study explored the moderating effect of psychosocial factors between clinical characteristics and dyspnea in patients with HF. To ...
Lauer Georg M - - 2013
Infection with hepatitis C virus (HCV) typically leads to persistent infection, with >170 million people estimated to be affected worldwide, putting them at risk for chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Importantly, 20%-30% of individuals are able to control the virus spontaneously, usually within 6 months of exposure. This ...
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