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Shi Julie J Department of Bioengineering and Molecular Engineering & Sciences Institute, University of Washington, Seattle, WA 98195, - - 2013
Quantitative analysis of the intracellular trafficking of nonviral vectors provides critical information that can guide the rational design of improved cationic systems for gene delivery. Subcellular fractionation methods, combined with radiolabeling, produce quantitative measurements of the intracellular trafficking of nonviral vectors and the therapeutic payload. In this work, differential and ...
Huang Tsuey-Yuan - - 2013
BACKGROUND:: Dyspnea is the most common and distressing symptom of heart failure (HF). Evidence from empirical studies has shown that multiple factors apart from pathophysiological changes may influence this symptom. PURPOSE:: This study explored the moderating effect of psychosocial factors between clinical characteristics and dyspnea in patients with HF. To ...
Sachs Adah - - 2013
This article examines the prevalence and types of modifications to professional boundaries that occur in the treatment of people with dissociative disorders (DDs) and considers some of the implications of the findings. The study is based on the replies of 163 professionals to a 20-question survey. The survey compared the ...
Lin Wenyu W Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, - - 2013
Human immunodeficiency virus (HIV) infection is a major cause of acceleration of hepatitis C virus-related liver disease, cirrhosis, and death. However, studies of liver disease pathogenesis in HIV/HCV coinfection have thus far been limited. Emerging data support multiple derangements attending HIV coinfection, including increases in profibrogenic cytokine expression and secretion, ...
St Onge Judith - - 2013
There is a growing call to include quality and safety content into nursing curricula that are already overburdened with content. Yet evidence suggests that many nursing schools have not yet done so. The authors describe 1 innovative, experiential approach to teaching quality and safety in the clinical environment. This approach, ...
Makhmoor Talat - - 2013
Context: In the course of searching hepatoprotective agents from natural sources, the protective effect of chemical constituents of the marine brown alga Spatoglossum variabile Figaro et DE Notar (Dictyoaceae) against CCl(4)-induced liver damage in Wistar rats was investigated. The compounds were first investigated for in vitro radical scavenging potential and ...
Arnetz Judith J Department of Family Medicine and Public Health Sciences, Division of Occupational and Environmental Health, Wayne State University School of Medicine, Detroit, MI 48201, - - 2013
Refugee research, to date, has predominantly focused on factors that make refugees more vulnerable for developing posttraumatic stress disorder (PTSD) and/or psychological distress. Few articles have studied potential protective factors such as resilience. A targeted nonrandom sample of Iraqi refugees (n = 75) and a control group of non-Iraqi Arab ...
Hao Guangtao - - 2013
A rapid, sensitive and specific HPLC-MS/MS method was developed and validated for the quantification of potassium oxonate (Oxo) in human plasma using [(13)C(2),(15)N(3)]-Oxo as an internal standard (IS). The target substance was separated from human plasma using the solid-phase extraction method. Chromatography separation was performed on a Waters:Atlantis dC(18) column ...
Ahmed Suleiman M M - - 2013
To evaluate the prevalence of tuberculosis (TB) stigma and to determine the relation between socio-demographic characteristics and TB stigma among TB cases and their controls in Gezira State, Sudan. A case-control study design was used. New smear-positive TB patients registered in Gezira State in 2010 (n = 425) and controls ...
Mauch V - - 2013
The National Tuberculosis Programs of Ghana, Viet Nam and the Dominican Republic. To assess the direct and indirect costs of tuberculosis (TB) diagnosis and treatment for patients and households. Each country translated and adapted a structured questionnaire, the Tool to Estimate Patients' Costs. A random sample of new adult patients ...
Gillespie Catherine W - - 2013
ABSTRACT: We evaluated 236 asymptomatic men for urethritis, assessed sexual behaviors, and tested urine for pathogens. Asymptomatic urethritis was present in 38 (16.1%). Of these, nearly half (42.1%) had a previously unrecognized discharge on examination; only 18.4% had a known pathogen. Correlates included black race, anal intercourse, and number of ...
Lönnroth K K Policy Strategy and Innovations, Stop TB Department, World Health Organization, Geneva, Switzerland. - - 2013
The impact of current interventions to improve early detection of tuberculosis (TB) seems to have been saturated. Case detection trends have stagnated. TB incidence is falling in most settings worldwide, but the rate of decline is far lower than expected. There is growing evidence from national TB prevalence surveys and ...
Chang Hui-Ying - - 2013
: Community health nurses are on the frontline of providing healthcare to multiethnic groups. Managing and providing effective, culture-specific healthcare can increase the health quality of Taiwan's recently immigrant women, a significant component of this country's population. : This study analyzes the cultural sensitivity of community health nurses and related ...
de Silva Samantha R - - 2013
New guidelines on glaucoma diagnosis and management were published by the National Institute of Clinical Excellence (NICE) in 2009. The aim of this study was to determine whether these guidelines on glaucoma referral have changed the numbers of patients diagnosed with glaucoma in Oxford and whether the severity of disease ...
Cheng Luyang - - 2013
The aim of this study was to evaluate the diagnostic value of 64-multislice spiral computed tomography (64-MSCT) for coronary stenosis compared with selective X-ray coronary angiography (SCA). Patients with chest pain, chest tightness or coronary stenosis received SCA and they acted as the controls. The sensitivity and accuracy of 64-MSCT ...
Garcea Giuseppe - - 2013
Chronic pancreatitis (CP) results in an extremely poor quality of life and substantially increases health care utilization. Few data exist regarding the cost-effectiveness of surgical treatment for CP. This article examined the cost-effectiveness of total pancreatectomy (TP) with islet cell autotransplantation (IAT) for CP. Sixty patients undergoing TP + IAT ...
Li Jianwen - - 2013
Intramedullary schwannoma is often misdiagnosed as other types of malignant tumour prior to surgery due to its atypical imaging appearance and low incidence. In the present study, a case of small intramedullary schwannoma was analysed using clinical and imaging data. Data concerning the surgery and follow-up process of this case ...
Haq Z - - 2013
A national-level study in four districts, one each in all four provinces of Pakistan, a high tuberculosis (TB) burden country. To examine how advocacy, communication and social mobilisation (ACSM) campaigns by the National Tuberculosis Programme (NTP) in Pakistan engaged the populations of interest, to what extent they were successful in ...
Sulkowski Mark S MS Johns Hopkins University School of Medicine, 600 N. Wolfe St., Baltimore, MD 21287, USA. - - 2013
As a result of shared routes of transmission, coinfection with hepatitis C virus (HCV) is common in human immunodeficiency virus (HIV)-infected patients. The prevalence of HIV/HCV coinfection is particularly high among persons who have used injection drugs; however, more recently, sexual transmission of HCV has been recognized among HIV-infected men ...
Song Jia-LE - - 2013
The present study was designed to investigate the protective effect of hot water extracts from Quercus salicina leaves (QSWE) on alloxan-induced oxidative stress in HIT-T15 Syrian hamster pancreatic insulinoma cells. The HIT-T15 cells were treated with alloxan (1 mM) for 1 h and then co-incubated with the QSWE for 24 ...
Hsu Hung-Chih - - 2013
Propyl gallate (PG) is an antioxidant that has been used as an additive in several foods to protect against oxidation. The present study examined the anti-inflammatory effect of PG on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in human THP-1 monocytes. Pretreatment with PG markedly inhibited the TPA-induced expression levels of cyclooxygenase-2 and prostaglandin ...
Basu Rajatava R Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. - - 2013
Discovery of the T-helper 17 (Th17) subset heralded a major shift in T-cell biology and immune regulation. In addition to defining a new arm of the adaptive immune response, studies of the Th17 pathway have led to a greater appreciation of the developmental flexibility, or plasticity, that is a feature ...
Bhat R Y - - 2013
In developing countries, acute lower respiratory tract infections (ALRTI) cause considerable morbidity, hospitalisation and mortality in children aged <5 years. A prospective case-control study was conducted to identify potential socio-demographic, nutritional and environmental risk factors for ALRTI. The World Health Organization definition for ALRTI was used for cases. Healthy children ...
Marchetti Antonio - - 2013
INTRODUCTION:: Recent clinical trials led to the approval of crizotinib (PF-02341066; Pfizer) by the U.S. Food and Drug Administration for the treatment of locally advanced or metastatic non-small-cell lung cancer (NSCLC) patients whose tumors are positive for anaplastic lymphoma kinase (ALK) alterations. The European Medicines Agency accepted the regulatory submission ...
Pontén Ingrid - - 2013
AZD9708 is a new chemical entity with selective and long-acting β2-agonistic properties currently being evaluated by AstraZeneca for potential use in treatment of respiratory diseases by the inhaled route. As part of the toxicological characterisation of this compound, an increased incidence of micronucleated immature erythrocytes (MIEs) was seen in the ...
Putnam Frank W - - 2013
Interrogation, the questioning of persons detained by police, military, or intelligence organizations, is designed to extract information that a subject may resist disclosing. Interrogation techniques are frequently predicated on inducing mental states of despair, dread, dependency, and debility that weaken an individual's resistance. Descriptions of techniques from 2 Central Intelligence ...
Golebiowski Blanka - - 2013
Assessment of corneal sensory function is more frequently being carried out using novel non-contact methods, which promise better stimulus control and a greater intensity range than more traditional techniques. An examination of the characteristics of the air-jet stimulus of these 'non-contact' aesthesiometers is important to enable an understanding of how ...
Chamoto Kenji K Laboratory of Adaptive and Regenerative Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, - - 2013
The intimate anatomic and functional relationship between epithelial cells and endothelial cells within the alveolus suggests the likelihood of a coordinated response during postpneumonectomy lung growth. To define the population dynamics and potential contribution of alveolar epithelial cells to alveolar angiogenesis, we studied alveolar Type II and I cells during ...
Rutz Sascha - - 2013
Interleukin-22 (IL-22) has important functions in host defense at mucosal surfaces as well as in tissue repair. It is unique as a cytokine that is produced by immune cells, including T-helper (Th) cell subsets and innate lymphocytes, but acts only on non-hematopoietic stromal cells, in particular epithelial cells, keratinocytes, and ...
Pickering Lucy - - 2013
There is a particular silence around the social life of defecation. Little analyzed, rarely discussed in polite conversation, it largely appears only at moments of dysfunction. For active heroin users, digestion is often characterized by such dysfunction and experienced through constipation; recovery, a welcome return to defecating 'normally.' Drawing on ...
de la Sierra Alejandro - - 2013
The main purpose in hypertension treatment is the reduction of cardiovascular disease burden. Among different first-line antihypertensive drug classes, angiotensin-receptor blockers are characterized by their both good effectiveness and tolerability. Furthermore, the interruption of the renin-angiotensin cascade is related with several benefits in target organ protection and cardiovascular prevention. Among ...
Humphrey P P Radiotherapy Department, Bristol Haematology and Oncology Centre, Bristol, UK. - - 2013
This quality assurance study assesses whether CT image-guided verification has led to improvements in the technique when compared with previous studies. The CT images were studied from a cohort of 105 consecutive patients with endometrial cancer having adjuvant brachytherapy to the vaginal vault in 2010. Images were taken at first ...
Vahedi Golnaz G Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, MD, - - 2013
CD4(+) T cells are critical for the elimination of an immense array of microbial pathogens. Among the ways they accomplish this task is to generate progeny with specialized, characteristic patterns of gene expression. From this perspective, helper cells can be viewed as pluripotent precursors that adopt distinct cell fates. Although ...
Sholl Lynette M LM Department of Pathology Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. - - 2013
ALK gene rearrangements occur in approximately 5% of lung adenocarcinomas (ACAs), leading to anaplastic lymphoma kinase (ALK) overexpression and predicting response to targeted therapy. Fluorescence in situ hybridization (FISH) is the standard procedure for detection of ALK rearrangements in lung ACA but requires specialized equipment and expertise. Immunohistochemistry (IHC) for ...
Jenkins H E - - 2013
The Republic of Moldova, in Eastern Europe, has among the highest reported nationwide proportions of tuberculosis (TB) patients with multidrug-resistant tuberculosis (MDR-TB) worldwide. Default has been associated with increased mortality and amplification of drug resistance, and may contribute to the high MDR-TB rates in Moldova. To assess risk factors and ...
Stephens Sally C - - 2013
Current data on sexual health in the United States is limited, in part, because of a lack of measurement tools. It is difficult for programs to develop a holistic approach to improving sexual health that is data-driven and evaluable without a tool that encompasses sexual health beyond the absence of ...
Zhao Qinghua - - 2013
Homo sapiens longevity assurance homolog 2 of yeast LAG1 (LASS2), a metastasis suppressor gene of human cancer, is the most abundantly expressed member of the ceramide synthase gene family. Expression of LASS2 has been reported in carcinomas of the prostate, liver and breast. However, there has been no report on ...
Sacher Adrian G - - 2013
: Elderly patients constitute the majority of patients with advanced non-small-cell lung cancer (NSCLC). The median age of newly diagnosed patients with lung cancer in the United States is approximately 70 years. Despite this, the elderly are significantly underrepresented in clinical trials. This has led to increasing uncertainty as to ...
McGee Matthew D - - 2013
Sexual dimorphism is common in nature and has the potential to increase intraspecific variation in performance and patterns of resource use. We sought to determine whether anadromous threespine stickleback, Gasterosteus aculeatus, exhibit sexual dimorphism in feeding kinematics. We filmed four males and four females consuming live prey in a total ...
Gendron Sébastien P - - 2013
In human skin, the 3895-bp deletion of mitochondrial DNA (mtDNA(3895)) is catalysed by ultraviolet (UV) light through the generation of reactive oxygen species. Given its function in vision, the human eye is exposed to oxidising UV and blue light in its anterior (cornea, iris) and posterior (retina) structures. In this ...
Chang Yu-Ting - - 2013
: Menstruation is a significant part of women's lives. It has been studied from many perspectives to draw various conclusions about biological and physiological development, gender differences, and sociocultural environments. : The purpose of this study was to explore how male and female pubescent students perceive and interpret menarche and ...
Curry Michael P - - 2013
Since the advent of highly active antiretroviral therapy, liver disease has been a major cause of morbidity and mortality in patients with human immunodeficiency virus (HIV) infection. Chronic viral hepatitis accounts for >80% of liver-related mortality. Liver-related morbidity is due to acceleration of hepatitis C virus (HCV) disease, drug-induced hepatotoxicity, ...
Meek Keith M KM Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK. - - 2013
To review cross-linking the cornea using riboflavin and ultraviolet A light, which has been widely adopted, refined and applied in a range of corneal surgeries and pathologies where the strength of the cornea might be compromised. A large number of clinical trials have been carried out, most of which have ...
Duncan Ryan P - - 2013
: The Four Square Step Test (4SST), a quick and simple test of multidirectional stepping, may be useful in predicting falls in people with Parkinson disease (PD). We studied the reliability of the 4SST and its ability to discriminate between freezers and nonfreezers, between fallers and nonfallers, and factors predictive ...
Zhai Jianwen - - 2013
The aim of this study was to investigate the expression levels of the death-associated protein kinase (DAPK) and E-cadherin in esophageal squamous cell carcinoma (ESCC) and their correlation with clinical and pathological factors. Immunohistochemistry [streptavidin-peroxidase (SP) method], in situ hybridization, immunoblot assays and reverse transcription-PCR (RT-PCR) were used to detect ...
Luo Sheng - - 2013
Patients with relapsed acute myeloid leukemia (AML) have unfavorable prognosis and require innovative therapeutic approaches. In this study we used fludarabine combined with a middle dose of cytosine arabinoside (Ara-C), mitoxantrone and granulocyte-colony stimulating factor (G-CSF) as a salvage therapy for patients with relapsed AML in China. Forty-five patients with ...
Santo Latonya - - 2013
To improve pass rates on the NCLEX-RN, many nursing programs have implemented progression policies that require a minimal passing score on a commercial standardized exit examination. In this article, the authors provide an overview of the controversy surrounding the use of these examinations in nursing education, including ethical, legal, cultural, ...
Liu Zhongmin - - 2013
The identification of T-helper 9 (Th9), Th17, Th22 cells as distinct subsets of CD4(+) T cells has extended the Th1/Th2 paradigm in the adaptive immunity. In the past decade, many studies in animal models and clinical transplantation have demonstrated that interleukin-17 (IL-17) is involved in allograft rejection. It appears that ...
Li Chih-Ping - - 2013
: Although numerous predictors of mortality hazard in later life have been identified, the precise relationship between life satisfaction and mortality hazards among elderly people remains unclear. : The purpose of this study was to examine and compare the relationship between life satisfaction and mortality hazards among elderly people in ...
Jansen Karine Aasgaard - - 2013
From March 2005 to April 2007 the French overseas department and Indian Ocean island of Réunion was significantly affected by an epidemic of chikungunya. Chikungunya is a vector-spread disease (by the aedes albopictus mosquito) that leads to painful rheumatic symptoms. The disease infected approximately one third of the island's total ...
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