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Przybyt Ewa - - 2013
ABSTRACT: BACKGROUND: Experimental clinical stem cell therapy has been used for more than a decade to alleviate the adverse aftermath of acute myocardial infarction (aMI). The post-infarcted myocardial microenvironment is characterized by cardiomyocyte death, caused by ischemia and inflammation. These conditions may negatively affect administered stem cells. As postnatal cardiomyocytes ...
Masetti Riccardo - - 2013
Pediatric cytogenetically-normal acute myeloid leukemia (CN-AML) is a heterogeneous subgroup of myeloid clonal disorders not harbouring known mutations. To investigate the mutation spectrum of pediatric CN-AML, we performed whole-transcriptome massively-parallel sequencing on bone marrow leukemia blasts of 7 CN-AML pediatric patients, identifying in 3 of them a recurrent cryptic inversion ...
Tonelli Marcello - - 2013
Many countries are developing or refining national strategies for noncommunicable chronic disease (NCD) prevention and control. Chronic kidney disease (CKD) is a cause and consequence of other NCDs; CKD acts as a risk multiplier for all four key NCDs as specified by the World Health Organization; CKD is associated with ...
Vandenplas Y - - 2013
In pediatrics, prebiotics and/or probiotics are added to infant formula, mainly to prevent diseases such as diarrheal disorders. Probiotic food supplements and medication are frequently used in the treatment of diarrheal disorders. This paper reviews the recent published evidence on these topics. Relevant literature published using PubMed and CINAHL was ...
Bagaria Sanjay P - - 2013
BACKGROUND: Lymph lymph node metastasis from melanoma ≤0.50 mm (ultrathin) is an infrequent event. However, because many newly diagnosed melanomas are ultrathin, a significant proportion of patients who present with lymph node disease have an ultrathin melanoma. The authors hypothesized that ultrathin melanomas that present with lymph node metastasis represent ...
Fan Shufang - - 2013
The influenza A virus NS1 protein affects virulence through several mechanisms, including the host's innate immune response and various signaling pathways. Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype continue to evolve through reassortment and mutations. Our recent phylogenetic analysis identified a group of HPAI H5N1 viruses with ...
Matsukawa Tetsuya - - 2013
ABSTRACT: INTRODUCTION: Increased expression of aggrecanase-1 (ADAMTS-4) has emerged as an important factor in osteoarthritis (OA) and other joint diseases. This study aimed to determine whether the expression of ADAMTS-4 in human chondrocytes is regulated by miRNA. METHODS: MiRNA targets were identified using bioinformatics. Chondrocytes were isolated from knee cartilage ...
Lari Parisa - - 2013
Diazinon (DZN) is one of the most widely used insecticides in agricultural pest control. Previous studies have shown that DZN may induce hepatotoxicity. Reactive oxygen species and apoptosis pathways are involved in the toxicity of DZN. Crocin, a constituent of saffron, has hepatoprotective effects due to its antioxidant activity. In ...
De Belvis Antonio Giulio - - 2013
OBJECTIVE: /st>This study describes and evaluates the application of a waiting list management program in ambulatory care. DESIGN: /st>Waiting list active management survey (telephone call and further contact); before and after controlled trial. SETTING: /st>Local Health Trust in Veneto Region (North-East of Italy) in 2008-09. PARTICIPANTS: /st>Five hundred and one ...
Cristia Alejandrina - - 2013
ABSTRACT Typically, the point vowels [i,ɑ,u] are acoustically more peripheral in infant-directed speech (IDS) compared to adult-directed speech (ADS). If caregivers seek to highlight lexically relevant contrasts in IDS, then two sounds that are contrastive should become more distinct, whereas two sounds that are surface realizations of the same underlying ...
Lang Jordan - - 2013
The expression of the gut tumor suppressor gene adenomatous polyposis coli (Apc) and its role in the oligodendroglial lineage are poorly understood. We found that immunoreactive APC is transiently induced in the oligodendroglial lineage during both normal myelination and remyelination following toxin-induced, genetic, or autoimmune demyelination murine models. Using the ...
He Fupo F Human Technology Research Institute, National Institute of Advanced Industrial Science and Technology, Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, - - 2013
Apatite (Ap), laminin-apatite composite (L5Ap, L10Ap, L20Ap and L40Ap) and albumin-apatite (AlbAp) composite layers were prepared on titanium (Ti) using a supersaturated calcium phosphate solution supplemented with laminin (0, 5, 10, 20 and 40 μg ml(-1)) or albumin (800 μg ml(-1)). With an increase in the concentrations of laminin in ...
Ngondo-Mbongo Richard Patryk - - 2013
ZNF143 is a zinc-finger protein involved in the transcriptional regulation of both coding and non-coding genes from polymerase II and III promoters. Our study deciphers the genome-wide regulatory role of ZNF143 in relation with the two previously unrelated transcription factors Notch1/ICN1 and thanatos-associated protein 11 (THAP11) in several human and ...
Feng Ke - - 2013
Ghrelin is a recently discovered brain-gut peptide in fish and mammals. It has two main physiological functions-stimulating growth hormone secretion and regulating appetite. To investigate the biological function of ghrelin in appetite regulation in grass carp Ctenopharyngodon idellus, the full-length cDNA sequence of the ghrelin gene was obtained by RT-PCR ...
Khalil Mohammed K - - 2013
This article describes the development of an interactive computer-based laboratory manual, created to facilitate the teaching and learning of medical histology. The overarching goal of developing the manual is to facilitate self-directed group interactivities that actively engage students during laboratory sessions. The design of the manual includes guided instruction for ...
Pinto Emilia M EM International Outreach Program, St. Jude Children's Research Hospital, Memphis, TN 38105, - - 2013
Pediatric adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy. Conventional chemotherapeutic agents have shown limited utility and are largely ineffective in treating children with advanced ACC. The lack of cell lines and animal models of pediatric ACC has hampered the development of new therapies. Here we report the ...
Mitiushkina Natalia V - - 2013
BACKGROUND: Although the molecular analysis of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) in archived lung cancer tissues is relatively well established, the genetic testing of cytological material has not yet become a routine. METHODS: The current study used cell samples that were obtained by bronchial brushing, ...
Rylski Bartosz B Department of Cardiovascular Surgery, Heart Centre Freiburg University, Freiburg, Germany. - - 2013
Previous investigators have reported a grave prognosis for iatrogenic acute aortic dissection (iAADA), but such studies are limited by their small sample sizes. The purpose of the current study was to analyse the clinical characteristics, current management and surgical outcomes in a large number of iAADA patients identified through a ...
Kopečny David D Department of Protein Biochemistry and Proteomics, Centre of the Region Haná for Biotechnological and Agricultural Research, Olomouc, Czech Republic. - - 2013
Plant ALDH10 family members are aminoaldehyde dehydrogenases (AMADHs), which oxidize ω-aminoaldehydes to the corresponding acids. They have been linked to polyamine catabolism, osmoprotection, secondary metabolism (fragrance), and carnitine biosynthesis. Plants commonly contain two AMADH isoenzymes. We previously studied the substrate specificity of two AMADH isoforms from peas (PsAMADHs). Here, two ...
van Schoor Albert - - 2013
The spine of L4 usually lies on a line drawn between the highest points of the iliac crests (Tuffier's line) in adults. Although its accuracy has been questioned, it is still commonly used to identify the spinous process of the 4th lumbar vertebra before performing lumbar neuraxial procedures. In children, ...
Hassan Mohammad Mahbubul - - 2013
Chemical vapor deposition (CVD) polymerization is a useful technique because of the possibility of forming very thin film of pure polymers on substrates with any geometric shape. In this work, thin films of poly(methyl methacrylate) or PMMA were formed on the surfaces of wool fabrics by a CVD polymerization process. ...
Wong Li Ping - - 2013
Abstract The objective of this study was to identify demographic characteristics and correlates of the uptake of HIV testing, willingness to be tested and perceived HIV-related stigma of Malaysian lay public. A cross-sectional computer-assisted telephone interview survey of a representative sample of multiracial Malaysians aged 18 years and above was ...
Stolla M C - - 2013
OBJECTIVES: To understand whether dysregulation of platelet signaling mechanisms contributes to the increased risk of thrombosis associated with diabetes using a Type I diabetic mouse model. METHODS AND RESULTS: Type I diabetes was induced in C57Bl6 mice following streptozotocin injection. Arterial thrombosis, platelet signaling and function were assessed 4 weeks ...
Haga Susanne B SB Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA. - - 2013
Variable health literacy and genetic knowledge may pose significant challenges to engaging the general public in personal genomics, specifically with respect to promoting risk comprehension and healthy behaviors. We are conducting a multistage study of individual responses to genomic risk information for Type 2 diabetes mellitus. A total of 300 ...
Noble Christian G - - 2013
We report a highly reproducible method to crystallize the RNA-dependent RNA polymerase (RdRp) domain of dengue virus serotype 3 (DENV-3), allowing structure refinement to a 1.79-Å resolution and revealing amino acids not seen previously. We also present a DENV-3 polymerase/inhibitor cocrystal structure at a 2.1-Å resolution. The inhibitor binds to ...
Stoneking Colin J - - 2013
We have isolated a K(+) selective, Ca(2+) dependent whole cell current and single channel correlate in the human erythroleukemia (HEL) cell line. The whole cell current was inhibited by the intermediate conductance K(Ca)3.1 inhibitors clotrimazole, TRAM-34 and charybdotoxin, unaffected by the small conductance, K(Ca)2 family inhibitor apamin, and the large ...
Chen Jie - - 2013
OBJECTIVE: /st>Factors associated with treatment compliance have been well studied. However, no study has examined treatment compliance under the context of physician-industry relationship. This study developed a conceptual framework of physician-industry relationship and treatment compliance, and empirically tested patients' treatment compliance and affordability under the physician-industry relationship in the USA. ...
Herrmann Doris D Institute of Farm Animal Genetics (FLI), Neustadt, - - 2013
Normal development depends on the precise sequence of changes in the configuration of chromatin; these are primarily related to specific biochemical modifications such as acetylation or methylation of histones and DNA methylation. While the role of DNA methylation during preimplantation development has been studied extensively, little is known about histone ...
Sheppard Sean C - - 2013
BACKGROUND: Few studies have investigated base rate estimates of risky driving behaviours among veterans of the wars in Afghanistan and Iraq despite evidence suggesting such behaviours result in increased death rates. In addition, published estimates of driving behaviours may be subject to a significant response bias via the impact of ...
Li Guoshi - - 2013
Cholinergic inputs from the basal forebrain regulate multiple olfactory bulb (OB) functions, including odor discrimination, perceptual learning, and short-term memory. Previous studies have shown that nicotinic cholinergic receptor activation sharpens mitral cell chemoreceptive fields, likely via intraglomerular circuitry. Muscarinic cholinergic activation is less well understood, though muscarinic receptors are implicated ...
Lo Yu-Sheng - - 2013
The potent anticancer drug actinomycin D (ActD) functions by intercalating into DNA at GpC sites, thereby interrupting essential biological processes including replication and transcription. Certain neurological diseases are correlated with the expansion of (CGG)n trinucleotide sequences, which contain many contiguous GpC sites separated by a single G:G mispair. To characterize ...
Mylonopoulou Eleonora - - 2013
Purpose: The present study aims to create and characterise a cell-embedding tissue-mimicking material (TMM) that has thermal and acoustic properties similar to liver tissue, in order to enable study and optimisation of protocols for ultrasound-induced hyperthermia and drug delivery. Materials and methods: An agarose-based, cell-embedding TMM was iteratively developed and ...
Palin Amy C AC Department of Pediatrics, Program in Immunology, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, - - 2013
Compared with older children and adults, human neonates have reduced and delayed CD4(+) T cell immunity to certain pathogens, but the mechanisms for these developmental differences in immune function remain poorly understood. We investigated the hypothesis that impaired human neonatal CD4(+) T cell immunity was due to reduced signaling by ...
Cleveland H-R - - 2013
OBJECTIVE: The aim of this study was to examine the association of lay attributions about causes of depression with attitudes and prejudiced behaviour towards people with depression. METHOD: Subjects (1631 German-speakers aged 18 and over, randomly selected) were interviewed in two German cities by telephone using a standardized questionnaire. The ...
Jlali M - - 2013
The aim of this study was to compare the effects of a new organic Se (2-hydroxy-4-methylselenobutanoic acid, HMSeBA) with routinely used mineral and organic Se sources (sodium selenite and selenized yeast) on chosen performance criteria and Se deposition in egg and muscle of laying hens. A total of 240 laying ...
Cowan Eileen - - 2013
PURPOSE OF REVIEW: Parenteral nutrition-associated liver disease (PNALD) is a major cause of morbidity and mortality in the parenteral nutrition-dependent population. Here, we review the most recent literature involving a fish oil-based lipid emulsion (FOLE) and its effects on PNALD. RECENT FINDINGS: Vegetable oil-based lipid emulsions (VBLEs) contribute to PNALD. ...
Dejmek Annika - - 2013
BACKGROUND: Personalized oncology requires molecular analysis of tumor cells. Several studies have demonstrated that cytological material is suitable for DNA analysis, but to the authors' knowledge there are no systematic studies comparing how the yield and quality of extracted DNA is affected by the various techniques used for the preparation ...
Kinoshita Manabu - - 2013
IL-18 has a potential to up-regulate the Th1 and Th2 immune responses. It is known that IL-18, in synergy with IL-12, augments the Th1 response to bacterial infections, but it also augments the Th2 response to allergic disorders in the absence of IL-12. Although the Th1 and Th2 immune responses ...
Church Timothy Robert - - 2013
BACKGROUND: As screening methods for colorectal cancer (CRC) are limited by uptake and adherence, further options are sought. A blood test might increase both, but none has yet been tested in a screening setting. OBJECTIVE: We prospectively assessed the accuracy of circulating methylated SEPT9 DNA (mSEPT9) for detecting CRC in ...
Shon Won-Jun - - 2013
OBJECTIVES: The aim of this study was to evaluate and compare the osseointegration of powder-injection molded (PIM) zirconia implants in rabbit tibiae with or without He plasma treatment. MATERIAL AND METHODS: Twenty-five rabbits received 4 types of external hex implants with identical geometry in the tibiae: PIM zirconia implants, roughened ...
Novella Isabel S - - 2013
Quasispecies theory is a case of mutation-selection balance for evolution at high mutation rates, such as those observed in RNA viruses. One of the main predictions of this model is the selection for robustness, defined as the ability of an organism to remain phenotypically unchanged in the face of mutation. ...
Wang Hui - - 2013
The rhamnolipid biosurfactants have been considered as possible "green" alternatives to synthetic surfactants due to their greater compatibility with the environment and excellent surface active properties. In order to understand the molecular orientation of rhamnolipids at the air-water interface, a new monorhamnolipid with two octadecyl chains, Rha-C18-C18, has been studied ...
Tanda M L - - 2013
Background:The prevalence and natural history of Graves' orbitopathy (GO) are poorly documented.Methods:A large series of 346 patients with newly diagnosed and recent onset Graves' hyperthyroidism seen at a single (nontertiary referral) center over an 8-year period were enrolled in an observational prospective study and evaluated for GO activity and severity ...
Stites Edward C - - 2013
Traditional experimental biology has provided a mechanistic understanding of cancer in which the malignancy develops through the acquisition of mutations that disrupt cellular processes. Several drugs developed to target such mutations have now demonstrated clinical value. These advances are unequivocal testaments to the value of traditional cellular and molecular biology. ...
Muhamad Azira - - 2013
A specific ligand targeting the immunodominant region of hepatitis B virus (HBV) is desired in neutralizing the infectivity of the virus. In a previous study, a disulfide constrained cyclic peptide cyclo S(1) ,S(9) Cys-Glu-Thr-Gly-Ala-Lys-Pro-His-Cys (S(1) , S(9) -cyclo-CETGAKPHC) was isolated from a phage displayed cyclic peptide library using an affinity ...
Goodson Kathy A - - 2013
The E. coli Lac repressor (LacI) tetramer binds simultaneously to a promoter-proximal DNA binding site (operator) and an auxiliary operator, resulting in a DNA loop, which increases repression efficiency. Induction of the lac operon by allolactose reduces the affinity of LacI for DNA, but induction does not completely prevent looping ...
Fukuda Atsuo - - 2013
In order to study how the formation of focal cortical malformations is attributed to perturbation of developmentally multimodal γ-aminobutyric acid (GABA) functions, we made a focal cortical freeze-lesion on a rodent cerebral cortex at P0 (postnatal day 0). The microgyrus was formed at P7. GABA neurons were accumulated in the ...
Conway Aaron - - 2013
Matched case-control research designs can be useful because matching can increase power due to reduced variability between subjects. However, inappropriate statistical analysis of matched data could result in a change in the strength of association between the dependent and independent variables or a change in the significance of the findings. ...
Stein Karen Farchaus - - 2013
Individual disclosure refers to the presumptive ethical responsibility of an investigator to communicate to a study participant information that was collected as a part of a research study protocol and is specific to the individual. Currently, there are no federal regulatory guidelines specifying the conditions and management of disclosure of ...
Klebe Stephan S Centre d'Investigation Clinique, Institut du Cerveau et de la Moelle épinière, Hôpital de la Pitié-Salpêtrière, 47 boulevard de l'Hôpital, Paris 75651 Cedex 13, - - 2013
The catechol-O-methyltranferase (COMT) is one of the main enzymes that metabolise dopamine in the brain. The Val158Met polymorphism in the COMT gene (rs4680) causes a trimodal distribution of high (Val/Val), intermediate (Val/Met) and low (Met/Met) enzyme activity. We tested whether the Val158Met polymorphism is a modifier of the age at ...
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