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Results 601 - 650 of 3295
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Canis Martin - - 2013
The main objective of this study is to assess the feasibility of transoral laser microsurgery (TLM) in the treatment of T4a laryngeal cancer and to report the oncological and functional outcomes. This is a retrospective case-series study, held in a single-institute, academic tertiary referral center. Seventy-nine patients with previously untreated ...
Esmon Charles T - - 2013
Inflammatory cytokines promote the activation of coagulation through the induction of tissue factor, downregulation of thrombomodulin and upregulation of plasminogen activator inhibitor. In addition to these mechanisms, infections can trigger the release of extracellular traps from leukocytes consisting of DNA and histones. Tissue injury results in release of nucleosomes. Either ...
Okita Yoshiki - - 2013
PURPOSE: To improve the selection of patients for percutaneous abscess drainage (PAD) to treat postoperative intra-abdominal abscess after gastrointestinal surgery, we investigated the factors predictive of outcome. METHODS: Of 143 consecutive patients with symptomatic postoperative intra-abdominal abscess after a gastrointestinal tract resection, 104 who underwent image-guided PAD as the initial ...
Ramamurthy Senthil - - 2013
We introduce the concept, benefits, and general architecture for acquiring, storing, and displaying digital photographs along with medical imaging examinations. We also discuss a specific implementation built around an Android-based system for simultaneously acquiring digital photographs along with portable radiographs. By an innovative application of radiofrequency identification technology to radiographic ...
Schuepbach W M M - - 2013
Subthalamic stimulation reduces motor disability and improves quality of life in patients with advanced Parkinson's disease who have severe levodopa-induced motor complications. We hypothesized that neurostimulation would be beneficial at an earlier stage of Parkinson's disease. In this 2-year trial, we randomly assigned 251 patients with Parkinson's disease and early ...
Kato Takao - - 2013
We report 2 cases of reversible ventricular hypertrophy in patients with takotsubo cardiomyopathy (stress-induced cardiomyopathy) during recovery of cardiac function. The first case involved a 72-year-old woman who presented with cerebral infarction. On admission, an elevated troponin I and decreased apical wall motion were observed with normal myocardial perfusion imaging. ...
Ehling Josef - - 2013
Noninvasive imaging plays an emerging role in preclinical and clinical cancer research and has high potential to improve clinical translation of new drugs. This article summarises and discusses tools and methods to image tumour angiogenesis and monitor anti-angiogenic therapy effects. In this context, micro-computed tomography (µCT) is recommended to visualise ...
Kim Mi-Hyun - - 2013
In previous studies, insulin reversed the cardiac toxicity gradually induced by a continuous infusion of bupivacaine. In this randomized controlled study, we intended to simulate a more relevant clinical situation by injecting bupivacaine rapidly as a bolus to induce sudden-onset circulatory collapse in dogs. We then evaluated the insulin effect. ...
Smith H A - - 2013
OBJECTIVE: Empirical evidence supports an inverse relationship between physical activity (PA) and adiposity, but studies using detailed measures of both are scarce. We described the relationship between regional adiposity and accelerometer-derived PA in men and women. DESIGN AND METHODS: Cross-sectional analysis included 253 participants from a weight loss study limited ...
Uribe-Herranz Mireia M Department of Microbiology and Immunology and Temple Autoimmunity Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, - - 2013
Munro's microabscesses contain polymorphonuclear leukocytes and form specifically in the epidermis of psoriasis patients. The mechanism whereby the neutrophils are recruited into the epidermis is poorly understood. Using a combination of human and mouse primary keratinocyte cell cultures and the imiquimod-induced psoriasis-like mouse model of skin inflammation, we explored the ...
Milton Jacqueline N JN Biostatistics, Boston University School of Medicine, 72 E. Concord St., Boston, MA 02118, - - 2013
Haemolytic anaemia is variable among patients with sickle cell anaemia and can be estimated by reticulocyte count, lactate dehydrogenase, aspartate aminotransferase and bilirubin levels. Using principal component analysis of these measurements we computed a haemolytic score that we used as a subphenotype in a genome-wide association study. We identified in ...
Halberstadt Adam L AL Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0804, USA. - - 2013
The head-twitch response (HTR) is a rapid side-to-side rotational head movement that occurs in rats and mice after administration of serotonergic hallucinogens and other 5-HT2A agonists. The HTR is widely used as a behavioral assay for 5-HT2A activation and to probe for interactions between the 5-HT2A receptor and other transmitter ...
Boeke Caroline E - - 2013
OBJECTIVE: We examined associations of perinatal and 3-year leptin with weight gain and adiposity through 7 years. DESIGN AND METHODS: In Project Viva, we assessed plasma leptin from mothers at 26-28 weeks' gestation (n=893), umbilical cord vein at delivery (n=540), and children at 3 years (n=510) in relation to body ...
Li Chunying C Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, - - 2013
Melanoma is the most highly malignant skin cancer, and nucleotide excision repair (NER) is involved in melanoma susceptibility. In this analysis of 1,042 melanoma patients, we evaluated whether genetic variants of NER genes may predict survival outcome of melanoma patients. We used genotyping data of 74 tagging single-nucleotide polymorphisms (tagSNPs) ...
Schueler J L - - 2013
OBJECTIVE: The presence of appetite hormones, namely glucagon-like peptide-1 (GLP-1), peptide YY (PYY) and leptin in breast milk may be important in infant feeding regulation and infant growth. This study evaluated whether concentrations of GLP-1, PYY and leptin change across a single feeding (from fore- to hindmilk), and are associated ...
Luu Kenneth T KT Department of Clinical Pharmacology, Pfizer Global Research and Development, 10555 Science Center Drive, San Diego, CA 92121, USA. - - 2013
The industry-wide biopharmaceutical (i.e., biologic, biotherapeutic) pipeline has been growing at an astonishing rate over the last decade with the proportion of approved new biological entities to new chemical entities on the rise. As biopharmaceuticals appear to be growing in complexity in terms of their structure and mechanism of action, ...
Lo Nigro Cristiana C Laboratory of Cancer Genetics and Translational Oncology, S Croce General Hospital, Cuneo, - - 2013
Transcriptional silencing of tissue factor pathway inhibitor 2 (TFPI2) occurs in several human tumors including melanoma. We investigated methylated TFPI2 as a biomarker of metastatic melanoma using qRT-PCR to assess TFPI2 expression and pyrosequencing to analyze CpG island methylation in malignant melanoma cell lines, in benign nevi, in 112 primary ...
Venkatakrishnan A J AJ MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK. - - 2013
G-protein-coupled receptors (GPCRs) are physiologically important membrane proteins that sense signalling molecules such as hormones and neurotransmitters, and are the targets of several prescribed drugs. Recent exciting developments are providing unprecedented insights into the structure and function of several medically important GPCRs. Here, through a systematic analysis of high-resolution GPCR ...
Li Xingsheng - - 2013
OBJECTIVE: To investigate the effect of risperidone on energy expenditure and weight gain in female C57BL/6J mice. DESIGN AND METHODS: Body weight and composition, food intake, energy expenditure, and activity were determined weekly. mRNA expression of uncoupling protein 1 in brown adipose tissue, orexin and brain-derived neurotrophic factor in the ...
Sanders Kathryn A KA VA Connecticut Healthcare System, West Haven, Connecticut, USA. - - 2013
Successful management of chronic kidney disease (CKD) typically involves consideration of several lifestyle changes and treatments that could improve patients' health outcomes. The complexity of behavioral changes and treatment decisions that must be made by patients, with the support of their treatment team, could diminish their motivation to address CKD ...
Chitty Lyn S LS Clinical and Molecular Genetics Unit, UCL Institute of Child Health, University College London, UK. - - 2013
To improve the prenatal diagnosis of thanatophoric dysplasia by defining the change in fetal size across gestation and the frequency of sonographic features, and developing non-invasive molecular genetic diagnosis based on cell-free fetal DNA (cffDNA) in maternal plasma. Fetuses with a confirmed diagnosis of thanatophoric dysplasia were ascertained, records reviewed, ...
Landi Daniel D Thomas L. Ortel, MD, PhD, Duke Thrombosis and Hemostasis Center, Box 3422 DUMC, Durham, NC 27710, - - 2013
The demographic and clinical characteristics of adults and children with lower extremity deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of an underlying prothrombotic state, and its presence in the setting of known disease ...
James P D PD Department of Medicine, Etherington Hall, Queen's University, Kingston, ON, - - 2013
Since the cloning of the gene that encodes von Willebrand factor (VWF), 27 years ago, significant progress has been made in our understanding of the molecular basis of the most common inherited bleeding disorder, von Willebrand disease (VWD). The molecular pathology of this condition represents a range of genetic mechanisms, some ...
Morgan E E EE University of California, San Diego, San Diego, CA, USA. - - 2013
This is a cross-sectional, observational study to evaluate the hypothesis that HIV-seropositive (HIV+) apolipoprotein E4 (APOE4) carriers are at increased risk for HIV-associated neurocognitive disorders (HAND) compared to APOE4 noncarriers with HIV in the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) Group sample. APOE genotype was determined in 466 CHARTER ...
Ray Wayne A WA Division of Pharmacoepidemiology, Department of Preventive Medicine, Nashville, TN 37212, USA. - - 2013
The opioid analgesic propoxyphene was withdrawn from the US market in 2010, motivated by concerns regarding fatality in overdose and adverse cardiac effects, including prolongation of the QT interval. These concerns were based on case reports, summary vital statistics, and surrogate endpoint studies. Using the linked Tennessee Medicaid database (1992-2007), ...
Miljkovic Iva - - 2013
Design and Methods: Skeletal muscle adipose tissue (AT) infiltration (myosteatosis) increases with aging and may contribute to the development of type 2 diabetes mellitus (T2DM). It remains unclear if myosteatosis is associated to glucose and insulin homeostasis independent of total and central adiposity. We evaluated the association between intermuscular AT ...
Luo Shan - - 2013
OBJECTIVE: Exposure to high-calorie foods may promote overeating by stimulating brain reward pathways and appetite. Abdominal fat has particularly adverse metabolic consequences and may alter brain pathways that regulate feeding behavior. Functional magnetic resonance imaging (fMRI) was used to test the hypothesis that high-calorie food cues activate brain reward regions ...
Chu Michael P - - 2013
OBJECTIVE: Little is known of the effect of body composition on glucose metabolism in the aging female non-human primate. We studied these variables in older female Rhesus macaques. DESIGN AND METHODS: Female Rhesus macaques (Macacamulatta, n = 19, age range 25-30 yrs) underwent magnetic resonance imaging and (1) H spectroscopy ...
Titus Shiny - - 2013
The underlying mechanism behind age-induced wastage of the human ovarian follicle reserve is unknown. We identify impaired ATM (ataxia-telangiectasia mutated)-mediated DNA double-strand break (DSB) repair as a cause of aging in mouse and human oocytes. We show that DSBs accumulate in primordial follicles with age. In parallel, expression of key ...
Guan Wei - - 2013
The important problem of how to generate lateral order for ion implantation patterning of substrates is solved by using a nanoporous anodic alumina membrane as a mask. Co and Pt implantation is used at two implantation doses. In order to observe the achieved implantation zones free from artifacts, electron transparent ...
Estrada Catalina - - 2013
Fungal symbionts that live asymptomatically inside plant tissues (endophytes) can influence plant-insect interactions. Recent work has shown that damage by leaf-cutting ants, a major Neotropical defoliator, is reduced to almost half in plants with high densities of endophytes. We investigated changes in the phenotype of leaves that could influence ants' ...
Orosco Michael John - - 2013
This case study describes the culturally responsive instruction of one special education teacher with Latino English language learners (ELLs) with learning disabilities in an urban elementary school setting. This study was situated in a social constructivist research based framework. In investigating this instruction with ELLs, this study focused on how ...
Merrill Ray M - - 2013
Abstract The objective of this study was to describe employees most likely to participate in a Personal Wellness Profile (PWP) and/or in a worksite Wellness Program (WP), and to identify whether an association exists between participation and trends in number of health care services and cost of services per person. ...
Puopolo Karen M - - 2013
PURPOSE OF REVIEW: Neonatal early-onset sepsis (EOS) is a very low-incidence, but potentially fatal condition among term and late preterm newborns. EOS algorithms based on risk-factor threshold values result in evaluation and empiric antibiotic treatment of large numbers of uninfected newborns, leading to unnecessary antibiotic exposures and maternal/infant separation. Ideally, ...
Fritsch Helga - - 2013
Literature on the development of the human vagina is abundant; however, contributions concerning the prenatal development of the entire utero-vaginal anlagen (UVA) are rare or carried out in rodents. The primary epithelial characteristics in the adult vagina and uterus are determined during prenatal development and depend on epithelio-mesenchymal stroma interaction; ...
Tseng Huan-Wei - - 2013
We describe the charge transfer interactions between photoexcited CdS nanorods and a mononuclear water oxidation catalyst derived from the [Ru(bpy)(tpy)Cl]+ parent structure. Upon excitation, hole transfer from CdS oxidizes the catalyst (Ru2+→Ru3+) on a 100 ps - 1 ns timescale. This is followed by 10 - 100 ns electron transfer ...
Takashima Hiroshi - - 2013
A ruthenium(II) complex-based carbonic anhydrase (CA) inhibitor, [Ru(bpy)(2)(bpybs)](2+) {bpy = 2,2'-bipyridine and bpybs = 4'-methyl-2,2'-bipyridinyl-4-carboxylic acid(2-{2-[(4-sulphamoylbenzoylamino)ethoxy]ethoxy}ethyl)amide}, tethering a benzenesulfonamide group and a [Ru(bpy)(3)](2+) moiety has been prepared. The CA activity was effectively suppressed by a synthetic [Ru(bpy)(2)(bpybs)](2+) inhibitor and the dissociation constant at pH = 7.2 and at 25 °C ...
Khanna Sahil - - 2013
Background. The incidence of Clostridium difficile infection (CDI) is increasing, even in populations previously thought to be at low-risk, including children. Most incidence studies have included only hospitalized patients, and are thus potentially influenced by referral or hospitalization biases.Methods. We performed a population-based study of CDI in pediatric residents (age 0-18 years) ...
Dorra Bouzid - - 2013
Inflammatory bowel diseases (IBDs), consisting of ulcerative colitis (UC) and Crohn's disease (CD), are complex disorders with multiple genes contributing to disease pathogenesis. We aimed to identify the associations of genetic variations in the ZAP70, PTPN6, BANK1, and CLEC2D genes encoding for intracellular signaling molecules with IBDs. One hundred seven ...
Abakumov A M - - 2013
Novel anion-deficient perovskite-based ferrites Pb(2)Ba(2)BiFe(5)O(13) and Pb(1.5)Ba(2.5)Bi(2)Fe(6)O(16) were synthesized by solid-state reaction in air. Pb(2)Ba(2)BiFe(5)O(13) and Pb(1.5)Ba(2.5)Bi(2)Fe(6)O(16) belong to the perovskite-based A(n)B(n)O(3n-2) homologous series with n = 5 and 6, respectively, with a unit cell related to the perovskite subcell a(p) as a(p)√2 × a(p) × na(p)√2. Their structures are ...
Phisitkul Phinit - - 2013
Background:For triple arthrodesis, a single medial incision has been proposed to avoid lateral wound complications and has demonstrated satisfactory fusion rates. This study aimed to compare the disruption to the arterial supply of the talus between the single-medial-incision approach and the 2-incision approach.Methods:The 2 approaches for triple arthrodesis were compared ...
Tang Chao-Hsiun - - 2013
BACKGROUND: Migraine is associated with a significant economic burden in Western countries. However, there is limited information regarding the impact of the cost of migraine in Asia. OBJECTIVES: To quantify and compare the direct medical costs of refractory migraine (RM) and other migraine, using health insurance claims data in Taiwan. ...
Hajirahimkhan Atieh - - 2013
Menopausal women suffer from a variety of symptoms, including hot flashes and night sweats, which can affect quality of life. Although it has been the treatment of choice for relieving these symptoms, hormone therapy has been associated with increased breast cancer risk leading many women to search for natural, efficacious, ...
Hubbard A R - - 2013
This document addresses two main objectives of product labelling - the first being to define the quantity of the active substance in the vial for manufacturing and marketing purposes, and the second to guide physicians on the dose to be used for treatment that would correlate with recovery data measured ...
Fletcher Jacqueline - - 2013
Recent efforts to address concerns about microbial contamination of food plants and resulting foodborne illness have prompted new collaboration and interactions between the scientific communities of plant pathology and food safety. This article provides perspectives from scientists of both disciplines, and presents selected research results and concepts that highlight existing ...
Aaronson Barak D B - - 2013
The influence of electrode surface structure on electrochemical reaction rates and mechanisms is a major theme in electrochemical research, especially as electrodes with inherent structural heterogeneities are used ubiquitously. Yet, probing local electrochemistry and surface structure at complex surfaces is challenging. In this paper, high spatial resolution scanning electrochemical cell ...
Zhang Yan - - 2013
Microarray based transcriptomics and one-dimensional proton nuclear magnetic resonance (1H-NMR) based metabonomics approaches were employed to investigate the health effects of nitrogenous disinfection by-products (N-DBPs) of trichloroacetamide (TCAcAm) on mice. Mice were exposed to TCAcAm at concentrations of 50, 500 and 5000 μg/L for 90 days, and hepatic transcriptome and ...
Wang Lian-Chin - - 2013
The Arabidopsis mutant heat-intolerant 4-1 (hit4-1) was isolated from an ethyl methanesulphonate-mutagenized M2 population on the basis of its inability to withstand prolonged heat stress (4 days at 37°C). Further characterization indicated that hit4-1 was impaired specifically in terms of basal but not acquired thermotolerance. Map-based cloning revealed that the ...
Lin M C - - 2013
BackgroundThis study evaluates the risk of benign brain tumors (BBTs) and malignant brain tumors (MBTs) associated with dental diagnostic X-ray, using a large population-based case-control study.Materials and methodsWe identified 4123 BBT cases and 16 492 controls without BBT (study 1) and 197 MBT cases and 788 controls without MBT (study ...
Williams Gareth R - - 2013
The formation of the layered double hydroxide [Cu(2)Cr(OH)(6)]Cl·yH(2)O from the reaction between CuO and aqueous CrCl(3)·6H(2)O was explored using synchrotron X-ray diffraction and ex situ analyses. The use of hard X-rays permitted time-resolved in situ studies to be performed as the reaction proceeded under a range of conditions. Additional information ...
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