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Results 551 - 600 of 3309
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Onyango Nelson Owuor - - 2013
We analyse a periodically driven SIR epidemic model for childhood related diseases, where the contact rate and vaccination rate parameters are considered periodic. The aim is to define optimal vaccination strategies for control of childhood related infections. Stability analysis of the uninfected solution is the tool for setting up the ...
Kala Petr - - 2013
Primary percutaneous coronary intervention is the best treatment of patients with ST elevation myocardial infarction (STEMI). When managing a STEMI patient, our approach must be rapid and aggresive in order to interrupt the pathological process of thrombus formation and stabilization. The therapy must be initiated prior to angiography (pretreatment), continued ...
Samhan Yasser M - - 2013
We are introducing a new continuous hydrostatic pressure system for identification and catheterization of epidural space in adults. One hundred and eight patients scheduled for elective endoscopic urological procedures were enrolled in this prospective randomized study. They were assigned to perform loss of resistance epidural technique by either the conventional ...
Gattas David J - - 2013
PURPOSE: To determine whether fluid resuscitation of acutely ill adults with 6 % hydroxyethyl starch (6 % HES 130) with a molecular weight of 130 kD and a molar substitution ratio of approximately 0.4 (6 % HES 130) compared with other resuscitation fluids results in a difference in the relative risk of death or ...
Blomquist Gustav A - - 2013
The aim of this work is to describe the radiographic findings of isolated trapezoid fractures and determine the utility of these findings in guiding treatment. A second aim is to heighten awareness of an uncommon sports-related injury that is often radiographically occult because of the lack of primary or overt ...
Schuepbach W M M - - 2013
Subthalamic stimulation reduces motor disability and improves quality of life in patients with advanced Parkinson's disease who have severe levodopa-induced motor complications. We hypothesized that neurostimulation would be beneficial at an earlier stage of Parkinson's disease. In this 2-year trial, we randomly assigned 251 patients with Parkinson's disease and early ...
Silverio Daniel L - - 2013
The discovery of catalysts that can be used to synthesize complex organic compounds by enantioselective transformations is central to advances in the life sciences; for this reason, many chemists aim to discover catalysts that allow for preparation of chiral molecules as predominantly one mirror-image isomer. The ideal catalyst should not ...
McConkey Roy - - 2013
BACKGROUND: Specialist short break services aim to provide enhanced support to family carers as a means of preventing children whose behaviours severely challenge from being placed in full-time residential care. To date, there is limited evidence as to the functioning and effectiveness of such services. METHODS: In all, 17 children ...
Korir Nicholas Kibet - - 2013
Presence of selected tomato (Solanum lycopersicon) microRNAs (sly-miRNAs) was validated and their expression profiles established in roots, stems, leaves, flowers and fruits of tomato variety Jiangshu14 by quantitative RT-PCR (qRT-PCR). In addition conservation characteristics these sly-miRNAs were analyzed and target genes predicted bioinformatically. Results indicate that some of these miRNAs ...
Goyal Shipra - - 2013
PROBLEM: This study was undertaken to evaluate the efficacy and safety of recombinant SP-10 protein for male contraception. METHODS OF STUDY: Adult male mice were divided into five groups. Group I was placebo-treated control while Groups II-V were immunized with recombinant SP-10 protein on day 0 and 21 with different ...
Huillet Thierry E - - 2013
We study a class of coalescents derived from a sampling procedure out of [Formula: see text] i.i.d. Pareto[Formula: see text] random variables, normalized by their sum, including [Formula: see text] -size-biasing on total length effects ([Formula: see text]). Depending on the range of [Formula: see text] we derive the large ...
Koss David J - - 2013
Several genetically engineered models exist that mimic aspects of the pathological and cognitive hallmarks of Alzheimer's disease (AD). Here we report on a novel mouse model generated by targeted knock-in of transgenes containing mutated human amyloid precursor protein (APP) and microtubule-associated protein tau genes, inserted into the HPRT locus and ...
Luo Shan - - 2013
OBJECTIVE: Exposure to high-calorie foods may promote overeating by stimulating brain reward pathways and appetite. Abdominal fat has particularly adverse metabolic consequences and may alter brain pathways that regulate feeding behavior. Functional magnetic resonance imaging (fMRI) was used to test the hypothesis that high-calorie food cues activate brain reward regions ...
Matsushita Yumi - - 2013
OBJECTIVE: To examine the incidences of metabolic risk factors according to changes in visceral fat area (VFA) in a large Japanese population. DESIGN AND METHODS: The subjects were 973 men who received a computed tomography (CT) examination in health check-ups twice (2004-2005 and 2007-2008), and not having two or more ...
Ebrahimpour Behnam - - 2013
In this research, a novel homogeneous liquid phase microextraction method was successfully developed based on applying octanoic acid as low density extraction solvent. The method was applied for extraction and determination of chlorophenols as model compounds. Twelve milliliters of the sample solution was poured into a home-designed glass vial. Sixty ...
Milton Jacqueline N JN Biostatistics, Boston University School of Medicine, 72 E. Concord St., Boston, MA 02118, - - 2013
Haemolytic anaemia is variable among patients with sickle cell anaemia and can be estimated by reticulocyte count, lactate dehydrogenase, aspartate aminotransferase and bilirubin levels. Using principal component analysis of these measurements we computed a haemolytic score that we used as a subphenotype in a genome-wide association study. We identified in ...
Haddas R - - 2013
Newcastle disease is a contagious and often fatal disease, capable of affecting all species of birds. A velogenic Newcastle disease virus (vNDV) outbreak occurred in an Israeli zoo, in which Little owls (Athene noctua) and African penguins (Spheniscus demersus) were found positive for presence of NDV. Some of them have ...
Dupont E - - 2013
Since ancient times, human beings have been trying to protect their skin against the adverse effects of the sun. From the first mineral sunscreens used by Egyptians, to the current more sophisticated ultraviolet (UVA/UVB) organic sunscreens, progress has been made in terms of sun protection and deeper knowledge of skin ...
Wu Fenqin - - 2013
Background: Much attention has been paid to the quality of life (QOL) in dialysis patients worldwide. However, differences in QOL between peritoneal dialysis (PD) and hemodialysis (HD) patients have not been clearly identified. The objectives of this study were to compare the differences of QOL between PD and HD patients, ...
Hamanaka Yoshitaka - - 2013
The butterfly Papilio xuthus has compound eyes with three types of ommatidia. Each type houses nine spectrally heterogeneous photoreceptors (R1-R9) that are divided into six spectral classes: ultraviolet, violet, blue, green, red, and broad-band. Analysis of color discrimination has shown that P. xuthus uses the ultraviolet, blue, green, and red ...
Krishtopenko S S - - 2013
We report a theoretical study of the energies of cyclotron resonance (CR) and electron spin resonance (ESR) for fractional quantum Hall states (FQHS) in n-type narrow-gap quantum well (QW) heterostructures. Using the generalized single-mode approximation (GSMA) based on the 8-band k ⋅p Hamiltonian, we calculate the many-body corrections to the ...
Ghassemian Artin - - 2013
We report the total chemical synthesis of human C3a by one-pot native chemical ligation of three unprotected peptide segments, followed by efficient in vitro folding that yielded the anaphylatoxin C3a in high yield and excellent purity. Synthetic C3a was fully active and its crystal structure at 2.1 Å resolution showed ...
Ruzevick J J Department of Neurosurgery, The Johns Hopkins University School of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, - - 2013
Head and neck squamous cell carcinoma (HNSCC) is notorious for local recurrence and metastatic spread to regional lymph nodes. Distant spread is uncommon, and brain involvement is rare. Over the past decade there has been a rising incidence of HPV-related HNSCC, but it is not known if this escalation has ...
Johnson Pieter T J - - 2013
Accelerating rates of species extinctions and disease emergence underscore the importance of understanding how changes in biodiversity affect disease outcomes. Over the past decade, a growing number of studies have reported negative correlations between host biodiversity and disease risk, prompting suggestions that biodiversity conservation could promote human and wildlife health. ...
Gaspar Alexandra - - 2013
Chromones are heterocyclic compounds of natural or synthetic origin that possess relevant pharmacological activities. Versatile functionalization of the chromone nucleus allows attaining of a chemical diversity suitable to perform structure-activity relationships in drug discovery and development programs. Accordingly, the synthesis and identification of novel chromone carboxamide derivatives with electron-donating and ...
Bhutani Surabhi - - 2013
Objective: This study examined whether the combination of Alternate day fasting (ADF) plus exercise produces superior changes in body composition and plasma lipid levels when compared to each intervention alone. Designs and Methods: Obese subjects (n = 64) were randomized to 1 of 4 groups for 12 weeks: 1) combination ...
Clark Kara - - 2013
An adolescent boy whose initial presentation consisted of an asymmetric, nonvesicular rash was eventually diagnosed with dermatitis herpetiformis (DH). Certain factors, including lesions limited to the genitals, an initial biopsy revealing nonspecific findings on microscopy studies, and the absence of characteristic direct immunofluorescence findings lessened initial clinical suspicions of DH ...
Gallicchio Lisa L The Prevention and Research Center, The Weinberg Center for Women's Health and Medicine, Mercy Medical Center, 227 St. Paul Place, 6th Floor, Baltimore, MD 21202, USA. - - 2013
Musculoskeletal pain is a common side effect of aromatase inhibitors (AIs), the adjuvant hormonal treatment of choice for postmenopausal estrogen-receptor-positive breast cancer. Although the pain is usually attributed to the estrogen depletion associated with AIs, not all women on AIs experience these symptoms. Thus, the goal of this study was ...
Elliott Beth - - 2013
This article describes a pilot project that provided a job preparedness program specifically designed for individuals who suffer from borderline personality disorder (BPD). The program called "The Connections Place" or "TCP" was based on a 16-week curriculum that focused on both helping individuals with BPD overcome emotional barriers to employment ...
Prado Guillermo - - 2013
Hispanic adolescents are disproportionately affected by externalizing disorders, substance use and HIV infection. Despite these health inequities, few interventions have been found to be efficacious for this population, and even fewer studies have examined whether the effects of such interventions vary as a function of ecodevelopmental and intrapersonal risk subgroups. ...
Patrzyk Maciej - - 2013
PURPOSE: Remaining urachal anomalies are seldom found but can result in long-standing recurrent symptoms and repeated surgery. In this single-centre study, we evaluated the laparoscopic approach of excision of the urachus leaving the umbilicus untouched. METHODS: Twenty-one patients were operated on for persisting symptomatic urachal anomalies between 1998 and 2011. ...
Pastromas Georgios - - 2013
PURPOSE: To investigate the incidence and clinical significance of platelet responsiveness in patients receiving clopidogrel after peripheral angioplasty procedures. MATERIALS AND METHODS: This prospective study included patients receiving antiplatelet therapy with clopidogrel 75 mg after infrainguinal angioplasty or stenting and who presented to our department during routine follow-up. Clopidogrel responsiveness was ...
Mietto Bruno Siqueira - - 2013
Wallerian degeneration (WD) comprises a series of events that includes activation of non-neuronal cells and recruitment of immune cells, creating an inflammatory milieu that leads to extensive nerve fragmentation and subsequent clearance of the myelin debris, both of which are necessary prerequisites for effective nerve regeneration. Previously, we documented accelerated ...
Fratev Filip - - 2013
The UNC-45 chaperone protein interacts with and affects the folding, stability and the ATPase activity of myosins. It plays a critical role in the cardiomyopathy development and in the breast cancer tumour growth. . Here we propose the first structural model of the UNC-45-myosin complex using various in silico methods. ...
Mashburn Andrew J - - 2013
Social and emotional learning programs are designed to improve the quality of social interactions in schools and classrooms in order to positively affect students' social, emotional, and academic development. The statistical power of group randomized trials to detect effects of social and emotional learning programs and other preventive interventions on ...
Dykstra Andrew B - - 2013
Post-translational modifications (PTMs) are known to play a significant role in many biological functions. The focus of this study is to optimize an integrated experimental/informatics approach to more confidently characterize the range of post-translational modifications of the cellulosome protein complex used by the bacterium Clostridium thermocellum to better understand how ...
Dong Min - - 2013
Even though ER-positive, HER2-negative breast tumors represent a subset of breast cancers with a better clinical outcome, approximately 12.7 % of patients in this subgroup ultimately develop cancer-related mortality. Recent studies had confirmed that hypoxia-induced autophagy-related gene Beclin 1 expression might be important for disease progression and be correlated with patient ...
Subramanian Melanie - - 2013
The bushmeat industry has been a topic of increasing importance among both conservationists and public health officials for its influence on zoonotic disease transmission and animal conservation. While the association between infectious diseases and the bushmeat trade is well established in the research community, risk perception among bushmeat hunters and ...
Mollicone Debra - - 2013
Challenged by the observation that newly admitted dialysis patients were often unaware of their treatment options, Fresenius Medical Care, North America developed a program to improve information delivered to chronic kidney disease (CKD) patients prior to their need for renal replacement therapy. Six years ago, the Treatment Options Program (TOPs) was ...
Pecina Jennifer L - - 2013
PURPOSE: Telemonitoring is being increasingly used for chronic disease monitoring. While the primary aim of telemonitoring is to improve chronic disease management and decrease hospitalizations, the potential impact on patient's health-related quality of life may be an additional benefit. METHODS: Two hundred and five patients aged 60 years and older with ...
Pérez Leirós Claudia - - 2013
Pregnancy challenges immune cells and immunomodulatory circuits of the mother and the developing fetus to dynamically adapt to each other in an homeostatic and tolerant environment for fetal growth. This entails the coordination of multiple cellular processes all devoted to accommodate and nourish the fetus while protecting the mother from ...
Janer Gemma - - 2013
Abstract Little information exists on the toxicological hazards associated to organo-modified clays. We evaluated the cytotoxicity of a series of pristine and organo-modified nanoclays in different cell lines. The calculated IC50 values for cell viability ranged from 1.4 to 47 μg/mL for the six organoclays used and were above 100 ...
Bonvoisin Jacques - - 2013
The electronic and geometrical features of a recently synthesized ruthenium β-diketonato complex with a protected ethynyl ligand ([Ru(dbm)(2)(acac-TIPSA)], dbm = dibenzoylmethanate ion, acac-TIPSA = 3-(triisopropylsilyl)acetylene-2,4-pentanedionate ion), a building block for molecular spintronic devices, were analyzed as a function of its oxidation degree using Density Functional Theory (DFT) and Time Dependent ...
Apovian Cm - - 2013
OBJECTIVE: To examine the effects of naltrexone/bupropion (NB) combination therapy on weight and weight-related risk factors in overweight and obese participants. DESIGN AND METHODS: CONTRAVE Obesity Research-II (COR-II) was a double-blind, placebo-controlled study of 1496 obese (body mass index 30-45 kg/m(2) ) or overweight (27-45 kg/m(2) with dyslipidemia and/or hypertension)participants ...
Michaud Andréanne - - 2013
Objective: We tested the hypothesis that high lipolytic responsiveness is related to increased expression of ATM genes in human adipose tissues. Design and Methods: Omental (OM) and subcutaneous (SC) fat samples were obtained surgically in 46 women (age:47.2±4.7 years, BMI: 26.9±5.2 kg/m(2) ). Body composition and fat distribution were measured ...
Bazi Tony - - 2013
INTRODUCTION AND HYPOTHESIS: The aim of this manuscript is to review the subject of urethral dilation (UD) in female patients and to conduct a critical appraisal of the available evidence for its use. METHODS: We used an online search of electronic databases. RESULTS: UD has been cited as a treatment ...
Gowda Srinath T - - 2013
BACKGROUND: To evaluate postdiscovery outcome of coronary artery fistulae (CAF). CAF treatment sequelae and risk factors for coronary thrombosis have not been adequately evaluated. METHODS: Outcome on follow-up of 16 patients with CAF was reviewed. Risk factors for adverse coronary events were assessed based on type, size, and treatment of ...
Kavanagh D O - - 2013
BACKGROUND: This study evaluated the clinicopathological features and survival rates of patients with inflammatory bowel disease who developed colorectal cancer (CRC). METHODS: A retrospective review was performed on a prospectively maintained institutional database (1981-2011) to identify patients with inflammatory bowel disease who developed CRC. Clinicopathological parameters, management and outcomes were ...
Sun Mao - - 2013
BACKGROUND: Some inflammatory factors play an important role in recurrent oral ulceration (ROU). The genetics mechanism of expression level of inflammatory factors is not clear in ROU, but from genetics the expression level of inflammatory factors at least partly depend on the gene polymorphisms. Therfore, we decided to investigate inflammatory ...
Ma Xujun - - 2013
Histone deacetylases (HDACs) mediate histone deacetylation and act in concert with histone acetyltransferases to regulate dynamic and reversible histone acetylation which modifies chromatin structure and function, affects gene transcription, thus, controlling multiple cellular processes. HDACs are widely distributed in almost all eukaryotes, and there have been many researches focusing on ...
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