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Cursiefen C C Zentrum für Augenheilkunde, Klinik und Poliklinik für Allgemeine Augenheilkunde, Universität zu Köln, Deutschland. - - 2013
The aim was to demonstrate the feasibility of targeted removal of a central visually disturbing roll in Descemet's membrane after complicated cataract surgery. a 76-year-old patient complained of halos and reduced visual acuity after external cataract surgery. At slit-lamp examination a central roll in Descemet's membrane was found (2 × 2 mm). A ...
Yarmus Lonny - - 2013
Prior to the 1980s, permanent feeding tube placement was limited to an open surgical procedure until Gauderer and colleagues described the safe placement of percutaneous endoscopic gastrostomy (PEG) tubes. This procedure has since expanded beyond the realm of surgeons to include gastroenterologists, thoracic surgeons, and interventional radiologists. In some academic ...
Rossen Lauren M LM Office of Analysis and Epidemiology, National Center for Health Statistics, Centers for Disease Control and Prevention, 3311 Toledo Rd, Room 6114, Hyattsville, MD 20782, USA. - - 2013
This study examined food availability along children's paths to and from elementary school, and associations with change in body mass index (BMI) and waist circumference over 1 year. Secondary data from 319 children aged 8-13 years from the "Multiple Opportunities to Reach Excellence" Project was used. Child anthropometry and demographic variables were ...
Calvin Andrew D AD Department of Health Services Research, Mayo Clinic, Rochester, MN 55905, - - 2013
Epidemiologic studies link short sleep duration to obesity and weight gain. Insufficient sleep appears to alter circulating levels of the hormones leptin and ghrelin, which may promote appetite, although the effects of sleep restriction on caloric intake and energy expenditure are unclear. We sought to determine the effect of 8 ...
Berger Kenneth I KI André Cournand Pulmonary Physiology Laboratory, the World Trade Center Environmental Health Center, Bellevue Hospital, New York, NY 10016, USA. - - 2013
The present study (1) characterizes a physiologic phenotype of restrictive dysfunction due to airway injury and (2) compares this phenotype to the phenotype of interstitial lung disease (ILD). This is a retrospective study of 54 persistently symptomatic subjects following World Trade Center (WTC) dust exposure. Inclusion criteria were reduced vital ...
McElrath M J MJ Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, - - 2013
Prevention of rectal HIV transmission is a high-priority goal for vaccines and topical microbicides because a large fraction of HIV transmissions occurs rectally. Yet, little is known about the specific target-cell milieu in the human rectum other than inferences made from the colon. We conducted a comprehensive comparative in situ ...
Bailey Alexander A Precision Spine & Orthopaedic Specialists, Overland Park, KS 66211, USA. - - 2013
Prospective, multicenter, single-blind, randomized, controlled clinical study. To investigate outcomes associated with repairing the anulus fibrosus after lumbar discectomy for the surgical management of herniated nucleus pulposus. In patients undergoing discectomy, the incidence of reherniation ranges from 10% to 15%. Repair of the anulus fibrosus defect after lumbar discectomy may ...
Kim Han Jo HJ Division of Spine Surgery, Department of Orthopaedic Surgery, Washington University School of Medicine, Saint Louis, MO 63110, - - 2013
Matched cohort comparison. To compare the use of bone morphogenetic protein (BMP) or iliac crest bone graft (ICBG) on the long-term outcomes in patients undergoing long fusions to the sacrum for adult spinal deformity. No long-term studies beyond a 2-year follow-up have been performed comparing the use of BMP versus ...
Muralidharan Rajanandini R Department of Neurology, Mayo Clinic, Rochester, MN 55905, - - 2013
Retrospective consecutive case series. To determine predictors of outcome in patients undergoing surgical treatment of spinal dural arteriovenous fistula (SDAVF). Most previous studies assessing postoperative outcome in patients with SDAVF have been limited due to small population size, lack of sufficient information on presurgical variables, or short time of postoperative ...
Yue James J Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06511, USA. - - 2013
Analysis of data collected prospectively from the United States Food and Drug Administration Investigational Device Exemption (U.S. FDA IDE) clinical trial for patients who underwent ProDisc-L arthroplasty at 1- and 2- levels performed at 2 study centers. To determine if there is any clinical or radiographical differences between patients who ...
Strauss Eric J - - 2013
Patellofemoral chondral lesions are unique and difficult-to-treat entities often affecting a young and active patient population. Recent advances in our understanding of cartilage injuries, surgical techniques, and surgical technology have provided treatment options for symptomatic patients with lesions of the patellofemoral compartment. A number of surgical treatment options are available, ...
Liu Lianxing L Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143-1270, - - 2013
Antiretroviral therapy (ART) significantly reduced the CD8 cell noncytotoxic anti-HIV response in 12 HIV-1-infected subjects (P < 0.0001). In separate experiments, CD8(+) cells from long-term survivors were cocultured with HIV-infected CD4(+) cells using varying concentrations of anti-HIV drugs. The antiviral function of CD8(+) cells from 4 of the 14 LTSs ...
Kim Lena H LH Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, CA 94143-0132, USA. - - 2013
To estimate the cost-effectiveness of HIV screening strategies for the prevention of perinatal transmission in Uganda, a resource-limited country with high HIV prevalence and incidence. We designed a decision analytic model from a health care system perspective to assess the vertical transmission rates and cost-effectiveness of 4 different HIV screening ...
Erlandson Kristine M KM Division of Infectious Diseases, Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA. - - 2013
Disability and frailty are associated with osteoporosis, obesity, and sarcopenia. HIV-infected persons have early functional impairment, but the association between body composition and functional impairment is unknown. HIV-1-infected participants on combination antiretroviral therapy with virologic suppression, aged 45-65 years, had standardized physical function measures. In a nested analysis, 30 low- ...
Kratzer Adelheid A Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado at Denver, Aurora, CO 80045, - - 2013
Chronic second-hand smoke (SHS) exposure comprises the main risk factor for nonsmokers to develop chronic obstructive pulmonary disease (COPD). However, the mechanisms behind the chronic inflammation and lung destruction remain incompletely understood. In this study, we show that chronic exposure of Sprague-Dawley rats to SHS results in a significant increase ...
Newcomb Dawn C DC Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. - - 2013
Mucous cell metaplasia is a hallmark of asthma, and may be mediated by signal transducers and activators of transcription (STAT)-6 signaling. IL-17A is increased in the bronchoalveolar lavage fluid of patients with severe asthma, and IL-17A also increases mucus production in airway epithelial cells. Asthma therapeutics are being developed that ...
Lozupone Catherine C Department of Chemistry and Biochemistry and Biofrontiers Institute, University of Colorado, Boulder, CO, - - 2013
Lung infections caused by opportunistic or virulent pathogens are a principal cause of morbidity and mortality in HIV infection. It is unknown whether HIV infection leads to changes in basal lung microflora, which may contribute to chronic pulmonary complications that increasingly are being recognized in individuals infected with HIV. To ...
Suissa Samy - - 2013
For 2 decades, long-acting β-agonists (LABAs) have been associated with increased asthma-related death risks in several randomized trials, even when added to inhaled corticosteroids (ICSs). In reaction, the US Food and Drug Administration (FDA) recently mandated that the manufacturers of LABAs conduct five large, noninferiority, randomized trials of the LABA+ICS ...
Heidemann Sabrina M SM Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI, - - 2013
To describe serum concentrations of zinc, selenium, and prolactin in critically ill children within 72 hours of PICU admission, and to investigate relationships between these immunomodulators and lymphopenia. An analysis of baseline data collected as part of the multicenter Critical Illness Stress Induced Immune Suppression (CRISIS) Prevention Trial. PICUs affiliated ...
Proudnikov Dmitri D Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA. - - 2013
Studies indicate cross-desensitization between opioid receptors (eg, kappa opioid receptor, OPRK1) and chemokine receptors (eg, CXCR4) involved in HIV infection. Whether gene variants of OPRK1 and its ligand, prodynorphin (PDYN), influence the outcome of HIV therapy was tested. Three study points, admission to the Women's Interagency HIV Study, initiation of ...
Hoffmann Christopher J CJ Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. - - 2013
To estimate the mortality impact of delay in antiretroviral therapy (ART) initiation from the time of entry into care. A state-transition Markov process model. This technique allows for assessing mortality before and after ART initiation associated with delays in ART initiation among a general population of ART-eligible patients without conducting ...
Meyer Vanessa J VJ Department of Neuroscience, University of Illinois at Chicago, Chicago, IL 60612, - - 2013
HIV infection and illicit drug use are each associated with diminished cognitive performance. This study examined the separate and interactive effects of HIV and recent illicit drug use on verbal memory, processing speed, and executive function in the multicenter Women's Interagency HIV Study. Participants included 952 HIV-infected and 443 HIV-uninfected ...
Taiwo Babafemi B Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. - - 2013
Transient low-level viremia (TLLV) of 50-400 HIV RNA copies per milliliter is common during antiretroviral therapy, but its pathogenesis, consequences, and optimal management are unclear. Heightened immune activation is associated with detrimental outcomes, including impaired CD4 T-cell reconstitution. Using CD38/HLA-DR expression on CD8 T cells measured in 2 large studies, ...
Cooke Colin R CR Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA. - - 2013
In the face of an overwhelmingly large and growing medical literature, providers often turn to clinical practice guidelines to inform the decisions they make with patients. By systematically appraising the evidence and providing transparent recommendations for practice, guidelines have the potential to improve both bedside decision-making and health policy. This ...
Holubkov Richard R Division of Critical Care, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA. - - 2013
Randomized clinical trials are commonly overseen by a Data and Safety Monitoring Board comprised of experts in medicine, ethics, and biostatistics. Data and Safety Monitoring Board responsibilities include protocol approval, interim review of study enrollment, protocol compliance, safety, and efficacy data. Data and Safety Monitoring Board decisions can affect study ...
Richter Hagen H Max-Planck-Institute for Terrestrial Microbiology, Marburg, - - 2013
The prokaryotic antiviral defense systems CRISP R (clustered regularly interspaced short palindromic repeats)/Cas (CRISP Rassociated) employs short crRNAs (CRISP R RNAs) to target invading viral nucleic acids. A short spacer sequence of these crRNAs can be derived from a viral genome and recognizes a reoccurring attack of a virus via ...
Xi Yongming Y Department of Spinal Surgery, Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong, - - 2013
Animal experimental study. To establish an early and reproducible intervertebral disc (IVD) degeneration model to provide a basis for studying IVD degeneration. The pathophysiology and pathogenesis of IVD degeneration, a common condition that causes low back pain, are not clearly understood. An experimental animal model of human IVD degeneration is ...
Kreitchmann Regis R HIV/AIDS Research Department, Irmandade da Santa Casa de Misericordia de Porto Alegre, RS, Brazil. - - 2013
Reduced atazanavir exposure has been demonstrated during pregnancy with standard atazanavir/ritonavir dosing. We studied an increased dose during the third trimester of pregnancy. International Maternal Pediatric Adolescent AIDS Clinical Trials Group 1026s is a prospective, nonblinded, pharmacokinetic study of HIV-infected pregnant women taking antiretrovirals for clinical indications, including 2 cohorts ...
Pandur Edina - - 2013
Hepcidin is the major regulatory peptide hormone of iron metabolism, encoded by the HAMP (hepcidin antimicrobial peptide) gene. Hepcidin is expressed mainly in hepatocytes, but is also found in the blood in both a mature and prohormone form. Although, the function of mature hepcidin and the regulation of the HAMP ...
Zhu Hongying H Electrical Engineering Department, University of California, Los Angeles, CA 90095, - - 2013
We demonstrate a compact and cost-effective imaging cytometry platform installed on a cell-phone for the measurement of the density of red and white blood cells as well as hemoglobin concentration in human blood samples. Fluorescent and bright-field images of blood samples are captured using separate optical attachments to the cell-phone ...
Zangari Maurizio - - 2013
Thromboses represent a major cause of morbidity and mortality in polycythemia vera but the contributing mechanisms are not fully described. To evaluate whether environmental conditions such as altitude/hypoxia could impact thrombosis history, we retrospectively analyzed thrombosis history in 71 polycythemia vera patients living at an elevation of 5000 feet or ...
Yohannan Jithin - - 2013
The World Health Organization recommends at least 3 annual mass drug administrations (MDAs) of azithromycin in places where the prevalence of follicular trachoma (FT) is greater than 10%. However, stopping MDA prior to 3 rounds, if monitoring indicates an absence of infection with Chlamydia trachomatis even if FT persists, may ...
Monach Paul A PA Vasculitis Center and Section of Rheumatology, Boston University School of Medicine, 72 East Concord Street, E-533, Boston, MA, 02118, USA, - - 2013
Having diagnosed a patient as having IgG4-related disease, I would have a low threshold for recommending immune-suppressive treatment, and would make that recommendation for any patient with vascular involvement. My initial approach would be prednisone at 40-60 mg/day with a plan to reduce the dose every two weeks, e.g., 40, 30, ...
Beslow Lauren A LA Section of Child Neurology, Departments of Pediatrics and Neurology, Yale University School of Medicine,POBox 208064, New Haven, CT 06520, USA. - - 2013
Seizures are believed to be common presenting symptoms in neonates and children with spontaneous intracerebral hemorrhage (ICH). However, few data are available on the epidemiology of acute symptomatic seizures or the risk for later epilepsy. To define the incidence of and explore risk factors for seizures and epilepsy in children ...
Muni Rajeev H RH Department of Ophthalmology and Vision Sciences, University of Toronto, St Michael’s Hospital, Toronto, Canada. - - 2013
This study demonstrates that increasing quintiles of baseline high-sensitivity C-reactive protein (hsCRP) level may be associated with higher risk of incident clinically significant macular edema, the leading cause of vision loss in working-aged individuals in North America. To determine whether baseline levels of hsCRP and intercellular adhesion molecule 1 (ICAM-1) ...
Mitta Vinod P VP Department of Epidemiology, Harvard School of Public Health, Boston, MA, - - 2013
This study adds to the evidence that elevated levels of high-sensitivity C-reactive protein (hsCRP) predict future risk of age-related macular degeneration (AMD). This information might shed light on underlying pathological mechanisms involving inflammation and could be of clinical utility in the identification of persons at high risk of AMD who ...
Borrell Luisa N LN Department of Health Sciences, Graduate Program in Public Health, Lehman College, City University of New York, Bronx, NY, USA. - - 2013
Obesity is associated with increased asthma morbidity, lower drug responsiveness to inhaled corticosteroids, and worse asthma control. However, most prior investigations on obesity and asthma control have not focused on pediatric populations, considered environmental exposures, or included minority children. To examine the association between body mass index categories and asthma ...
Gan Wen Qi WQ Department of Population Health, Hofstra North Shore-LIJ School of Medicine, Great Neck, NY 11021, USA. - - 2013
Ambient air pollution has been suggested as a risk factor for chronic obstructive pulmonary disease (COPD). However, there is a lack of longitudinal studies to support this assertion. To investigate the associations of long-term exposure to elevated traffic-related air pollution and woodsmoke pollution with the risk of COPD hospitalization and ...
Chong James J H JJ Center for Cardiovascular Biology, University of Washington, Seattle, Washington 98109, - - 2013
Platelet-derived growth factors (PDGFs) and their tyrosine kinase receptors play instrumental roles in embryonic organogenesis and diseases of adult organs. In particular, platelet-derived growth factor receptor-alpha (PDGFRα) is expressed by multipotent cardiovascular progenitors in mouse and human embryonic stem cell systems. Although cardiac PDGFRα expression has been studied in multiple ...
Tameris Michele D MD South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa. - - 2013
BCG vaccination provides incomplete protection against tuberculosis in infants. A new vaccine, modified Vaccinia Ankara virus expressing antigen 85A (MVA85A), was designed to enhance the protective efficacy of BCG. We aimed to assess safety, immunogenicity, and efficacy of MVA85A against tuberculosis and Mycobacterium tuberculosis infection in infants. In our double-blind, ...
Chen Fang F State Key Laboratory of Experimental Hematology, National Engineering Research Center of Stem Cells, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, - - 2013
All-trans retinoic acid (ATRA) induces clinical remission in most acute promyelocytic leukemia (APL) patients by inducing terminal differentiation of APL cells toward mature granulocytes. Here we report that human umbilical cord-derived mesenchymal stem cells (UC-MSCs) are capable of inducing granulocytic differentiation of the APL-derived NB4 cell line as well as ...
Li Yiwei Y Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, - - 2013
Oxidative stress has been mechanistically linked with aging and chronic diseases, including cancer. In fact, oxidative stress status, chronic disease-related inflammation, and cancer occurred in the aging population are tightly correlated. It is well known that the activation of nuclear factor kappa B (NF-κB) plays important roles in oxidative stress, ...
Thyrhaug Erling E Nano-Science Center & Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 København Ø, - - 2013
To fully exploit the capabilities of fluorescence probes in modern experiments, where advanced instrumentation is used to probe complex environments, other photophysical properties than emission color and emission intensity are monitored. Each dye property can be addressed individually as well as collectively to provide in-depth information unavailable from the standard ...
Ashburn Jean H - - 2013
: Long-term consequences of anastomotic leak after restorative proctectomy for rectal cancer, in terms of bowel function and quality of life, have been poorly delineated. : The purpose of this study is to evaluate the impact of anastomotic leak, when intestinal continuity can still be maintained, on bowel function and ...
Bañares Rafael - - 2013
Liver support systems aim to provide temporary support of liver function while maintaining extra-hepatic function in patients with liver failure. Important advances have been achieved in the design of artificial and bio-artificial devices, but the current systems are far from meeting the ideal. Artificial devices provide detoxification through different dialysis ...
Liu Wendy Y - - 2013
: Ligation of intersphincteric fistula tract is a novel surgical technique in the treatment of transsphincteric fistula-in-ano that has been shown to be successful in the short term. Median follow-up in current literature ranges from 5 to 9 months. However, the long-term success rate is unknown. : This study describes ...
Margariti Aikaterini - - 2013
: Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, but it may also be present in lean individuals. We evaluated the characteristics of NAFLD patients, focusing on those with normal body mass index (BMI). : One hundred and sixty-two of 185 consecutive NAFLD patients were included. Demographic, clinical, somatometric, ...
Talbert Steven - - 2013
: The purpose of this article was to discuss common issues associated with large databases and present possible solutions to improve the quality and usefulness of large database research. : The volume of electronic healthcare-related data is growing exponentially. Some of these data are being stored in registries and administrative ...
Sturgeon Duveen - - 2013
: Lynch syndrome contributes to 5% of all colorectal cancers. Patients seen in most surgical clinics have limited or no family histories documented and are rarely assessed for hereditary syndromes. In 2007 a clinic-based hereditary colorectal cancer registry was established to screen for Lynch syndrome and facilitate genetic counseling/testing. : ...
Scherer Thomas - - 2013
Besides the well-characterized effects of brain insulin and leptin in regulating food intake, insulin and leptin signaling to the central nervous system modulates a variety of metabolic processes, such as glucose and lipid homeostasis, as well as energy expenditure. This review summarizes the current literature on the contribution of central ...
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