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Results 401 - 450 of 2394
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Tsakos Michail - - 2013
The first organocatalytic asymmetric reaction between 1,4-cyclohexanedione and nitroalkenes has been studied, affording bicyclo[3.2.1]octane derivatives containing four continuous stereogenic centres. The products were obtained through a domino Michael-Henry process as a single diastereoisomer with excellent enantioselectivities.
Rodger M W M - - 2013
The ancillary (non-sounding) body movements made by expert musicians during performance have been shown to indicate expressive, emotional, and structural features of the music to observers, even if the sound of the performance is absent. If such ancillary body movements are a component of skilled musical performance, then it should ...
Mak Yim Ling - - 2013
Ciguatera fish poisoning (CFP) is a food intoxication caused by exposure to ciguatoxins (CTXs) in coral reef fish. Rapid analytical methods have been developed recently to quantify Pacific-CTX-1 (P-CTX-1) in fish muscle, but it is destructive and can cause harm to valuable live coral reef fish. Also fish muscle extract ...
Saba Anna - - 2013
OBJECTIVE: To compare obese v. non-obese consumers in terms of their general food-related lifestyles and to explore possible food-related factors affecting obesity in Italy. DESIGN: The data were collected using a self-completion questionnaire. Data included sociodemographic information, measures of the Food-Related Lifestyle scale (FRL) and self-reported weight and height. A ...
Schummer Claude - - 2013
Sudan dyes are red, synthetic azo dyes that are not allowed in foodstuffs in the European Union (Council Directive 94/36/EC). However, sub-ppm levels of Sudan dye in spices are regularly reported and it is assumed that these appearances are due to cross-contamination. In this paper, we present a newly-developed fast ...
Lawrentschuk Nathan - - 2013
Imaging for urothelial cancer, particularly that located in the bladder, has generally been based on computed tomography (CT). However in more recent times the role of positron emission tomography-CT (PET-CT) has emerged and increasingly magnetic resonance (MR) imaging has become utilised. This concise review will outline the role of these ...
Chapman C M C - - 2013
PURPOSE: Multi-species probiotic preparations have been suggested as having a wide spectrum of application, although few studies have compared their efficacy with that of individual component strains at equal concentrations. We therefore tested the ability of 4 single probiotics and 4 probiotic mixtures to inhibit the urinary tract pathogens Escherichia ...
Delaunois Bertrand - - 2013
ABSTRACT: BACKGROUND: The extracellular space or apoplast forms a path through the whole plant and acts as an interface with the environment. The apoplast is composed of plant cell wall and space within which apoplastic fluid provides a means of delivering molecules and facilitates intercellular communications. However, the apoplastic fluid ...
Murono Koji - - 2013
PURPOSE: Both hepatic steatosis (HS) and colorectal cancer (CRC) are conditions associated with metabolic syndrome. The liver is the most frequent site of distant metastasis of CRC; however, the impact of HS on the incidence of liver metastasis of CRC is not clearly defined. Then, the correlation with the presence ...
Sezgin Melek - - 2013
To investigate the associations between Fas and FasL gene polymorphisms and susceptibility to knee osteoarthritis. Genomic DNA was obtained from 146 patients with knee osteoarthritis and 102 healthy controls. Genotype distributions and allelic frequencies of four polymorphisms of Fas (-670 G>A rs1800682, -1377 G>A rs2234767) and FasL (IVS2nt-124 A>G rs5030772, ...
McKinney Denise M DM La Jolla Institute for Allergy and Immunology, La Jolla, San Diego, CA 92037, - - 2013
Classic ways to determine MHC restriction involve inhibition with locus-specific antibodies and antigen presentation assays with panels of cell lines matched or mismatched at the various loci of interest. However, these determinations are often complicated by T cell epitope degeneracy and promiscuity. We describe a selection of 46 HLA DR, ...
Nishimura Taki T Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, - - 2013
Autophagosome formation is a dynamic process that is strictly controlled by autophagy-related (Atg) proteins. However, how these Atg proteins are recruited to the autophagosome formation site or autophagic membranes remains poorly understood. Here, we found that FIP200, which is involved in proximal events, directly interacts with Atg16L1, one of the ...
Fraga Garth R - - 2013
ABSTRACT:: Necrotizing infundibular crystalline folliculitis (NICF) is a rare entity manifesting as waxy folliculocentric papules comprised of filamentous birefringent crystalline deposits. We report a case of NICF in an 85-year-old man, presenting as gritty, cream-colored, and erythematous papules across the midline back. Biopsy demonstrated a pale plug comprised of copious ...
Shi Deheng - - 2013
The potential energy curves (PECs) of twenty-four Λ-S states and fifty- four Ω states of the C2+ cation are studied in detail using an ab initio quantum chemical method. All the PEC calculations are made for internuclear separations from 0.09 to 1.11 nm by the complete active space self-consistent field ...
Bernards Daniel A DA Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, - - 2013
The identification of biomaterials that are well tolerated in the eye is important for the development of new ocular drug delivery devices and implants, and the application of micro- and nanoengineered devices to biomedical treatments is predicated on the long-term preservation within the target organ or tissue of the very ...
Simanovsky Natalia - - 2013
ABSTRACT BACKGROUND Cystic fibrosis (CF) genotypes characterized by pancreatic sufficiency (CF-PS) are generally associated with milder disease versus those with pancreatic insufficiency (CF-PI); however, the correlation between pancreatic status and type and severity of structural lung changes has not been studied. We aimed to evaluate differences in the severity and ...
Yabushita Setsuko - - 2013
Pancreatic ductal adenocarcinoma (PDAC) is one of the most debilitating malignancies in humans, and one of the reasons for this is the inability to diagnose this disease early in its development. To search for biomarkers which can be used for early diagnosis of PDAC, we established a rat model of ...
An Jiabin - - 2013
Clear cell renal cell carcinomas (RCC), the major histologic subtype of RCC accounting for more than 80% of cases, are typified by biallelic inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene. Although accumulation of hypoxia-inducible factor alpha (HIF-α) is the most well-studied effect of VHL inactivation, direct inhibition of ...
Fernández-Hidalgo Nuria - - 2013
The aim of this study was to compare the effectiveness of the ampicillin plus ceftriaxone (AC) and ampicillin plus gentamicin (AG) combinations for treating Enterococcus faecalis infective endocarditis (EFIE). An observational, nonrandomized, comparative multicenter cohort study was conducted at 17 Spanish and 1 Italian hospitals. Consecutive adult patients diagnosed of ...
Varshney Gopal Kishore - - 2013
The diffusion kinetics of a hemicyanine dye, LDS-698, across model membrane bilayers was studied in real time by the surface specific second harmonic technique. Using liposomes made from different head groups it has been established that the diffusion is initiated by electrostatic adsorption of the positively charged dye to the ...
Moon Jae Hoon - - 2013
Context:There are still some controversies regarding the cutoff value and the influential factors of thyroglobulin (Tg) concentration in washout fluid from fine-needle aspiration (FNA) biopsy (FNA-Tg) on cervical lymph nodes (LNs) in patients with papillary thyroid cancer (PTC).Objective:Our aims were to validate the cutoff value of FNA-Tg in diagnosing malignant ...
Natarajan Rajalaxmi - - 2013
Mutations in the Tuberous Sclerosis Complex (TSC) are associated with various forms of neurodevelopmental disorders, including autism and epilepsy. The heterodimeric TSC complex, consisting of Tsc1 and Tsc2 proteins, regulates the activity of the TOR (Target of Rapamycin) complex via Rheb, a small GTPase. TOR, an atypical serine/threonine kinase, forms ...
Phillips Damilola D DD Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, - - 2013
Anthrax toxin protective antigen (PA) delivers its effector proteins into the host cell cytosol through formation of an oligomeric pore, which can assume heptameric or octameric states. By screening a highly directed library of PA mutants, we identified variants that complement each other to exclusively form octamers. These PA variants ...
Mende Marika - - 2013
ABSTRACT: BACKGROUND: A better understanding of patients' views on the benefit and burden obtained from palliative chemotherapy would facilitate shared decision making. We evaluated palliative cancer patients' reported outcomes (PROs) for toxicity and investigated the survival threshold for which they would repeat chemotherapy (CTx). METHODS: Patients who had received a ...
Zhao Yuechao Y Department of Molecular and Integrative Physiology, University of Illinois and College of Medicine at Urbana-Champaign, Urbana, IL 61801, - - 2013
Successful implantation and maintenance of pregnancy require the transformation of uterine endometrial stromal cells into distinct decidualized cells. Although estrogen and progesterone (P4) receptors are known to be essential for decidualization, the roles of steroid receptor coregulators in this process remain largely unknown. In this study, we have established a ...
Pan Tao - - 2013
The Emberiza pusilla is a common bunting with very wide geographical range. Here, the complete mitochondrial genome of E. pusilla (16,790 bp in length) has been analyzed for building the database. The results showed that it consisted of 13 protein-coding genes, 22 transfer RNA genes, 2 ribosomal RNA genes, and 1 ...
Xie Jian J Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United - - 2013
The use of a powerful intramolecular [4 + 2]/[3 + 2] cycloaddition cascade of an 1,3,4-oxadiazole in the divergent total synthesis of kopsinine (1), featuring an additional unique SmI(2)-promoted transannular cyclization reaction for formation of the bicyclo[2.2.2]octane central to its hexacyclic ring system, is detailed.
Bernard Valérie - - 2013
BACKGROUND: Refractory hypoglycemia in patients with metastatic insulinoma is an important cause of morbidity and mortality. Everolimus could be a new therapeutic option. METHODS: Within the French Group, we conducted a retrospective, multicentric study of endocrine tumors to evaluate the time to first recurrence of symptomatic hypoglycemia, after everolimus initiation, ...
Bartley Laura E - - 2013
Grass cell wall properties influence food, feed, and biofuel feedstock usage efficiency. The glucuronoarabinoxylan of grass cell walls is esterified with the phenylpropanoid-derived hydroxycinnamic acids, ferulic acid (FA) and para-coumaric acid (p-CA). Feruloyl esters undergo oxidative coupling with neighboring phenylpropanoids on glucuronoarabinoxylan and lignin. Examination of rice (Oryza sativa) mutants ...
Brandner Sebastian - - 2013
In recent years, the measurement of biomarkers following neurotrauma assisted in improving outcome prediction and guiding therapy. The use of neuroproteins as diagnostic parameters requires a detailed knowledge of their dynamics in biological fluids for an appropriate interpretation. S100B is the most widely studied neuromarker, and its concentration in serum ...
Park Shin-Young SY Aab Cardiovascular Research Institute, University of Rochester, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, - - 2013
Thioredoxin-interacting protein (TXNIP) is an α-arrestin protein whose function is important for the regulation of vascular endothelial growth factor receptor 2 (VEGFR2) signaling and endothelial cell survival. Because VEGFR2 is critical for angiogenesis, we explored the role of TXNIP in VEGF-induced angiogenesis. TXNIP knockdown inhibited VEGF-induced endothelial cell tube formation ...
Haines David E - - 2013
BACKGROUND: -Cerebral diffusion-weighted MRI lesions have been observed after catheter ablation of atrial fibrillation. We hypothesized that conditions predisposing to microembolization could be identified using a porcine model of pulmonary vein ablation and an extracorporeal circulation loop. METHODS AND RESULTS: -Ablations of the pulmonary veins were performed in 18 swine ...
Saraswat Mayank - - 2013
It is often desirable to obtain gene libraries with the greatest possible number of variants. We tested two different methods for desalting the products of library ligation reactions (silica-based microcolumns and drop dialysis), and examined their effects on final library size. For both intramolecular and intermolecular ligation, desalting by drop ...
Seo Myung-Ji - - 2013
L-Arabinose isomerase from Bacillus thermoglucosidasius KCTC 1828 (BTAI) was expressed in Escherichia coli. The optimal temperature and pH for the activity of the purified BTAI were 40 °C and pH 7.0. The Mn(2+) ion was an activator of BTAI activity. The kinetic parameters of BTAI for D-galactose were a K(m) ...
Soh Junyi - - 2013
AIMS: Fourier transform infrared (FT-IR) imaging is increasingly being applied to biomedical specimens, but strong IR absorption by water complicates live cell imaging. This study investigates the viability of adherent epithelial cells maintained for short periods under mineral oils in order to facilitate live cell spectroscopy using FT-IR with subsequent ...
Ruiz-Rosado Azucena A Department of Physiology, Biophysics and Neurosciences, CINVESTAV, IPN, C.P.07360, Mexico City, - - 2013
We analyze the effect of chronic undernourishment on extensor digitorum longus (EDL) muscle maturation in the rat. Cytochrome c oxidase (COX) and alkaline ATPase histoenzymatic techniques were used to determine the relative proportion of different fiber types (oxidative/glycolytic and type I, IIa/IId, or IIb, respectively) and their cross-sectional area in ...
Liu Yuchen - - 2013
AgOTf can catalyze an addition-cyclization tandem between alkyne-azomethine and a nucleophile such as ketone, nitroalkane, water, and terminal alkyne to give a polycyclic amide via six-exo-trig selectivity.
Collao Bernardo - - 2013
OmpW is a minor porin that has been involved in osmoregulation and the uptake of ceftriaxone. Evidence obtained in our laboratory indicates that in S. Typhimurium 14028s its expression is increased by SoxS, upon exposure to paraquat, and is required for the resistance to the toxic compound. SoxS belongs to ...
Zhang Qi-Lin - - 2013
The complete mitochondrial genome (mitogenome) of Dolycoris baccarum (Hemiptera: Pentatomidae) has been sequenced and annotated in this study. This mitogenome is 16,549 bp in length with an A+T content of 73.4%, and contains the typical 37 genes that are arranged in the same order as that of the putative ancestor ...
Macé Aurélie - - 2013
The reactions of 1-silyl-3-boryl-2-alkenes with various electrophilic reagents (Selectfluor, N-halosuccinimides, benzhydryl, and propargylic alcohols in the presence of a Lewis acid, N-alkoxycarbonyliminium ion) have been investigated as new routes to α-substituted allylboronates. Further functional transformations, including allylboration, Suzuki coupling, protodeboronation, and cycloisomerization, have been carried out to illustrate the synthetic ...
Keeney James A - - 2013
With increased use of total knee arthroplasty (TKA) technique, the burden of revision surgery for all causes including periprosthetic fractures is anticipated to increase substantially in the coming decades. Although periprosthetic TKA fractures are most frequently managed with operative repair, there are circumstances where fracture characteristics or patient factors may ...
Robinson David M - - 2013
Manganese oxides occur naturally as minerals in at least 30 different crystal structures, providing a rigorous test system to explore the significance of atomic positions on the catalytic efficiency of water oxidation. In this study, we chose to systematically compare eight synthetic oxide structures containing Mn(III) and Mn(IV) only, with ...
Dweck Marc R MR Centre for Cardiovascular Science, University of Edinburgh, Little France Crescent, Edinburgh, UK. - - 2013
The pathophysiology of aortic stenosis shares many similarities with atherosclerosis and skeletal bone formation. Using non-invasive imaging, we compared aortic valve calcification and inflammation activity with that measured in atherosclerosis and bone. Positron emission and computed tomography was performed using 18F-sodium fluoride (18F-NaF, calcification) and 18F-fluorodeoxyglucose (18F-FDG, inflammation) in 101 ...
Kim Su-Jin - - 2013
The incretins, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are gastrointestinal hormones conferring a number of beneficial effects on β-cell secretion, survival and proliferation. In an earlier study, it was demonstrated that delayed rectifier channel protein Kv2.1 contributes to β-cell apoptosis and that prosurvival effects of incretins involve Kv2.1 ...
Kapahi Ruhi R Human Cytogenetics Laboratory, Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, - - 2013
The aim of the present study was to assess the role of the vascular endothelial growth factor (VEGF) -2549 insertion/deletion (I/D) polymorphism in susceptibility to sporadic breast cancer. DNA samples of 94 breast cancer patients and 94 unrelated healthy control individuals with matched age and gender from the same geographical ...
Lluch Girbés Enrique - - 2013
Osteoarthritis is one of the most frequent, disabling, and costly pathologies of modern society. Among the main aims of osteoarthritis management are pain control and functional ability improvement. The exact cause of osteoarthritis pain remains unclear. In addition to the pathological changes in articular structures, changes in central pain processing ...
Mooney Joshua J - - 2013
ABSTRACT BACKGROUND: It is unknown whether the radiographic fibrosis score predicts mortality in persistent hypersensitivity pneumonitis (HP) and if survival is similar to that observed in idiopathic pulmonary fibrosis (IPF) when adjusting for the extent of radiographic fibrosis. METHODS: We reviewed records from 177 HP and 224 IPF patients whose ...
Lin Heng-Huei - - 2013
Increased cardiac stromal cell-derived factor-1α (SDF-1α) expression promotes neovascularization and myocardial repair after ischemic injury through recruiting stem cells and reducing cardiomyocyte death. Previous studies have shown that heme oxygenase-1 and its reaction byproduct, carbon monoxide (CO), induce SDF-1α expression in ischemic heart. However, the mechanism underlying heme oxygenase-1/CO-induced cardiac ...
Lenzi Andrea - - 2013
ABSTRACT: BACKGROUND: Human Papillomavirus (HPV) is a very resistant, ubiquitous virus that can survive in the environment without a host. The decision to analyze HPV-related diseases in males was due to the broad dissemination of the virus, and, above all, by the need to stress the importance of primary and ...
Galay Remil L - - 2013
Ticks are obligate hematophagous parasites and important vectors of diseases. The large amount of blood they consume contains great quantities of iron, an essential but also toxic element. The function of ferritin, an iron storage protein, and iron metabolism in ticks need to be further elucidated. Here, we investigated the ...
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