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Ba Ming-Chen MC Intracelom Hyperthermic Perfusion Therapy Center, Cancer Hospital of Guangzhou Medical College, Guangzhou 510095, China. - - 2013
Clinical efficacy of B-ultrasound-guided and laparoscopy-assisted continuous hyperthermic intraperitoneal perfusion chemotherapy (CHIPC) for treatment of malignant ascites was investigated. Sixty-two patients with malignant ascites induced by ovarian or gastrointestinal cancers were randomly treated with B-ultrasound-guided CHIPC (therapeutic group) or laparoscopy-assisted CHIPC (control group) performed at the same center. Hospitalization costs ...
Jiang Tongying - - 2013
Abstract Background: Organic porous material is a promising carrier for enhancing the dissolution of poorly water soluble drug. The aim of the present study was to enhance dissolution and oral bioavailability of lovastatin (LV) by preparing a porous starch microsphere foam (PSM) using a novel method, meanwhile, looking into the ...
Traore Fousseyni - - 2013
Retinoblastoma (RB) is a rare embryonic tumour that represents 1/16,000 births in France. In Mali, a study showed the characteristics of a hospital series of cases seen in Bamako in the Pediatric Oncology Unit of Gabriel Touré Teaching Hospital and in the Tropical Ophthalmology Institute of Africa (IOTA) between January 2005 and ...
Tarique Qaiser - - 2013
The objectives of this study were to evaluate the infaunal, facultative deposit-feeding clam Amiantis umbonella as a bioindicator of trace-metal contamination and the relative importance of clam burrow sediment and porewater to total accumulation in an urban/industrial coastal environment. Concentrations of eight trace metals (cadmium [Cd], chromium, copper, mercury [Hg], ...
Zamanian Mohammadreza - - 2013
Calreticulin (CRT) as a multi-functional endoplasmic reticulum protein is involved in a spectrum of cellular processes which ranges from calcium homeostasis and chaperoning to cell adhesion and finally malignant formation and progression. Previous studies have shown a contributing role for CRT in a range of different cancers. This present review ...
Nicolai M P J - - 2013
BACKGROUND: In patients with cardiovascular disease, sexual dysfunction is frequently encountered. Erectile dysfunction shares the same modifiable risk factors as coronary artery disease and the fear of triggering cardiovascular events can create stress and anxiety impacting the sexual lives of patients and their partners. To optimise healthcare, knowledge of cardiologists' ...
Lv Zhi-Dong - - 2013
Peritoneal metastases are one reason for the poor prognosis of scirrhous gastric cancer (SGC), and myofibroblast provides a favorable environment for the peritoneal dissemination of gastric cancer. The aim of this study was to determine whether myofibroblast originates from peritoneal mesothelial cells under the influence of the tumor microenvironment. Immunohistochemical ...
- - 2013
'...lower mortality among overweight and moderately obese patients' but higher mortality for those with a BMI >35.
Tennant I I Medical Research Council MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, - - 2013
Cells dying by apoptosis are normally cleared by phagocytes through mechanisms that can suppress inflammation and immunity. Molecules of the innate immune system, the pattern recognition receptors (PRRs), are able to interact not only with conserved structures on microbes (pathogen-associated molecular patterns, PAMPs) but also with ligands displayed by apoptotic ...
Boyarskikh Ul'yana A - - 2013
There is ample experimental evidence supporting the hypothesis that the brain serotonergic system is involved in the control of chronic social defeat stress (CSDS), depression, and anxiety. The study aimed to analyze mRNA levels of the serotonergic genes in the raphe nuclei of midbrain that may be associated with chronic ...
Biggar Patrick - - 2013
The development of ESAs (Erythropoiesis Stimulating Agents) revolutionized the treatment of renal anemia. However, the initial euphoria has abated and, in the last few years, studies have shown that ESAs should not be administered without caution as the rate of cardiovascular events and possibly tumor related deaths may increase with ...
Tong Zhongsheng - - 2013
We report a case of subcutaneous phaeohyphomycosis due to Phialophora verrucosa in a 64-year-old Chinese farmer suffering from CD4+ lymphopenia. He presented with diffuse and infiltrated plaques involving the entire face including the eyes, neck, occiput, and extending to the dorsal regions of his torso. The patient is notable for ...
Kettunen Pyry - - 2013
Landmarks constitute an essential basis for a structural understanding of the spatial environment. Therefore, they are crucial factors in external spatial representations such as maps and verbal route descriptions, which are used to support wayfinding. However, selecting landmarks for these representations is a difficult task, for which an understanding of ...
Amin Alpesh N - - 2013
ABSTRACT: BACKGROUND: Deep-vein thrombosis (DVT) and pulmonary embolism (PE) are frequent and life-threatening complications of ischemic stroke. We evaluated rates of symptomatic DVT/PE, and of in-hospital and post-discharge thromboprophylaxis in patients with acute ischemic stroke (AIS). METHODS: In a retrospective US database analysis, data were extracted from the Premier PerspectiveTM-i3 ...
Day Andrew R - - 2013
BACKGROUND: Laparoscopic colorectal surgery is known to provide increased benefits to patients during the postoperative recovery period. Initial scepticism over the oncological adequacy of resection has been dismissed by a number of major randomized trials. Emerging evidence indicates that laparoscopic surgery may provide a potential survival benefit in colorectal cancer. ...
Liu Shasha - - 2013
The ubiquitously expressed hypoxia-inducible factor-1α (HIF-1α) acts as a key transcription factor in regulating metabolism, development, cellular survival, proliferation and pathology under hypoxia condition. Compared to mammals, fish are more vulnerable to hypoxia stress and contamination; however, the regulation of HIF-1α in fish remains obscure. In this study, zebrafish HIF-1α ...
Sabeti Faran - - 2013
BACKGROUND: Early age-related macular degeneration (AMD) is common among the elderly. While only a small number progress to sight-threatening stages of AMD, identifying prognostic functional markers remains paramount. Here, we objectively evaluate retinal function in patients with large drusen by multifocal pupillographic objective perimetry (mfPOP). Different temporal presentation rates and ...
Li You-Qiong - - 2013
Hb Constant Spring [Hb CS, α142, Term→Gln, TAA>CAA (α2)] is a nondeletional form of α-thalassemia (α-thal) that is most prevalent in Southern Chinese and Southeast Asian populations. We previously found that Hb CS trait could efficiently be screened using Sebia Capillarys2. In this study, we report that Hb CS heterozygotes ...
Sarath Babu V - - 2013
Ten cell lines established from Indian marine, brackishwater and freshwater fish were tested for their susceptibility to fish nodavirus. In addition, the efficiency of betanodavirus replication was tested in these cell lines. Multiple vacuolation, a typical cytopathic effect for virus infection, was observed in infected SISK, SISS, SIGE and ICF ...
Kulkarni Manjusha M - - 2013
The digenetic protozoan Leishmania is dependent on ergosterol synthesis for growth and viability. We compared the in vitro activity of ergosterol synthesis inhibitor voriconazole with fluconazole and ketoconazole against cutaneous and visceral Leishmania species. We found the IC(50) of voriconazole was comparable to ketoconazole and both were superior to fluconazole. ...
Hilakivi-Clarke Leena L Department of Oncology, Georgetown University, Washington, DC 20057, USA. - - 2013
Women are using estrogens for many purposes, such as to prevent pregnancy or miscarriage, or to treat menopausal symptoms. Estrogens also have been used to treat breast cancer which seems puzzling, since there is convincing evidence to support a link between high lifetime estrogen exposure and increased breast cancer risk. ...
Yri Olav E - - 2013
ABSTRACT We analyzed the allelic distribution in 12 candidate polymorphisms in a large retrospective study of 486 diffuse large B-cell lymphoma (DLBCL) patients treated at Oslo University Hospital with 1056 blood donors serving as controls. Variants in TNFα (rs1800629) (GG vs. AG/AA, p <0.001), LTA (rs909253) (AA vs. AG/GG, p= ...
Blumenberg Miroslav - - 2013
ABSTRACT: BACKGROUND: One challenge of systems biology is the integration of new data into the preexisting, and then re-interpretation of the integrated data. Here we use readily available metaanalysis computational methods to integrate new data on the transcriptomic effects of EGF in primary human epidermal keratinocytes with preexisting transcriptomics data ...
Rochman Deborah L - - 2013
Abstract Purpose: Deficiencies in pain knowledge and attitudes among students and health practitioners are well documented. Occupational therapists (OTs) commonly care for patients who present with pain, and their knowledge of the field presumably impacts that care. This study presents the results of testing OT students' pain knowledge in order ...
Fromm Michael - - 2013
Bourassa et al. (Reports, 6 July 2012, p. 78) report on the 13 June 2011 eruption of the Nabro volcano and satellite observations of stratospheric aerosol that they attribute to troposphere to stratosphere ascent via the Asian monsoon. They claim (citing another source) that the 13 June top injection height ...
Shin J-Y - - 2013
As hepatocellular carcinoma (HCC) is one of the most common tumors worldwide, development of novel therapeutic approaches for HCC is urgently needed. Two different genes, LETM1 and CTMP, which target mitochondrial functions, were chosen and linked using 2A-peptide sequence. Successful self-cleavage of 2A-peptide induced synergistic antitumor effect in the liver ...
Uh Mitchell - - 2013
Crowned dens syndrome (CDS) is a rare but underrecognized cause of severe neck pain in older adults. It is characterized by acute onset pain and stiffness of the cervical spine. Accompanying fever and elevated inflammatory markers often lead to misdiagnosis. It is frequently associated with calcium pyrophosphate deposition disease, hydroxyapatite ...
Singh Hari Ji - - 2013
The present work deals with the theoretical estimation of ion-pair binding energies and the energetic properties of four ion pairs formed by combining the 1-butyl-2,4-dinitro-3-methyl imidazolium ion with nitrate (I), perchlorate (II), dinitramide (III), or 3,5-dinitro-1,2,4-triazolate (IV) anions. The counterpoise-corrected ion-pair binding energies were calculated for each ion pair at ...
Deng Yong Y Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, - - 2013
Lymphatic vessels are thought to arise from PROX1-positive endothelial cells (ECs) in the cardinal vein in response to induction of SOX18 expression; however, the molecular event responsible for increased SOX18 expression has not been established. We generated mice with endothelial-specific, inducible expression of an RAF1 gene with a gain-of-function mutation ...
Locke M - - 2013
Objective To assess adoption of endodontic nickel-titanium (NiTi) rotary technology by general dental practitioners and identify factors influencing its uptake.Design Postal questionnaire.Setting General dental practitioners working in Wales.Methods General dental practitioners (n = 584) were approached regarding their usage or otherwise of nickel-titanium rotary instrumentation during root canal shaping. The ...
Li Bi-Lan - - 2013
Endometrial cancer (EC) is the most common gynecologic malignancy, but the molecular events involved in the development and progression of EC remain unclear. Certain microRNAs (miRNAs) and DICER1 play important roles in cell motility and survival. This study investigated the role of miR-130b and DICER1 in EC. We profiled miR-130b ...
Carone Dawn M DM Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, - - 2013
The proper functioning of centromeres requires a complex cascade of epigenetic events involving chromatin and kinetochore assembly; however, the precise mechanism by which this cascade proceeds is unknown. The pivotal event during kinetochore formation is the "loading," or deposition, of CENP-A. This histone H3 variant is specific to centromeres and ...
Sim Ji Ye JY Department of Radiology, Daejin Medical Center Bundang Jesaeng General Hospital, 255-2, Seohyun-dong, Bundang-gu, Sungnam-si, Gyeonggi-do 463-774, Republic of - - 2013
To prospectively estimate the additional diagnostic value of ultrasound (US) re-evaluation for patients with equivocal computed tomography (CT) findings of acute appendicitis. Between April 2011 and October 2011, 869 consecutive patients with suspected appendicitis who were referred for CT were included. The likelihood of appendicitis was prospectively categorized into five ...
Römer Piero - - 2013
OBJECTIVE: This study aims to demonstrate in vitro the synergistic effect of orthodontic forces and periodontal pathogens on cyclooxygenase-2 regulation and the subsequent receptor activator of nuclear factor kappa-B ligand (RANKL) production from periodontal ligament (PDL) cells. MATERIALS AND METHODS: In comparison to a control group, three experimental groups were ...
Trębacz Hanna - - 2013
The aim of the study was to investigate whether a fatigue induced weakening of cortical bone was revealed in microstructure and mechanical competence of demineralized bone matrix. Two types of cortical bone samples (plexiform and Haversian) were use. Bone slabs from the midshaft of bovine femora were subjected to cyclical ...
Casiraghi M - - 2013
The 'worst case scenario' (also known as the minimax approach in optimization terms) is a common approach to model the effect of delivery uncertainties in proton treatment planning. Using the 'dose-error-bar distribution' previously reported by our group as an example, we have investigated in more detail one of the underlying ...
Duttwyler Simon S Department of Chemistry, Yale University, New Haven, CT 06520, - - 2013
Piperidines are prevalent in natural products and pharmaceutical agents and are important synthetic targets for drug discovery and development. We report on a methodology that provides highly substituted piperidine derivatives with regiochemistry selectively tunable by varying the strength of acid used in the reaction. Readily available starting materials are first ...
Hara Hironori - - 2013
The SYNTAX score stratifies risk among drug-eluting stent-treated patients and is based on lesion characteristics alone. The Clinical SYNTAX Score (CSS) combines the SYNTAX score with age, ejection fraction, and creatinine clearance. We assessed its ability to stratify long-term outcomes in sirolimus-eluting stents (SES)-treated patients. Between August 2004 and March ...
Murphy Robert F - - 2013
At 7 months, an infant born with a third limb attached to a lumbosacral mass with an associated lipomyelomeningocele underwent removal of the limb and spinal cord detethering. Depending on the complexity of the pathology and proximity of the limb to viscera, consultation with neurosurgical and surgical colleagues is recommended.
Meran Soma - - 2013
Antibody-mediated pure red cell aplasia (PRCA) is a rare complication of erythropoietin (EPO) therapy. Identification and demonstration of functional activity of EPO antibodies required to diagnose this condition is difficult and only performed in selected laboratories worldwide. In this article we report a recent cluster of three cases of antibody-mediated ...
Csernátony Zoltán Z Department of Orthopaedics, University of Debrecen Medical Health and Science Center, Nagyerdei Krt. 98, Debrecen, 4032, Hungary. - - 2013
In our article, we would like to introduce a new auxiliary implant called the CAB hook, for use in posterior approach scoliosis surgery. Since 2007, we operated 42 patients with the CAB hook with an average preoperative Cobb angle of 59.3° (28°-92°). In three cases, the posterior approach was preceded ...
Chen Chien-Lin - - 2013
BACKGROUND: Secondary peristalsis contributes to clearance of retained refluxate or material from the esophagus. AIM: The goal of our study was to investigate the effects of hydrochloric acid (HCl) on physiological characteristics of esophageal secondary peristalsis in healthy adults. METHODS: After recording esophageal motility baseline for primary peristalsis, secondary peristalsis ...
Jiao Zhanjiang - - 2013
The association between MHTFR Glu429Val polymorphism and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 29 studies including 8,649 cases and 18,672 controls were involved in this meta-analysis. Overall, no significant associations were found between MTHFR Glu429Ala ...
Fontanarosa Davide - - 2013
Conventional ultrasound (US) devices use the time of flight (TOF) of reflected US pulses to calculate distances inside the scanned tissues and thus create images. The speed of sound (SOS) is assumed to be constant in all human soft tissues at a generally accepted average value of 1540 m s(-1). This ...
- - 2013
The 2012 BDA Christmas lecture was delivered by Alastair Sloan, from the University of Cardiff, on the topic of 'Regenerative dentistry and stem cells: current thoughts and research'. The complimentary BDA Christmas lecture webcast is now available for BDA members to view via the BDA website at www.bda.org.
Zhou Jin - - 2013
BACKGROUND: The aim of the present study was to compare elective transjugular intrahepatic portosystemic shunt (TIPS) and laparoscopic splenectomy (LS) plus preoperative endoscopic varices ligation (EVL) in their efficacy in preventing recurrent bleeding and improving the long-term liver function in patients with liver cirrhosis and portal hypertension. METHODS: Between January ...
von Felden Johann - - 2013
Introduction: Herbal and dietary supplements are widely used as measures to improve and preserve health and well-being. Among the bestselling preparations are dietary supplement containing glucosamine and chondroitine sulfate taken to improve symptoms of osteoarthritis. Methods and results: We here present a case of a male patient with biopsy-proven acute ...
Sallum Adriana M E AM Department of Pediatrics, Children Institute, School of Medicine, University of Sao Paulo, Sao Paulo, - - 2013
Pediatric normal brachial biceps (14 specimens) and quadriceps muscles (14 specimens) were studied by immunohistochemistry to quantify fiber-type, diameter and distribution, capillary density, presence of inflammatory cells (CD3, CD20, CD68) and expression of neonatal myosin and MHC class 1 proteins. Brachial biceps showed more fast-twitch fibers and lower capillary/fiber ratio ...
Zakharova A - - 2013
Time hierarchies, arising as a result of interactions between system's components, represent a ubiquitous property of dynamical biological systems. In addition, biological systems have been attributed switch-like properties modulating the response to various stimuli across different organisms and environmental conditions. Therefore, establishing the interplay between these features of system dynamics ...
Heider Barbara - - 2013
Sensorimotor transformation for reaching movements in primates requires a large network of visual, parietal, and frontal cortical areas. We performed intrinsic optical imaging over posterior parietal cortex including areas 7a and the dorsal perilunate in macaque monkeys during visually guided hand movements. Reaching was performed while foveating one of nine ...
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