Search Results
Results 451 - 500 of 2394
< 5 6 7 8 9 10 11 12 13 14 15 >
Bacqué-Cazenave Julien - - 2013
We studied the effects of molting hormone, 20-hydroxyecdysone (20E), on leg sensory-motor networks of the red swamp crayfish Procambarus clarkii. The hormone was injected in isolated crayfishes and network activity was analyzed three days after 20E injection, using electrophysiology on an in vitro preparation of the leg locomotor network. We ...
Nakagawa Youji - - 2013
Tolerance of microorganisms to diverse stresses (i.e., multistress tolerance) is a very useful property with industrial applications. We have developed a simple method for isolating multistress-tolerant semidominant mutants of the budding yeast Saccharomyces cerevisiae by one-step selection under lethal hydrogen peroxide (H(2)O(2)) stress condition, which we named the lethal concentration ...
Li Xueni X Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, - - 2013
Prp8 stands out among hundreds of splicing factors as a protein that is intimately involved in spliceosomal activation and the catalytic reaction. Here, we present the first comprehensive in vivo RNA footprints for Prp8 in budding yeast obtained using CLIP (cross-linking and immunoprecipitation)/CRAC (cross-linking and analyses of cDNAs) and next-generation ...
Pisapia Laura - - 2013
Major histocompatibility complex class II (MHCII) molecules are heterodimeric surface proteins involved in the presentation of exogenous antigens during the adaptive immune response. We demonstrate the existence of a fine level of regulation, coupling the transcription and processing of mRNAs encoding α and β chains of MHCII molecules, mediated through ...
Struss Anjali Kumari - - 2013
The opportunistic bacterial pathogen Pseudomonas aeruginosa causes chronic lung infections in cystic fibrosis (CF) patients. Importantly, virulence factor expression and biofilm formation in P. aeruginosa is coordinated by quorum sensing (QS) and one of the key QS signaling molecules is 3-oxo-C12-HSL. Remarkably, a tetramic acid, (C12-TA), with antibacterial properties is ...
Wu Yishi - - 2013
The first example of donor linked di(perylene bisimide)s is reported. UV-vis absorption spectra of these newly synthesized dyads showed intense absorption across the entire visible region, demonstrating their excellent light-harvesting activities. The severe fluorescence quenching event probed by steady-state and time-resolved emission spectroscopy, and the free-energy calculations suggested the possibility ...
Jandorf Lina L Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA, Population Studies and Disparities Research Program, Department of Oncology, School of Medicine, Karmanos Cancer Institute, Wayne State University, 4100 John R, MM03CB Detroit, MI 48201, USA and Mailman School of Public Health, Columbia University, 722 West, 168th Street, New York, NY 10032, - - 2013
Low-income minorities often face system-based and personal barriers to screening colonoscopy (SC). Culturally targeted patient navigation (CTPN) programs employing professional navigators (Pro-PNs) or community-based peer navigators (Peer-PNs) can help overcome barriers but are not widely implemented. In East Harlem, NY, USA, where approximately half the residents participate in SC, 315 ...
Maffulli Nicola - - 2013
BACKGROUND:Less-extensive and gentler exposure and dissection of deep soft tissues could reduce the times of recovery and rehabilitation after Achilles tendon reconstruction. HYPOTHESIS:A minimally invasive semitendinosus autologous graft reconstruction of the Achilles tendon preserves skin integrity and reduces wound breakdown. STUDY DESIGN:Case series; Level of evidence, 4. METHODS:A total of ...
Barton Gabor J - - 2013
ABSTRACT: BACKGROUND: Good control of trunk and pelvic movements is necessary for well controlled leg movements required to perform activities of daily living. The nature of movement coupling between the trunk and pelvis varies and depends on the type of activity. Children with cerebral palsy often have reduced ability to ...
Ravera Maura - - 2013
BACKGROUNDSubclinical cardiac damage has recently emerged as a potential predictor of adverse renal outcome. We therefore retrospectively evaluated the effect of left-ventricular hypertrophy (LVH), diagnosed electrocardiographically, on the renal outcome of hypertensive patients managed in primary care.METHODSFrom a historical cohort of 39,525 hypertensive individuals evaluated in 2005, we retrieved 5-year ...
Lu Wei - - 2013
The preparation of polymer-functionalized graphene nanoribbons (PF-GNRs) in a one-pot synthesis is described. Multiwalled carbon nanotubes (MWCNTs) were intercalated by potassium under vapor- or liquid-phase conditions, followed by addition of vinyl or epoxide monomers, resulting in PF-GNRs. Scanning electron microscopy, thermogravimetric mass spectrometry and X-ray photoelectron spectroscopy were used to ...
Dejardin O O U1086 INSERM UCBN, Cancers & Preventions, Caen, - - 2013
Few international population-based studies have provided information on potential determinants of international disparities in cancer survival. This population-based study was undertaken to identify the principal differences in disease characteristics and management that accounted for previously observed poorer survival in English compared with French patients with colorectal cancer. The study population ...
Yu Xiaobin - - 2013
Our previous study demonstrated that Erxian Decoction (EXD), a traditional Chinese herbal formula, inhibited angiogenesis in zebrafish embryos. To further investigate the anti-angiogenic activity and mechanism of EXD, we evaluated its inhibitory effect on angiogenesis in mammalian endothelial cells in vitro. Cell based assays included proliferation, apoptosis, migration, tube formation ...
O'Rourke Eyleen J EJ Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, - - 2013
Adaptation to nutrient scarcity depends on the activation of metabolic programs to efficiently use internal reserves of energy. Activation of these programs in abundant food regimens can extend life span. However, the common molecular and metabolic changes that promote adaptation to nutritional stress and extend life span are mostly unknown. ...
Zhang Yubin Y Wadsworth Center, New York State Department of Health and The State University of New York at Albany School of Public Health, Albany, New York 12201, - - 2013
Developmental HgCl2 exposures of F1 offspring (H-2(q/s)) from unsociable SJL/J (H-2(s)) dams with high susceptibility to Hg-induced autoimmunity (SFvF1) and from highly sociable FVB/NJ (FVB; H-2(q)) dams with lower susceptibility to Hg-induced autoimmunity (FvSF1) were investigated. Hg exposure increased the serum IgG levels of all offspring at postnatal day 21 ...
Tsurui-Nishimura Noriko - - 2013
Drosophila imaginal discs are an excellent model system for studies of developmental plasticity. In imaginal discs, most cells adhere strictly to their specific identity, but some cells undergo transdetermination, a process wherein the determined identity switches to another disc-specific identity. In this study, we performed gain-of-function screening and identified a ...
Shibata Katsumi - - 2013
Valproic acid (VPA) is a short-chained, branched fatty acid that is widely used in humans as an anticonvulsant and mood stabilizer, and has been reported to increase the liver NAD concentration. We investigated the effects of VPA on the conversion of tryptophan to nicotinamide. Rats were fed diets containing various ...
Bahramali Ehsan - - 2013
Angiotensin (Ang) II is believed to be a potential pro-inflammatory factor. The capability of Ang II to stimulate C-reactive protein (CRP) production has recently been described. Genetic polymorphisms of renin angiotensin system (RAS) components have been described to be associated with the development of coronary artery disease (CAD). This study ...
Wójtowicz Halina - - 2013
Porphyromonas gingivalis, a major etiological agent of chronic periodontitis, acquires haem from host haemoproteins through a haem transporter HmuR and a haemophore HmuY. The aim of this study was to analyse the binding specificity of HmuY towards non-iron metalloporphyrins which may be employed as antimicrobials to treat periodontitis. HmuY binds ...
Paik Nam Chull - - 2013
Study Design. An analysis of imaging data.Objective. To investigate concurrent numeric and morphological variations of presacral vertebrae and to propose a modified designation for the lumbosacral transitional vertebra (LSTV).Summary of Background Data. During the assessment of the lumbosacral vertebra, variations from typical anatomy (numeric, morphological, or both) may confuse the ...
Barahona María-José - - 2013
Objective:Increased cardiovascular risk persists in Cushing's syndrome (CS), despite remission of hypercortisolism. The aim of this study was to evaluate the prevalence of coronary artery disease in patients after long-term cure of CS.Methods:Cardiac multidetector computed tomography was performed in 29 cured CS patients (5 men, 21 of pituitary origin, 50 ...
Widjaja E - - 2013
BACKGROUND AND PURPOSE:Patients with focal intractable epilepsy and normal MR imaging findings frequently undergo further diagnostic tests to localize the epileptogenic zone. The aim of this study was to determine the cost-effective diagnostic strategy that will identify the epileptogenic zone in patients with suspected focal intractable epilepsy and normal MR ...
Milenkovic Dusanka - - 2013
Replication of the mammalian mitochondrial DNA (mtDNA) is dependent on the minimal replisome, consisting of the heterotrimeric mitochondrial DNA polymerase (POLG), the hexameric DNA helicase TWINKLE and the tetrameric single-stranded DNA-binding protein (mtSSB). TWINKLE has been shown to unwind DNA during the replication process and many disease-causing mutations have been ...
Soggiu Alessio - - 2013
In the last few decades a negative association between the level of milk production and fertility has been observed. Currently, the most utilized method of measuring male fertility employed by the livestock industry is related to the Non-Return Rate (NRR). Through differential proteome analysis, this study evaluated changes in the ...
Liu Yang Y Enteric Diseases Department, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, Maryland 20910, - - 2013
CfaE, the tip adhesin of enterotoxigenic Escherichia coli colonization factor antigen I fimbriae, initiates binding of this enteropathogen to the small intestine. It comprises stacked β-sandwich adhesin (AD) and pilin (PD) domains, with the putative receptor-binding pocket at one pole and an equatorial interdomain interface. CfaE binding to erythrocytes is ...
Schmalzbauer Björn - - 2013
A concise total synthesis of dysidavarone A possessing the new "dysidavarane" carbon skeleton has been accomplished by a convergent strategy, involving a stereoselective reductive alkylation of a Wieland-Miescher type ketone under Birch conditions and an advantageous intramolecular palladium-catalyzed α-arylation of a sterically hindered ketone. Dysidavarone A showed potent antimicrobial and ...
Lattimer C R - - 2013
Objectives: It has been suggested that quantification of haemodynamic parameters of venous disease may complement clinical assessment and may help identify a group of patients with severe venous disease or alternatively patients with early venous disease. However, there has been very little work to prove this hypothesis. The venous filling ...
Lewis Joshua P JP Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, - - 2013
BACKGROUND- Aspirin or dual antiplatelet therapy with aspirin and clopidogrel is a standard therapy for patients who are at increased risk for cardiovascular events. However, the genetic determinants of variable response to aspirin (alone and in combination with clopidogrel) are not known. METHODS AND RESULTS- We measured ex vivo platelet ...
Fedson David S DS Sergy Haut, - - 2013
Since December 2011, influenza virologists and biosecurity experts have been engaged in a controversial debate over research on the transmissibility of H5N1 influenza viruses. Influenza virologists disagreed with the NSABB's recommendation not to publish experimental details of their findings, whereas biosecurity experts wanted the details to be withheld and future ...
Furumoto Toshio - - 2013
Two additional anthraquinone derivatives containing a (Z)-dienyl side-chain, dehydroanthrasesamones A (2) and B (3), were isolated from a hairy root culture of Sesamum indicum after preventing light throughout all experimental procedures. Their respective structures were determined to be 1-hydroxy-2-[(Z)-4-methylpenta-1,3-dien-1-yl]anthraquinone and 1,4-dihydroxy-2-[(Z)-4-methylpenta-1,3-dien-1-yl]anthraquinone by spectroscopic methods.
Dufault Aaron M - - 2013
We tested the effect of light and pCO(2) on the calcification and survival of Pocillopora damicornis recruits settled from larvae released in southern Taiwan. In March 2011, recruits were incubated at 31, 41, 70, 122, and 226 μmol photons m-2s-1 under ambient (493 μatm) and high pCO(2) (878 μatm). After ...
Morimoto Kenji - - 2013
When an M31 strain of Agrobacterium tumefaciens was grown in a mineral salt medium at 30 °C containing 1.0% lactitol as sole carbon source, a keto-sugar was efficiently accumulated in the supernatant. This oxidation from lactitol to the keto-sugar was caused by M31 cells grown with medium containing a disaccharide ...
Guilbert Anne-Sophie - - 2013
OBJECTIVES:: To assess the feasibility of ultrasound-guided supraclavicular catheterization of the subclavian vein in pediatric and neonatal ICU. DESIGN:: Retrospective cohort. SETTING:: Ten-bed pediatric medicosurgical ICU and 15-bed neonatal ICU. PATIENTS:: Children and newborns undergoing supraclavicular ultrasound-guided subclavian vein catheterization from March 2010 to September 2010. MEASUREMENTS:: The placement of ...
Riedel Tomáš - - 2013
The resistance of polyethylene glycol (PEG) against protein adsorption is crucial and has been widely utilized in various biomedical applications. In this work, complete protein composition of biofilms deposited on PEG-based surfaces from human blood plasma (BP) was identified for the first time using nanoLC-MS/MS, a powerful tool in protein ...
Liu Yong - - 2013
Our previous studies suggested S. aureus L-forms were able to pass through placental barrier from maternal side to fetal body and affect fetal growth and development, but little is known about direct influence of S. aureus L-forms on embryos during the critical period of organogenesis. Mice embryos at gestational day ...
Cowan Campbell - - 2013
OBJECTIVES: To investigate the use of oral anticoagulants (AC) and antiplatelet agents (AP) in the management of atrial fibrillation (AF) among patients in primary care in England. DESIGN: Epidemiological study. SETTING: 1857 general practices in England representing a practice population of 13.1 million registered patients. PATIENTS: 231 833 patients with ...
Chen Jian - - 2013
A novel architecture of graphene paper is proposed to consist of "1D metallic nanowires/defect-free graphene sheets". Highly conductive and flexible papers of 1D silver nanowires (Ag NWs) and chemical vapor deposition (CVD) graphene sheets as an example were fabricated by a simple filtration method. CVD graphene paper possesses much higher ...
Reisman Darcy S DS University of Delaware, Newark, DE 19716, USA. - - 2013
Previous studies suggest that error augmentation may be used as a strategy to achieve longer-term changes in gait deficits after stroke. The purpose of this study was to determine whether longer-term improvements in step length asymmetry could be achieved with repeated split-belt treadmill walking practice using an error augmentation strategy. ...
Li Xiaojin - - 2013
Targeting on the tumor enriched Fe3+, we propose a novel molecular platform integrated cancer iron chelation therapy for 1H-MRI detection of β-gal activity. Following this idea, we have designed, synthesized and characterized a series of β-D-galactosides conjugated with various chelators, and demonstrated the feasibility of this concept for assessing β-gal ...
Mahut Marek - - 2013
Plasmid DNA may exist in three isoforms, the linear, open-circular (oc, "nicked") and covalently closed circular (ccc, "supercoiled") form. We have recently reported on the chromatographic separation of supercoiled plasmid topoisomers on cinchona-alkaloid modified silica-based stationary phases. Herein, we present a selectivity switching mechanism to achieve separation of isoforms and/or ...
Myers Jonathan - - 2013
BACKGROUND: -Cardiopulmonary exercise test (CPX) responses are strong predictors of outcomes in patients with heart failure (HF). We recently developed a CPX score that integrated the additive prognostic information from CPX. The purpose of this study was to validate the score in a larger, independent sample of patients. METHODS AND ...
Peng Yahui - - 2013
Purpose:To evaluate the potential utility of a number of parameters obtained at T2-weighted, diffusion-weighted, and dynamic contrast material-enhanced multiparametric magnetic resonance (MR) imaging for computer-aided diagnosis (CAD) of prostate cancer and assessment of cancer aggressiveness.Materials and Methods:In this institutional review board-approved HIPAA-compliant study, multiparametric MR images were acquired with an ...
Tran Thai Hoa - - 2013
OBJECTIVES:: To assess potential hypercoagulability during diabetic ketoacidosis in children. DESIGN:: A prospective, controlled pilot study. SETTING:: University-affiliated pediatric critical care unit and emergency department in a tertiary care children's hospital. PATIENTS:: Children (1-18 yr) admitted with an episode of diabetic ketoacidosis and healthy children as controls. All patients with ...
Hu Li-Yen R LY Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, - - 2013
Obscurins comprise a family of giant (~870- to 600-kDa) and small (~250- to 55-kDa) proteins that play important roles in myofibrillogenesis, cytoskeletal organization, and cell adhesion and are implicated in hypertrophic cardiomyopathy and tumorigenesis. Giant obscurins are composed of tandem structural and signaling motifs, including 2 serine/threonine kinase domains, SK1 ...
Srirangalingam Umasuthan - - 2013
ABSTRACT: BACKGROUND: Apolipoprotein B (APOB) is an integral component of the chylomicron and the atherogenic lipoproteins LDL and Lp(a). Exon 26 of the APOB pre-mRNA is unusually long at 7,572 nt and is constitutively spliced. It is also subject to RNA editing in the intestine, which generates a shortened isoform, ...
Harris Jenine K - - 2013
Most state health departments (SHDs) have adopted and are using Facebook and/or Twitter. Among the friends and followers of SHD Facebook and Twitter pages are other SHDs. These connections form networks with the potential to facilitate dissemination of evidence around effective public health practice among health departments nationwide. To better ...
Kistler Kurt A - - 2013
In this report we benchmark Coulombic excitonic couplings between various pairs of chromophores calculated using transition charges localized on the atoms of each monomer chromophore, as derived from a Mulliken population analysis of the monomeric transition densities. The systems studied are dimers of 1-methylthymine, 1-methylcytosine, 2-amino-9-methylpurine, all-trans-1,3,5-hexatriene, all-trans-1,3,5,7-octatetraene, trans-stilbene, naphthalene, ...
Zou Wei - - 2013
A simple and effective method for the synthesis of 7-oxabicyclo[2.2.1]heptanes and 8-oxabicyclo[3.2.1]octanes from acetonyl C-glycoside substrates is described, which involves an intramolecular cyclization reaction through a nucleophilic substitution at C-5 or C-6 of C-glycosides by a 2'-enamine intermediate formed in the presence of pyrrolidine. Because anomeric epimerization occurs under these ...
Algra Selma O - - 2013
ABSTRACT: BACKGROUND: A robust inflammatory response occurs in the hours and days following cerebral ischemia. However, little is known about the immediate innate immune response in the first minutes after an ischemic insult in humans. We utilized the use of circulatory arrest during cardiac surgery to assess this. METHODS: Twelve ...
Massanella Marta - - 2013
BACKGROUND:: Detection of episomal HIV cDNA has been associated with greater levels of CD8 and CD4 T-cell activation in HIV-1-infected HAART-suppressed individuals. However, HAART intensification exclusively reduced CD8 T cell activation. METHODS:: We evaluated activation markers 12 weeks after raltegravir withdrawal in a previously described 48-week raltegravir-intensification study. Subjects (n=34) ...
< 5 6 7 8 9 10 11 12 13 14 15 >