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Results 451 - 500 of 2387
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Yin Ji-Ye - - 2013
RPA2 is a subunit of a trimeric RPA complex important for DNA repair and replication. Although it is known that RPA activity is regulated by post-translational modification, whether RPA expression is regulated and the mechanism therein is currently unknown. eIF3a, the largest subunit of eIF3, is an important player in ...
Taniguchi Ryoo - - 2013
The populations of the Kii Peninsula in Japan and of Guam present high incidences of amyotrophic lateral sclerosis and Parkinsonism-dementia complex. It is thought that low levels of calcium (Ca) and magnesium (Mg) in the drinking water are involved in the pathogenesis of these diseases. The present study aimed to ...
Davalos Maria Caridad - - 2013
OBJECTIVE:: To describe the incidence and severity of hyponatremia after initiation of arginine vasopressin therapy in children recovering from cardiothoracic surgery, and to compare these patients with a control group with similar disease complexity and severity who did not receive arginine vasopressin. DESIGN:: Retrospective chart review. SETTING:: PICU at a ...
Mouritsen Annette - - 2013
Background:Longer androgen receptor gene CAG trinucleotide repeats, AR (CAG)n, have been associated with reduced sensitivity of the androgen receptor (AR) in vitro as well as in humans. Furthermore, short AR (CAG)n have been associated with premature adrenarche.Objective:The aim of the study was to evaluate associations between the AR (CAG)n polymorphism ...
Abramowitz Matthew K - - 2013
BACKGROUND AND OBJECTIVES: Metabolic acidosis contributes to muscle breakdown in patients with CKD, but whether its treatment improves functional outcomes is unknown. The choice of dose and tolerability of high doses remain unclear. In CKD patients with mild acidosis, this study evaluated the dose-response relationship of alkali with serum bicarbonate, ...
Chuckpaiwong Bavornrit - - 2013
Background:Forefoot and tarsometatarsal surgery may be performed on the first and second metatarsal through the intermetatarsal space. However, no study has identified the safety area of the proximal metatarsal bone to avoid vascular injury.Methods:One hundred and twenty-two uninjured embalmed feet of 31 female and 33 male cadavers aged 15 to ...
Valdes de Luxan Alvaro - - 2013
Reduced dimensional quantum dynamics calculations of the infrared spectrum of the H_5^+ and D_5^+ clusters are reported in both low, 300--2200 cm^{-1}, and high, 2400--4500 cm^{-1}, energy regions. The proposed four-dimensional quantum model describes the motion of the proton between the two vibrating hydrogen molecules. The simulations are performed using ...
Jusoh Mohd Lokman - - 2013
ABSTRACT: This study aims to assess the effect of EM application on the composting process of rice straw with goat manure and green waste and to evaluate the quality of both compost treatments. There are two treatment piles in this study, in which one pile was applied with EM and ...
Green Michael D - - 2013
ABSTRACT: BACKGROUND: Malaria morbidity and mortality have been significantly reduced through the proper use of insecticide-treated mosquito nets, but the extra protection afforded by the insecticide diminishes over time. The insecticide depletion rates vary according to location where wash frequency and wear are influenced by cultural habits as well as ...
Maruta Takanori - - 2013
We isolated an Arabidopsis knockout line lacking glutamate decarboxylase 1 (GAD1), one that produced γ-aminobutyrate (GABA), as an oxidative stress-insensitive mutant, and found that chloroplastic H(2)O(2) enhances GAD1 expression and GABA levels. This suggests a possible relationship between GABA metabolism and the chloroplastic H(2)O(2)-mediated stress response.
Varma Manthena V S - - 2013
Repaglinide is mainly metabolized by cytochrome-P-450 (CYP)2C8 and CYP3A4, and is also a substrate to hepatic uptake transporter, organic anion transporting polypeptide (OATP)1B1. The purpose of this study is to predict the "dosing-time" dependent pharmacokinetic interactions of repaglinide with rifampicin, using mechanistic models. In vitro hepatic transport of repaglinide, characterized ...
Qian Chunqi - - 2013
Purpose:To assess the feasibility of imaging deep-lying internal organs at high spatial resolution by imaging kidney glomeruli in a rodent model with use of a newly developed, wireless amplified nuclear magnetic resonance (MR) detector.Materials and Methods:This study was approved by the Animal Care and Use Committee at the National Institutes ...
Berois Nora - - 2013
OBJECTIVES: Persistent infection with specific genotypes of human papillomaviruses (HPVs) is the main cause of invasive cervical cancer (ICC). Only a few of the various HPV types account for most of the cases worldwide, and geographical differences in their distribution are evident. Data from locally prevalent genotypes are essential in ...
Rowan Courtney M - - 2013
OBJECTIVES:: A catheter thrombosis and the presence of a catheter-associated bloodstream infection (CBSI) often occur simultaneously, but it is unclear if or to what degree the two complications relate. Several animal and adult studies indicate a relationship between fibrin sheaths and thrombi in the development of CBSIs. To date, there ...
Weng Tingting - - 2013
Chronic obstructive pulmonary disease (COPD) is characterized by persistent inflammation and tissue remodeling and is a leading cause of death in the United States. Increased apoptosis of pulmonary epithelial cells is thought to play a role in COPD development and progression. Identification of signaling pathways resulting in increased apoptosis in ...
Jódar-Sánchez Francisco - - 2013
We conducted a pilot study of the effectiveness of home telehealth for patients with advanced chronic obstructive pulmonary disease treated with long-term oxygen therapy. Patients were randomized into a telehealth group (n &frac14; 24) and a control group (n &frac14; 21) who received usual care. Patients in the telehealth group ...
Behrens Christine L - - 2013
Aims: Sunburn in childhood is a known risk factor for melanoma and non-melanoma skin cancer. Based on a theoretical model, we tested the hypothesis that parental attitudes and behaviour are related to the risk of sunburn in their children. Methods: We analysed the association between behaviour in the sun and ...
Gega Lina - - 2013
Abstract This case series compares patient experiences and therapeutic processes between two modalities of cognitive behaviour therapy (CBT) for depression: computerized CBT (cCBT) and therapist-delivered CBT (tCBT). In a mixed-methods repeated-measures case series, six participants were offered cCBT and tCBT in sequence, with the order of delivery randomized across participants. ...
Crutzen Rik - - 2013
Background: In the motivational model of alcohol use, there are two dimensions underlying the classification of drinking motives resulting in four drinking motive categories: enhancement, social, coping, and conformity motives. Methods: Using confirmatory factor analysis, the current study provides evidence on the best fitting factor structure in a large representative ...
Pan Peiwen - - 2013
An alpha-carbonic anhydrase (CA, EC 4.2.1.1) has been identified, cloned and characterized from the unicellular protozoan Trypanosoma cruzi, the causative agent of Chagas disease. The enzyme (TcCA) has a very high catalytic activity for the CO2 hydration reaction, being similar kinetically to the human (h) isoform hCA II, although it ...
Battelle Barbara-Anne - - 2013
Dark and light adaptation in photoreceptors involve multiple processes including those which change protein concentrations at photosensitive membranes. Light and dark-adaptive changes in protein levels at rhabdoms have been described in detail in white eyed Drosophila maintained under artificial light. Here we tested whether protein levels at rhabdoms change significantly ...
de Bruyn Mark - - 2013
Understanding factors driving diversity across biodiversity hotspots is critical for formulating conservation priorities in the face of ongoing and escalating environmental deterioration. While biodiversity hotspots encompass a small fraction of Earth's land surface, more than half the world's plants and two-thirds of terrestrial vertebrate species are endemic to these hotspots. ...
Ponec Robert - - 2013
The electronic structure of the trinuclear symmetric complex [(tmedaCu)(3)S(2)]((3+)), whose Cu(3)S(2) core represents a model of the active site of metalloenzymes involved in biological processes, has been in recent years the subject of vigorous debate. The complex exists as an open-shell triplet and discussions concerned the question whether there is ...
Olsen Anders Krüger - - 2013
Wnt signalling is often constitutively active in colorectal cancer cells. The expression of the intestinal specific transcription factor CDX2 is found transiently decreased in invasive cells at the tumor/stroma interface. A recent ChIP-Seq study has indicated that several Wnt signalling-related genes are regulated by CDX2. The aim was to investigate ...
Zhang Zhongyuan - - 2013
Fucoidan, a fucose-rich polysaccharide extracted from brown seaweed, has antitumor, anticoagulant, antiviral, anti-inflammatory, and antibacterial activities. Several studies have shown that a fucoidan treatment of cancer cells induced cytotoxicity and apoptosis and inhibited angiogenesis and invasion. We investigated in the present study the effect of low-molecular-weight fucoidan (LMWF) on apoptosis ...
Ishimura Eiji - - 2013
Background:It has been reported that there is a significant positive relationship between PTH and body weight or body mass index in the general population. However, little is known about this relationship in dialysis patients in whom PTH levels are higher. It is also not known whether fat mass or lean ...
Witcombe John R - - 2013
ABSTRACT: BACKGROUND: Crop yields have to increase to provide food security for the world's growing population. To achieve these yield increases there will have to be a significant contribution from genetic gains made by conventional plant breeding. However, the breeding process is not efficient because crosses made between parental combinations ...
Tao Jeremiah P - - 2013
PURPOSE:: To evaluate the efficacy of a midface seal drape in eliminating fire risk oxygen concentrations from nasal cannulated oxygen delivery compared with a standard open oculofacial surgical field. METHODS:: Controlled experiment using the SimMan patient simulator and an oxygen detector. Oxygen concentrations were measured at 9 facial surgical locations ...
Economides James M - - 2013
Background Lower extremity soft tissue defects pose a challenging problem to patients with comorbidities. Reconstruction with tissue transfer offers an effective alternative to amputation in this population. Although abundant with data on success and complication rates, the literature has not focused on assessing patient-centered outcomes of these reconstructive procedures.Methods A ...
Devries J George - - 2013
Background:Tibiotalocalcaneal (TTC) arthrodesis using a nail has been shown to be an effective salvage technique; however, there is a risk of major amputation. A better understanding of the relative risk of amputation after TTC fusion and the factors that influence this could help the preoperative consultation and guide discussion on ...
Cai Shaobo - - 2013
In this work, novel electrospun scaffolds with fibers oriented randomly and evenly in three dimensions (3D) including in the thickness direction were developed based on the principle of electrostatic repulsion. This unique structure is different from most electrospun scaffolds with fibers oriented mainly in one direction. The structure of novel ...
Sachan Amit Kumar - - 2013
Determination of orientation of nanoscale collapse structures formed within a Langmuir film at the air-aqueous interface has not been possible by existing experimental techniques. This is however of special importance for pulmonary surfactant films, which form reversible surface-associated reservoirs (SARs) under dynamic lateral compression and expansion. The direction of these ...
Lee Yong-Hyun - - 2013
Cell injury associated with reactive oxygen species (ROS) has been reported in various muscular disorders. We found that a Cichorium intybus (Cii) extract reduced H(2)O(2)-induced viability loss in C2C12 myoblasts, inhibited oxidative stress-induced apoptosis and increased intracellular heat shock protein 70 (Hsp 70) expression. Cii also inhibited the level of ...
Segal Leonie - - 2013
OBJECTIVEBest-practice diabetes care can reduce the burden of diabetes and associated health care costs. But this requires access to a multidisciplinary team with the right skill mix. We applied a needs-driven evidence-based health workforce model to describe the primary care team required to support best practice diabetes care, paying particular ...
Zhang Keqiang - - 2013
Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on chromosome 12q13-15 that is frequently amplified in liposarcomas. The significance of FRS2 and FGFR signaling in high-grade liposarcomas is unknown. Herein, we first comparatively examined ...
Galgani Jose E - - 2013
Context:Skeletal muscle insulin resistance is proposed to result from impaired skeletal muscle lipid oxidative capacity. However, there is no evidence indicating that muscle lipid oxidative capacity is impaired in healthy otherwise insulin-resistant individuals.Objective:The objective of the study was to assess muscle lipid oxidative capacity in young, nonobese, glucose-tolerant, insulin-resistant vs ...
Wallia Amisha - - 2013
Context:Postpartum, diabetes insipidus (DI) can be part of Sheehan's syndrome or lymphocytic hypophysitis in combination with anterior pituitary hormone deficiencies. In contrast, acute onset of isolated DI in the postpartum period is unusual.Case Presentation:This patient presented at 33 weeks gestation with placental abruption, prompting a cesarean delivery of twins. Immediately ...
Zoicas Flavius - - 2013
BACKGROUND: Patients with hypothalamic pathology often develop morbid obesity causing severe metabolic alterations resulting in increased morbidity and mortality. Glucagon-like-peptide-1 (GLP-1) analogues improve glycemic control in type 2 diabetic patients and cause weight loss in obese patients by yet unknown mechanisms. Here we tested, whether GLP-1 analogues were also effective ...
Huang Nan-Lan - - 2013
In primitive and higher plants, intracellular storage lipid droplets (LDs) of triacylglycerols are stabilized with a surface layer of phospholipids and oleosin. In Chlorophytes (green algae), a protein termed major lipid-droplet protein (MLDP) rather than oleosin on LDs was recently reported. We explored whether MLDP was present directly on algal ...
Hall Wiley A - - 2013
The aging of fresh secondary organic aerosol (SOA), formed in a flow tube reactor by α-pinene ozonolysis, was studied by passing the fresh SOA into a second chamber for reaction with high levels of the hydroxyl radical. Two types of experiments were performed: 1) injection of a short plug of ...
Abdou Asmaa G - - 2013
ABSTRACT:: Many inflammatory mediators and other biological markers are upregulated in psoriatic lesions; some of these alterations also persist in nonlesional skin. Glucose is the major source of energy for cells, and glucose transporter 1 is the most common glucose transporter in humans (GLUT-1). The present study aimed at evaluating ...
Edvardson Simon - - 2013
BACKGROUND: Agenesis of corpus callosum has been associated with several defects of the mitochondrial respiratory chain and the citric acid cycle. We now report the results of the biochemical and molecular studies of a patient with severe neurodevelopmental disease manifesting by agenesis of corpus callosum and optic nerve hypoplasia. METHODS ...
Paula Jayter Silva - - 2013
Abstract Purpose: Vascular endothelial growth factor (VEGF) may contribute to the scarring process resulting from glaucoma filtration surgery, since this cytokine may stimulate fibroblast proliferation. The aim of this study was to describe a new bevacizumab-loaded polyurethane implant (BPUI) and to evaluate its effectiveness as a new drug delivery system ...
Seo Myung-Ji - - 2013
The 1-deoxynojirimycin (DNJ) biosynthetic gene cluster of Bacillus amyloliquefaciens 140N isolated from traditional Korean fermented food was isolated by PCR screening. It showed 78.9% inhibitory activity against α-glucosidase and produced 0.8 g/L of DNJ in an optimized medium containing 2% soluble starch, 1% tryptone, 0.05% KH(2)PO(4), and 0.05% (NH(2))(4)SO(4). Soybean ...
Gan Wen Qi - - 2013
RATIONALE: Ambient air pollution has been suggested as a risk factor for chronic obstructive pulmonary disease (COPD). However, there is a lack of longitudinal studies to support this assertion. OBJECTIVES: To investigate the associations of long-term exposure to elevated traffic-related air pollution and woodsmoke pollution with the risk of COPD ...
Kim Han Jo - - 2013
ABSTRACT: Study Design. Matched Cohort ComparisonObjective. To compare the use of BMP or ICBG on the long term outcomes in patients undergoing long fusions to the sacrum for adult spinal deformity.Summary of Background Data. No long term studies beyond a 2 year f/u have been performed comparing the use of ...
Massaro An N - - 2013
OBJECTIVES:: To determine if candidate biomarkers, ubiquitin carboxyl-terminal esterase L1 and glial fibrillary acidic protein, are elevated in neonates with hypoxic ischemic encephalopathy who die or have severe MRI injury compared with surviving infants with minimal or no injury on brain MRI. DESIGN:: Prospective observational study. SETTING:: Level IIIC outborn ...
Given C A CA - - 2013
SUMMARYFD-OCT is a new imaging technique that allows unprecedented in vivo microlevel assessment of human carotid plaque morphologic patterns and stent-vessel interactions. Prior reports describing the use of this technique have used balloon occlusion of the target vessel or iodinated contrast media to facilitate imaging. We report, for the first ...
Koksvik Hege Svean - - 2013
OBJECTIVE: To study the effect of individual nursing consultations in patients treated with disease-modifying antirheumatic drugs (DMARDs) in a rheumatology outpatient setting. METHODS: Patients with inflammatory arthritides (IA) who had started with a DMARD regimen 3 months before were randomised to two different follow-up consultation systems: either follow-up by a ...
Kar S P - - 2013
Genome-wide association studies (GWAS) have successfully identified several loci associated with primary biliary cirrhosis (PBC) risk. Pathway analysis complements conventional GWAS analysis. We applied the recently developed linear combination test for pathways to datasets drawn from independent PBC GWAS in Italian and Canadian subjects. Of the Kyoto Encyclopedia of Genes ...
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