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Results 301 - 350 of 2969
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O'Callaghan Grace - - 2013
Despite studies demonstrating that inhibition of cyclooxygenase-2 (COX-2)-derived prostaglandin E(2) (PGE(2) ) has significant chemotherapeutic benefits in vitro and in vivo, inhibition of COX enzymes is associated with serious gastrointestinal and cardiovascular side-effects, limiting the clinical utility of these drugs. PGE(2) signals through four different receptors, (EP1 -EP4), and targeting ...
Ofek E O - - 2013
Some observations suggest that very massive stars experience extreme mass-loss episodes shortly before they explode as supernovae, as do several models. Establishing a causal connection between these mass-loss episodes and the final explosion would provide a novel way to study pre-supernova massive-star evolution. Here we report observations of a mass-loss ...
Trefz Phillip - - 2013
Needle trap devices (NTDs) have shown many advantages such as improved detection limits, reduced sampling time and volume, improved stability, and reproducibility if compared with other techniques used in breath analysis such as solid-phase extraction and solid-phase micro-extraction. Effects of sampling flow (2-30 ml/min) and volume (10-100 ml) were investigated in dry ...
Han Dale - - 2013
BACKGROUND: The utility of sentinel lymph node biopsy (SLNB) for desmoplastic melanoma (DM) is debated. We describe a large single-institution experience with SLNB for DM to determine clinicopathologic factors predictive of SLN metastasis. METHODS: Retrospective review identified 205 patients with DM who underwent SLNB from 1992 to 2010. Clinicopathologic characteristics ...
Yadav Arvind K - - 2013
An efficient and operationally simple synthesis of fluoroalkanes by deoxygenative hydrofluorination of carbonyl compounds via their tosylhydrazone surrogates is reported. The reaction can be carried out in a one-pot procedure directly from carbonyl compounds.
Chandra Subani - - 2013
ABSTRACT: BACKGROUND: The increased use of computed tomography pulmonary angiography (CTPA) is often justified by finding alternative diagnoses explaining patients' symptoms. However, this has not been rigorously examined. METHODS: We retrospectively reviewed CTPA done at our center over an eleven year period (2000 -- 2010) in patients with suspected pulmonary ...
Park Wook-Ha - - 2013
It is generally accepted that mitochondrial deficits cause many common age-associated diseases including type 2 diabetes. However, it has not been understood what causes mitochondrial damages and how to interrupt the development of the diseases in patients. Recent epidemiologic studies demonstrated a positive correlation between serum concentrations of environmental pollutants ...
Graña E - - 2013
Citral is a linear monoterpene which is present, as a volatile component, in the essential oil of several different aromatic plants. Previous studies have demonstrated the ability of citral to alter the mitotic microtubules of plant cells, especially at low concentrations. The changes to the microtubules may be due to ...
Lowenthal Alexander - - 2013
In chronic aortic insufficiency (AI), left-ventricular (LV) dysfunction must be detected early to allow timely surgery. Strain and strain rate have been used for this purpose in adults, but the value of this method in pediatric AI has not been established. Forty patients with moderate to severe AI were included ...
da Silva Thais Freitas - - 2013
ABSTRACT: BACKGROUND: Lippia sidoides Cham., also known as pepper-rosmarin, produces an essential oil in its leaves that is currently used by the pharmaceutical, perfumery and cosmetic industries for its antimicrobial and aromatic properties. Because of the antimicrobial compounds (mainly thymol and carvacrol) found in the essential oil, we believe that ...
Pinto Joana - - 2013
The structures of three azines derived from 2-formylimidazole, 4(5)-formylimidazole, and 4(5)-formyl-5(4)-methylimidazole have been determined in solution and in the solid state. Density Functional Theory (DFT) Polarizable Continuum Model (PCM) calculations (geometries, energies, and chemical shifts), NMR [solution and cross polarization magic-angle spinning (CPMAS)], and X-ray crystallography [azine of 4(5)-formylimidazole] have ...
Zhu Shaojun - - 2013
EMMPRIN/CD147 has been proved to be associated with tumor invasion and metastasis in various human malignancies. In the present study, we investigated the expression of CD147 and its association with disease-free survival of colorectal cancer patients. CD147 expression was investigated in 328 cases of colorectal cancer by immunohistochemistry assay. Statistical ...
Meister B - - 2013
Delta-like 1 homologue (DLK1), also known as preadipocyte factor-1 (Pref-1), fetal antigen (FA1) or pG2, is a transmembrane protein belonging to the epidermal growth factor (EGF)-like superfamily. The protein becomes soluble and biologically active after cleavage of the TACE enzyme. DLK1 is involved in the differentiation of several cell types, ...
Cui Lixia - - 2013
The objective of the present study is to test the validity of the integrated cognitive model of depression proposed by Kwon and Oei () with a Chinese adolescent sample. A two-wave panel design was used. We hypothesized that the interaction between dysfunctional attitudes measured at time 1 and adolescents' negative ...
Skjelsager A - - 2013
BACKGROUND: Open radical retropubic prostatectomy (ORRP) is associated with moderate pain. We hypothesized that a transversus abdominis plane (TAP) block would reduce post-operative pain, morphine consumption and opioid-related side effects compared with wound infiltration and placebo in this population. METHODS: This was a randomized, double-blind and placebo-controlled study. The operations ...
Astroth Kim S - - 2013
AIMS AND OBJECTIVES: To identify barriers and facilitators to nurses' decisions regarding activation of rapid response teams (RRTs) in hospitals. BACKGROUND: Hospitalised patients in the United States who experience cardiopulmonary arrest seldom recover. Most of these patients show signs of clinical deterioration prior to cardiopulmonary arrest. RRTs have been shown ...
Zhao Fu-Jie - - 2013
This study was to investigate the differences between neonate mice born to Schistosoma japonicum-infected mothers and those born to non-infected mothers in subsequent challenge. The intensity of infection (evidenced by worm burden and liver egg burden) and liver immunopathology (number and size of liver granulomas) were significantly reduced in neonates ...
Basaglia-Pappas S - - 2013
ABSTRACT Background: In mild Alzheimer's disease (AD), a deficit in episodic memory, particularly autobiographical memory, is clearly established. Several recent studies have also shown impaired semantic memory from the onset of the disease. Musical memory capacities may be especially preserved and listening to music might encourage autobiographical recall. The aim ...
Zwanikken Prisca Ac - - 2013
ABSTRACT: BACKGROUND: The 'human resources for health' crisis has highlighted the need for more health (care) professionals and led to an increased interest in health professional education, including master's degree programmes. The number of these programmes in low- and middle-income countries (LMIC) is increasing, but questions have been raised regarding ...
Thukral Anu - - 2013
The authors report a preterm infant with Rh-isoimmunization, who had persistent hepato-splenomegaly with conjugated hyperbilirubinemia, transaminitis, and hyperammonemia. Ultrasound abdomen revealed an intrahepatic portosystemic venous shunt (PSVS). The child was managed conservatively. On follow up at 2.4 y of age, the child is having normal growth and development, but with persisting ...
Pickwell Kristy M - - 2013
BACKGROUND: Healing of heel ulcers in patients with diabetes is considered to be poor, but there is relatively little information on the influence of ulcer location on ulcer healing. METHODS: The influence of ulcer location on time to healing of diabetic foot ulcers was analyzed by multivariate Cox regression analysis ...
Walter Catherine J - - 2013
BACKGROUND: Optimal analgesia following laparoscopic colorectal resection is yet to be determined; however, recent studies have questioned the role of postoperative epidural anaesthesia, suggesting other analgesic modalities may be preferable. The aim of this randomised controlled trial was to assess the effect of transversus abdominis plane (TAP) blocks on opioid ...
Draenert Miriam - - 2013
Background: Cancellous bone defects surrounded by still intact bone structures never heal. Ceramics offer a solution providing osteoconductive scaffolds. Purpose: The purpose of the study is to evaluate whether structured β-TCP and HA implants can reconstruct cancellous bone defects, which role micro- and macro-porosity, stiffness and surface area play; finally ...
Green David C - - 2013
Self-supporting superconducting replicas of pasta shapes are reported, yielding products of differing 3D architectures. Functioning high-temperature superconductor wires are developed and refined from replicas of spaghetti, demonstrating a unique sol-gel processing technique for the design and synthesis of novel macroscopic morphologies of complex functional materials.
van Schie Kevin - - 2013
Research on retrieval suppression has produced varying results concerning whether negatively valenced memories are more or less suppressible than neutral memories. This variability may arise if, across studies, participants adopt different approaches to memory control. Cognitive and neurobiological research points to two mechanisms that achieve retrieval suppression: thought-substitution and direct ...
Mahmoud Mahmoud A - - 2013
There are two main classes of metallic nanoparticles: solid and hollow. Each type can be synthesized in different shapes and structures. Practical use of these nanoparticles depends on the properties they acquire on the nanoscale. Plasmonic nanoparticles of silver and gold are the most studied, with applications in the fields ...
Gonzalez Cayetano - - 2013
For decades, lower-model organisms such as Drosophila melanogaster have often provided the first glimpse into the mechanism of action of human cancer-related proteins, thus making a substantial contribution to elucidating the molecular basis of the disease. More recently, D. melanogaster strains that are engineered to recapitulate key aspects of specific ...
Yoshida Yoichiro - - 2013
ABSTRACT: BACKGROUND: The start of chemotherapy usually requires a delay of about 4 weeks after surgical resection of colorectal cancer. However, there is no evidence for the required length of this delay interval. In addition, there is a chance that a patient may die because postoperative chemotherapy was not started ...
Areberg Cecilia - - 2013
Abstract Objective: To investigate the effectiveness of Individual Placement and Support (IPS) with regard to non-vocational outcomes among individuals with severe mental illness. Methods: A randomized controlled trial was carried out, comparing IPS with traditional vocational rehabilitation. The Empowerment Scale, the Worker Role Interview, the Profile of Occupational Engagement, and ...
Yang Junbing - - 2013
We report on the use of a petroleum coke-based activated carbon (AC) with very high surface area for a Li-O(2) battery cathode without the use of any additional metal catalysts. Electrochemical measurement in a tetra(ethylene) glycol dimethyl ether-lithium triflate (TEGDME-LiCF(3)SO(3)) electrolyte results in two voltage plateaus during charging at 3.2-3.5 ...
Antoine Besnard - - 2013
Over the past few years multiple studies have attempted to uncover molecular signatures of memory reconsolidation when compared to consolidation. In the present study we used immunocytochemical detection of the MAPK/ERK1/2 pathway, to track activated neuronal circuits in the hippocampus and amygdala recruited during the consolidation and reconsolidation of a ...
Khadrawy Yasser A - - 2013
Brain cooling has pronounced effects on seizures and epileptic activity. The aim of the present study is to evaluate the anticonvulsant effect of brain cooling on the oxidative stress and changes in Na(+), K(+)-ATPase and acetylcholinesterase (AchE) activities during status epilepticus induced by pilocarpine in the hippocampus of adult male ...
Hameury Sophie - - 2013
The reactions of NiCl(2)·2H(2)O or [NiCl(2)(DME)] (DME = dimethoxyethane) with 2-methyl-1-(pyridin-2-yl)propan-2-ol (HL) and 2-(pyridin-2-yl)ethanol (HL(Et)), in a 1 : 1 ratio, afforded the tetranuclear, cubane-type clusters [Ni(μ(3)-Cl)Cl(HL)](4) () and [Ni(μ(3)-Cl)Cl(HL(Et))](4) (), respectively. These are tetramers of the hypothetical mononuclear formula-isomers [NiCl(2)(HL)] and [NiCl(2)(HL(Et))], respectively, and represent rare examples of structurally characterized cubane-like ...
Kim Sung Kuk - - 2013
The multitopic ion-pair receptor is able to recognize and extract various cesium and potassium salts via three different ion recognition modes. Furthermore, it is capable of extracting and then releasing KNO(3)via ion-pair metathesis with CsClO(4), allowing KNO(3) recovery.
Keith L J - - 2013
Resting aortic stiffness (pulse wave velocity; aortic PWV (aPWV)) independently predicts end-organ damage and mortality. Exercise haemodynamics have been shown to unmask cardiovascular abnormalities, otherwise undetectable at rest, but the response of aPWV to exercise has never been examined. This study aimed to develop a technique to measure exercise aPWV, ...
Ozanne Anneli O - - 2013
AIM AND OBJECTIVES: To illuminate how people with amyotrophic lateral sclerosis (ALS) create meaning despite the disease. BACKGROUND: Coping strategies for living with ALS have already been investigated. However, there is a lack of studies on how people with the disease find meaning and what helps and hinders this. DESIGN: ...
García Stephany - - 2013
A microwave-assisted heating method allows for the convenient and reproducible synthesis of defined Au-Rh core-shell metallic nanoparticles with tuneable shell thicknesses. Nanoparticles with shells as thin as two Rh monolayers can be prepared, which are effective in vapour-phase hydrogenation catalysis at room temperature without the need for pre-treatment. Particles with ...
Li Ming-Hsien - - 2013
A parasitological survey for Metagonimus yokogawai metacercariae was carried out by examining a total of 321 freshwater fish comprising of 7 species. Of the 321 fish samples examined, 182 (56.7 %) were found to be infected with M. yokogawai metacercariae. The prevalence of M. yokogawai metacercariae in Opsariichthys pachycephalus was 93.4 % ...
Ahmad Muthanna - - 2013
Porous silicon (PS) has been prepared using a microwave-assisted hydrofluoric acid (HF) etching method from a silicon wafer pre-implanted with 5 MeV Cu ions. The use of microbeam proton-induced X-ray emission (micro-PIXE) and microbeam Rutherford backscattering techniques reveals for the first time the capability of these techniques for studying the ...
Thomas Franziska - - 2013
The chemical synthesis of proteins has facilitated functional studies of proteins due to the site-specific incorporation of post-translational modifications, labels, and non-proteinogenic amino acids. Moreover, native chemical ligation provides facile access to proteins by chemical means. However, the application of the native chemical ligation reaction in the synthesis of parallel ...
Bundschuh Ralph A - - 2013
PURPOSE: PET has been proven to be helpful in the delineation of gross tumour volume (GTV) for external radiation therapy in several tumour entities. The aim of this study was to determine if [(11)C]choline PET could be used to localize the carcinomatous tissue within the prostate in order to specifically ...
Otsuka Rei - - 2013
Docosahexaenoic acid (DHA) and arachidonic acid (ARA) are the predominant long-chain polyunsaturated fatty acids (PUFA) among membrane phospholipids in the mammalian brain and neural tissues. This cross-sectional study examined age effects on serum eicosapentaenoic acid (EPA), DHA, and ARA compositions assessed with reference to dietary intakes among 1,014 Japanese men ...
Lehrer Steven - - 2013
INTRODUCTION: Proper sleep is associated with reduced cancer risk. For example, multiple studies have found that habitual sleeping pill usage is related to death from cancer, suggesting that sleep derangement may increase cancer mortality. However, other studies have not found a definite connection between sleep and cancer deaths. For this ...
Chaudhary Safee Ullah - - 2013
MOTIVATION: Computational multiscale models help cancer biologists to study the spatiotemporal dynamics of complex biological systems and to reveal the underlying mechanism of emergent properties. To facilitate the construction of such models, we have developed a next generation modeling platform for cancer systems biology, termed 'ELECANS' (electronic cancer system). It ...
Deng Chao - - 2013
Identifying the signalling pathways underlying the pathophysiology of schizophrenia is an essential step in the rational development of new antipsychotic drugs for this devastating disease. Evidence from genetic, transgenic and post-mortem studies have strongly supported neuregulin-1 (NRG1)-ErbB4 signalling as a schizophrenia susceptibility pathway. NRG1-ErbB4 signalling plays crucial roles in regulating ...
Tringali Debora - - 2013
Objective: The study was designed to explore the subjective perspective on end-of-life practices in three different groups of pediatric onco-hematologic nurses. Method: In 2004-2005 each member of the nursing staff of the Pediatric Onco-Hematology Ward of the University of Padua, Italy, and the Oncology Ward and Home Assistance Module of ...
Aigner Daniel - - 2013
Novel pH sensors relying on 1-aminoperylene bisimide dyes covalently grafted onto cross-linked poly(acryloylmorpholine) are presented. They feature fluorescence in the near infra-red range and a large Stokes shift (>90 nm).
Ustuner Evren - - 2013
PURPOSE: Familiarity with the localization of the nerves in the neurovascular bundle that constitutes the axillary segment of the brachial plexus (BP) is important when applying ultrasound (US)-guided block anesthesia. Therefore in this study we aimed to delineate the anatomy of the median, radial, and ulnar nerves of the BP ...
Chaurasia Sunita - - 2013
Purpose:  To report the results of Descemet's stripping endothelial keratoplasty (DSEK) for failed therapeutic penetrating keratoplasty (PK). Methods:  Twenty-seven eyes of 27 patients undergoing DSEK for failed therapeutic PK were analysed. Results:  The mean age of the patients was 36 ± 13.9 years (range: 14-70 years). The median size of the therapeutic graft was ...
Chaudhary Nivedita - - 2013
Intraspecific variation in six cultivars of clover Trifolium alexandrinum L., (Bundel, Wardan, JHB-146, Saidi, Fahli, and Mescavi) has been studied with ambient and elevated O(3) (ambient + 10 ppb O(3)) in open top chambers. Significant effect of elevated O(3) was detected on different morphological, physiological, and biochemical parameters depicting differential response among the ...
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