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Dangel K C - - 2013
Knowledge of natural Anguillicola infections of Short-finned eels (Anguilla australis) in New Zealand is very limited. So far, no study contains data on all life cycle stages of Anguillicola novaezelandiae in naturally infected eels. In order to study the frequency of A. novaezelandiae in New Zealand Short-finned eels, we examined ...
Qi Cheng - - 2013
Programmed cell death 4 (PDCD4) has been recognized as a tumor suppressor gene that may inhibit neoplastic transformation and tumor promotion/progression. It was demonstrated that PDCD4 expression was associated with prognosis of multiple types of tumors and cancers. However, PDCD4 expression in salivary adenoid cystic carcinoma (ACC) has not been ...
Graff Jochen - - 2013
The direct factor Xa (FXa) inhibitors rivaroxaban, apixaban and edoxaban, and the thrombin inhibitor dabigatran etexilate (dabigatran) have gained approval for use in several indications, most notably for the prevention and treatment of venous thromboembolism (VTE) and for the prevention of stroke in patients with atrial fibrillation. Hepatic impairment can ...
Kocken Paul L - - 2013
The objective of this paper is to assess parental beliefs and intentions about genetic testing for their children in a multi-ethnic population with the aim of acquiring information to guide interventions for obesity prevention and management. A cross-sectional survey was conducted in parents of native Dutch children and children from ...
Zhang Hongxia - - 2013
AIMS AND OBJECTIVES: To investigate the clinical characteristics of rejection after upper abdominal cluster transplantation. BACKGROUND: Abdominal organ cluster transplantation is used to treat multiple abdominal organ diseases. Delay in monitoring and treatment can lead to graft failure. DESIGN: A descriptive study. METHODS: Data collected from eight patients who underwent ...
Barhoum Suliman - - 2013
Pulsed-field-gradient nuclear magnetic resonance (PFG-NMR) is used to obtain the true hydrodynamic size of complexes of peptides with sodium dodecyl sulfate SDS micelles. The peptide used in this study is a 19-residue antimicrobial peptide, GAD-2. Two smaller dipeptides, alanine-glycine (Ala-Gly) and tyrosine-leucine (Tyr-Leu), are used for comparison. We use PFG-NMR ...
Kundu Debasree - - 2013
A novel 4-nitrotoluene-degrading bacterial strain was isolated from pesticides contaminated effluent-sediment and identified as Rhodococcus pyridinivorans NT2 based on morphological and biochemical properties and 16S rDNA sequencing. The strain NT2 degraded 4-NT (400 mg l(-1)) with rapid growth at the end of 120 h, reduced surface tension of the media from 71 to ...
Kim B-J - - 2013
Although the presence of metabolic syndrome (MetS) and increasing numbers of MetS components were associated with attenuated bone loss at various skeletal sites in postmenopausal women, this beneficial effect of MetS on bone mass can be mainly explained by higher mechanical loading in the affected subjects. INTRODUCTION: Previous cross-sectional epidemiological ...
Auner Holger W - - 2013
ABSTRACT Progression or relapse occurs in the vast majority of patients with multiple myeloma (MM) who undergo up-front autologous haematopoietic cell transplantation (AHCT1), which remains a cornerstone of treatment in the era of novel agents. Limited data are available regarding the value of salvage therapy with a second AHCT (AHCT2) ...
Hansen Hanne Demant - - 2013
Imaging the cerebral serotonin 2A (5-HT(2A) ) receptors with positron emission tomography (PET) has been carried out in humans with [(11) C]MDL 100907 and [(18) F]altanserin. Recently, the MDL 100907 analogue [(18) F]MH.MZ was developed combining the selectivity profile of MDL 100907 and the favourable radiophysical properties of fluorine-18. Here, ...
Kobayashi Ryota - - 2013
Many mechanisms of neural processing rely critically upon the synaptic connectivity between neurons. As our ability to simultaneously record from large populations of neurons expands, the ability to infer network connectivity from this data has become a major goal of computational neuroscience. To address this issue, we employed several different ...
Nahrwold Markus - - 2013
Tumor targeting anticancer drug conjugates that contain a tumor recognition motif (homing device) are of high current relevance. Cryptophycins, naturally occurring cytotoxic cyclo-depsipeptides have been modified by total synthesis to provide analogs suitable for conjugation to peptide-based homing devices. An array of functionalized β2-amino acids was synthesized and incorporated into ...
Lin Mei-Chen - - 2013
ABSTRACT To further address the potential factors that lead up to elder abuse in domestic settings, this paper proposes a model from a communication approach to explain dyadic influences between the family caregiver and the elderly care receiver that give rise to the abuse. That is, dysfunctional communication between the ...
Shimada Hiroyuki - - 2013
BACKGROUND: To examine the efficacy of complying with an infection control manual for intravitreal injection of anti-vascular endothelial growth factor (VEGF) preparations in reducing the rate of endophthalmitis. METHODS: We retrospectively reviewed intravitreal anti-VEGF injections conducted by vitreoretinal specialists at the outpatient injection room of a single university hospital between ...
Moore Jonathan D - - 2013
Cyclin-dependent kinases (CDKs) are regulated by both cyclin abundance and cyclin localization. Increased cyclin expression in cancer was first observed two decades ago, and its role in pathogenesis has been investigated in great depth. This Opinion article focuses on the spatial deregulation of cyclin expression and its potential link to ...
Al-khattawi Ali - - 2013
Orally disintegrating tablets (ODTs) have emerged as one of the novel solid oral dosage forms with a potential to deliver a wide range of drug candidates to both paediatric and geriatric patient populations. Of the plethora of available technologies, compression of excipients offers a cost-effective and translatable methodology for the ...
Burger Irene A IA Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065, - - 2013
Based on prior reports suggesting a positive correlation between fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET)/CT and total sperm count and concentration, we sought to identify changes in testicular FDG uptake over the course of chemotherapy in young men with Hodgkin's lymphoma. Fifty-two patients with a mean age of ...
Bhide Nirmal N Behavioral Neuroscience Program, Department of Psychology, Binghamton University, Binghamton, NY 13902-6000, - - 2013
L-DOPA continues to be the primary treatment for patients with Parkinson's disease; however, the benefits of long-term treatment are often accompanied by debilitating side effects known as dyskinesias. In recent years, several 5-HT1A receptor agonists have been found to reduce dyskinesia in clinical and experimental models of PD. The purported ...
Hendrix An - - 2013
The secretory Rab27B small GTPase promotes invasive growth and metastasis in estrogen receptor (ER)α-positive breast cancer cells by orchestrating the peripheral targeting of vesicles secreting pro-invasive growth regulators. Increased Rab27B expression is associated with poor prognosis in breast cancer patients. The molecular mechanisms of peripheral Rab27B secretory vesicle distribution are ...
Gandy Johanna C - - 2013
Glycogen synthase kinase-3β (GSK3β) activity has been previously linked to Alzheimer's disease (AD) by its phosphorylation of tau and activation by amyloid. GSK3β intracellular distribution is important in regulating its activity by restricting access to compartment-specific substrates. This study investigated regional and intracellular distribution of GSK3β in a mouse model ...
Boerner Leigh J K - - 2013
Thermal Bergman cyclization of Pt(ii) dialkynylporphyrins reveals a marked reduction in the cyclization temperature relative to the free base and Zn(ii) derivatives. In contrast, photogenerated (3)ππ* population produces no detectable Bergman photocyclization, suggesting that the photoreactivities of the related free base and Zn(ii) derivatives occurs via the (1)ππ* state.
Deng Shengyuan - - 2013
A novel ferrocenyl-terminated dendrimer with an electron-relay framework was designed as an efficient tracing tag to quench the cathodic electrochemiluminescence emission of quantum dots, which led to a dual quenching effect via both electron and energy transfer for construction of a sensitive bioanalysis strategy.
Silveira Bruna Maria - - 2013
OBJECTIVE: The present study investigated how trans-fat is reported on the packaging of foods sold in a Brazilian supermarket. DESIGN: The present descriptive, cross-sectional study analysed the ingredient list, nutrition facts label and claims of no trans-fat on the packaging. SETTING: A large supermarket in Florianópolis, Brazil. SUBJECTS: All food ...
Low James A - - 2013
Background: We describe the experience of managing the dying moments of a nursing home patient via telemedicine. Case presentation: Ms. C was a 92-year-old frail woman with multiple medical problems, living in a nursing home. She spent her final days in the nursing home, choosing not to be transferred to ...
Muller Matthew D - - 2013
When exposed to a cold environment, a barehanded person experiences pain, cold sensation, and reduced manual dexterity. Both acute (e.g. exercise) and chronic (e.g. cold acclimatization or habituation) processes might lessen these negative effects. The purpose of this experiment was to determine the effect of cold habituation on physiology, perception, ...
Liebert Melissa A - - 2013
Background: Market integration (MI), the suite of social and cultural changes that occur with economic development, has been associated with negative health outcomes such as cardiovascular disease; however, key questions remain about how this transition manifests at the local level. Aim: The present paper investigates the effects of MI on ...
Kumar Ajit - - 2013
A pyrimidine-naphthalene anchored Schiff base (receptor ) showed Al(3+) selective conformational arrest by inhibition of its C[double bond, length as m-dash]N isomerization (cis-trans) leading to its fluorescent switching in aqueous medium. Nevertheless the H(2)PO(4)(-)/HSO(4)(-) bailed receptor from the Al(3+) arrest leading to its switching 'off'. This conformational arrest and bail ...
Shi Wendian - - 2013
Leukocyte differential count is one of the most frequently ordered clinical tests in hospitals. This paper reports a point-of-care test for the leukocyte count by using a microflow cytometer and a fluorescent dye assay. The dye assay relied on fluorescent detection alone to count leukocytes in blood and to identify ...
Aoki Kazuhiro - - 2013
The progress in imaging technology with fluorescent proteins has uncovered a wide range of biological processes in developmental biology. In particular, genetically-encoded biosensors based on the principle of fluorescence resonance energy transfer (FRET) have been used to visualize spatial and temporal dynamics of intracellular signaling in living cells. However, development ...
Klettner Alexa - - 2013
Purpose:  Toll-like receptor 3 (TLR3) is a receptor of the innate immune system, recognizing double-stranded RNA. TLR3 can lead to cytokine release or apoptosis and has recently been associated with the development of geographical atrophy via cytotoxic effects on the retinal pigment epithelium (RPE). The current study was conducted to ...
Ding Qiulan Q Alireza R. Rezaie, PhD, Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, 1100 S. Grand Blvd., St. Louis, MO 63104, - - 2013
Protein C is a vitamin K-dependent serine protease zymogen in plasma which upon activation to activated protein C (APC) by thrombin down-regulates the clotting cascade by limited proteolysis of the procoagulant cofactors Va and VIIIa. In addition to its anticoagulant activity, APC also exhibits potent cytoprotective and anti-inflammatory activities. While ...
Ranganath S - - 2013
Aortitis due to Haemophilus influenzae especially involving the descending thoracic aorta is rarely encountered. We present a case and literature review concerning Haemophilus influenzae aortitis. This article serves to enhance the awareness of this extremely rare disease.
Kim Seungjin - - 2013
The purpose of this study was to enhance the efficiency of anaerobic co-digestion with sewage sludge using pretreatment technologies and food waste. We studied the effects of various pretreatment methods (thermal, chemical, ultrasonic, and their combination) on hydrogen production and the characteristics of volatile fatty acids (VFAs) using sewage sludge ...
Dekaris Iva - - 2013
Purpose:  To describe a modified graft-over-host (MGOH) surgical technique which was used to prevent serious complications in cases of positive vitreal pressure during penetrating keratoplasty (PKP) and to compare the endothelial cell density (ECD) loss and clinical outcome between eyes undergoing MGOH or standard PKP. Methods:  In the proposed MGOH ...
Rodwell John - - 2013
AIMS: To investigate the relationship between three types of organizational resources (job control, social support and organizational justice) and the impact of job demands on nurse's well-being and attitudes towards their work. BACKGROUND: The negative impact of work-related stress on nurse's health and attitudes towards their work has been established. ...
Faivre C - - 2013
We propose a mathematical model that takes into account a classical maximum tolerated dose (MTD) chemotherapy regimen (whose primary targets are the tumor cells) as well as a metronomic chemotherapy regimen (whose primary targets are the tumor endothelial cells) for the administration of temozolomide (Temodal(®)) in order to compare the ...
Carradori Simone - - 2013
Human carbonic anhydrase (hCA) IX is involved in tumorigenesis and metastasis through pathways modulating extracellular pH regulation and cell adhesion control. As a consequence, hCA IX represents a promising antitumor target for the development of new drugs in order to treat/image hypoxic cancers, and different agents targeting hCA IX are ...
Mahmoud Mahmoud A - - 2013
There are two main classes of metallic nanoparticles: solid and hollow. Each type can be synthesized in different shapes and structures. Practical use of these nanoparticles depends on the properties they acquire on the nanoscale. Plasmonic nanoparticles of silver and gold are the most studied, with applications in the fields ...
Gonzalez Cayetano - - 2013
For decades, lower-model organisms such as Drosophila melanogaster have often provided the first glimpse into the mechanism of action of human cancer-related proteins, thus making a substantial contribution to elucidating the molecular basis of the disease. More recently, D. melanogaster strains that are engineered to recapitulate key aspects of specific ...
Yoshida Yoichiro - - 2013
ABSTRACT: BACKGROUND: The start of chemotherapy usually requires a delay of about 4 weeks after surgical resection of colorectal cancer. However, there is no evidence for the required length of this delay interval. In addition, there is a chance that a patient may die because postoperative chemotherapy was not started ...
Areberg Cecilia - - 2013
Abstract Objective: To investigate the effectiveness of Individual Placement and Support (IPS) with regard to non-vocational outcomes among individuals with severe mental illness. Methods: A randomized controlled trial was carried out, comparing IPS with traditional vocational rehabilitation. The Empowerment Scale, the Worker Role Interview, the Profile of Occupational Engagement, and ...
Yang Junbing - - 2013
We report on the use of a petroleum coke-based activated carbon (AC) with very high surface area for a Li-O(2) battery cathode without the use of any additional metal catalysts. Electrochemical measurement in a tetra(ethylene) glycol dimethyl ether-lithium triflate (TEGDME-LiCF(3)SO(3)) electrolyte results in two voltage plateaus during charging at 3.2-3.5 ...
Antoine Besnard - - 2013
Over the past few years multiple studies have attempted to uncover molecular signatures of memory reconsolidation when compared to consolidation. In the present study we used immunocytochemical detection of the MAPK/ERK1/2 pathway, to track activated neuronal circuits in the hippocampus and amygdala recruited during the consolidation and reconsolidation of a ...
Khadrawy Yasser A - - 2013
Brain cooling has pronounced effects on seizures and epileptic activity. The aim of the present study is to evaluate the anticonvulsant effect of brain cooling on the oxidative stress and changes in Na(+), K(+)-ATPase and acetylcholinesterase (AchE) activities during status epilepticus induced by pilocarpine in the hippocampus of adult male ...
Hameury Sophie - - 2013
The reactions of NiCl(2)·2H(2)O or [NiCl(2)(DME)] (DME = dimethoxyethane) with 2-methyl-1-(pyridin-2-yl)propan-2-ol (HL) and 2-(pyridin-2-yl)ethanol (HL(Et)), in a 1 : 1 ratio, afforded the tetranuclear, cubane-type clusters [Ni(μ(3)-Cl)Cl(HL)](4) () and [Ni(μ(3)-Cl)Cl(HL(Et))](4) (), respectively. These are tetramers of the hypothetical mononuclear formula-isomers [NiCl(2)(HL)] and [NiCl(2)(HL(Et))], respectively, and represent rare examples of structurally characterized cubane-like ...
Climo Michael W MW Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA 23249, USA. - - 2013
Results of previous single-center, observational studies suggest that daily bathing of patients with chlorhexidine may prevent hospital-acquired bloodstream infections and the acquisition of multidrug-resistant organisms (MDROs). We conducted a multicenter, cluster-randomized, nonblinded crossover trial to evaluate the effect of daily bathing with chlorhexidine-impregnated washcloths on the acquisition of MDROs and ...
Salplachta Jiří - - 2013
In this study electrophoretic and mass spectrometric analysis of three types of bacterial sample (intact cells, cell lysates, and "washed pellets") were used to develop an effective procedure for the characterization of bacteria. The samples were prepared from specific bacterial strains. Five strains representing different species of the family Rhizobiaceae ...
Aigner Julia - - 2013
OBJECTIVE: A recent, randomized trial (ACOSOG Z0011) has demonstrated that omission of completion axillary lymph node dissection (ALND) in patients with one or two sentinel lymph node (SLN) metastases treated with breast conserving therapy (BCT) does not have a negative impact on survival. This study evaluates the impact of omitting ...
Ma Tingting - - 2013
Phthalic acid esters (PAEs) pollution in agricultural soils caused by widely employed plastic products is becoming more and more widespread in China. PAEs polluted soil can lead to phytotoxicity in higher plants and potential health risks to human being. We evaluated the individual toxicity of di-n-butyl phthalate (DnBP) and bis(2-ethylhexyl) ...
Villalpando-Arteaga Edgar Vinicio - - 2013
The growing incidence of obesity is a worldwide public health problem leading to a risk factor for non-alcoholic fatty liver disease, which extends from steatosis to steatohepatitis and cirrhosis. We investigated whether the aqueous extract of Hibiscus sabdariffa L. (Hs) reduces body weight gain and protects the liver by improving ...
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