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Mallet Cindy - - 2013
: Many commissural reconstruction techniques have been described for the treatment of syndactyly. This study is the first to compare long-term results of 2 commissural dorsal flap procedures (T-flap and omega-flap). : Fifty-nine web-spaces in 39 patients, operated on between 1991 and 2008, were retrospectively analyzed. Thirty-six T-flap and 23 ...
Ya Ru R Department of Biological Sciences, Marquette University, Milwaukee, WI 53233, - - 2013
Oocyte activation is an important process triggered by fertilization that initiates embryonic development. However, parthenogenetic activation can occur either spontaneously or with chemical treatments. The LT/Sv mouse strain is genetically predisposed to spontaneous activation. LT oocytes have a cell cycle defect and are ovulated at the metaphase I stage instead ...
Kim Young S - - 2013
Mast cell sarcoma (MCS) is an extremely rare neoplasm with a clinically aggressive course. Because of its rarity, its morphologic and molecular characteristics are still not well defined. We report a case of a 15-year-old girl with MCS of the temporal bone extending into the posterior fossa creating a mass ...
Hardesty Christina K - - 2013
: The purpose of this study was to determine if digital enhancements could improve upon published and interobserver variability for Cobb angle measurements of idiopathic scoliosis using a commercially available PACS system. The study also sought to determine if experience of the observer affected overall variability and to evaluate the ...
Powell Suzanne K - - 2013
Observation status is at the center of a lawsuit and a legislative effort and is a challenge to hospitals, case managers, and, especially, Medicare beneficiaries. This Editorial discusses the problems, the efforts, and hopeful solutions to this health care dilemma.
Gardner Brooke M BM Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94158, - - 2013
Secretory and transmembrane proteins enter the endoplasmic reticulum (ER) as unfolded proteins and exit as either folded proteins in transit to their target organelles or as misfolded proteins targeted for degradation. The unfolded protein response (UPR) maintains the protein-folding homeostasis within the ER, ensuring that the protein-folding capacity of the ...
Tenenbaum Shay - - 2013
: Nonaccidental pediatric injuries are major cause of morbidity and mortality, with fractures being second to soft-tissue injuries as the most common presentation. As the orthopedic surgeon might be the only physician an abused child would encounter, the role of the orthopedic surgeon is of great importance. It includes recognition, ...
Liberman Boaz - - 2013
: Hip transient synovitis (TS) is a common pediatric orthopaedic problem. Although a self-limiting illness, it often makes the patient temporarily disabled and poses a diagnostic difficulty because of its similarity to septic arthritis in clinical manifestations. The aim of this study was to evaluate the use of a single ...
Hanson R Karl - - 2013
This article reviews the research evidence, practice guidelines and accreditation standards for the psychological treatment of individuals who commit sexually motivated crimes. Overall, the sexual offender treatment outcome research is not well developed, which limits strong conclusions. There is, however, strong research evidence concerning the effectiveness of interventions for general ...
Berry Joel D JD Center for Phage Technology, Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, - - 2013
The λ Rz and Rz1 proteins are the subunits of the spanin complex, required for the disruption of the outer membrane during host lysis. Rz, the inner membrane or i-spanin, has a largely alpha-helical periplasmic domain, whereas Rz1, the outer membrane or o-spanin, has a 25% proline content with no ...
Vincent Ludovic G LG Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, - - 2013
Mesenchymal stem cells (MSCs) respond to the elasticity of their environment, which varies between and within tissues. Stiffness gradients within tissues can result from pathological conditions, but also occur through normal variation, such as in muscle. MSC migration can be directed by shallow stiffness gradients before differentiating. Gradients with fine ...
Chen Jieming J Integrated Graduate Program in Physical and Engineering Biology, Yale University, New Haven, Connecticut 06520, - - 2013
Protein-protein interactions play key roles in many cellular processes and their affinities and specificities are finely tuned to the functions they perform. Here, we present a study on the relationship between binding affinity and the size and chemical nature of protein-protein interfaces. Our analysis focuses on heterodimers and includes curated ...
Slingsby Christine C Department of Biological Sciences, Crystallography, Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, United Kingdom. - - 2013
The camera eye lens of vertebrates is a classic example of the re-engineering of existing protein components to fashion a new device. The bulk of the lens is formed from proteins belonging to two superfamilies, the α-crystallins and the βγ-crystallins. Tracing their ancestry may throw light on the origin of ...
Akkaladevi N N Department of Biochemistry, University of Kansas Medical Center, Kansas City, Kansas, - - 2013
We have devised a procedure to incorporate the anthrax protective antigen (PA) pore complexed with the N-terminal domain of anthrax lethal factor (LFN ) into lipid nanodiscs and analyzed the resulting complexes by negative-stain electron microscopy. Insertion into nanodiscs was performed without relying on primary and secondary detergent screens. The ...
Berglund E Carina EC Department of Molecular Biology and Chemistry, Analytical Chemistry, University of Gothenburg, Kemivägen 10, SE-412 96 Gothenburg, - - 2013
Micellar electrokinetic capillary chromatography with electrochemical detection has been used to quantify biogenic amines in freeze-dried brains of Drosophila melanogaster. Freeze-drying samples offers a way to preserve the biological sample while making dissection of these tiny samples easier and faster. Fly samples were extracted in cold acetone and dried in ...
Abe Masahiro M Department of Protein Structure, Function and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, - - 2013
Sugars, which function as osmolytes within cells, retard the amyloid fibril formation of the amyloidosis peptides and proteins. To examine the mechanism of this retardation in detail, we analyzed the effect of sugars (trehalose, sucrose, and glucose) on the polypeptide chains in 3Hmut Wil, which is formed by the mutation ...
Guo Yudi Y Department of Chemistry, School of Science, Harbin Institute of Technology, Harbin 150001, - - 2013
We describe a controllable method to fabricate hexagonally close-packed Langmuir-Blodgett (LB) monolayers with stearic acid (SA) as co-surfactant and methanol as co-solvent. The optimal SA concentrations and volume ratios of chloroform to methanol are 0.8 mg/mL and 3:1 for particles of 140 nm, 0.50 mg/mL and 4:1 for particles of ...
Liu Ce Feng CF Department of Chemistry and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454, - - 2013
Autoinducer inactivator A (AiiA) is a metal-dependent N-acyl homoserine lactone hydrolase that displays broad substrate specificity but shows a preference for substrates with long N-acyl substitutions. Previously, crystal structures of AiiA in complex with the ring-opened product N-hexanoyl-l-homoserine revealed binding interactions near the metal center but did not identify a ...
Ekkebus Reggy R Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The - - 2013
Active-site directed probes are powerful in studies of enzymatic function. We report an active-site directed probe based on a warhead so far considered unreactive. By replacing the C-terminal carboxylate of ubiquitin (Ub) with an alkyne functionality, a selective reaction with the active-site cysteine residue of de-ubiquitinating enzymes was observed. The ...
You Jianlan J Natural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, OK 73019-5251, - - 2013
A new class of fungal biofilm inhibitors represented by shearinines D (3) and E (4) were obtained from a Penicillium sp. isolate. The inhibitory activities of 3 and 4 were characterized using a new imaging flow-cytometer technique, which enabled the rapid phenotypic analysis of Candida albicans cell types (budding yeast ...
Li Jiabei - - 2013
A wide-wavelength tunable laser is demonstrated on a single non-doped CdSe nanowire (NW) by gradually cutting the NW shorter, without changing other experimental conditions such as pumping intensity and position. The corresponding mechanism for the large wavelength shifts is determined as the absorption-emission-absorption process in polar CdSe NWs. This new ...
Zhou Qi-Hai - - 2013
Infanticide by males is a common phenomenon in mammals, especially primates, as lactation lasts much longer than gestation in many species. Usually, infanticidal episodes occur soon after group takeovers, and are traditionally considered a male reproductive strategy (i.e., support the sexual selection hypothesis, Hrdy, 1974). To verify the validity of ...
- - 2013
During November 24-27, 2012, the Arizona Department of Health Services (ADHS) was notified that eight male inmates of prison A, a maximum security prison, had been hospitalized for treatment of an acute neurologic condition suspected to be botulism. Botulism is a serious paralytic illness caused by a nerve toxin produced ...
- - 2013
Background: Cigarette smoking remains the leading cause of preventable morbidity and mortality in the United States. Despite overall declines in cigarette smoking, a high prevalence of smoking persists among certain subpopulations, including persons with mental illness. Methods: Combined data from the 2009-2011 National Survey on Drug Use and Health (NSDUH) ...
Lardone María C - - 2013
PURPOSE: To determine the prevalence of South Amerindian Y chromosome in Chilean patients with spermatogenic failure and their association with classical and/or AZFc-partial Y chromosome deletions. METHODS: We studied 400 men, 218 with secretory azo/oligozoospermia (cases) and 182 controls (116 fertile and/or normozoospermic, and 66 azoospermic with normal spermatogenesis). After ...
Huang Zhengxing - - 2013
A clinical process is typically a mixture of various latent treatment patterns, implicitly indicating the likelihood of what clinical activities are essential/critical to the process. Discovering these hidden patterns is one of the most important components of clinical process analysis. What makes the pattern discovery problem complex is that these ...
Uher Jana - - 2013
This article develops a comprehensive philosophy-of-science for personality psychology that goes far beyond the scope of the lexical approaches, assessment methods, and trait concepts that currently prevail. One of the field's most important guiding scientific assumptions, the lexical hypothesis, is analysed from meta-theoretical viewpoints to reveal that it explicitly describes ...
Terry Louise M - - 2013
BACKGROUND:In the United Kingdom, many nurses who were educated overseas and are not native English speakers are undertaking continuing professional development study within their host country. This study investigated the effect of fluency in English on the teaching and learning of registered nurses undertaking continuing professional development within a health ...
Luo Ying - - 2013
This study aimed to discuss the energy budget of Elliot's pheasant Syrmaticus ellioti in different seasons, with life and health, good growth and normal digestion of Elliot's pheasant as the tested objects, The energy budget of Elliot's pheasant was measured by daily collection of the trial pheasants' excrement in the ...
Galea Nicola - - 2013
The right ventricle (RV) has been defined as the "forgotten chamber", as its role in cardiac physiopathology has long been underestimated. Nevertheless, the RV is involved in a wide range of pathological conditions and its altered function may significantly affect the patient's clinical status. A selection of the most common ...
Wang Guanghuan - - 2013
We aimed to explore the association of blood Zn, Fe, and Cu concentrations and changes in the pediatric risk of mortality (PRISM) score in critically ill children, to predict prognosis. We included 31 children (22 boys and 9 girls, 1 month to 5 years old), who had been admitted to the intensive ...
Patidar Kavish R KR Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA, - - 2013
The treatment of hepatic encephalopathy (HE) is complex and therapeutic regimens vary according to the acuity of presentation and the goals of therapy. Most treatments for HE rely on manipulating the intestinal milieu and therefore antibiotics that act on the gut form a key treatment strategy. Prominent antibiotics studied in ...
Wold Judith Lupo - - 2013
This article describes a formal nurse educator train-the-trainer program initiated to educate qualified health professionals to teach contemporary nursing continuing education in the country of Georgia, formerly part of the Soviet Union. A 3-month intensive train-the-trainer program model was used to educate potential nurse educators to provide a foundation for ...
Zhang Ming-Ming - - 2013
Although differences in food-hoarding tactics both reflect a behavioral response to cache pilferage among rodent species and may help explain their coexistence, differentiation in cache pilfering abilities among sympatric rodents with different hoarding strategies is seldom addressed. We carried out semi-natural enclosure experiments to investigate seed hoarding tactics among three ...
Guan Zhen-Hua - - 2013
We investigated the structure and seasonality of the proximity network in a group of polygynous western black crested gibbons (Nomascus concolor) using social network analysis. The spatial proximity changed seasonally and was affected by temperature and rainfall. Preferred proximity association was not distributed randomly among individuals. Kinship was one explanation ...
Yürekli Vedat Ali - - 2013
It is well known that oxidative stress plays an important role in the etiology of epilepsy. We investigated effects of selenium (Se) and topiramate (TPM) combination supplementation on antioxidant and oxidant values in control and patients with epilepsy and refractory epilepsy. For the aim, we used control (n = 19), epilepsy + ...
Fan Yao-Dong - - 2013
Association between the reward caused by consuming drugs and the context in which they are consumed is essential in the formation of morphine-induced conditioned place preference (CPP). Glucocorticoid receptor (GRs) activation in different regions of the brain affects reward-based reinforcement and memory processing. A wide array of studies have demonstrated ...
Schott M - - 2013
Thyrotoxicosis is mainly caused by autonomous adenomas of the thyroid gland and by Graves' disease. A less frequent cause for thyrotoxicosis is Hashimoto's thyroiditis. Thyrotoxicosis in autonomous adenomas and Graves' disease is caused by an increased thyroid hormone production whereas hyperthyroidism in Hashimoto's thyroiditis results from destruction of the thyroid ...
- - 2013
The American Academy of Pediatrics recognizes breastfeeding and human milk as the "normative standards for infant feeding." Given the documented health benefits, the Academy recommends exclusive breastfeeding for 6 months, followed by continued breastfeeding for at least 12 months as complementary foods are introduced. To better understand trends during 2000-2008 ...
Hamel J - - 2013
The majority of tarsal coalitions are located in the calcaneonavicular and talocalcaneal regions and other locations are rare. Complete early ossified synostoses are found not only in major limb deficiencies but also in otherwise normal feet. Magnetic resonance imaging (MRI) and computed tomography (CT) scans are the most important imaging ...
Malaguarnera Michele - - 2013
Hepatic encephalopathy is a common complication of hepatic cirrhosis. The clinical diagnosis is based on two concurrent types of symptoms: impaired mental status and impaired neuromotor function. Impaired mental status is characterized by deterioration in mental status with psychomotor dysfunction, impaired memory, and increased reaction time, sensory abnormalities, poor concentration, ...
Gonçalves Susana - - 2013
Alpha-synuclein (aSyn) is implicated in Parkinson's disease and several other neurodegenerative disorders. To date, the function and intracellular dynamics of aSyn are still unclear. Here, we tracked the dynamics of aSyn using photoactivatable green fluorescent protein as a reporter. We found that the availability of the aSyn N terminus modulates ...
Foster Kim N - - 2013
BACKGROUND:Physical and mental health problems are interconnected, and registered nurses need to be competent in performing comprehensive physical and mental health assessment. This article reports on a pilot evaluation of education in comprehensive health assessment and clinical judgment for registered nurses enrolled in a master of nursing program. METHODS:Observation and ...
Robeva Ralitsa - - 2013
Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects mainly females. Therefore, interrelations between the reproductive and immune system have been assumed. Considering the complex influence of hormones and receptors, we aimed to investigate the influence of androgens and androgen receptor (AR) polymorphism in women with SLE. One hundred ...
Zavitsanou Katerina - - 2013
Brain inflammation in early life has been proposed to play important roles in the development of anxiety and psychosis-related behaviours in adulthood, behaviours that rely on the integrity of dopamine and /or serotonin systems. Moreover recent behavioural and anatomical evidence suggests involvement of CB1 receptors in the control of emotion ...
Charrier Jean-Damien - - 2013
ITK is a member of the Tec family of nonreceptor protein tyrosine kinases that plays a central role in T-cell signaling. Its inhibition is seen as an attractive approach to the treatment of immune-mediated disorders. Insight into the function of ITK has emerged from studies on ITK-deficient mice, which exhibit ...
Haselboeck J - - 2013
Data on the in vivo function of platelets induced by the thrombopoietin receptor agonist eltrombopag are scarce. To assess a possible influence of eltrombopag we compared platelet function of eltrombopag-treated immune thrombocytopenia (ITP) patients (group 1; n=10) after treatment response to that from control ITP patients (group 2; n=12). We ...
Naitoh Sae - - 2013
The relationship between Y-chromosome single-nucleotide polymorphisms (SNPs) registered in the Japanese SNP (JSNP) database (http://snp.ims.u-tokyo.ac.jp) and Y-binary haplogroup lineages was investigated to identify new Y-chromosomal binary haplogroup markers and further refine Y-chromosomal haplogroup classification in the Japanese population. We used SNPs for which it was possible to construct primers to ...
Miller Seth - - 2013
BACKGROUND: Single-incision laparoscopic colectomy (SILC) is touted to be an improved approach for minimally invasive surgery although no data currently exists regarding the acquisition of skills for the safe performance of this technique. The authors report their early experience with proctoring of surgical residents in SILC by experienced colorectal surgeons. ...
Storr-Paulsen Allan - - 2013
Purpose:  To investigate corneal endothelial cell density and morphology in type II diabetic and non-diabetic patients and to relate potential differences to the glycaemic status. Methods:  A prospective clinical study including 107 patients with type II diabetes and 128 non-diabetic patients. Sample size was based on a power calculation (power = 0.90; ...
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