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Results 701 - 750 of 2982
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Santini Massimo - - 2013
BACKGROUND: -Syncope in patients with bifascicular block (BFB) is a common event whose causes might be difficult to assess. METHODS AND RESULTS: -PRESS is a multicenter, prospective, randomized, single blinded study designed to demonstrate a reduction in symptomatic events in patients with BFB and syncope of undetermined origin implanted with ...
Goyal Lipika - - 2013
Hepatocellular carcinoma (HCC) is a significant cause of cancer-related morbidity and mortality worldwide. Despite improvements in local therapies including surgical resection, liver transplantation, and transarterial embolization, the prognosis remains poor for the majority of patients who develop recurrence or present with advanced disease. Systemic therapy with the tyrosine kinase inhibitor ...
Farquharson Barbara - - 2013
AIM: To examine the effects of nursing tasks (including their physiological and psychological demands, and the moderating effects of reward and control) on distress and job performance in real time. BACKGROUND: Nurses working in hospital settings report high levels of occupational stress. Stress in nurses has been linked to reduced ...
Khan Atta U - - 2013
The crystal structure of Ti(8)(Ti(x)Mn(1-x))(6)Mn(39), x = 0.187, was obtained from x-ray single-crystal diffraction data, confirming it to have rhombohedral symmetry (space group [Formula: see text]; a(hex) = 1.100 70(2) nm, c(hex) = 1.944 11(4) nm; R(F) = 0.0293) and isotypism with the prototype Mo(0.38)Cr(0.16)Co(0.46) (the so-called R-phase). On the basis of electron probe micro-analyser results and structure determination, the homogeneity region ...
Burbey Thomas J - - 2013
Reverse water-level fluctuations have been widely observed in aquitards or aquifers separated from a pumped confined aquifer (Noordbergum effect) immediately after the initiation of pumping. This same reverse fluctuation has been observed in a fractured crystalline-rock aquifer at the Coles Hill uranium site in Virginia in which the reverse water-level ...
Tufano M - - 2013
The management of de novo hepatitis B (HBV) infection in children after liver transplantation is not well defined. Because this infection may induce severe liver disease in the graft liver, an efficient antiviral therapy is desirable. Here, we describe the favorable viral outcome observed in a liver transplanted girl with ...
Carnelli Davide D Department of Structural Engineering, LaBS-Laboratory of Biological Structure Mechanics, Politecnico di Milano, P.zza L. da Vinci 32, 20133 Milan, Italy. - - 2013
Anisotropy is one of the most peculiar aspects of cortical bone mechanics; however, its anisotropic mechanical behaviour should be treated only with strict relationship to the length scale of investigation. In this study, we focus on quantifying the orientation and size dependence of the spatial mechanical modulation in individual secondary ...
Yamashita Teppei - - 2013
Abstract Background: We sought to detect specimen mix-up by developing a new cumulative delta-check method applicable to a mixture of test items with heterogeneous units and distribution patterns. Methods: The distributions of all test results were successfully made Gaussian using power transformation. Values were then standardized into z-score (zx) based ...
Kaiser Stephen E SE Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, - - 2013
Central to most forms of autophagy are two ubiquitin-like proteins (UBLs), Atg8 and Atg12, which play important roles in autophagosome biogenesis, substrate recruitment to autophagosomes, and other aspects of autophagy. Typically, UBLs are activated by an E1 enzyme that (1) catalyzes adenylation of the UBL C terminus, (2) transiently covalently ...
Topor Lisa Swartz - - 2013
ABSTRACT: BACKGROUND: To identify factors that predict low bone mineral density (BMD) in pediatric patients referred for dual-energy x-ray absorptiometry assessments. METHODS: This is a retrospective cohort study of 304 children and adolescents referred for dual-energy x-ray absorptiometry assessments at a tertiary care center. Outcomes included risk factors which predicted ...
von Ruesten A - - 2013
Background/Objectives:There is still a need for scientific evidence about which foods characterize a healthy diet in terms of primary prevention of major chronic diseases. Therefore, we aimed to give a comprehensive overview on health-related foods, based on 8 years of follow-up of the European Prospective Investigation into Cancer and Nutrition ...
Cusack Lynette - - 2013
Despite recent health gains for Australian Aboriginal people their significantly poorer health status compared with that of non-Aboriginal Australians remains significant. Within the context of high levels of mortality and morbidity, research highlights significant barriers to timely health-care, access and safe use of prescribed and over-the-counter medicines. The risks to ...
Fteropoulli Theodora - - 2013
Aims This review explores the quality of life of adult congenital heart disease patients and the relationship between disease severity and quality of life. METHODS: We searched seven electronic databases and the bibliography of articles. The 31 selected studies fulfilled the following criteria: adult population; quantitative; assessment of quality of ...
Lehman Rebecca K - - 2013
Juvenile Huntington disease (JHD)-Huntington disease (HD) with an onset ≤20 years-accounts for approximately 10% of all HD cases. Like the adult form of the disorder, JHD is a hereditary neurodegenerative disease characterized by dementia and behavioral changes, caused by an expanded CAG repeat within the first exon of the huntingtin ...
Rosenberg Eran - - 2013
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Recurrence and progression prediction in urothelial cancer is currently based on clinical and pathological factors: tumour grade, tumour stage, number of lesions, tumour size, previous recurrence rate, and presence of concomitant carcinoma in situ. These factors are not specific ...
Yeh Yu-Ming - - 2013
Metastasis is the major factor affecting patient survival in ovarian cancer. However, its molecular mechanisms remain unclear. The present study used isogenic pairs of low and high invasive ovarian cancer cell lines to demonstrate the downregulation of miRNA-138 in the highly invasive cells, and its functioning as an inhibitor of ...
Vranic Sandra - - 2013
ABSTRACT: BACKGROUND: The uptake of nanoparticles (NPs) by cells remains to be better characterized in order to understand the mechanisms of potential NP toxicity as well as for a reliable risk assessment. Real NP uptake is still difficult to evaluate because of the adsorption of NPs on the cellular surface. ...
van der Ploeg René - - 2013
The rod-shaped bacterium Escherichia coli grows by insertion of peptidoglycan into the lateral wall during cell elongation and synthesis of new poles during cell division. The monofunctional transpeptidases PBP2 and PBP3 are part of specialized protein complexes called elongasome and divisome, respectively, which catalyse peptidoglycan extension and maturation. Endogenous immunolabelled ...
Heller William T - - 2013
The interaction of proteins with aqueous solutions of ionic liquids (ILs) has attracted considerable recent attention owing to the challenges of finding biocompatible water-free ILs. These systems remain of great interest because of the potential for using ILs as designer solvents for biocatalytic processes. Increasing evidence demonstrates that aqueous solutions ...
Schneider Marc A - - 2013
The minor capsid protein L2 of human papillomaviruses (HPVs) has multiple functions during the viral life cycle. Although L2 is required for effective invasion and morphogenesis, only a few cellular interaction partners are known so far. Using yeast two-hybrid screening, we identified the transcription factor TBX2 as a novel interaction ...
Vavken Patrick - - 2013
The objective of this study was to conduct a meta-analysis and cost-effectiveness analysis of the effect of glenoid design on radiolucency, loosening, and revision after total shoulder arthroplasty. We conducted a systematic review of PubMed, MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and CINAHL with use of a ...
Andersen R - - 2013
Background/objectives:To determine seasonal variation in vitamin D status in healthy Caucasian adolescent girls and elderly community-dwelling women living in Denmark, and to quantify the impact of sun exposure and intake on the seasonal changes in vitamin D status.Subjects/methods:A 1-year longitudinal observational study of 54 girls (11-13 years) and 52 women ...
Wu Weixun - - 2013
Flowering time (i.e., heading date in crops) is an important ecological trait that determines growing seasons and regional adaptability of plants to specific natural environments. Rice (Oryza sativa L.) is a short-day plant that originated in the tropics. Increasing evidence suggests that the northward expansion of cultivated rice was accompanied ...
Blay Jean-Yves - - 2013
ABSTRACT: BACKGROUND: The long term outcome of advanced sarcoma patients treated with trabectedin outside of clinical trials and the utility of maintenance treatment has not been reported. METHODS: Between 2003 and 2008, patients with advanced sarcoma failing doxorubicin could be treated within a compassionate use program (ATU, Temporary Use Authorization) ...
Akematsu Yuji - - 2013
We analysed data on the medical expenditure of 199 telecare users in Nishi-aizu Town, Fukushima Prefecture, which has one of the oldest ongoing telecare implementations in Japan. As controls, 450 out of 3528 non-users residents covered by National Health Insurance were randomly selected in the same age and sex ratios ...
You Young-Hyun YH Center for Renal Translational Medicine, Division of Nephrology-Hypertension, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, - - 2013
NADPH oxidase (Nox) isoforms have been implicated in contributing to diabetic microvascular complications, but the functional role of individual isoforms in diabetic kidney are unclear. Nox2, in particular, is highly expressed in phagocytes and may play a key inflammatory role in diabetic kidney disease. To determine the role of Nox2, ...
Cohen Alexander D AD Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Translational Brain Tumor Research Program, Medical College of Wisconsin, Milwaukee, Wisconsin, - - 2013
To characterize the influence of perfusion on the measurement of diffusion changes over time when ADC is computed using standard two-point methods. Functional diffusion maps (FDMs), which depict changes in diffusion over time, were compared with rCBV changes in patients with brain tumors. The FDMs were created by coregistering and ...
Warr Matthew R - - 2013
Blood production is ensured by rare, self-renewing haematopoietic stem cells (HSCs). How HSCs accommodate the diverse cellular stresses associated with their life-long activity remains elusive. Here we identify autophagy as an essential mechanism protecting HSCs from metabolic stress. We show that mouse HSCs, in contrast to their short-lived myeloid progeny, ...
Dahodwala Mufaddal Q - - 2013
BACKGROUND: Hemangiopericytomas are typically found in soft-tissue, but only rarely found in the sinonasal tract. Sinonasal hemangiopericytomas have been reported mostly through case studies, and optimal treatment is considered surgical excision. Classically, open surgical methods of tumor extirpation have been considered standard of care. With the wider use of endoscopic ...
Harper Kaid C - - 2013
The effectiveness of a new asymmetric catalytic methodology is often weighed by the number of diverse substrates that undergo reaction with high enantioselectivity. Here we report a study that quantifies substrate and ligand steric effects to enantioselectivity for the propargylation of aliphatic ketones. The mathematical model is shown to be ...
Mehling I - - 2013
The purpose of this study was to analyze the practicability and benefit of intraoperative C-arm computed tomography (CT) imaging in volar plate osteosynthesis of unstable distal radius fractures. During a 1 year period, intraoperative three dimensional (3D) imaging with the ARCADIS Orbic 3D was performed in addition to standard fluoroscopy ...
Shaffer David W - - 2013
A new tridentate redox-active ligand platform, derived from bis(2-mercapto-p-tolyl)amine, [SNS(cat)]H(3), has been prepared in high yields by a four-step procedure starting from commericially available bis(p-tolyl)amine. The redox-active pincer-type ligand has been coordinated to tungsten to afford the six-coordinate, homoleptic complex W[SNS](2). To benchmark the redox behavior of the [SNS] ligand, ...
Liang Kae-Woei - - 2013
We compared midterm prognostic predictors of peripheral artery disease (PAD) with or without diabetes mellitus (DM) presenting with critical lower limb ischemia (CLI). A total of 172 patients with PAD (109 DM; 63 non-DM) were enrolled. The major adverse events (MAEs) were death or amputation. The diabetic group had a ...
Barbadoro Pamela - - 2013
Behavioral distress and dysfunctions of hypothalamic-pituitary-adrenocortical (HPA) axis play a central role in alcohol abuse. Omega-3 fatty acids are proposed as having antistress, regulatory effects on HPA responsiveness, but a possible protective role in ethanol addiction is unexplored.A randomized, doubleblind, placebo-controlled trial was performed in male alcoholics undergoing residential rehabilitation ...
Carvalho Maranho Daniel Augusto - - 2013
Varying degrees of femoral deformity may result as Legg-Calvé-Perthes disease heals. Our aims were to investigate the prevalence of abnormalities of the acetabular labrum and cartilage, using noncontrast magnetic resonance imaging, and to correlate the findings with radiographic deformities that may exist after the healing of Legg-Calvé-Perthes disease. In a ...
Zang L - - 2013
Leukemia related protein 16 (LRP16) was first cloned from acute myeloid leukemia cells in our laboratory. In the present study, we sought to investigate the role of LRP16 in insulin action and sensitivity, using LRP16-depleted and -overexpressing 3T3-L1 cells. LRP16 silencing resulted in a reduction of the expression and secretion ...
Kong Desheng - - 2013
Layered materials consist of molecular layers stacked together by weak interlayer interactions. They often crystallize to form smooth thin films, nanotubes, and platelet or fullerene-like nanoparticles due to the anisotropic bonding. Structures that predominately expose edges of the layers exhibit high surface energy and are often considered unstable. In this ...
Pons Roser - - 2013
The objective of this study was to characterize levodopa (l-dopa)-induced dyskinesias in patients with tyrosine hydroxylase deficiency. Clinical observation was carried out on 6 patients who were diagnosed with tyrosine hydroxylase deficiency and were treated with escalating doses of l-dopa. All 6 patients showed l-dopa-induced dyskinesias of variable intensity early ...
Hwang Dae-Sik - - 2013
The complete mitochondrial genome was sequenced from the freshwater gudgeon, Gobiobotia nakdongensis. The genome sequence was 16,609 bp in size, and the gene order and contents were identical with other previously reported fish mitochondrial genomes. Of the 13 protein-coding genes (PCGs), 3 genes (CO2, CO3, and Cytb) had incomplete stop codons. ...
Ansar Siyam M - - 2013
Mechanism of sodium borohydride removal of organothiols from gold nanoparticles (AuNPs) was studied using an experimental investigation and computational modeling. Organothiols, and other AuNP surface adsorbates such as thiophene, adenine, Rhodamine, small anions (Br- and I-), and a polymer (PVP, poly(N-vinylpyrrolidone)) can all be rapidly and completely removed from the ...
Hebert Liesi E LE Rush Institute for Healthy Aging, Chicago, IL, USA. - - 2013
To provide updated estimates of Alzheimer disease (AD) dementia prevalence in the United States from 2010 through 2050. Probabilities of AD dementia incidence were calculated from a longitudinal, population-based study including substantial numbers of both black and white participants. Incidence probabilities for single year of age, race, and level of ...
Marwick Charis - - 2013
ABSTRACT: BACKGROUND: Residents of care homes are at risk of colonisation and infection with antibiotic resistant bacteria, but there is little evidence that antibiotic resistance among such patients is associated with worse outcomes than among older people living in their own homes. Our aim was to compare the prevalence of ...
Sánchez-Jiménez Carmen - - 2013
ABSTRACT: BACKGROUND: T-cell intracellular antigen (TIA) proteins function as regulators of cell homeostasis. These proteins control gene expression globally at multiple levels in response to dynamic regulatory changes and environmental stresses. Herein we identified a micro(mi)RNA signature associated to transiently TIA-depleted HeLa cells and analyzed the potential role of miRNAs ...
Besnard G G CNRS-UPS-ENFA, EDB, UMR 5174, Bât. 4R1, 31062 Toulouse Cedex 9, France. - - 2013
The location and timing of domestication of the olive tree, a key crop in Early Mediterranean societies, remain hotly debated. Here, we unravel the history of wild olives (oleasters), and then infer the primary origins of the domesticated olive. Phylogeography and Bayesian molecular dating analyses based on plastid genome profiling ...
Rosado-Odom V M - - 2013
Initial presentation of invasive fungal infections such as histoplasmosis can include non-specific clinical manifestations, especially in immunocompromised patients. A high index of suspicion is required to identify atypical manifestations of these diseases, which carry a high risk of mortality, if the diagnosis is delayed or missed. We describe a case ...
Murakami Katsuhiko S KS Department of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA. - - 2013
Escherichia coli RNA polymerase (RNAP) is the most studied bacterial RNAP and has been used as the model RNAP for screening and evaluating potential RNAP-targeting antibiotics. However, the x-ray crystal structure of E. coli RNAP has been limited to individual domains. Here, I report the x-ray structure of the E. ...
Hardouin Emilie A EA Max Planck Institute for Evolutionary Biology, Plön, Germany. - - 2013
Island colonizations are excellent models for studying early processes of evolution. We found in a previous study on mice that had colonized the sub-Antarctic Kerguelen Archipelago about 200 years ago that they were derived from a single founder lineage and that this showed an unexpectedly large number of new mutations ...
Klionsky Daniel J - - 2013
These days, when we talk about the origin of a protein, or even a pathway, we are typically referring to evolutionary lineages based on nucleotide sequences. For example, is a particular protein's function conserved? How far back did it first appear? Are there homologs in higher eukaryotes? However, a simpler ...
Khandelwal Puneet P Department of Medicine, University of Pittsburgh, Pittsburgh, PA, - - 2013
Multiple Rabs are associated with secretory granules/vesicles, but how these GTPases are coordinated to promote regulated exocytosis is not well understood. In bladder umbrella cells a subapical pool of discoidal/fusiform-shaped vesicles (DFVs) undergoes Rab11a-dependent regulated exocytosis in response to bladder filling. We show that Rab11a-associated vesicles are enmeshed in an ...
Resnik David B - - 2013
How can we best address the threat posed by dual-use research? By concentrating on the benefits of the knowledge and publishing it anyway? By keeping some of the research secret from the general public, making it available in full only to responsible scientists? Or by not publishing it -- or, ...
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