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Matre Kjell - - 2013
BACKGROUND: Both intramedullary nails and sliding hip screws are used with good results in the treatment of intertrochanteric and subtrochanteric fractures. The aim of our study was to assess whether use of the TRIGEN INTERTAN nail, as compared with a sliding hip screw, resulted in less postoperative pain, improved functional ...
Glas Martin - - 2013
Cellular heterogeneity, e.g. the intratumoral coexistence of cancer cells with and without stem cell characteristics, represents a potential root of therapeutic resistance and a significant challenge for modern drug development in glioblastoma (GBM). We propose here that activation of the innate immune system by stimulation of innate immune receptors involved ...
Goetz Christopher G - - 2013
Numerous scales assess dyskinesia in Parkinson's disease (PD), variably focusing on anatomical distribution, phenomenology, time, severity, and disability. No study has compared these scales and their relative ability to detect change related to an established treatment. We conducted a randomized placebo-controlled trial of amantadine, assessing dyskinesia at baseline and at ...
George James N - - 2013
When a patient presents with unexpected microangiopathic hemolytic anemia and thrombocytopenia, the diagnosis of thrombotic thrombocytopenic purpura (TTP) is often considered. However, many different disorders, including many different systemic infections and malignancies, can cause thrombotic microangiopathy (TMA), with the clinical features of microangiopathic hemolytic anemia and thrombocytopenia. Other etiologies include ...
Ciccone Alfonso - - 2013
In patients with ischemic stroke, endovascular treatment results in a higher rate of recanalization of the affected cerebral artery than systemic intravenous thrombolytic therapy. However, comparison of the clinical efficacy of the two approaches is needed. We randomly assigned 362 patients with acute ischemic stroke, within 4.5 hours after onset, ...
Leonhardt Ralf M - - 2013
PMEL (also called Pmel17 or gp100) is a melanocyte/melanoma-specific glycoprotein that plays a critical role in melanosome development by forming a fibrillar amyloid matrix in the organelle for melanin deposition. Although ultimately not a component of mature fibrils, the PMEL N-terminal region (NTR) is essential for their formation. By mutational ...
Wever Kimberley E - - 2013
BackgroundRenal ischaemia-reperfusion injury (IRI) is a common clinical problem associated with significant mortality and morbidity. One strategy to reduce this damage is remote ischaemic preconditioning (RIPC), in which brief ischaemia of a limb protects the kidney against a prolonged ischaemic insult. The mechanism of renal RIPC has not yet been ...
Thibault Bernard - - 2013
Although the benefits of cardiac resynchronization therapy are well established in selected patients with heart failure and a prolonged QRS duration, salutary effects in patients with narrow QRS complexes remain to be demonstrated. The Evaluation of Resynchronization Therapy for Heart Failure (LESSER-EARTH) trial is a randomized, double-blind, 12-center study that ...
Li Qian - - 2013
Human bocavirus (HBoV), closely related to canine minute virus (MVC) and bovine parvovirus (BPV), is a new member of the Bocavirus genus within the Parvoviridae family. The non-structural protein NP1 of HBoV is a nuclear localized protein and plays important role in DNA replication as well as in the evasion ...
Griffiths Howard - - 2013
Mesophyll conductance, g(m) , representing the transfer of CO(2) from sub-stomatal cavity to chloroplast, is a process comprising ∼20 to ∼50% of photosynthetic limitation (Evans and von Caemmerer, 2013). The need to understand and maximize g(m) has increasingly become apparent (Sharkey, 2012), as one of the three physiological processes classically ...
Crudo Ariann - - 2013
The late-gestation surge in fetal plasma cortisol is critical for maturation of fetal organ systems. As a result, synthetic glucocorticoids (sGCs) are administered to pregnant women at risk of delivering preterm. However, animal studies have shown that fetal exposure to sGC results in increased risk of behavioral, endocrine, and metabolic ...
Lemay Geneviève - - 2013
We conducted a chart review on all patients who had received home telemonitoring after an admission for heart failure at the University of Ottawa Heart Institute. During a 5 year period (2005-2009) a total of 645 patients had home monitoring. A total of 594 patients met the inclusion criteria for ...
Dickinson Brent A - - 2013
AIMS: Recent studies have shown that microRNAs (miRNAs), besides being potent regulators of gene expression, can additionally serve as circulating biomarkers of disease. The aim of this study is to determine if plasma miRNAs can be used as indicators of disease progression or therapeutic efficacy in hypertension-induced heart disease. METHODS ...
Kumar Neeraj - - 2013
We have defined three sets of HLA-DR3(+) haplotypes that provide maximum risk of type 1 disease development in Indians: (1) a diverse array of B8-DR3 haplotypes, (2) A33-B58-DR3 haplotype, and (3) A2-B50-DR3 occurring most predominantly in this population. Further analysis has revealed extensive diversity in B8-DR3 haplotypes, particularly at the ...
Morris Marvin E - - 2013
Meningococcal sepsis and purpura fulminans is a rare but highly lethal disease process that requires a multidisciplinary team of experts to optimise morbidity and mortality outcomes due to the breadth of complications of the disease. The surgical perspective involves the critical care management which utilises all currently available measured outcomes ...
Constable Edwin C - - 2013
We report the synthesis of copper(i) complexes of three ligands which contain a potential P,N,N,P-metal binding site. Elemental analysis confirms that the bulk products possess a composition of [CuL][PF(6)] where L = , or . Electrospray mass spectrometry (ESI MS) provides evidence for speciation in MeCN or MeOH solutions and ...
Qian Xiang-Ying - - 2013
Four new layered silver(I) organoarsonates, namely, [Ag(3)(L(3))(CN)] (1) (H(2)L(3) = (PhAsO(2)H)(2)O), [Ag(3)(L(4))(CN)] (2) (H(2)L(4) = (2-NO(2)-C(6)H(4)-AsO(2)H)(2)O), [Ag(3)(HL(5))(H(2)L(5))] (3) (H(3)L(5) = 3-NO(2)-4-OH-C(6)H(3)-AsO(3)H(2)) and [Ag(2)(HL(5))] (4), were synthesized under solvothermal conditions. During the preparations of 1 and 2, condensation of organoarsonate ligands (H(2)L(1) = Ph-AsO(3)H(2); H(2)L(2) = 2-NO(2)-C(6)H(4)-AsO(3)H(2)) and the decomposition of ...
Bi S S - - 2013
BACKGROUND: /st>Sevoflurane and remifentanil are commonly combined to produce the hypnotic and analgesic effects required for clinical anaesthesia. Previous studies have characterized interactions between several i.v. drugs and inhalation agents. Aiming to extend this effort, we developed two new mathematical models to characterize the interactions manner and strength between sevoflurane ...
Prasad Raju Y - - 2013
The widespread use of titanium dioxide (TiO2) nanoparticles in consumer products increases the probability of exposure to humans and the environment. Although TiO2 nanoparticles have been shown to induce DNA damage (comet assay) and chromosome damage (micronucleus assay, MN) in vitro, no study has systematically assessed the influence of medium ...
Akpinar-Elci Muge - - 2013
BACKGROUND: Water damage in buildings has been associated with reports of upper airway inflammation among occupants. METHODS: This survey included a questionnaire, allergen skin testing, nasal nitric oxide, and nasal lavage on 153 participants. We conducted exposure assessments of 297 workstations and analyzed collected dust for fungi, endotoxin, and (1 → 3)-β-D-glucan ...
Cuspidi Cesare - - 2013
BACKGROUNDLeft atrial enlargement (LAE) is a marker of hypertensive heart disease associated with increased cardiovascular risk. We reviewed recent literature about the prevalence of LAE, as assessed by echocardiography, to update our information about the clinical relevance of this cardiac phenotype in human hypertension.METHODSWe performed a search of MEDLINE using ...
Im Eung-Jun - - 2013
A human immunodeficiency virus type 1 (HIV-1) vaccine that induces potent immune responses in the gastrointestinal mucosa would be highly desirable. Here we show that attenuated recombinant Listeria monocytogenes, administered orally utilizing its natural route of infection, induces potent mucosal as well as systemic immune responses in mice. Moreover, these ...
Teunis Peter P Epidemiology and Surveillance Unit, RIVM, Bilthoven, The Netherlands. - - 2013
Observations on infectious diseases often consist of a sample of cases, distinguished by symptoms, and other characteristics, such as onset dates, spatial locations, genetic sequence of the pathogen and/or physiological and clinical data. Cases are often clustered, in space and time, suggesting that they are connected. By defining kernel functions ...
Crotti Lia L Section of Cardiology, Department of Molecular Medicine, University of Pavia, Pavia, - - 2013
Life-threatening disorders of heart rhythm may arise during infancy and can result in the sudden and tragic death of a child. We performed exome sequencing on 2 unrelated infants presenting with recurrent cardiac arrest to discover a genetic cause. We ascertained 2 unrelated infants (probands) with recurrent cardiac arrest and ...
Kim M - - 2013
BACKGROUND/OBJECTIVE:We aimed to examine the accuracy of segmental multi-frequency bioelectrical impedance analysis (SMF-BIA) for the assessment of whole-body and appendicular fat mass (FM) and lean soft tissue mass (LM) in frail older women, using dual-energy X-ray absorptiometry (DXA) as a reference method.SUBJECTS/METHODS:All 129 community-dwelling Japanese frail older women with a ...
Ordonez Felipe - - 2013
BACKGROUND: Small bowel transplantation has now become a recognized treatment of irreversible, permanent, and subtotal intestinal failure. OBJECTIVE: The aim of this study was to assess intestinal absorption at the time of weaning from parenteral nutrition in a series of children after intestinal transplantation. DESIGN: Twenty-four children (age range: 14-115 ...
Tripathi Shailesh - - 2013
In this article, we focus on the analysis of competitive gene set methods for detecting the statistical significance of pathways from gene expression data. Our main result is to demonstrate that some of the most frequently used gene set methods, GSEA, GSEArot and GAGE, are severely influenced by the filtering ...
Lin A - - 2013
BACKGROUND: Individuals at ultra-high risk (UHR) for psychosis show reduced neurocognitive performance across domains but it is unclear which reductions are associated with transition to frank psychosis. The aim of this study was to investigate differences in baseline neurocognitive performance between UHR participants with (UHR-P) and without transition to psychosis ...
Knopman David S - - 2013
Persons with mild cognitive impairment (MCI) have overt changes in thinking and memory, but they are still largely independent in daily affairs. They have a far higher rate of developing dementia (progressing to a more debilitating state of cognitive impairment) than cognitively normal persons, but at the individual patient level, ...
Korja M - - 2013
Apolipoprotein E plays an important role in neurodegenerative processes in adulthood, whereas its neurodevelopmental role is uncertain. We aimed to study the effect of apolipoprotein E on neurodevelopment in a cohort liable to neurodevelopmental changes. The cohort consisted of very preterm (< 32 gestational weeks) and/or very low birth weight ...
Leyton Cristian E - - 2013
OBJECTIVE: To track cognitive and language changes over time in patients with logopenic (lv-PPA) and semantic (sv-PPA) variants of primary progressive aphasia (PPA). METHODS: Thirteen consecutive patients with lv-PPA and 11 patients with sv-PPA underwent yearly evaluation for a mean of 3 years. Nineteen patients (11 lv-PPA, 8 sv-PPA) had ...
Soyer Philippe - - 2013
Background: Because of an expanded role for CT in the evaluation of patients with acute abdominal pain, it is not rare that acute cholecystitis is depicted by CT. However, the sensitivity and the specificity of a given CT variable for the diagnosis of acute cholecystitis is not known.Purpose: To quantitatively ...
Wada Keiko - - 2013
The effects of soy or isoflavone intake on breast cancer need to be examined further in epidemiologic studies. We assessed the associations of soy and isoflavone intake with breast cancer incidence in a population-based prospective cohort study in Japan. Participants were members from the Takayama study, aged 35 years or ...
Ghulman Motaz Ahmed - - 2013
Purpose: The aim of this study was to evaluate and compare the total color difference (ΔE) between natural teeth and fabricated crowns from three ceramic systems with different thicknesses. Materials and Methods: The color of ninety maxillary central incisors was measured from the middle third of the labial surface with ...
Bhattacharjee Sandipan - - 2013
BACKGROUND: Antidepressant use has been linked to new-onset diabetes. However, the existing literature on this relationship has yielded inconsistent findings. The primary objective of this study was to systematically synthesize the literature on the relationship between antidepressant use and new-onset diabetes using meta-analysis. METHODS: A systematic literature search was conducted ...
Hofmann Heike - - 2013
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel bunyavirus that recently emerged in China. Infection with SFTSV is associated with case-fatality rates of up to 30%, and neither antivirals nor vaccines are available at present. Development of antiviral strategies requires the elucidation of virus-host cell interactions. Here, we ...
Agarwala Prachi - - 2013
Transforming Growth Factor β2 (TGFβ2) is a versatile cytokine with prominent role in cell migration, invasion, cellular development and immunomodulation. TGFβ2 promotes the malignancy of tumors by inducing epithelial-mesenchymal transition (EMT), angiogenesis and immunosuppression. As it is well documented that nucleic acid secondary structure can regulate gene expression, we assessed ...
Marshall Kristin N KN Graduate Degree Program in Ecology, Colorado State University, Fort Collins, CO 80523-1499, USA. - - 2013
Efforts to restore ecosystems often focus on reintroducing apex predators to re-establish coevolved relationships among predators, herbivores and plants. The preponderance of evidence for indirect effects of predators on terrestrial plant communities comes from ecosystems where predators have been removed. Far less is known about the consequences of their restoration. ...
King Kindra K Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, - - 2013
Saccharomyces cerevisiae cells exposed to a variety of physiological stresses transiently delay bud emergence or bud growth. To maintain coordination between bud formation and the cell cycle in such circumstances, the morphogenesis checkpoint delays nuclear division via the mitosis-inhibitory Wee1-family kinase, Swe1p. Swe1p is degraded during G2 in unstressed cells ...
Zimmermann Stefan - - 2013
A 60-year-old patient with aplastic anemia presented with vesicular varicella-like skin lesions on her face, arms, legs, back, and abdomen. However, diagnosis for herpetic infection was negative. Findings of a skin biopsy led to a tentative histologic diagnosis of toxoplasmosis, and infection with Toxoplasma gondii was confirmed by immunohistochemistry and ...
Arruda Brenden C - - 2013
Ultrafast broadband UV-visible transient absorption spectroscopy is used to characterize the photochemistry of α-terpinene, a 1,4-disubstituted-1,3-cyclohexadiene natural product. These results are compared with experiments probing the analogous ring-opening reaction of 7-dehydrocholesterol (DHC, provitamin D(3)) and the subsequent relaxation of previtamin D(3). The major experimental results are as follows: (1) Like ...
Musso G - - 2013
Obstructive sleep apnoea syndrome (OSAS) and non-alcoholic fatty liver disease (NAFLD) are common in clinical practice. NAFLD encompasses simple steatosis and non-alcoholic steatohepatitis (NASH): both confer an increased risk of cardiovascular disease and diabetes; NASH increases also liver-related risk. Growing experimental evidence connects chronic intermittent hypoxia of OSAS to NAFLD. ...
Burney Patrick R - - 2013
Ionic liquids (ILs) and organic chemicals can be used as solvents in biochemical reactions to influence the structural and dynamic features of the enzyme, sometimes detrimentally. In this work we report the results for molecular dynamics simulations of Candida rugosa lipase (CRL) in ILs BMIM-PF6 and BMIM-NO3, as well as ...
Kaczmarek Monika M - - 2013
Introduction of semen into the female reproductive tract may induce molecular and cellular changes facilitating conception and pregnancy. Since prostaglandins (PGs) and appropriate vascularization of the endometrium are crucial for pregnancy success, the effect of seminal plasma (SP) on PGs synthesis and angiogenesis was investigated. Gilts received at estrus 100 ...
Christensen Merrill J - - 2013
BACKGROUND: High dietary intake of soy or selenium (Se) is associated with decreased risk of prostate cancer. Soy constituents and various chemical forms of Se have each been shown to downregulate expression of the androgen receptor (AR) and AR-regulated genes in the prostate. We hypothesized that downregulation of AR and ...
Smith Caroline J CJ Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA. - - 2013
Regional variation in sweating over the human body is widely recognized yet variation in vasomotor responses and mechanisms causing this variation remain unclear. This study aimed to explore the relation between regional sweating rates (RSR) and skin blood flow (SkBF) responses to thermal and pharmacological stimuli in young, healthy subjects. ...
Omar Mohamed Shamun - - 2013
BACKGROUND: Many newly constructed green buildings (GB) are certified using the United States Green Building Council (USGBC) Leadership in Energy and Environmental Design (LEED) rating system for new construction and major renovation which focuses on architectural and mechanical design to conserve energy, reduce environmental harm, and enhance indoor quality for ...
Kang Koung Mi - - 2013
PURPOSE: To investigate the added value of diffusion-weighted imaging (DWI) to magnetic resonance cholangiopancreatography (MRCP) with unenhanced MR imaging for predicting the malignancy or invasiveness of intraductal papillary mucinous neoplasms (IPMNs). MATERIALS AND METHODS: Following Institutional Review Board (IRB) approval, this retrospective study included 52 patients with surgically resected IPMNs ...
Zöttl Markus M Department of Behavioural Ecology, Institute of Ecology and Evolution, University of Bern, 3032 Hinterkappelen, Switzerland. - - 2013
Environmental factors can determine which group size will maximize the fitness of group members. This is particularly important in cooperative breeders, where group members often serve different purposes. Experimental studies are yet lacking to check whether ecologically mediated need for help will change the propensity of dominant group members to ...
Waheed Faiza - - 2013
Transactivation of the Epidermal Growth Factor Receptor (EGFR) by Tumor Necrosis Factor-α (TNF-α) is a key step in mediating RhoA activation, and cytoskeleton and junction remodelling in the tubular epithelium. In this study we explored the mechanisms underlying TNF-α-induced EGFR activation. We show that TNF-α stimulates the TNF-α Convertase Enzyme ...
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