Search Results
Results 551 - 600 of 2969
< 7 8 9 10 11 12 13 14 15 16 17 >
Thuma Florian - - 2013
Pancreatic cancer has a dismal prognosis due to early metastatic spread, a suggested feature of cancer-initiating cells (CIC). To control for a functional contribution of the pancreatic CIC-marker EpCAM, we explored metastasis formation by a stable EpCAM-knockdown (ASML-EpC(kd) ) of the rat pancreatic adenocarcinoma line BSp73ASML (ASML(wt) ). As EpCAM ...
Kumar Manjeet - - 2013
From an endophytic fungus, a close relative of Talaromyces sp., found in association with Cedrus deodara, four compounds including two new ones (2 and 4) were isolated and characterized. The structures of two compounds (1 and 4) were confirmed by X-ray crystallography. The compounds displayed a range of cytotoxicities against ...
Wang Tiantian - - 2013
Water-solubilized quantum dots have led to a promising application in cellular labeling and biological imaging. The physicochemical properties of water-solubilized quantum dots, particularly in a physiological environment, are strongly dependent on their size. In this paper, we systematically studied the stability of mercaptosuccinic acid-coated CdTe quantum dots (MSA-QDs) of about ...
Sayah D M - - 2013
Despite the adoption of antifungal prophylaxis, fungal infections remain a significant concern in lung transplant recipients. Indeed, some concern exists that such prophylaxis may increase the risk of infection with drug-resistant fungal organisms. Here, we describe a case of disseminated Scedosporium prolificans infection, presenting as pericarditis, which developed in a ...
Ljung R - - 2013
Prophylaxis is considered the optimal treatment regimen for patients with severe haemophilia, and may be especially important in the prevention of joint disease. Novel coagulation factor concentrates with prolonged half-lives promise to improve patient treatment by enabling prophylaxis with less frequent dosing. With the call to individualize therapy in haemophilia, ...
Murphy Richard James - - 2013
There is an evolving interest in shoulder ultrasound performed by orthopaedic surgeons as part of routine clinical assessment of the rotator cuff in a so-called one-stop clinic. This study investigated the accuracy of ultrasound assessment of rotator cuff integrity performed by orthopaedic surgeons without prior experience of ultrasound who were ...
Cramer Holger - - 2013
OBJECTIVES: To assess the effects of a 9-week yoga intervention on chronic nonspecific neck pain 12 months after completion. DESIGN: Twelve-month follow-up of the pooled data of both arms of a randomized, controlled trial. SETTING: Department of Internal and Integrative Medicine at an academic teaching hospital. SUBJECTS: Fifty-one patients with ...
Litvinchuk A P - - 2013
Polarized second-order Raman scattering spectra of CuO single crystals are reported. It is shown that for some scattering geometries the second-order processes dominate the inelastic light scattering spectra. Group-theoretical symmetry analysis of the selection rules for the first- and second-order scattering processes is performed and phonon dispersion relations are calculated ...
Ikeda Yasumasa - - 2013
Excess iron causes oxidative stress through hydroxyl-radical production via Fenton/Haber-Weiss reactions. Recently, body iron reduction has been found to ameliorate diabetes. In the present study, we examined the protective effect of dietary iron restriction against diabetic nephropathy in the db/db mouse model of diabetic nephropathy using db/m mice as controls. ...
Dorgan Vincent E - - 2013
We study the intrinsic transport properties of suspended graphene devices at high fields (≥1 V/μm) and high temperatures (≥1000 K). Across 15 samples, we find peak (average) saturation velocity of 3.6×10^7 cm/s (1.7×10^7 cm/s), and peak (average) thermal conductivity of 530 W/m/K (310 W/m/K), at 1000 K. The saturation velocity ...
Rovner Eric - - 2013
AIMS: To evaluate the effect of onabotulinumtoxinA on urodynamic outcomes in patients with urinary incontinence (UI) due to neurogenic detrusor overactivity (NDO). METHODS: Results from two pivotal Phase III trials (n = 691) were pooled. MS or SCI patients with NDO, received intradetrusor onabotulinumtoxinA 200 U (n = 227), 300 U (n = 223), or placebo (n = 241). Change ...
Kotecha Sailesh - - 2013
BACKGROUND: Surfactant protein D (SP-D) is a soluble oligomeric C-type lectin known to protect against lipopolysaccharide and ventilator-induced lung injury in preterm lambs. Here we assess the expression and functional status of SP-D in bronchoalveolar lavage fluid (BALF) from preterm infants at risk of chronic lung disease (CLD) of prematurity ...
Robin Mathew P - - 2013
Dithiomaleimides (DTMs) with alkyl substituents are herein shown to be a novel class of highly emissive fluorophores. Variable solubility, and further functionalization, can be easily tailored through choice of N- and S-substituents. Insertion of the DTM unit into the disulfide bond of salmon calcitonin (sCT), or inclusion into a RAFT ...
Elsaka Shaymaa E - - 2013
Purpose: This study evaluated the effect of etching solution surface treatments on the surface characteristics of titanium and adhesion of titanium/porcelain system by means of strain energy release rate (G-value, J/m(2) ). Materials and Methods: Two hundred and forty five specimens of cp Ti plates were prepared. The specimens were ...
Mack Andrew W - - 2013
Open proximal femoral fractures are rare injuries that often result from wartime high-energy causes. Limited data exist regarding the treatment and complications of these injuries. We retrospectively reviewed the records of combat casualties treated at two institutions between March 2003 and March 2008. The casualty patient databases, medical records, radiographs, ...
Ma Yingyu - - 2013
Epidemiological data suggest an important role of vitamin D signaling in cancer development and progression, and experimental studies demonstrate that the active vitamin D metabolite 1α, 25-dihydroxyvitamin D 3 (1,25D 3) has broad spectrum antitumor activity. Hypercalcemia has often been suggested to limit the clinical application of these data. The ...
Garmendia Maria L - - 2013
OBJECTIVE: In post-transitional countries, obesity disproportionally affects women. Longitudinal studies can detect high-risk groups in whom to target actions. We investigated the magnitude and velocity of BMI changes in Chilean women of reproductive age and evaluated whether these trends vary in specific groups. DESIGN: Longitudinal study. We measured weight and ...
Orton Trent H - - 2013
ABSTRACT: BACKGROUND: The purpose of this study is to evaluate the relationship between American College of Radiology (ACR) in-training examination scores and performance on the Royal College of Physicians and Surgeons of Canada (RCPSC) radiology licensing examination. METHODS: Percentile ACR examination scores for 67 residents were obtained from 1995 to ...
Wang Hongwei - - 2013
The MTT (3-(4,5-dimethyl-2-thiazol)-2,5-diphenyl-2H-tetrazolium bromide) reduction method is widely used for measuring cell viability and proliferation. However, when MTT was used to study cells on silicon nanowire arrays (SiNWAs), the measured viability was much higher than normal values, resulting in a misleading estimate of cell viability. Our results demonstrated that the ...
Lee Chih-Ting - - 2013
Although simple renal cysts are thought to be related to hypertension, no reports have examined the relationship between simple renal cysts and prehypertension. Here, we evaluated the effects of simple renal cysts on prehypertension and hypertension and the role of serum renin levels in the cyst-related prehypertension/hypertension in adults. A ...
Prestia Annapaola - - 2013
OBJECTIVES: The current model of Alzheimer disease (AD) stipulates that brain amyloidosis biomarkers turn abnormal earliest, followed by cortical hypometabolism, and finally brain atrophy ones. The aim of this study is to provide clinical evidence of the model in patients with mild cognitive impairment (MCI). METHODS: A total of 73 ...
Annesi James J - - 2013
Results from behavioral treatments for obesity have been disappointing due to an inability to sustain healthy eating. The concurrent use of theory, research, and practical application has the potential of reducing overeating through innovative treatments. When overweight individuals begin an exercise program their eating tends to improve, however, the basis ...
Müller Arne C - - 2013
MOTIVATION: Flux variability analysis (FVA) is an important tool to further analyze the results obtained by flux balance analysis (FBA) on genome-scale metabolic networks. For many constraint-based models FVA identifies unboundedness of the optimal flux space. This reveals that optimal flux solutions with net flux through internal biochemical loops are ...
Ali Nicholas - - 2013
The central tenet of this study was to develop, validate and apply various individualised 3D musculoskeletal models of the human body for application to single-leg landings over increasing vertical heights and horizontal distances. While contributing to an understanding of whether gender differences explain the higher rate of non-contact anterior cruciate ...
Abele Travis A - - 2013
PURPOSE: To evaluate bSSFP (balanced steady state free precession) and half-Fourier RARE (rapid acceleration with relaxation enhancement) MRI sequences in their ability to demonstrate fetal anatomic landmarks, quantify the degree of cerebellar herniation in Chiari II malformations and level and length of the associated open neural tube defects, as well ...
Huang John - - 2013
Expression of T antigen (Galbeta1, 3GalNAc) is associated with enhanced metastatic potential and poor prognosis in colorectal cancer. Cosmc is a molecular chaperone required for the formation of an active T-synthase, which catalyzes the synthesis of T antigen. However, the expression and role of Cosmc in colorectal cancer are still ...
Vollman Andrew T - - 2013
This study reports cerebral angiographic findings observed after stent retriever thrombectomy that is suggestive of a higher risk of hemorrhagic transformation (HT). A woman aged 65-75 presented with a right middle cerebral artery syndrome confirmed by non-contrast CT brain scan. Endovascular revascularization using the Solitaire device was placed across the ...
Peddibhotla Swetha S D - - 2013
Junctional Adhesion Molecule-A (JAM-A) is a member of the immunoglobulin family with diverse functions in epithelial cells, including cell migration, cell contact maturation and tight junction formation. In endothelial cells, JAM-A has been implicated in bFGF-regulated angiogenesis through incompletely understood mechanisms. Here, we identify tetraspanin CD9 as novel binding partner ...
Ahi Yadvinder S - - 2013
Adenovirus (AdV) is thought to follow a sequential assembly pathway similar to that observed in dsDNA bacteriophages and herpesviruses. First, empty capsids are assembled, and then, the genome is packaged through a ring-like structure, referred to as a portal, located at a unique vertex. In human AdV serotype 5 (HAdV5), ...
Faustino Lucas - - 2013
We have previously shown that regulatory T (Treg) cells that accumulate in the airways of allergic mice upregulate CC-chemokine receptor 4 (CCR4) expression. These Treg cells suppressed in vitro Th2 cell proliferation but not type 2 cytokine production. In the current study, using a well-established murine model of allergic lung ...
Jelic Vesna - - 2013
Previous findings demonstrated an altered pattern of amyloid-β protein precursor (AβPP) expression in platelets of Alzheimer's disease (AD) patients compared with either healthy control subjects or patients with non-Alzheimer-type dementia. In an attempt to explore the diagnostic potential of platelet AβPP metabolism, we have generated monoclonal antibodies directed to the ...
Kashani Kianoush - - 2013
ABSTRACT: INTRODUCTION: Acute kidney injury (AKI) can evolve quickly and clinical measures of function often fail to detect AKI at a time when interventions are likely to provide benefit. Identifying early markers of kidney damage has been difficult due to the complex nature of human AKI, in which multiple etiologies ...
Sadowsky Steven J - - 2013
Evidence-based criteria for differential implant planning for the partially edentulous patient have been lacking despite the exponential use of implant reconstructions. Anecdotal reports are often the basis for training of dental students and the continuing education of dentists and specialists. Decision-making metrics for optimal dental treatment are best predicated on ...
Bazzicalupi Carla - - 2013
The second-generation poly(ethylene imine) dendrimer (L), based on ammonia as the initiating core molecule, forms stable metal complexes in aqueous solution. Speciation of the complex species formed and determination of the relevant stability constants were performed by means of potentiometric titration in 0.10 M NMe(4)Cl solution at 298.1 K. The ...
Tashiro Sanki - - 2013
Facultative heterochromatin is reversibly established and disrupted during differentiation, but its regulation remains mechanistically unclear. Here, we show that two meiotic gene loci in fission yeast, mei4 and ssm4, comprise facultative heterochromatin that is regulated in a developmental stage-dependent manner. This heterochromatin coordinates expression levels by associating with a chromodomain ...
Sheng Liming - - 2013
Previous studies found that the ABO blood type alters the individual susceptibility of some malignancies. However, whether such an association exists between ABO blood type and nasopharyngeal carcinoma (NPC) remains unknown. A case-control study was conducted, with 1538 patients who had NPC and 1260 cancer-free controls. The association between ABO ...
Chan Tak Kwong - - 2013
Adults without the capacity to make their own medical decisions have their rights protected under the Mental Capacity Act (2005) in the UK. The underlying principle of the court's decisions is the best interests test, and the evaluation of best interests is a welfare appraisal. Although the House of Lords ...
Moreira Nuno Canto - - 2013
Objective :  To evaluate the ability of brain-targeted magnetic resonance imaging (MRI) to assess the anatomy of the fetal upper lip and palate. Design :  Two independent readers made a blind retrospective review of 60 brain-targeted MRIs of fetuses from 20 to 38 gestational weeks (GW). Fifty-five MRIs were normal ...
Hood R Lyle - - 2013
BACKGROUND AND OBJECTIVES: The fiberoptic microneedle device (FMD) seeks to leverage advantages of both laser-induced thermal therapy (LITT) and convection-enhanced delivery (CED) to increase volumetric dispersal of locally infused chemotherapeutics through sub-lethal photothermal heat generation. This study focused on determination of photothermal damage thresholds with 1,064 nm light delivered through the ...
Demir Mehmet - - 2013
Non-dipper hypertension is associated with increased cardiovascular morbidity and mortality. Neutrophil/lymphocyte ratio (NLR) has been associated with poor outcomes in patients with cardiovascular diseases. However, little is known about the role of NLR in patients with non-dipper hypertension. In this study, NLR between dipper and non-dipper hypertensive patients was compared.This ...
- - 2013
The Underside of the Silver Tsunami - Older Adults and Mental Health Care Perspective, N Engl J Med 2013;368:493-496. In the penultimate paragraph (page 496), the first sentence should have read, "We believe that steps should be taken to mandate the inclusion of older adults in federally funded research unless ...
Della Marca Giacomo - - 2013
OBJECTIVE: To measure the presence of the alpha-sleep anomaly in facioscapulohumeral muscular dystrophy (FSHD) and to evaluate the association between the sleep electroencephalogram (EEG) pattern and the presence of musculoskeletal pain. DESIGN: Cross-sectional study. SETTING: Sleep laboratory. SUBJECTS: Fifty-five consecutive adult FSHD patients, 26 women and 29 men, age 49.6 ± 15.1 ...
Sahoo Prativa - - 2013
PURPOSE: To modify the generalized tracer kinetic model (GTKM) by introducing an additional tissue uptake leakage compartment in extracellular extravascular space (LTKM). In addition, an implicit determination of voxel-wise local arterial input function (AIF) C(p) (t) was performed to see whether these changes help in better discrimination between low- and ...
Jereb Marjan - - 2013
Iodine was demonstrated to be an efficient catalyst for disproportionation of aryl-substituted ethers under solvent-free reaction conditions. Variously substituted 1,1,1',1'-tetraaryldimethyl ethers were transformed into the corresponding diarylketone and diarylmethane derivatives. I(2)-catalyzed transformation of 4-methoxyphenyl substituted ethers yielded mono- and dialkylated Friedel-Crafts products as well. Treatment of trityl alkyl and trityl ...
King Albert W - - 2013
The complex [Ru(bpy)(2)(bpSO)](PF(6))(2), where bpy is 2,2'-bipydine and bpSO is 1,2-bis(phenylsulfinyl)ethane, exhibits three distinct isomers which are accessible upon metal-to-ligand charge-transfer (MLCT) irradiation. This complex and its parent, [Ru(bpy)(2)(bpte)](PF(6))(2), where bpte is 1,2-bis(phenylthio)ethane, have been synthesized and characterized by UV-visible spectroscopy, NMR, X-ray crystallography, and femtosecond transient absorption spectroscopy. A ...
Paanalahti Markku - - 2013
Objective: The aims of this study were to explore the perspective of functioning in community-dwelling people with prior stroke and to confirm, if possible, the Comprehensive International Classification of Functioning, Disability and Health (ICF) Comprehensive Core Set for stroke. Methods: Qualitative interviews were analysed (using the content analysis method and ...
Polychronakis Nick - - 2013
Purpose: This survey was conducted to study the prevalence of partial edentulism, the type of removable partial denture (RPD) support, the type of major connectors, and the frequency of their use in relation to the partial edentulism classes encountered, concerning patients in Athens, Greece. Materials and Methods: The material comprised ...
Cui B - - 2013
We demonstrate that the uniaxial magnetic anisotropy (UMA) of amorphous CoFeB films can be tuned by crystallinity and orbital moment ratio, combining the results of magnetization reversal and ferromagnetic resonance with high-resolution transmission electron microscopy, x-ray-absorption near-edge structure and x-ray magnetic circular dichroism. Isotropic polycrystalline buffers of tungsten (W), tantalum ...
Pompach Petr - - 2013
Haptoglobin is a liver secreted glycoprotein with four N-glycosylation sites. Its glycosylation was reported to change in several cancer diseases which prompted us to examine site specific glycoforms of haptoglobin in liver cirrhosis and hepatocellular carcinoma. To this end, we have used two dimensional separation composed of hydrophilic interaction and ...
Zaidel Jacob - - 2013
Known analytical solutions of groundwater flow equations are routinely used for verification of computer codes. However, these analytical solutions (e.g., the Dupuit solution for the steady-state unconfined unidirectional flow in a uniform aquifer with a flat bottom) represent smooth and continuous water table configurations, simulating which does not pose any ...
< 7 8 9 10 11 12 13 14 15 16 17 >