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Tallus Jussi J Department of Psychology, Centre for Cognitive Neuroscience, University of Turku, Turku, Finland. - - 2013
Mild traumatic brain injury (mTBI) may cause diffuse damage to the brain, especially to the frontal areas, that may lead to persistent symptoms. We studied participants with past mTBI by means of navigated transcranial magnetic stimulation (nTMS) combined with electroencephalography (EEG). Eleven symptomatic and 8 recovered participants with a history ...
Vivier Pierre-Hugues PH NYU Langone Medical Center, Department of Radiology, New York, NY, USA. - - 2013
The aim of this study was to assess the impact of oral water and intravenous furosemide challenges on blood oxygenation level-dependent magnetic resonance imaging measurements in the kidney and to examine the contribution of R2 (=1/T2) to changes in R2* (=1/T2*). This Health Insurance Portability and Accountability Act-compliant study had ...
Langat Agnes A Department of Paediatrics and Child Health, University of Nairobi, Nairobi, - - 2013
Early highly active antiretroviral therapy (HAART) is recommended for HIV-1-infected infants. There are limited data on lipid changes during infant HAART. Nonfasting total (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol and triglycerides (TG) were measured at 0, 6 and 12 months. Correlates of lipid levels and ...
Taylor Anna N AN Department of Neurobiology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Box 951763, Los Angeles, CA 90095-1763, USA. - - 2013
We previously reported that traumatic brain injury (TBI) produced by moderate controlled cortical impact (CCI) attenuates the stress response of the hypothalamic-pituitary-adrenal (HPA) axis between 21 and 70 days postinjury and enhances the sensitivity of the stress response to glucocorticoid negative feedback. In the current study, we investigated two possible ...
Turner Russell T RT Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA. - - 2013
Estrogen deficiency after menopause results in rapid bone loss, predisposing women to osteoporotic fractures. Genistein, a phytoestrogen present in high concentrations in soy, is an ingredient in dietary supplements aggressively marketed for bone health. However, in a recent long-duration clinical trial in postmenopausal women, the efficacy of soy extracts in ...
Almoosawi Suzana S Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK. - - 2013
The role of circadian rhythm of energy and macronutrient intake in influencing cardiometabolic risk factors is increasingly recognized. However, little is known of the association between time of energy intake and blood pressure. We examined the association between time-of-day of energy intake and subsequent hypertension and change in blood pressure. ...
Lee Jeffrey H JH Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, MA, - - 2013
Fat grafting has become routine in plastic surgery because of low donor-site morbidity, a low complication rate, and fast recovery time. The optimal technique, however, has yet to be defined. Two critical variables are pressure and shear, both defined as force divided by area. In this study, the authors examined ...
Weichman Katie E KE Department of Plastic Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, - - 2013
Prior breast irradiation increases the rate of postoperative complications, including capsular contracture, in tissue expander/implant reconstruction. Acellular dermal matrix is heralded to decrease capsular contracture, but recent evidence suggests a possible increase in postoperative complications. The authors evaluated outcomes in patients undergoing bilateral tissue expander/implant reconstruction with acellular dermal matrix ...
Kasahara Yasuhiko Y Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Kita-Ku, Sapporo, - - 2013
There is limited information regarding the cause of revision TKA in Asia, especially Japan. Owing to differences in patient backgrounds and lifestyles, the modes of TKA failures in Asia may differ from those in Western countries. We therefore determined (1) causes of revision TKA in a cohort of Japanese patients ...
Amberg Gregory C GC Vascular Physiology Research Group, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA. - - 2013
Smooth muscle cells are ultimately responsible for determining vascular luminal diameter and blood flow. Dynamic changes in intracellular calcium are a critical mechanism regulating vascular smooth muscle contractility. Processes influencing intracellular calcium are therefore important regulators of vascular function with physiological and pathophysiological consequences. In this review we discuss the ...
Huang Jiaoti J Departments of Pathology and Urology, Jonsson Comprehensive Cancer Center and Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1732, USA. - - 2013
This article reviews recently identified genomic mutations in prostate cancer. Advanced sequencing technologies have made it possible to obtain large amounts of data on genomes and transcriptomes of cancers. Such technologies have been used to sequence prostate cancer of different stages, from treatment-naive cancers, to advanced, castration-resistant cancers to the ...
Frank Tino T ETH Zurich, Department of Biosystems Science and Engineering, Mattenstrasse 26, 4058 Basel, - - 2013
An automated microfluidic cell culture platform that creates and maintains independently programmable diffusion-based gradients is reported. Temporal modulation of the source and sink flow patterns allow generation of extremely stable spatial gradients. We developed a system that integrates 30 parallel gradients in a single device, with 10 different chemical formulations ...
Perez Alejandro - - 2013
Many pharmacologic options are available for prevention and treatment of venous thromboembolism (VTE). The anticoagulant selected may vary according the individual patient situation such as the acute versus chronic setting, renal function and indication for either VTE prevention or treatment. Established methods of pharmacologic prophylaxis agents include heparinoids, injectable anti-Xa ...
Skrobik Yoanna - - 2013
Delirium and sedative-induced coma are described as incremental manifestations of cerebral dysfunction. Both may be associated with sedative or opiate doses and pharmacokinetic or pharmacogenetic variables, such as drug plasma levels (exposure), drug metabolism, and/or their transport across the blood-brain barrier. To compare biological and drug treatment characteristics in patients ...
Patel Bhakti K BK Department of Pulmonary/Critical Care, University of Chicago Medical Center, Chicago, Illinois, - - 2013
Physiotherapy in the perioperative period is emerging as an important component of postoperative recovery. This review highlights recent advances in the implementation of physiotherapy in the perioperative period and its enhancement of postsurgical outcomes. Physical therapy in the preoperative period can improve physical deconditioning and potentially affect subsequent postsurgical outcomes. ...
Acosta Colleen D CD National Perinatal Epidemiology Unit, University of Oxford, UK. - - 2013
Despite global progress towards reducing maternal mortality, sepsis remains a leading cause of preventable maternal death. This review focuses on current measurement challenges, trends, causes and efforts to curb maternal death from sepsis in high and low-income countries. Under-reporting using routine registration data, compounded by misclassification and unreported deaths, results ...
Luebke Justin L JL Department of Chemistry, Indiana University, Bloomington, IN 47405-7102, - - 2013
Staphylococcus aureus CstR (CsoR-like sulfur transferase repressor) is a member of the CsoR family of transition metal sensing metalloregulatory proteins. Unlike CsoR, CstR does not form a stable complex with transition metals but instead reacts with sulfite to form a mixture of di- and trisulfide species, CstR2(RS-SR') and CstR2(RS-S-SR')n)n=1 or ...
El-Hattab Ayman W AW Division of Medical Genetics, Department of Pediatrics, The Children's Hospital, King Fahad Medical City and Faculty of Medicine, King Saud bin Abdulaziz University for Health Science, Riyadh, Kingdom of Saudi - - 2013
Mitochondrial DNA (mtDNA) depletion syndromes (MDS) are a genetically and clinically heterogeneous group of autosomal recessive disorders that are characterized by a severe reduction in mtDNA content leading to impaired energy production in affected tissues and organs. MDS are due to defects in mtDNA maintenance caused by mutations in nuclear ...
Hueper Katja K Johns Hopkins University, Baltimore, MD, - - 2013
The aim of this study was to evaluate the quantitative and semiquantitative measures of regional pulmonary parenchymal perfusion in patients with chronic obstructive pulmonary disease (COPD) in relationship to global lung perfusion (GLP) and lung diffusing capacity (DLCO). A total of 143 participants in the Multiethnic Study of Atherosclerosis COPD ...
Gwinner Frederik F Department of Genomes and Genetics, Systems Biology Laboratory, Institut Pasteur, Paris, - - 2013
In this study, we developed a novel computational approach based on protein-protein interaction networks to identify a list of proteins that might have remained undetected in differential proteomic profiling experiments. We tested our computational approach on two sets of human smooth muscle cell protein extracts that were affected differently by ...
Diringer Michael N MN Neurocritical Care Section, Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA. - - 2013
To discuss trends in the use of osmotic therapy. Use of osmotic therapy has evolved from bolus administration of mannitol to routine use of hypertonic saline as a bolus as well as in continuous infusions to creating a sustained hyperosmolar state.In a survey of neurointensivists 55% favored hypertonic saline over ...
Mayaud Louis L Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom. - - 2013
To determine if a prediction rule for hospital mortality using dynamic variables in response to treatment of hypotension in patients with sepsis performs better than current models. Retrospective cohort study. All ICUs at a tertiary care hospital. Adult patients admitted to ICUs between 2001 and 2007 of whom 2,113 met ...
Beigelman Avraham A Department of Pediatrics, Washington University and St. Louis Children's Hospital, St. Louis, Missouri, - - 2013
PROPOSE OF REVIEW: Cumulative evidence suggest that early life bronchiolitis is a major risk factor for subsequent wheezing episodes and asthma. The purpose of this review is to present the recent findings and current perspectives regarding the interplay between bronchiolitis and long-term respiratory outcomes. Recent studies have supported the long-recognized ...
Gilbert Kimberly K Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee, - - 2013
Peroxisome proliferator-activated receptor α agonists reduce blood pressure in rodents, but clinical trials provide conflicting data regarding their effects in humans. We tested the hypothesis that the effect of fenofibrate on blood pressure depends on salt sensitivity. Thirty-one hypertensive volunteers (17 salt-resistant, 14 salt-sensitive) completed a randomized, crossover, double-blind protocol ...
Whittaker Stacey-Ann SA School of Medicine, University of Pennsylvania, Pulmonary, Allergy, and Critical Care Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, - - 2013
The epidemiology of severe sepsis is derived from administrative databases that rely on International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes to select cases. We compared the sensitivity of two code abstraction methods in identifying severe sepsis cases using a severe sepsis registry. Single-center retrospective cohort study. Tertiary ...
Brugman Martijn H MH Institute of Experimental Hematology, Hannover Medical School, Hannover, - - 2013
Retroviral gene transfer has proven therapeutic potential in clinical gene therapy trials but may also cause abnormal cell growth via perturbation of gene expression in the locus surrounding the insertion site. By establishing clonal marks, retroviral insertions are also used to describe the regenerative potential of individual cells. Deep sequencing ...
- - 2013
Natural bond orbital lone pairs and antibonds participating in hydrogen bonds between biotin (magenta sticks) and the avidin binding pocket within the entire 8006-atom protein structure are treated quantum mechanically using linear-scaling density functional theory, as presented by Louis P. Lee, Daniel J. Cole, Mike C. Payne, and Chris-Kriton Skylaris ...
- - 2013
The cover shows how the segregation of atoms to the surface of the binary rare-gas cluster varies with both the atomic size ratio (vertical arrow, σ(BB) /σ(AA) ) and the relative strength of the pair interactions (horizontal arrow, ϵ(BB) /ϵ(AA) ); σ(BB) /σ(AA) = 1.0, 1.02, 1.04, 1.06, and 1.08, ...
Spencer Charles T CT Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA. - - 2013
It is generally assumed that the MHC class I antigen (Ag)-processing (CAP) machinery - which supplies peptides for presentation by class I molecules - plays no role in class II-restricted presentation of cytoplasmic Ags. In striking contrast to this assumption, we previously reported that proteasome inhibition, TAP deficiency or ERAAP ...
Liu Hongtao - - 2013
Hematopoietic stem cell transplantation (SCT) can be curative for myeloid malignancies such as acute myeloid leukemia (AML). Advancements in human leukocyte antigen (HLA) typing and supportive care have improved the risk-benefit ratio for SCT, expanding its indications. Allogeneic SCT is an established treatment for AML with intermediate-risk and high-risk cytogenetics ...
Billmeier Sarah E - - 2013
: To assess factors associated with nursing home admission, severe functional impairment, or death 1 year after surgery for stage I-IIIa non-small cell lung cancer. : Patients perceive long-term disability to be one of the most undesirable complications of lung cancer treatment. : A multiregional cohort was surveyed 12 months ...
Guerette Rob T - - 2013
ABSTRACT. Objective: Research in the area of bystander intervention in the prevention of alcohol-impaired driving (AID) has mostly focused on the influence of existing factors (such as status or relationships) on the likelihood of intervening and has relied mostly on samples of college-age students. It remains unknown whether exposure to ...
Singer Pierre - - 2013
Recent studies on the optimal modalities to feed patients during the ICU stay show divergent results. The level and the timing of energy provision is a critical issue, associated with the clinical outcome. These results questioned the clinical relevance of the recent guidelines issued by American, Canadian and European academic ...
Rawat Anoop - - 2013
The SH4 domain of Src family of nonreceptor protein tyrosine kinases represents the extreme N-terminal 1-16 amino acid region which mediates membrane association of these proteins and facilitates their functions. The SH4 domains among Src members lack well-defined sequence consensus and vary in the net charge. However, they readily anchor ...
Kumari Priyanka - - 2013
In India, as in other parts of the world, nonsyndromic cleft lip with or without cleft palate (NSCL +/- P) is a highly prevalent birth defect, its incidence in males being twice that in females. A case-control association study has been carried out with respect to homocysteine level and MTHFR ...
Pollard Peter C - - 2013
Seagrass ecosystems provide unique coastal habitats critical to the life cycle of many species. Seagrasses are a major store of organic carbon. While seagrasses are globally threatened and in decline, in Cairns Harbour, Queensland, on the tropical east coast of Australia, they have flourished. We assessed seagrass distribution in Cairns ...
Monickaraj Finny - - 2013
Telomere shortening is emerging as a biological indicator of accelerated aging and aging-related diseases including type 2 diabetes. While telomere length measurements were largely done in white blood cells, there is lack of studies on telomere length in relation to oxidative stress in target tissues affected in diabetes. Therefore, the ...
Brunet Salut - - 2013
Patients with acute myeloid leukemia (AML) traditionally classified as having an intermediate cytogenetic risk [mostly cytogenetically normal AML (CN-AML)] really include a significant proportion of cases with a poor outcome. This is based on the molecular findings at diagnosis, mainly the presence of internal tandem duplication in the FMS-like tyrosine ...
Barua Anurup Gohain - - 2013
Continuous light could be produced from the firefly by making it inhale vapours of ethyl acetate. Here we perform such a control experiment on the Indian species of the firefly Luciola praeusta Kiesenwetter 1874 (Coleoptera : Lampyridae : Luciolinae), and analyse the light in the microsecond time scale. The amplitude ...
Noel Pierre - - 2013
In 2012, idiopathic hypereosinophilic syndrome (HES) is still the prevalent diagnosis in patients with persistent eosinophilia, in which a primary or secondary cause of eosinophilia has not been identified. HES is considered a provisional diagnosis until a primary or secondary cause of hypereosinophilia is established. The discovery of imatinib-sensitive fusion ...
Abid Shadaan - - 2013
The Y-chromosome-encoded gene RBMY (RNA-binding motif on Y) is a male germline RNA-binding protein and is postulated to be a RNA-splicing regulator. In order to understand the roles of RBMY in different stages of male gamete maturation, the present study aimed at determining its cellular expression during spermatogenesis, spermeogenesis and ...
Galanter Marc - - 2013
ABSTRACT. Objective: Narcotics Anonymous (NA) is an abstinence-based fellowship with more than 58,000 groups worldwide. There has, however, been little research reported on its members. This study was designed to clarify the nature of the participants in NA who are primarily abstinent, long-term members. Method: A protocol was implemented to ...
Radakovic Milena - - 2013
Amitraz is formamidine pesticide widely used as insecticide and acaricide. In veterinary medicine, amitraz has important uses against ticks, mites and lice on animals. Also, amitraz is used in apiculture to control Varroa destructor. It this study, the alkaline Comet assay was used to evaluate DNA damaging effects of amitraz ...
Goldstein Abby L - - 2013
ABSTRACT. Objective: The purpose of this study was to examine the relationship between childhood maltreatment and alcohol use disorders (AUDs), treatment utilization, and barriers to treatment in a national sample of emerging adults. Multiple types of maltreatment were examined, including childhood emotional abuse and neglect. Method: The analyses are based ...
Kavas Aysegul - - 2013
The aim of this study was to investigate the effects of Raloxifene (Ral) on degeneration-related changes in osteoarthritis (OA)-like chondrocytes using two- and three-dimensional models. Five-azacytidine (Aza-C) was used to induce OA-like alterations in rat articular chondrocytes and the model was verified at molecular and macrolevels. Chondrocytes were treated with ...
Frutos Ma Dolores - - 2013
: The use of single-incision laparoscopic surgery may represent an improvement over conventional laparoscopic surgery. In recent years, more and more articles have been published demonstrating the feasibility of this approach. Hence, for this reason, we present this randomized prospective study to compare the 2 techniques. : Between September 2009 ...
Hayden Jacob - - 2013
Vacuolar protein sorting 1 (Vps1), the yeast homolog to human dynamin, is a GTP hydrolyzing protein, which plays an important role in protein sorting and targeting between the Golgi and late endosomal compartments. In this study, we assessed the functional significance of Vps1 in the membrane traffic towards the vacuole. ...
Silasi Michelle - - 2013
A role for microbial invasion leading to inflammation in the amniotic cavity and subsequent pre-term delivery has been well established. For years, the role of viral infections in pregnancy has been minimized and thought of as harmless, with a few exceptions. Recent evidence now encourages us to expand our thinking ...
Kubal Timothy - - 2013
Acute myeloid leukemia (AML) is a devastating disease, in which the majority of afflicted patients eventually experience relapse and die from their disease. Clinical and molecular characterization of the disease have greatly aided in prognostication in both primary and relapsed settings, which may broadly guide therapy, but truly effective standards ...
Silvestri Mark M - - 2013
ABSTRACT. Objective: Drinking games contribute to heavy drinking on college campuses because the rules often result in rapid alcohol consumption and increased risk of negative consequences. The current study used the Simulated Drinking Game Procedure (SDGP) to observe and describe drinking game behavior under controlled laboratory conditions. Method: Participants (N ...
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