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Results 351 - 400 of 2956
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Shishido Seiichiro - - 2013
BACKGROUND: Recurrence of focal segmental glomerulosclerosis (FSGS) in pediatric kidney allografts is associated with poor graft survival. Several therapeutic regimens have been proposed, with conflicting results. METHODS: Ten pediatric patients with recurrent FSGS after kidney transplantation were treated with a protocol of methylprednisolone (MP) infusions in combination with cyclosporine (CsA)-based ...
Liese Juliane - - 2013
INTRODUCTION: Total splenectomy leads to an immunocompromised state, with an increased lifetime risk of infection. The lifetime risk of developing overwhelming postsplenectomy infection is 5 %, with a mortality rate of approximately 50 %. In addition to vaccination and antibiotic prophylaxis, partial splenectomy is believed to improve patient safety. METHODS: We performed ...
Palm Frederick - - 2013
Data on seasonal differences in stroke incidence are conflicting. Little is known about seasonal variability in etiological stroke subtypes and population-based data on possible trigger factors are lacking. The Ludwigshafen Stroke Study is a prospective population-based stroke registry. All residents of the city of Ludwigshafen who suffer from acute stroke ...
Atias Nir - - 2013
Large scale screening experiments have become the workhorse of molecular biology, producing data at an ever increasing scale. The interpretation of such data, particularly in the context of a protein interaction network, has the potential to shed light on the molecular pathways underlying the phenotype or the process in question. ...
Yu Changlin - - 2013
Noble metal/semiconductor nanocomposites play an important role in high efficient photocatalysis. Herein, we demonstrate a facile strategy for fabrication of hollow Pt-ZnO nanocomposite microspheres with hierarchical structure under mild solvothermal conditions using Zn (CH(3)COO)(2)·2H(2)O and HPtCl(4) as the precursors, and polyethylene glycol-6000 (PEG-6000) and ethylene glycol as the reducing agent ...
Skupski Daniel W - - 2013
OBJECTIVE: The aim of this study was to develop a simple clinical algorithm for prediction of donor and recipient death using 'yes'or 'no' questions through the process of recursive partitioning for patients undergoing laser therapy for twin to twin transfusion syndrome (TTTS). The intent was to identify a subset of ...
Fang Changxun - - 2013
Gene expression of phenylalanine ammonia-lyase (PAL) in allelopathic rice PI312777 was inhibited by RNA interference (RNAi). Transgenic rice showed lower levels of PAL gene expression and PAL activity than wild type rice (WT). The concentrations of phenolic compounds were lower in the root tissues and root exudates of transgenic rice ...
Chen Song - - 2013
Free-standing, micropatterned silica nanotube membranes are in situ fabricated using a micropatterned silica-coated collagen hybrid hydrogel as template. They are substrate-free, and not only maintained their micropatterned microstructure well, but also exhibited strong cell contact guidance ability to direct cell alignment and differentiation, indicating their good potential for biomedical applications.
Romanenko Lyudmila A - - 2013
The aim of this study was to survey microorganisms from the deep surface sediment samples collected from the Sea of Japan and to screen them for antimicrobial and antagonistic effects. Phylogenetic analysis revealed most isolates sharing 98-100 % sequence similarity to recognized species, including those recovered previously from marine or saline ...
Munck Dorete Frydshou - - 2013
We would like to report the rare occurrence of a pregnancy in a non-communicating rudimentary uterine horn in an obese woman which evaded diagnosis, ruptured, and resulted in major intra-abdominal hemorrhage. A nulliparous woman, with a BMI of 36, presented at 21-weeks gestation with a history of abdominal pain. Prior ...
Klabbers Gonnie - - 2013
Considering many psychosocial health risk factors are interrelated, determining psychosocial health risk might benefit from a more person-centered perspective. This paper explores to what extent a psychosocial profile that combines potentially synergistic effects of different psychosocial characteristics, including psychological attributes and functioning, coping styles and social support, predicts self-rated health, ...
Wadley Glenn D - - 2013
It is clear that at pathologically high chronic levels reactive oxygen species (ROS) are cytotoxic. However, it is also now clear that during contraction ROS are produced at low (physiological) levels and play an important role in cell signalling in normal healthy skeletal muscle (reviewed in (Powers and Jackson, 2008)). ...
Fariña Juan Pablo - - 2013
We tested the effect of OS (oxidative stress) inhibition in rats fed with an FRD (fructose-rich diet; 10% w/v in drinking water) for 3 weeks. Normal adult male rats received a standard CD (commercial diet) or an FRD without or with an inhibitor of NADPH-oxidase, APO (apocynin; 5 mM in ...
Shen Li-Hua - - 2013
We report that ultra-small, monodisperse, water-dispersible magnetite (Fe(3)O(4)) nanoparticles can be synthesized by a facile one-pot approach using trisodium citrate as crystal grain growth inhibitor and stabilizer in polyol solution. The resultant Fe(3)O(4) nanoparticles exhibit an excellent long-term colloidal stability in various buffer solutions without any modification. They are also ...
Baines Katherine J - - 2013
ABSTRACT: BACKGROUND: Rhinovirus (RV) is a major cause of chronic obstructive pulmonary disease (COPD) exacerbations, and primarily infects bronchial epithelial cells. Immune responses from BECs to RV infection are critical in limiting viral replication, and remain unclear in COPD. The objective of this study is to investigate innate immune responses ...
Shin Dong Wook - - 2013
BACKGROUND: Helicobacter pylori (HP) eradication may reduce the risk of gastric cancer, and professional guidelines recommend eradication based on patients' preference. However, little data exist regarding individual's preference for HP eradication to prevent gastric cancer. We explored healthy Korean populations' preference for HP "screen and treat" strategy and its associated ...
Mennucci Benedetta - - 2013
In this perspective, an overview of the recent progress in the combination of quantum mechanical (QM) simulations of spectroscopies with classical models to include environment effects is presented. Both atomistic and continuum formulations of the classical models are reviewed together with a critical analysis of their respective pros and cons. ...
Killingsworth Bryan A - - 2013
The ∼635 Ma Marinoan glaciation is marked by dramatic Earth system perturbations. Deposition of nonmass-dependently (17)O-depleted sulfate (SO(4)(2-)) in worldwide postglacial sediments is, thus far, unique to this glaciation. It is proposed that an extremely high-pCO(2) atmosphere can result in highly (17)O-depleted atmospheric O(2), or the Marinoan Oxygen-17 Depletion (MOSD) ...
White Yohann - - 2013
Abstract Interleukin-7 (IL-7) mediates T-cell homeostasis through its effects on T-cell development, survival, and function. In human T-cell lymphotropic virus type 1 (HTLV-1) infection, which is causally implicated in adult T-cell leukemia (ATL), the efficiency with which CD8(+) cytotoxic T-lymphocytes (CTLs) clear HTLV-1-infected cells mediates viral control and may be ...
Clajus Christin - - 2013
INTRODUCTION: The purpose of this retrospective review was to present our experience in using the Solitaire™ AB Neurovascular Remodeling Device in the stent-assisted treatment of intracranial aneurysms, focusing on midterm results. To date, this is the largest series using the Solitaire™ AB Neurovascular Remodeling Device. METHODS: From February 2008 to ...
Zheng C - - 2013
The development of peptides and proteins is hampered by their rapid clearance in liver and other body tissues by proteolytic enzymes, so these drugs are difficult to administer except for the injection. Here, we designed and fabricated a novel biodegradable and redox-responsive submicron capsules through the layer-by-layer technique with poly(L-aspartic ...
Vieno Alessio - - 2013
OBJECTIVES: The aim of this study was to investigate time trend changes in frequency of drunkenness among Italian adolescents. Gender convergence in adolescent drunkenness was evaluated in different geographical regions. METHODS: The survey reported here is part of the larger cross-sectional (2002/2006/2010) "Health Behaviour in School-aged Children" (HBSC) trans-national study. ...
Nolin Frédérique - - 2013
The cell is a crowded volume, with estimated mean mass percentage of macromolecules and of water ranging from 7.5 to 45 and 55 to 92.5 %, respectively. However, the concentrations of macromolecules and water at the nanoscale within the various cell compartments are unknown. We recently developed a new approach, correlative ...
Weismüller Tobias J - - 2013
The indication for mandatory screening colonoscopies in liver transplant candidates is controversial. Since the introduction of MELD-based allocation, patients with advanced liver disease and often severe comorbidities are prioritized for liver transplantation (LT). This study evaluated safety and outcome of colonoscopy in this high-risk patient group. During a two-yr period, ...
Akwaa Frank - - 2013
Abstract The natural history of the chronic phase (CP) of chronic myeloid leukemia (CML) and the high response rates achieved with BCR-ABL inhibitor therapy necessitate long-term evaluation of survival-based outcome measures. Prior to the availability of long-term BCR-ABL inhibitor data, short-term surrogate end points predictive of longer-term outcomes have been ...
Musshoff Frank - - 2013
In a preliminary test, four single hairs of a drug abuser were analyzed for the presence of drugs by MALDI Fourier transform mass spectrometry (MALDI-FTMS). Washed hair strains were directly fixed on a sample plate using pressure stable, double-sided adhesive tape; α-cyano-4-hydroxycinnamic acid matrix was manually spotted onto the hair ...
Hewitt Lauren Y - - 2013
When people discuss their experiences, they can later report seeing things that they never saw, simply because they heard about those things in the discussion. One factor that may contribute to this effect is the order in which people speak; some research has investigated this issue, but it remains unclear ...
Van De Wauwer Caroline - - 2013
Donations after circulatory death (DCD) lung grafts are an alternative to extend the donor pool in lung transplantation. This study investigates the use of an in situ lung perfusion system (ISLP) in the donor to evaluate category I-II lungs. Pigs were sacrificed by ventricular fibrillation. All animals underwent 20 min of ...
Reile Rainer - - 2013
OBJECTIVES: To examine possible differences in the correlates of positive and negative self-rated health (SRH). METHODS: Data for 2,127 men and 2,385 women in the 25-74 age group came from the Estonian Health Interview Survey 2006. Multinomial logistic regression analysis was used to study the association of socio-demographic, physical and ...
Deangelo D J - - 2013
Panobinostat is a potent oral pan-deacetylase inhibitor that leads to acetylation of intracellular proteins, inhibits cellular proliferation, and induces apoptosis in leukemic cell lines. A phase Ia/II study was designed to determine the maximum tolerated dose (MTD) of daily panobinostat, administered on two schedules: three times a week every week ...
Villar-Menéndez Izaskun - - 2013
Adenosine A(2A) receptor (A(2A)R) is a G-protein-coupled receptor highly expressed in basal ganglia. Its expression levels are severely reduced in Huntington's disease (HD), and several pharmacological therapies have shown its implication in this neurodegenerative disorder. The main goal of this study was to gain insight into the molecular mechanisms that ...
Sandoval H - - 2013
DNA primers were designed from the 18S rRNA sequence from the relevant digenean trematode Dicrocoelium dendriticum to evaluate a polymerase chain reaction-based diagnostic method of this parasite from its eggs in faeces of naturally and experimentally infected sheep. In order to get DNA from D. dendriticum eggs, several hatching mechanisms ...
Duarte Filomena L - - 2013
Pure selected cultures of Saccharomyces cerevisiae starters are regularly used in the wine industry. A survey of S. cerevisiae populations during red wine fermentations was performed in order to evaluate the influence of oenological additives on the implantation of the inoculated strain. Pilot scale fermentations (500 L) were conducted with active ...
Pallela Venkat R - - 2013
A stereoselective and efficient method for free radical addition of benzyl thiol to aryl acetylene in the presence of Et(3)B-hexane has been developed for the synthesis of (Z) and (E)-styryl benzyl sulfides where base catalyzed hydrothiolations have failed. The scope of this reaction was successfully extended for the synthesis of ...
Mdzinarashvili Tamaz - - 2013
Continuous, real-time observation of bacterial growth has a great advantage for studying the mechanisms of interactions of various compounds with the bacterial cell membrane. With the use of physical methods, which are specific for assessment of continuous changes in turbidity over time, we have shown that bacterial growth was affected ...
Akin Ibrahim - - 2013
BACKGROUND: Second-generation drug-eluting stents (DES) have provided better results over both bare-metal stents and first-generation DES. However, comparative data of different first- and second-generation DES in a clinical setting of all-comers have not been well studied. METHODS AND RESULTS: Baseline clinical and angiographic characteristics and in-hospital and follow-up events were ...
Fanciullino Raphaelle - - 2013
PURPOSE: Drug resistance and severe toxicities are limitations when handling 5-FU. We have developed a triple liposomal formulation of 5-FU combined to 2'-deoxyinosine and folinic acid to improve its efficacy-toxicity balance. METHODS: Stealth liposomes were obtained using the thin-film method. Antiproliferative activity was tested on human colorectal and breast cancer ...
Weitz Charles A - - 2013
While many studies have compared Tibetans and low-altitude born Han living at high altitude, few have carefully controlled the chronological age at which lowlanders migrated, the length of time they had lived at high altitude, their nutrition, and their socio-economic status. This has produced an array of results that frequently ...
Cyr André - - 2013
This paper presents a novel bio-inspired habituation function for robots under control by an artificial spiking neural network. This non-associative learning rule is modelled at the synaptic level and validated through robotic behaviours in reaction to different stimuli patterns in a dynamical virtual 3D world. Habituation is minimally represented to ...
Whittle Samuel L - - 2013
CLINICAL QUESTION Do the benefits of opioid analgesics outweigh the risks in patients with persistent pain due to rheumatoid arthritis? BOTTOM LINE Weak opioids (such as codeine, dextropropoxyphene, and tramadol) may be effective in the short-term management of rheumatoid arthritis pain, but adverse effects are common and may outweigh the ...
Xie Fengxian - - 2013
A simple one-step method is reported to synthesize low-temperature solution-processed transition metal oxides (TMOs) of molybdenum oxide and vanadium oxide with oxygen vacancies for a good hole-transport layer (HTL). The oxygen vacancy plays an essential role for TMOs when they are employed as HTLs: TMO films with excess oxygen are ...
Said Samir M - - 2013
OBJECTIVE: We retrospectively assessed the incidence of hemorrhagic complications associated with pacemaker implantation in patients receiving one or more antiplatelet agents. DESIGN AND SETTING: Retrospective multicenter case-control study. Data were collected from three cardiac units in Germany from 2006 to 2010. METHODS: A total of 495 pacemaker patients were enrolled. ...
Redpath Nicholas T - - 2013
Gene deletion studies in mice have revealed critical roles for interleukins-4 and -13 in asthma development, with the latter controlling lung airways resistance and mucous secretion. We have now developed human neutralizing monoclonal antibodies against the human IL-13 receptor α1 subunit that prevent activation of the receptor complex by both ...
Scarpa Angela - - 2013
This study investigated the psychometric properties of the modified checklist for autism in toddlers (M-CHAT) in a diverse rural American low-socioeconomic status (SES) sample. Four hundred and forty-seven English (n = 335) and Spanish (n = 112) speaking caregivers completed the M-CHAT during their toddler's 18- or 24-month well visit in a Southwest Virginia ...
Kato-Noguchi Hisashi - - 2013
Large field screening programs and laboratory experiments in many countries have indicated that rice is allelopathic and releases allelochemical(s) into its environment. A number of compounds, such as phenolic acids, fatty acids, phenylalkanoic acids, hydroxamic acids, terpenes, and indoles, have been identified as potential rice allelochemicals. However, the studies reviewed ...
Sampaio Rute - - 2013
PURPOSE: The aim of this study was to examine the joint role of demographic, clinical, psychological and family coping variables as predictors of adherence patterns to auto-adjusting positive airway pressure (APAP). METHODS: A total of 153 patients diagnosed with obstructive sleep apnea syndrome (OSAS) were assessed during a 6-months APAP ...
Ferraroni Marta - - 2013
The salicylate 1,2-dioxygenase (SDO) from the bacterium Pseudaminobacter salicylatoxidans BN12 is a versatile gentisate 1,2-dioxygenase (GDO) that converts in addition to gentisate (2,5-dihydroxybenzoate) also various monohydroxylated substrates. Several variants of this enzyme were rationally designed based on the previously determined enzyme structure and sequence differences between the SDO and the ...
Ekiz Bilir B - - 2013
Abstract Hyperthyroidism is not a rare entity in pregnancy and 85% of these cases attributed to Graves' disease (GD). There is no therapeutic modality for GD considered as totally safe in pregnancy. Fetal and neonatal risks of maternal hyperthyroid disease are related to the hyperthyroidism itself and/or to the medical ...
Zhang Binglan - - 2013
PURPOSE: The overexpression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) has been proved to inhibit tumor growth and metastasis through degradation of prostaglandin E2 (PGE2), which is often overexpressed in various cancers and accelerates tumor progression. Cyclooxygenase-2 (COX-2), a synthase of PGE2, actively produces much PGE2 to counteract the 15-PGDH-induced antitumor efficacy. Here, ...
Mellon Matthew J - - 2013
PURPOSE: Open partial nephrectomy (OPN) and robotic partial nephrectomy (RPN) are widely utilized techniques for small renal masses. The lack of tactile feedback and limitations of laparoscopy may result in differences in the surgical specimen that may impact oncologic outcome. We present postoperative pathological outcomes data in a cohort of ...
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