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Pharikronburee Vannapha - - 2013
PhSCF(2)SiMe(3) () underwent fluoride-catalyzed nucleophilic addition to the carbonyl group of anhydrides to provide the corresponding γ-difluoro(phenylsulfanyl)methyl γ-lactols, which were employed for the synthesis of γ-difluoromethylated γ-lactams.
Zhang Mian - - 2013
Autophagy is a cell protective mechanism for maintaining cellular homeostasis. The present study aimed to investigate whether autophagy is enhanced in the biomechanically induced degenerative cartilage of the temporomandibular joint (TMJ) and the potential role of mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) and mammalian Target of rapamycin (mTOR) ...
Liu Weifeng - - 2013
OBJECTIVE: Hibernoma is a benign neoplasm comprised of brown fat and characteristic hibernoma cells often occurring in adults with proximal extremity/truncal predilection. Limited reports regarding imaging appearance and clinicopathological features of this rare tumor are available. Four histological subtypes have been described. We present nine patients with hibernoma evaluating preoperative ...
Bhat Rukhmi - - 2013
BACKGROUND/PURPOSE: Extrahepatic portal vein obstruction (EHPVO) is an important cause of chronic portal hypertension in children. Although usually idiopathic in etiology, genetic and acquired thrombophilia have been implicated in EHPVO. Meso-Rex bypass is increasingly used to treat EHPVO in children. OBJECTIVE: The objective of this study is to assess the ...
Schulz Margot - - 2013
The allelopathic potency of rye (Secale cereale L.) is due mainly to the presence of phytotoxic benzoxazinones-compounds whose biosynthesis is developmentally regulated, with the highest accumulation in young tissue and a dependency on cultivar and environmental influences. Benzoxazinones can be released from residues of greenhouse-grown rye at levels between 12 ...
Dabertrand Fabrice F Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05405-0068, - - 2013
It has been proposed that prostaglandin E(2) (PGE(2)) is released from astrocytic endfeet to dilate parenchymal arterioles through activation of prostanoid (EP(4)) receptors during neurovascular coupling. However, the direct effects of PGE(2) on isolated parenchymal arterioles have not been tested. Here, we examined the effects of PGE(2) on the diameter ...
Killingsworth Bryan A - - 2013
The ∼635 Ma Marinoan glaciation is marked by dramatic Earth system perturbations. Deposition of nonmass-dependently (17)O-depleted sulfate (SO(4)(2-)) in worldwide postglacial sediments is, thus far, unique to this glaciation. It is proposed that an extremely high-pCO(2) atmosphere can result in highly (17)O-depleted atmospheric O(2), or the Marinoan Oxygen-17 Depletion (MOSD) ...
White Yohann - - 2013
Abstract Interleukin-7 (IL-7) mediates T-cell homeostasis through its effects on T-cell development, survival, and function. In human T-cell lymphotropic virus type 1 (HTLV-1) infection, which is causally implicated in adult T-cell leukemia (ATL), the efficiency with which CD8(+) cytotoxic T-lymphocytes (CTLs) clear HTLV-1-infected cells mediates viral control and may be ...
Clajus Christin - - 2013
INTRODUCTION: The purpose of this retrospective review was to present our experience in using the Solitaire™ AB Neurovascular Remodeling Device in the stent-assisted treatment of intracranial aneurysms, focusing on midterm results. To date, this is the largest series using the Solitaire™ AB Neurovascular Remodeling Device. METHODS: From February 2008 to ...
Zheng C - - 2013
The development of peptides and proteins is hampered by their rapid clearance in liver and other body tissues by proteolytic enzymes, so these drugs are difficult to administer except for the injection. Here, we designed and fabricated a novel biodegradable and redox-responsive submicron capsules through the layer-by-layer technique with poly(L-aspartic ...
Xiaoxi Ji J Department of Orthopedic Surgery, First People's Hospital Affiliated to Shanghai Jiaotong University, 100 Haining Road, Hongkou District, Shanghai, 200080, People's Republic of - - 2013
To obtain a series of parameters describing the shape and bone thickness of the fixation route along the superior border of the arcuate line, so as to provide references for pelvic and acetabular surgery and design pelvic anatomic internal fixators. A total of 175 complete pelvic computed tomography (CT) scans ...
Vieno Alessio - - 2013
OBJECTIVES: The aim of this study was to investigate time trend changes in frequency of drunkenness among Italian adolescents. Gender convergence in adolescent drunkenness was evaluated in different geographical regions. METHODS: The survey reported here is part of the larger cross-sectional (2002/2006/2010) "Health Behaviour in School-aged Children" (HBSC) trans-national study. ...
Nolin Frédérique - - 2013
The cell is a crowded volume, with estimated mean mass percentage of macromolecules and of water ranging from 7.5 to 45 and 55 to 92.5 %, respectively. However, the concentrations of macromolecules and water at the nanoscale within the various cell compartments are unknown. We recently developed a new approach, correlative ...
Saha Suman - - 2013
PURPOSE: We report a case of mycotic keratitis caused by a rare fungus Schizophyllum commune. METHODS: Clinical examination, slit-lamp examination, and microbiological evaluation of the corneal ulcer were done, and its treatment outcome was studied. The fungal etiology was established by conventional microbiological techniques, polymerase chain reaction and speciation by ...
Bradshaw Jill - - 2013
BACKGROUND: The provision of skilled support is dependent on staff knowledge and understanding (Beadle-Brown J., Beecham J., Mansell J., Baumker T., Leigh J., Whelton R. & Richardson L, unpublished data). Influencing staff knowledge and understanding is an important component of interventions. MATERIALS AND METHODS: Fourteen individual semi-structured interviews elicited staff views and ...
Prados Jose - - 2013
Accessory (supernumerary) intrathoracic ribs are a very rare congenital disorder. Here, we present the first case of multiple supernumerary intrathoracic ribs in an adult, which are present consecutively between ribs 1 and 4 and without articulation with the vertebrae. Despite this, anatomical variation is usually silent and accidentally discovered; its ...
Kim Yun Jung - - 2013
BACKGROUND/AIM: Endoscopic treatments of colorectal neoplasms have yet to be standardized. This study aimed to compare efficacy and tolerability of different endoscopic resection methods for colorectal epithelial tumors. METHODS: Patients with non-pedunculated colorectal tumors undergoing endoscopic treatments were consecutively enrolled, and their medical records were reviewed retrospectively. The resection methods ...
Park Yong Seo - - 2013
The bioactivity of two kiwifruit's cultivars growing under organic and conventional conditions were studied and compared. The bioactive compounds were extracted with water and ethanol using similar conditions which are applied in pharmaceutical applications and for daily fruit consumption such as tea drink. Antioxidant radical scavenging assays [ferric-reducing/antioxidant power (FRAP); ...
Peterson Julie A JA Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226-3548, US. - - 2013
Neonatal alloimmune thrombocytopenia, (NAIT) is caused by maternal antibodies raised against alloantigens carried on fetal platelets. Although many cases are mild, NAIT is a significant cause of morbidity and mortality in newborns and is the most common cause of intracranial haemorrhage in full-term infants. In this report, we review the ...
Selmke Markus - - 2013
Photothermal correlation spectroscopy (PhoCS) is a powerful counterpart to fluorescence correlation spectroscopy (FCS). Using PhoCS it is possible to probe the dynamics of non-fluorescent and non-bleaching ultra-stable metal-nanoparticles in solution and biological specimen, where they can be used as tracers and markers. This paper complements the absorption correlation method by ...
Pieter Hoogland E R - - 2013
Kidneys from uncontrolled donors after cardiac death (DCD) expand the donor pool, but are associated with more primary nonfunction (PNF) and delayed graft function (DGF) compared with more conventional donor kidneys. It remains unclear, which factors influence outcome of uncontrolled donation. Therefore, we studied which donor, graft, and recipient characteristics ...
Arakelyan Valeri B - - 2013
In the present work, the adsorption kinetics of extended ligands on DNA duplexes at small fillings when molecules of DNA duplexes are on the underlayer within diffusion layer has been investigated. Both diffusion of ligands in solution (diffusion stage) and adsorption of ligands (kinetic stage) are taken into consideration at ...
Sugiyama Hitoshi - - 2013
The Japan Renal Biopsy Registry (J-RBR) was started in 2007 and the Japan Kidney Disease Registry (J-KDR) was then started in 2009 by the Committee for Standardization of Renal Pathological Diagnosis and the Committee for the Kidney Disease Registry of the Japanese Society of Nephrology. The purpose of this report ...
Wang Xiao-Guang - - 2013
ABSTRACT: BACKGROUND: We summarize our experience of the diagnosis, surgical treatment, and prognosis of solid pseudopapillary tumors (SPTs). METHODS: We carried out a retrospective study of clinical data from a series of 17 patients with SPT managed in two hospitals between October 2001 and November 2011. RESULTS: All of the ...
Crocetti Elisabetta - - 2013
Adolescents at-risk for problem behaviors can have more difficulties in developing a firm sense of personal identity. Hence the purpose of this prospective longitudinal study was to scrutinize how externalizing problems in early adolescence impact identity development in middle to late adolescence. Participants were 443 (43.12 % female) Dutch adolescents. Teachers ...
Zhao Yunjun - - 2013
Endo-1,4-β-mannanase is able to hydrolyze mannan-type polysaccharides in cell wall remodeling while its function in regulating wall thickening is little studied. Here we show a Populus endo-1,4-β-mannanase gene, named PtrMAN6, suppresses cell wall thickening during xylem differentiation. PtrMAN6 is specifically expressed in xylem tissue and its encoded protein is localized ...
Upshur Ross - - 2013
Obesity has been described as pandemic and a public health crisis. It has been argued that concerted research efforts are needed to enhance our understanding and develop effective interventions for the complex and multiple dimensions of the health challenges posed by obesity. This would provide a secure evidence base in ...
Alipour Misagh - - 2013
Abstract The safety and pharmacokinetic profile of liposomal formulations containing combinations of the antioxidants α-tocopherol, γ-tocopherol, or N-acetylcysteine in beagle dogs was examined. Each group consisted of beagle dogs of both genders with a control group receiving empty dipalmitoylphosphatidylcholine (DPPC) liposomes (330 mg/kg DPPC, EL), and test groups receiving liposomes ...
Nezhad Rezvan Mohammadi - - 2013
Metallothioneins (MTs) are ubiquitous, low molecular mass and cysteine-rich proteins that play important roles in maintaining intracellular metal homeostasis, eliminating metal toxification and protecting the cells against oxidative damages. MTs are able to bind metal ions through the thiol groups of their cysteine residues. Plants have several MT isoforms which ...
Dierks C - - 2013
Hitherto, the only known mutant gene leading to the long-hair phenotype in mammals is the fibroblast growth factor 5 (FGF5). In many dog breeds, the previously discovered FGF5:p.Cys95Phe mutation appeared completely concordant with the long-hair phenotype, but for some breeds, the long-hair phenotype could not be resolved. First, we studied ...
Yun Xiang X Department of Bioengineering, Clemson University, Clemson, SC, - - 2013
Stroke is one of the major causes of death and disability in the United States. After cerebral ischemia and reperfusion injury, the generation of reactive oxygen species (ROS) and reactive nitrogen species may contribute to the disease process through alterations in the structure of DNA, RNA, proteins, and lipids. We ...
Bučková Maria - - 2013
The use of indigenous bacterial strains is a valuable bioremediation strategy for cleaning the environment from hydrocarbon pollutants. The isolation and selection of hydrocarbon-degrading bacteria is therefore crucial for obtaining the most promising strains for site decontamination. Two different media, a minimal medium supplemented with a mixture of polycyclic aromatic ...
Payne Rupert A - - 2013
BACKGROUND AND OBJECTIVE: Falls are a major cause of morbidity and mortality in the elderly. This study examined the frequency of hospital admission for falls or fractures, and the association with a recent change in the use of cardiovascular and psychotropic medications. METHODS: We conducted a retrospective case-cohort study of ...
Fan Qing - - 2013
PURPOSE: It is unclear whether volatile general anesthetics have sustained adverse effects on the immature brains of children. We performed a self-controlled study to evaluate the effects of strabismus surgery under sevoflurane-based general anesthesia on the cognitive function of pediatric patients. METHODS: The study included 100 children of ages 4 ...
Sugawara Hitoshi - - 2013
Modulation of muscle activation in superficial and deeper regions may be induced by tactile stimulation. The purpose of this study was to examine changes in muscle activation with skin friction. Subjects performed an isometric elbow flexion at 30% maximal voluntary cotraction (MVC) with skin friction at different frequencies (0.5-2.7 Hz). Surface ...
Bitar Malak - - 2013
It is well established that surface topography greatly affect cell-surface interactions. In a recent study we showed that microstructured stainless steel surfaces characterized by the presence of defined hexagonally arranged hemisphere-like structures significantly affected cell architecture (shape and focal adhesion size) of primary human bone mesenchymal stromal cells. This study ...
Groetch Marion - - 2013
Although the need for nutritional and dietary intervention is a common thread in food allergy management, the type of food allergic disorder and the identified food allergen will influence the approach to dietary intervention. A comprehensive nutrition assessment with appropriate intervention is warranted in all children with food allergies to ...
Bruno Stefania - - 2013
Results from recent studies suggest that the beneficial effect of stem cell-based therapy is mainly dependent on a paracrine effect. The paracrine hypothesis implicates the ability of stem cells to limit injury or coordinate repair through the release of soluble factors. Among these factors microvesicles (MVs) have emerged as a ...
Stroppa A - - 2013
On the basis of first-principles calculations, we design a novel Cr-based metal-organic framework to be both multiferroic and magnetoelectric. The compound shows a "double-hybrid" nature: it is a hybrid organic-inorganic compound and it shows hybrid improper ferroelectricity. Here, the coupling of non-polar distortions, such as Jahn-Teller pseudo-rotations and tilting, pave ...
Moroni Beatrice - - 2013
Aerosol dust samples and quartz raw materials from different working stations in foundry plants were characterized in order to assess the health risk in this working environment. Samples were analysed by scanning and transmission electron microscopy coupled with image analysis and microanalysis, and by cathodoluminescence spectroscopy. In addition, the concentration ...
Song Haihan - - 2013
T cell immunoglobulin- and mucin-domain-containing molecule 3 (TIM-3) has been established as a negative regulatory molecule and plays a critical role in inflammatory diseases such as rheumatoid arthritis, hepatitis B and C, and human immunodeficiency virus (HIV)-related inflammation. Recent studies have shown that chronic inflammation may greatly affect the pathogenesis ...
He Wenbo - - 2013
OBJECTIVE: To investigate autonomic involvement in different types of idiopathic premature ventricular contractions (PVCs) grouped by heart rate (HR) dependency. METHODS: One hundred and sixty PVC patients and 31 controls were enrolled. Holter ECG was used to evaluate PVC occurrence, and spectral analysis of heart rate variability (HRV) was calculated ...
Liu Wei - - 2013
BACKGROUND: Damage to the vascular endothelium may be one of the pathophysiological causes of in-stent thrombosis and restenosis. Endothelial progenitor cell (EPC) capture stents (ECS) have the ability to accelerate the damage repair process. However, the clinical outcomes of ECS remain unknown thus far. OBJECTIVES: To evaluate the impact of ...
Chowdhury Dipanjan D Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA. - - 2013
During the past decade, evolutionarily conserved microRNAs (miRNAs) have been characterized as regulators of almost every cellular process and signalling pathway. There is now emerging evidence that this new class of regulators also impinges on the DNA damage response (DDR). Both miRNAs and other small non-coding RNAs (ncRNAs) are induced ...
Torii Hajime - - 2013
It is becoming recognized that the behavior of electrons in hydrogen-bonded systems is far more complicated than previously thought. One key problem would be its relation to the local/extended nature of molecular dipole, i.e., whether it is a true "molecular" property. The present study shows, based on analyses of electron ...
Vannucci Anna A Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, - - 2013
To investigate the association between binge features and clinical validators. The Eating Disorder Examination assessed binge features in a sample of 549 college-age women: loss of control (LOC) presence, binge frequency, binge size, indicators of impaired control, and LOC severity. Clinical validators were self-reported clinical impairment and current psychiatric comorbidity, ...
Munn A J - - 2013
We used doubly labelled water to measure field metabolic rates (FMR) and water turnover rates (WTR) in one of Australia's largest native herbivores, the red kangaroo (Macropus rufus) and one of Australia's dominant livestock species, the wool-breed Merino sheep, under free-living conditions in a typical Australian rangeland. Also, we used ...
Toyoda Keisuke - - 2013
Glioblastoma multiforme (GBM) cells invade along the existing normal capillaries in brain. Normal capillary endothelial cells function as the blood-brain barrier (BBB) that limits permeability of chemicals into the brain. To investigate whether GBM cells modulate the BBB function of normal endothelial cells, we developed a new in vitro BBB ...
Hassan Tahsin - - 2013
The time delay between two surface electromyograms (EMGs) acquired along the conduction path is used to estimate mean action potential conduction velocity. Modeling the linear impulse response between "upstream" and "downstream" EMG signals permits an estimate of the distribution of velocities, providing more information. In this work, we analyzed EMG ...
Akita Hidetaka - - 2013
SS-cleavable proton-activated lipid-like material (ssPalm) functions as a key element in a lipid nanoparticle in which pDNA is encapsulated. The ssPalm contains dual sensing motifs that can respond to the intracellular environment; a proton-sponge unit (tertiary amines) that functions in response to an acidic environment (endosome/lysosome), and disulfide bonding that ...
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