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Martins Karen A O - - 2013
Filoviruses are hemorrhagic fever viruses endemic to parts of Africa and the Philippines. Infection carries with it a mortality rate of up to 90% and currently there are no effective vaccines or therapeutics available to combat infection. However, the filovirus virus-like particles (VLP), which are currently under development, have been ...
Chiang Ya-Yu - - 2013
A pinched-flow deflection technology was developed for rapid single cell switching between biochemical microenvironments. Millisecond switching was used to stimulate and preserve epidermal growth factor receptor (EGFR) autophosphorylation transitions. Intramolecular phosphorylation initiates signal transduction, is silenced by phosphatase activity until EGFR dimerization enables intermolecular phosphorylation to initiate downstream signalling.
Okamatsu Masatoshi - - 2013
ABSTRACT: BACKGROUND: The pandemic 2009 (H1N1) influenza virus has spread throughout the world and is now causing seasonal influenza. To prepare for the emergence of pandemic influenza, we have established a library of virus strains isolated from birds, pigs, and humans in global surveillance studies. METHODS: Inactivated whole virus particle ...
Abbruzzese L - - 2013
Peripheral blood stem cell cryopreservation is associated with cell damage and decreased viability. We evaluated the impact of up to 10 years of cryopreservation (5% DMSO) on viability of CD34(+) cells utilizing graft samples of consecutive patients (2002-2012) with different malignancies who underwent stem cell collection and transplantation. Viability of CD34(+) ...
Heinrichs Guido - - 2013
Formation of tenacious and massive black biofilms was occasionally observed at the water-air interphase of water taps and in associated habitats at several locations in Germany. Exophiala lecanii-corni was proven to be the dominant component of these biofilms. Water utility companies were interested to understand by which route fungi building ...
Cadoret K - - 2013
Formaldehyde-based fixatives are generally employed in histopathology despite some significant disadvantages associated with their usage. Formaldehyde fixes tissue by covalently cross-linking proteins, a process known to mask epitopes which in turn can reduce the intensity of immunohistochemical stains widely used in disease diagnostics. Additionally, formaldehyde fixation greatly limits the ability ...
Hegyi Alex Nathan - - 2013
We propose a novel biomedical imaging technique, called nanodiamond imaging, that non-invasively records the three-dimensional distribution of biologically-tagged nanodiamonds in-vivo. Our technique performs optically-detected electron spin resonance of nitrogen-vacancy centers in nanodiamonds, a non-toxic nanomaterial that is easily biologically functionalized. We demonstrate the feasibility of the technique by imaging multiple ...
Schmid Baptiste - - 2013
Reproducing parents face the difficult challenge of trading-off investment in current reproduction against presumed future survival and reproduction. Glucocorticoids are supposed to mediate this trade-off because the adrenocortical response to stress disrupts normal reproductive behaviour in favour of self-maintenance and own survival. According to the brood-value hypothesis, individuals with a ...
Tisoncik-Go Jennifer - - 2013
Influenza A virus poses a great threat to global health, and oseltamivir (trade marked as Tamiflu), which targets influenza surface glycoprotein neuraminidase (NA), is used clinically as a major anti-influenza treatment. However, certain substitutions in NA can render an influenza virus resistant to this drug. In this study, using a ...
Wenker Shirley D - - 2013
Inflammation is a physiological response of defense but may also represent a potential pathological process in neurological diseases. In this regards, microglia have a crucial role upon either progression or amelioration of degenerative neuronal damage. Because of the role of hypoxia in proinflammatory mechanisms in the nervous system, and the ...
Lv Chao - - 2013
PURPOSE: The published data on the evaluation of feasibility and safety of single-incision laparoscopic colorectal surgery (SILC) compared with traditional multiport laparoscopic colorectal surgery (MLC) remained controversial. The present cumulative meta-analysis and systematic review were performed to provide a more objective and precise estimate. MATERIALS AND METHODS: PubMed, the Cochrane ...
Masjedi Milad - - 2013
BACKGROUND: Cam type femoroacetabular impingement (FAI) is an anatomical disorder that can lead to osteoarthritis (OA) of the hip joint. With existing surgical options there is invariably a tendency for under-resection or over-resection of the cam lesion, both having dire consequences. This study assessed the application of robotic technology in ...
Lee Jong Hoon - - 2013
To evaluate the efficacy and toxicity for patients with hepatic oligometastases, receiving hypofractionated radiotherapy with Tomotherapy to the liver. A total of 42 patients with 54 hepatic lesions, who had been treated from 2007 to 2011 at two institutions, were retrospectively reviewed for this study. All the patients received radical ...
Kwatra Neha - - 2013
The spectrum of manifestations of duplex kidneys on (99m)Tc-dimercaptosuccinic acid (DMSA) renal cortical scans and correlating findings on other imaging modalities are presented. Relevant embryology of the duplex systems and technical aspects of DMSA scintigraphy are reviewed.
Wellmann Mathias - - 2013
BACKGROUND: Reverse shoulder arthroplasty (RSA) has shown promising results for cuff tear arthropathy but the indication has been extended to fracture sequelae and revision shoulder arthroplasty with different preconditions. Further, the clinical relevance of inferior scapular notching for different etiologies is uncertain. Our hypothesis was that preoperative etiology as well ...
Wang Wenbo - - 2013
ABSTRACT: BACKGROUND: Glycans on the human immunodeficiency virus (HIV) envelope glycoprotein (Env) play an important role in viral infection and evasion of neutralization by antibodies. In this study, all 25 potential N-linked glycosylation sites (PNGS) on the HIV-1 CRF07_BC Env, FE, were mutated individually to study the effect of their ...
Spack Norman P - - 2013
Gender identity disorder (transgenderism) is poorly understood from both mechanistic and clinical standpoints. Awareness of the condition appears to be increasing, probably because of greater societal acceptance and available hormonal treatment. Therapeutic options include hormone and surgical treatments but may be limited by insurance coverage because costs are high. For ...
Krause P - - 2013
Nearly 50 % of colorectal cancer (CRC) patients develop liver metastases with liver resection being the only option to cure patients. Residual micrometastases or circulating tumor cells are considered a cause of tumor relapse. This work investigates the influence of partial hepatectomy (PH) on the growth and molecular composition of CRC ...
Zhang Tingting - - 2013
Ustilaginoidea virens is the causal agent of a serious disease of rice. Here, we report the presence of five dsRNA bands ranging from about 1.2, 1.5, 1.7, and 1.8 to 5.6 kb in an isolate of this fungus from China and the complete sequence of the largest dsRNA segment, putatively representing ...
Kornblihtt Alberto R - - 2013
Alternative splicing was discovered simultaneously with splicing over three decades ago. Since then, an enormous body of evidence has demonstrated the prevalence of alternative splicing in multicellular eukaryotes, its key roles in determining tissue- and species-specific differentiation patterns, the multiple post- and co-transcriptional regulatory mechanisms that control it, and its ...
Buske C - - 2013
Waldenstrom's macroglobulinemia (WM) is very distinct from other indolent lymphoma subtypes: by definition it is accompanied by a monoclonal IgM gammopathy; it presents always with bone marrow infiltration and often with clinical symptoms such as neuropathy or hyperviscosity. These disease characteristics and the frequently advanced age of the WM patient ...
de Bruijn Renée F A G - - 2013
Several studies have associated physical activity with the risk of dementia, but mostly did so during short follow-up. It remains unclear whether physical activity also affects dementia during longer follow-up. We examined the association between physical activity and risk of dementia during a follow-up period up to 14 years. From ...
Santini Tiziana - - 2013
ABSTRACT: BACKGROUND: In Bacillus mycoides, as well as in other members of the B. cereus group, the tubulin-like protein of the division septum FtsZ is encoded by the distal gene of the cluster division and cell wall (dcw). Along the cluster the genes coding for structural proteins of the division ...
Breik Omar - - 2013
The new thrombin inhibitors have provided an exciting opportunity for effective thromboprophylaxis without some of the disadvantages of the current anticoagulants. These drugs are orally administered, have predictable pharmacokinetics and dose-response, do not require monitoring and have an acceptable safety profile when used appropriately. However, inappropriate prescribing of these drugs ...
Glanville N - - 2013
Most asthma exacerbations are triggered by virus infections, the majority being caused by human rhinoviruses (RV). In mouse models, γδT cells have been previously demonstrated to influence allergen-driven airways hyper-reactivity (AHR) and can have antiviral activity, implicating them as prime candidates in the pathogenesis of asthma exacerbations. To explore this, ...
Coombes Brooke K - - 2013
Corticosteroid injection and physiotherapy, common treatments for lateral epicondylalgia, are frequently combined in clinical practice. However, evidence on their combined efficacy is lacking. To investigate the effectiveness of corticosteroid injection, multimodal physiotherapy, or both in patients with unilateral lateral epicondylalgia. A 2 × 2 factorial, randomized, injection-blinded, placebo-controlled trial was ...
Sánchez-García Carolina C Departament de Tecnologies de la Informació i les Comunicacions, Center of Brain and Cognition (CBC), Universitat Pompeu Fabra, c/Roc Boronat 138, 08018, Barcelona, - - 2013
The sight of a speaker's facial movements during the perception of a spoken message can benefit speech processing through online predictive mechanisms. Recent evidence suggests that these predictive mechanisms can operate across sensory modalities, that is, vision and audition. However, to date, behavioral and electrophysiological demonstrations of cross-modal prediction in ...
Tall Gregory G GG Department of Pharmacology and Physiology, University of Rochester Medical Center , Rochester, NY, USA. - - 2013
Resistance to inhibitors of cholinesterase 8 proteins (Ric-8A and Ric-8B) collectively bind the four classes of heterotrimeric G protein α subunits. Ric-8A and Ric-8B act as non-receptor guanine nucleotide exchange factors (GEFs) toward the Gα subunits that each binds in vitro and seemingly regulate diverse G protein signaling systems in ...
Chowdhury Dipanjan D Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA. - - 2013
During the past decade, evolutionarily conserved microRNAs (miRNAs) have been characterized as regulators of almost every cellular process and signalling pathway. There is now emerging evidence that this new class of regulators also impinges on the DNA damage response (DDR). Both miRNAs and other small non-coding RNAs (ncRNAs) are induced ...
Mat Hadzir Nursyamsyila N Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. - - 2013
Fatty acid esters are long-chain esters, produced from the reaction of fatty acids and alcohols. They possess potential applications in cosmetic and pharmaceutical formulations due to their excellent wetting behaviour at interfaces and a non-greasy feeling when applied on the skin surfaces. This preliminary work was carried out to construct ...
Vagefi Parsia A PA Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, - - 2013
Type 1 hepatorenal syndrome (HRS) is characterized by rapid deterioration of renal function. We sought to assess native kidney function after combined kidney-liver transplant (CLKTx) performed for type 1 HRS. We performed a retrospective, cross-sectional, single-center study. All patients with Type 1 HRS who received a CLKTx at the University ...
Agha Sharifah Shameem SS Child and Adolescent Psychiatry Section, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK. - - 2013
Although Attention Deficit Hyperactivity Disorder (ADHD) is recognised to be a familial and heritable disorder, little is known about the broader family characteristics of having a parent with ADHD problems. The main aim of this study was to investigate the relationship between parent ADHD problems, child clinical presentation and family ...
Arlet V V Department of Orthopaedic Surgery, University of Pennsylvania, 235 S 8th Street, Philadelphia, 19106 PA, USA. - - 2013
Junctional spinal disorders have become one of the greatest challenges in spinal deformity surgery. They can occur at any age but are mostly seen in adult deformity surgery and are most often observed as the patient gets older. Different forms can be individualized according to their types and location: one ...
Kupinski Meredith K MK College of Optical Sciences, University of Arizona, Tucson, AZ 85721, USA. - - 2013
In tomographic medical imaging, a signal activity is typically estimated by summing voxels from a reconstructed image. We introduce an alternative estimation scheme that operates on the raw projection data and offers a substantial improvement, as measured by the ensemble mean-square error (EMSE), when compared to using voxel values from ...
Docherty L E LE Faculty of Medicine, University of Southampton, Mailpoint 105, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, - - 2013
6q24 transient neonatal diabetes mellitus (TNDM) is a rare form of diabetes presenting in the neonatal period that remits during infancy but, in a proportion of cases, recurs in later life. We aim to describe the clinical presentation of 6q24 TNDM in the largest worldwide cohort of patients with defined ...
Ahimastos Anna A AA Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Rd Central, Melbourne, Victoria, 8008 Australia. - - 2013
Approximately one-third of patients with peripheral artery disease experience intermittent claudication, with consequent loss of quality of life. To determine the efficacy of ramipril for improving walking ability, patient-perceived walking performance, and quality of life in patients with claudication. Randomized, double-blind, placebo-controlled trial conducted among 212 patients with peripheral artery ...
Gibon Emmanuel E Department of Orthopaedic and Reconstructive Surgery, Clinical Orthopaedic Research Centre, Service A, Cochin Teaching Hospital, Paris School of Medicine, 27 rue du Faubourg Saint Jacques, 75014, Paris, France. - - 2013
With the population aging, total joint replacements which are an effective method to restore patient's mobility are an increasing necessity. However, such operations are known to entail serious blood loss, which may have dramatic consequences in patients with chronic diseases or when the prosthesis is revised, a situation where the ...
Mori Ryo R Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima City, 734-8551, Japan. - - 2013
The purpose of this study was to examine retrospectively the effectiveness of Sugioka's transtrochanteric valgus osteotomy (TVO) combined with the shelf procedure for patients who had advanced osteoarthritis (OA) of the hip with severe acetabular dysplasia. Sixty-two hips in 61 patients were reviewed retrospectively between April 1993 and March 2009. ...
Dabertrand Fabrice F Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05405-0068, - - 2013
It has been proposed that prostaglandin E(2) (PGE(2)) is released from astrocytic endfeet to dilate parenchymal arterioles through activation of prostanoid (EP(4)) receptors during neurovascular coupling. However, the direct effects of PGE(2) on isolated parenchymal arterioles have not been tested. Here, we examined the effects of PGE(2) on the diameter ...
Stiehler Maik M Department of Orthopaedics, University Hospital Carl Gustav Carus at Technische Universität Dresden, Fetscherstr. 74, Building 29, 01307, Dresden, Germany. - - 2013
The aim of the study was to evaluate the effects of imageless computer-assisted surgery (CAS) on the accuracy of positioning of the femoral component and on the short-term clinical outcome in hip resurfacing (HR) using a randomised prospective design. A total of 75 consecutive patients undergoing HR were randomly allocated ...
Yun Xiang X Department of Bioengineering, Clemson University, Clemson, SC, - - 2013
Stroke is one of the major causes of death and disability in the United States. After cerebral ischemia and reperfusion injury, the generation of reactive oxygen species (ROS) and reactive nitrogen species may contribute to the disease process through alterations in the structure of DNA, RNA, proteins, and lipids. We ...
Vagi Kevin J KJ Division of Violence Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. - - 2013
Dating violence is a serious public health problem. In recent years, the U.S. Centers for Disease Control and Prevention and other entities have made funding available to community based agencies for dating violence prevention. Practitioners who are tasked with developing dating violence prevention strategies should pay particular attention to risk ...
Mbulaiteye Sam M SM Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. - - 2013
Case reports of Burkitt lymphoma (BL) in transplant recipients suggest that the risk is markedly elevated. Therefore, we investigated the incidence of BL in 203,557 solid organ recipients in the U.S. Transplant Cancer Match Study (1987-2009) and compared it with the general population using standardized incidence ratios. We also assessed ...
Cordova Fabiano M FM Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-900, - - 2013
While manganese (Mn) is essential for proper central nervous system (CNS) development, excessive Mn exposure may lead to neurotoxicity. Mn preferentially accumulates in the basal ganglia, and in adults it may cause Parkinson's disease-like disorder. Compared to adults, younger individuals accumulate greater Mn levels in the CNS and are more ...
Teno Joan M JM Warren Alpert Medical School of Brown University, 121 S Main St, Providence, RI 02912, USA. - - 2013
A recent Centers for Disease Control and Prevention report found that more persons die at home. This has been cited as evidence that persons dying in the United States are using more supportive care. To describe changes in site of death, place of care, and health care transitions between 2000, ...
Peterson Julie A JA Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226-3548, US. - - 2013
Neonatal alloimmune thrombocytopenia, (NAIT) is caused by maternal antibodies raised against alloantigens carried on fetal platelets. Although many cases are mild, NAIT is a significant cause of morbidity and mortality in newborns and is the most common cause of intracranial haemorrhage in full-term infants. In this report, we review the ...
Vannucci Anna A Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, - - 2013
To investigate the association between binge features and clinical validators. The Eating Disorder Examination assessed binge features in a sample of 549 college-age women: loss of control (LOC) presence, binge frequency, binge size, indicators of impaired control, and LOC severity. Clinical validators were self-reported clinical impairment and current psychiatric comorbidity, ...
Xiaoxi Ji J Department of Orthopedic Surgery, First People's Hospital Affiliated to Shanghai Jiaotong University, 100 Haining Road, Hongkou District, Shanghai, 200080, People's Republic of - - 2013
To obtain a series of parameters describing the shape and bone thickness of the fixation route along the superior border of the arcuate line, so as to provide references for pelvic and acetabular surgery and design pelvic anatomic internal fixators. A total of 175 complete pelvic computed tomography (CT) scans ...
Geisler Stefanie S Institute of Neuroscience and Medicine, INM-4-Medical Imaging Physics, Research Centre Jülich, Jülich, - - 2013
After cerebral ischemia or trauma, secondary neurodegeneration may occur in brain regions remote from the lesion. Little is known about the capacity of cerebral gliomas to induce secondary neurodegeneration. A previous study showed that cis-4-[(18)F]fluoro-D-proline (D-cis-[(18)F]FPro) detects secondary reactions of thalamic nuclei after cortical infarction with high sensitivity. Here we ...
Clarkson Andrew N AN Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, - - 2013
Recent studies show a limited capacity for neural repair after stroke, which includes remapping of sensorimotor functions and sprouting of new connections. However, physiologic and connectional plasticity of sensory maps during long-term functional recovery in the mouse have not been determined. Using a photothrombotic stroke model, we targeted the motor ...
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