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Eack Shaun M SM School of Social Work, University of Pittsburgh, Pittsburgh, PA 15260, USA. - - 2013
Cognitive rehabilitation is an emerging set of potentially effective interventions for the treatment of autism spectrum disorder, yet the applicability of these approaches for "high functioning" adults who have normative levels of intelligence remains unexplored. This study examined the initial cognitive performance characteristics of 40 verbal adults with autism enrolled ...
Surrey David D Department of Radiology, Thomas Jefferson University Hospital, 132 South 10th Street, Main Building 10th Floor, Philadelphia, PA 19107, - - 2013
Diagnostic radiology training programs must produce highly skilled diagnostic radiologists capable of interpreting radiological examinations and communicating results to clinicians. Established training performance tools evaluate interpretive skills, but trainees' competency in reporting skills is also essential. Our semi-automated passive electronic tool entitled the Quantitative Reporting Skills Evaluation (QRSE) allows radiology ...
Glick Abigail B AB Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio 44106, - - 2013
Autoimmune thyroid disease (AITD) pathogenesis may result from a loss of immune tolerance to thyroid antigens. Regulatory T cells (Tregs) control immune responses, prevent excessive inflammation, and may be dysfunctional in AITD. We investigated the role of Tregs in Hashimoto's thyroiditis (HT) and Graves' disease (GD), complicated by Down syndrome ...
Iwata Takahiro T Department of Orthopaedic Surgery, Ibi Kousei Hospital, Gifu, - - 2013
In vivo measurement of lumbar foramen using computed tomography and an axial loading device in healthy young subjects. To investigate the effects of axial loading on the morphology of the lumbar foramen in vivo. In vitro studies have shown morphologic changes in the lumbar foramen in response to axial loading. ...
Alberg Anthony J AJ Hollings Cancer Center and Division of Biostatistics and Epidemiology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA. - - 2013
Rigorous outcome evaluation is essential to monitor progress toward achieving goals and objectives in comprehensive cancer control plans (CCCPs). This report describes a systematic approach for an initial outcome evaluation of a CCCP. Using the Centers for Disease Control and Prevention evaluation framework, the evaluation focused on (1) organizing cancer ...
Mahdi Ali A Department of Diagnostic Medicine/Pathobiology, Kansas State University, 1800 Denison Avenue, Manhattan, KS 66506, - - 2013
Pet dogs and cats in the USA are commonly exposed to potentially hazardous substances found in domestic environments. Requests for assistance and advice received by the Kansas State Veterinary Diagnostic Laboratory regarding exposures in dogs and cats to substances perceived by their caretakers to be potentially harmful included 1,616 phone ...
Tompsett Carolyn J CJ Department of Psychology, Bowling Green State University, Bowling Green, OH, USA. - - 2013
Adolescents who experience homelessness are at higher risk for abusing substances, and for being exposed to substance-using peers. The current study used a longitudinal design to track substance abuse, affiliation with substance-using peers, and episodes of homelessness among a sample of 223 adolescents who were housed at the baseline data ...
Sogawa Kazuyuki K Clinical Proteomics Research Center, Chiba University Hospital, Chiba, - - 2013
Clinical application of biomarker candidates discovered by proteomic analysis is challenging. The purpose of this study was to standardize preanalytical conditions for measurement of serum levels of fibrinogen alpha C-chain 5.9 kDa fragment (FIC 5.9) and to test the diagnostic value of this peptide for detection of early hepatic fibrosis ...
Seeley Erin H EH Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, - - 2013
Although Crohn's colitis (CC) and ulcerative colitis (UC) share several clinical features, they have different causes, mechanisms of tissue damage, and treatment options. Therefore, the accurate diagnosis is of paramount importance in terms of medical care. The distinction between CC/UC is made on the basis of clinical, radiologic, endoscopic, and ...
Geiser David M - - 2013
In this letter, we advocate recognizing the genus Fusarium as the sole name for a group that includes virtually all Fusarium species of importance in plant pathology, mycotoxicology, medicine, and basic research. This phylogenetically guided circumscription will free scientists from any obligation to use other genus names, including teleomorphs, for ...
Wilkinson-Berka Jennifer L - - 2013
Pathological angiogenesis is a key feature of many diseases including retinopathies such as ROP (retinopathy of prematurity) and DR (diabetic retinopathy). There is considerable evidence that increased production of ROS (reactive oxygen species) in the retina participates in retinal angiogenesis, although the mechanisms by which this occurs are not fully ...
Xiao Qian Q Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA. - - 2013
Calcium intake has been promoted because of its proposed benefit on bone health, particularly among the older population. However, concerns have been raised about the potential adverse effect of high calcium intake on cardiovascular health. To investigate whether intake of dietary and supplemental calcium is associated with mortality from total ...
Haldar Swati S 1 Department of Pathology, Case Western Reserve University , Cleveland, - - 2013
Most biomarkers used for the premortem diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) are surrogate in nature, and provide suboptimal sensitivity and specificity. We report that CJD-associated brain iron dyshomeostasis is reflected in the cerebrospinal fluid (CSF), providing disease-specific diagnostic biomarkers. Analysis of 290 premortem CSF samples from confirmed cases of ...
Rogala Barbara - - 2013
IL-33, a member of the IL-1 cytokine family and a ligand to receptor ST2, has great potential to induce a T helper 2-type inflammatory response. IL-33 is proven to be released by epithelial cells during their injury by different environmental stimuli such as airborne allergens, viruses, and air pollutants. IL-33 ...
Kelly Aaron S AS Department of Pediatrics, University of Minnesota Medical School, 420 Delaware St, SE, MMC 715, Minneapolis, MN 55455, USA. - - 2013
Medical treatment options for pediatric obesity remain limited. Glucagon-like peptide-1 (GLP-1) receptor agonists induce weight loss by suppressing appetite and increasing satiety, but few studies have evaluated this therapy as a treatment for obesity. To evaluate the effects of exenatide on body mass index (BMI; calculated as weight in kilograms ...
Irwin David J DJ Center for Neurodegenerative Disease Research and Institute on Aging, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, - - 2013
Growing evidence of cell-to-cell transmission of neurodegenerative disease (ND)-associated proteins (NDAPs) (ie, tau, Aβ, and α-synuclein) suggests possible similarities to the infectious prion protein (PrPsc) in spongiform encephalopathies. There are limited data on the potential human-to-human transmission of NDAPs associated with Alzheimer disease (AD) and other non-PrPsc ND. To examine ...
Brand Richard A RA Clinical Orthopaedics and Related Research, 1600 Spruce Street, Philadelphia, PA 19103, USA. - - 2013
This biographical sketch on Franz König corresponds to the historic text, The Classic: Ueber freie Körper in den Gelenken [On loose bodies in the joint] (1887), available at DOI 10.1007/s11999-013-2824-y (Translated by Drs. Richard A. Brand and Christian-Dominik Peterlein).
Bauer Nerissa S NS Indiana University School of Medicine, Department of General Pediatrics, Section of Children's Health Services Research, 410 W 10th St, Ste 1000, Indianapolis, IN 46202, USA. - - 2013
Children with known exposure to intimate partner violence (IPV) or maternal depression are at risk for negative mental health outcomes as early as preschool age. Active ongoing surveillance for these risk factors can lead to earlier mental health intervention for children. To examine the association between parent reports of IPV ...
Paoletti Ernesto - - 2013
Available data on the role of renin-angiotensin system blockade in renal transplantation are inconclusive. Herein, we report the long-term results of a randomized controlled trial planned to evaluate the impact of angiotensin-converting enzyme inhibitors (ACE-i) on the cardiovascular outcome of renal transplant recipients (RTRs) receiving calcineurin inhibitors, steroids, and mycophenolate ...
Ingavle Ganesh C GC Department of Chemical and Petroleum Engineering, University of Kansas, Lawrence, Kansas 66045-7609, - - 2013
Interpenetrating network (IPN) hydrogels were recently introduced to the cartilage tissue engineering literature, with the approach of encapsulating cells in thermally gelling agarose that is then soaked in a poly(ethylene glycol) diacrylate (PEGDA) solution, which is then photopolymerized. These IPNs possess significantly enhanced mechanical performance desirable for cartilage regeneration, potentially ...
Mach Albert J AJ University of California, Los Angeles - Bioengineering, 5121E Engineering V University of California, Los Angeles, California 90095-1600, - - 2013
The cellular components of body fluids are routinely analyzed to identify disease and treatment approaches. While significant focus has been placed on developing cell analysis technologies, tools to automate the preparation of cellular specimens have been more limited, especially for body fluids beyond blood. Preparation steps include separating, concentrating, and ...
Gopinathan Gokul G UIC Brodie Laboratory for Craniofacial Genetics, UIC College of Dentistry, Chicago, Illinois 60612, - - 2013
Epigenetic mechanisms, such as histone modifications, play an active role in the differentiation and lineage commitment of mesenchymal stem cells. In the present study, epigenetic states and differentiation profiles of two odontogenic neural crest-derived intermediate progenitor populations were compared: dental pulp (DP) and dental follicle (DF). ChIP on chip assays ...
Gabriel Nishanth N Department of Hematology, Christian Medical College, Vellore 632004, Tamil Nadu, - - 2013
We hypothesized that the AAV2 vector is targeted for destruction in the cytoplasm by the host cellular kinase/ubiquitination/proteasomal machinery and that modification of their targets on AAV2 capsid may improve its transduction efficiency. In vitro analysis with pharmacological inhibitors of cellular serine/threonine kinases (protein kinase A, protein kinase C, casein ...
He Rongjun R Department of Biochemistry and Molecular Biology, Chemical Genomics Core Facility, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, - - 2013
Mycobacterium protein tyrosine phosphatase B (mPTPB) is essential for the survival and persistence of Mycobacterium in the host. Thus small molecule inhibitors of mPTPB are potential anti-TB agents. We developed an efficient organocatalytic multicomponent reaction (MCR) between pyrrole, formaldehyde and aniline, affording a potent and selective mPTPB inhibitor with an ...
Shapiro Stuart Z SZ Vaccine Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases , Bethesda, - - 2013
This article discusses HIV vaccine discovery and candidate vaccine testing in the context of current realities of funding and clinical trial practice. Lacking perfect animal models for testing candidate HIV vaccines, clinical investigators have proposed a strategy of iterative exploratory clinical trials in the model of cancer chemotherapy development. Problems ...
Lin Qin - - 2013
Zebrafish neuromast is an ideal model for investigating hair cell (HC) death and regeneration following ototoxic insults. HC undergoes rapid and robust replacement in larval zebrafish after neomycin damage. However, the origin of new HCs remains unclear. Our data showed that asymmetric cell division was involved in the process of ...
Gantenbein Andreas R - - 2013
Electrophysiological studies of stimulus-evoked brain activation suggest that sensory processing in migraine patients is abnormal between attacks. The main findings are increased amplitudes and decreased habituation of cortical evoked potentials. Recent findings in healthy individuals showed that evoked potentials result mainly from phase resetting of background electroencephalographic activity. We recorded ...
Nigri Anna A Neuroradiology Unit, Besta Neurological Institute, Milan, - - 2013
The majority of existing functional MRI studies on olfactory perception have addressed the relationship between stimulus features and the intensity of activity in separate regions considered in isolation. However, anatomical studies as well as neurophysiological recordings in rats and insects suggest that odor features may also be represented in a ...
Angel Lucie - - 2013
In this experiment, event-related potentials were used to examine whether the neural correlates of encoding processes predicting subsequent successful recall differed from those predicting successful source memory retrieval. During encoding, participants studied lists of words and were instructed to memorize each word and the list in which it occurred. At ...
Thornton K A KA Division of Medical Oncology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, - - 2013
There are few effective therapies for high-risk sarcomas. Initial chemosensitivity is often followed by relapse. In vitro, mammalian target of rapamycin (mTOR) inhibition potentiates the efficacy of chemotherapy on resistant sarcoma cells. Although sarcoma trials using mTOR inhibitors have been disappointing, these drugs were used as maintenance. We conducted a ...
Li W-H WH YouAn Hospital, Capital Medical University, Beijing, - - 2013
In China, the majority of human immunodeficiency virus (HIV) infections are predominately subtype B. It is important to characterize the HIV-1 subtype B-specific and its T cell response within the Chinese population, with the aim of identifying protective correlates of immunity to control HIV-1 infections. In this study, we performed ...
Liu Min M Harvard NeuroDiscovery Center, Harvard University , 65 Landsdowne Street, #452, Cambridge, Massachusetts 02139, United - - 2013
A number of well-known type II inhibitors (ATP-noncompetitive) that bind kinases in their DFG-out conformation were tested against wild-type LRRK2 and the most common Parkinson's disease-linked mutation, G2019S. We found that traditional type II inhibitors exhibit surprising variability in their inhibition mechanism between the wild type (WT) and the G2019S ...
Stein Derek R - - 2013
There is still a fundamental lack of understanding of what protected vaccinee's in the moderately successful RV144 Thailand trial. It is clear that better tools are needed to identify and study correlates of protection and immune responses to vaccine challenge. Quantitative mass spectrometry (MS) has evolved considerably to become a ...
Yu Miao M Department of Neuroscience and Physiology, Upstate Medical University, Syracuse, NY 13210, - - 2013
Dystroglycanopathies are a group of congenital muscular dystrophies (CMD) often caused by mutations in genes encoding glycosyltransferases that lead to hypoglycosylation of α-dystroglycan (α-DG) and reduce its extracellular matrix-binding activity. Overexpressing LARGE (formerly known as like-glycosyltransferase) generates an extracellular matrix-binding carbohydrate epitope in cells with CMD-causing mutations in not only ...
Coustan-Smith Elaine - - 2013
In patients with acute myeloid leukemia (AML), measuring response to treatment is essential to guide clinical decisions. Methods for detecting disease beyond the resolution limit of morphology (i.e., minimal residual disease, MRD) are now widely available. We here discuss their merits and the results of side-to-side comparisons. The ever-increasing comprehension ...
Buchwald Sabine - - 2013
To examine the associations between factors of socio-economic status (SES), systemic inflammation and the progression of periodontitis and incidence of tooth loss. Data of 2566 participants from the Study of Health in Pomerania (SHIP) with a 5-year follow-up were analysed. We evaluated attachment loss and tooth loss with regard to ...
Chéramy M M Division of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. - - 2013
Previous studies have indicated phenotypical differences in glutamic acid decarboxylase 65 autoantibodies (GADA) found in type 1 diabetes (T1D) patients, individuals at risk of developing T1D and stiff-person syndrome (SPS) patients. In a Phase II trial using aluminium-formulated GAD(65) (GAD-alum) as an immunomodulator in T1D, several patients responded with high ...
Bosch Ronald J RJ Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts 02115, USA. - - 2013
The dramatic increase in the number and type of immune biomarkers that can be measured, particularly those assessing immune activation, has led to numerous investigations in HIV-infected individuals to explore pathogenesis and to assess therapeutic interventions that aim to attenuate immune activation. An overview is provided on study designs and ...
Kiderman Alexander - - 2013
Objective:  To propose a possible link between dental extraction and intra-ocular complications. Background:  Several publications in medical literature describe intra-ocular complications after different dental procedures. Results:  Retinal detachment and vitreous hemorrhage following dental extraction with an appropriate anesthesia. Conclusion:  Systemic complications following dental treatments should not be neglected and proper ...
Zhu S S Paediatric Liver Disease Therapy and Research Center, 302 Hospital, Beijing, - - 2013
Interleukin (IL)-17-mediated immune response has been shown to play a critical role in inflammation-associated disease. However, its role in the pathogenesis of chronic hepatitis B virus (HBV) in paediatric patients remains unknown. We investigated the frequency of T helper type 17 (Th17) cells and evaluated the association between the Th17 ...
Kraljevic K K Department of Medicine, University of Sydney, Sydney, - - 2013
B-1 cells are innate-like lymphocytes characterized by spontaneous production of 'natural' polyspecific antibodies, often of self-specificity, and thought to be responsible for tissue homeostasis, mucosal protection, maintaining resting serum immunoglobulin (Ig)M levels and for early immunoglobulin production following infection. Although defined most clearly in mice, a human B-1 cell counterpart, ...
Sauce Delphine - - 2013
The pathogenesis of HIV infection is highly complex and involves numerous actors of the immune system. On the one hand, our immunity has a predominant role in limiting HIV replication and the depletion of its targets, but on the other hand, the persistent infection established by the virus is associated ...
Ranasinghe Priyanga - - 2013
Diabetes in South Asia represents a different disease entity in terms of its onset, progression, and complications. In the present study, we systematically analyzed the medical research output on diabetes in South Asia. The online SciVerse Scopus database was searched using the search terms "diabetes" and "diabetes mellitus" in the ...
Buford Thomas W TW Department of Aging and Geriatric Research, College of Medicine, University of Florida, PO Box 112610, Gainesville, FL 32611, USA. - - 2013
The early 21st century has witnessed a steady push by scientists, industry leaders, and government officials to make medicine more personalized. To date, the concept of personalized medicine has referred largely to the field of pharmacogenomics. In contrast, relatively few data exist regarding the application of preventive strategies such as ...
Sanders Mathijs A - - 2013
Acute myeloid leukaemia (AML) is a heterogeneous disease with a variable response to therapy. The heterogeneity of AML is evident from variations in morphology, immunophenotype, cytogenetics and molecular abnormalities. The introduction of genome-wide technologies has enabled an even more detailed molecular analysis of AML. As a result, the molecular landscape ...
Bustamante M F MF Centre d'Esclerosi Múltiple de Catalunya, CEM-Cat, Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, - - 2013
We investigated cellular immune responses at baseline in peripheral blood mononuclear cells (PBMC) of patients with multiple sclerosis (MS) treated with interferon (IFN)-β and classified into responders and non-responders according to clinical response criteria. Levels for IFN-γ, interleukin (IL)-17A, IL-17F, IL-10 and IL-4 were determined in activated PBMC of 10 ...
Goraya Nimrit - - 2013
Most patients with chronic kidney disease (CKD) have progressive decline in glomerular filtration rate (GFR), despite current treatment practices. Recent studies support that dietary acid reduction with oral sodium based alkali or base-inducing food types add kidney protection to that provided by current kidney-protective interventions. Related studies also support that ...
Csuka D D Third Department of Internal Medicine, Semmelweis University, Budapest, Hungary. - - 2013
Several studies suggest that infection by Epstein-Barr virus (EBV) might be one of the environmental factors which facilitates the development of autoimmune disorders in genetically susceptible individuals. Recent data indicate that high anti-Epstein-Barr nuclear antigen 1 (EBNA)-1 immunoglobulin (Ig)G titre is a strong risk factor for multiple sclerosis (MS) in ...
Sharkey Mark - - 2013
In this review, methods with which investigators detect and monitor HIV persistence will be described. In particular, we will focus on the work that provides evidence that low-level virus replication persists despite the suppressive effects of therapy and the approaches that can be employed to measure and characterize the ongoing ...
Cooper S E J SE Department of Immunology, St James's Hospital and Trinity College Dublin, Dublin, - - 2013
Coeliac disease is a gluten-sensitive enteropathy that develops in genetically susceptible individuals. The disease exhibits many features of an autoimmune disorder. These include the production of highly specific anti-endomysial autoantibodies directed against the enzyme tissue transglutaminase. It is well accepted that wheat-, barley- and rye-based foods should be excluded in ...
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