Search Results
Results 401 - 450 of 3603
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Cheng Qinghao - - 2013
Oxidative stress has been associated with mild cognitive impairment (MCI) and Alzheimer's disease (AD). However, little is known about oxidative stress in postoperative cognitive dysfunction (POCD) in aging. The aim of this study was to investigate urinary excretion rate of 8-isoprostane:creatinine (U8-isoPG:Cr) and malonaldehyde:creatinine (UMDA:Cr) to predict short-term POCD in ...
Bidard François-Clément - - 2013
In the context of metastatic disease, preclinical models have been used primarily to decipher different steps of the metastatic cascade. Numerous molecular processes operate in these model systems, but none of these has been successfully translated to the clinic. We discuss some of the successes and failures of preclinical models ...
Sherwood Matthew W MW The Duke Clinical Research Institute, North Pavilion, 2400 Pratt Street, Durham, NC 27705, - - 2013
In a meta-analysis of predominantly observational data, blood transfusion was independently associated with adverse outcomes in patients with myocardial infarction. These findings are consistent with previously published research, but clinical application of these data is hindered by the lack of prospective, randomized trials and the inherent bias in observational studies.
Shikata Hisaharu - - 2013
BACKGROUND: Febrile neutropenia (FN) is one of the serious complications of chemotherapy. However, the hematological nadir after chemotherapy and the timing of prophylaxis for FN remain unclear, especially for outpatients. METHODS: We prospectively analyzed laboratory data from outpatients treated with a single chemotherapy regimen, rituximab (R)-CHOP, on three consultation days ...
Galanter William L - - 2013
To quantify the extent of patient sharing and inpatient care fragmentation among patients discharged from a cohort of Chicago hospitals. Admission and discharge dates and patient ZIP codes from 5 hospitals over 2 years were matched with an encryption algorithm. Admission to more than one hospital was considered fragmented care. The ...
Panyutina A A - - 2013
New data on the mechanisms of movements of the shoulder girdle and humerus of bats are described; potential mobility is compared to the movements actually used in flight. The study was performed on the basis of morphological and functional analysis of anatomical specimens of 15 species, high speed and high ...
Kwon Ha-Jeong - - 2013
Astragalosides are among the most predominant of the bioactive compounds in the root of Astragalus membranaceus and are differentially concentrated depending on the anatomical part of the root in question. The aim of this study was to analyse astragaloside contents in the periderm, cortex, and xylem of A. membranaceus root, ...
McElroy Susan L - - 2013
OBJECTIVE: To assess preliminarily the effectiveness of a novel opioid antagonist, ALKS-33, in binge eating disorder (BED). METHOD: In this randomized, placebo-controlled, flexible dose, proof-of-concept trial, 62 outpatients with BED and obesity received ALKS-33 (N = 26) or placebo (N = 36) for 6 weeks. Outcome measures of binge eating, ...
Yu Yong-Liang - - 2013
A low temperature micro-plasma generated in a dielectric barrier discharge (DBD) was used as a radiation source for the excitation of iodine and its determination by vapor generation-optical emission spectrometry. A piece of ceramic tube served as an excitation chamber to provide a small gas path for introducing a helium ...
Chouliara Z - - 2013
ACCESSIBLE SUMMARY: Adopting a model of personally meaningful recovery places demands on the therapeutic relationship, on clinical governance and supervision of clinicians. The recovery journey from childhood sexual abuse (CSA) starts at the point of disclosure. Findings support the use of shame-based and compassion-focused interventions with CSA survivors. ABSTRACT: Research ...
Banu Tahmina - - 2013
There is unequal access to surgical health care in underdeveloped countries such as Bangladesh. Bangladesh has a large young population, with 70 % of the population living in rural areas. All of the pediatric surgical services of the country are situated in major cities. We therefore organized an outreach service with ...
Viatte Sebastien S Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, - - 2013
Investigators have made key advances in rheumatoid arthritis (RA) genetics in the past 10 years. Although genetic studies have had limited influence on clinical practice and drug discovery, they are currently generating testable hypotheses to explain disease pathogenesis. Firstly, we review here the major advances in identifying RA genetic susceptibility ...
Hassan M K - - 2013
In spite of all the efforts to control H5N1 in Egypt, the virus still circulates endemically, causing significant economic losses in the poultry industry and endangering human health. This study aimed to elucidate the role of clinically healthy ducks in perpetuation of H5N1 virus in Egypt in mid-summer, when the ...
Stankiewicz M J MJ Department of Medicine, Northwestern University, Chicago, IL 60611, - - 2013
The requirement that leukemic Gata1 mutations be present in cells harboring trisomy 21 led to the discovery that overexpression of ERG drives aberrant megakaryopoiesis. Given that constitutive PI3K/AKT signaling is a frequent component of hematologic malignancies and the relationship between AKT and Notch in this lineage, we studied the crosstalk ...
Davy Jonathan - - 2013
This study compared the effects of a 1 h self-selected recovery period to those of a standard night shift arrangement (with a total break time of 1-h) over a simulated three-day night shift schedule in a laboratory setting. Results showed that the inclusion of the flexible nap scheme resulted in higher ...
Ferreira Luciano Ambrosio - - 2013
A prospective, double-blind, randomized, and placebo-controlled trial was conducted in patients with chronic temporomandibular disorder (TMD) to check the analgesic efficacy of infrared low-power GaAlAs diode laser applied to acupuncture points. Forty female subjects, ranging in age from 20 to 40 years, with diagnoses of chronic myofascial pain and arthralgia were ...
Rnic K - - 2013
It is critical for prostate cancer researchers and clinicians to have access to comprehensive, sensitive and simple-to-use symptom measures that allow them to understand and quantify the subjective patient experience. The purpose of the current review is to provide a comprehensive review, detailed tool descriptions and objectively defined quality criteria ...
Ulsemer Philippe - - 2013
The tumor-specific Thomsen-Friedenreich antigen (TFα, CD176) is an attractive target for a cancer vaccine, especially as TF-directed antibodies play an important role in cancer immunosurveillance. However, synthetic TF vaccines have not overcome the low intrinsic immunogenicity of TF. Since natural TF-directed antibodies present in human sera are generated in response ...
Wuttge Dm - - 2013
Objective: To study serum type I interferon (IFN) activity in patients with early systemic sclerosis (SSc). Method: Serum type I IFN activity was measured in 33 consecutive patients with SSc and a disease duration of < 2 years and in 13 healthy individuals by calculating a type I IFN score ...
Yang Ju-Wen - - 2013
PURPOSE: To investigate the correlation between stereoacuity, as analyzed by the Titmus stereotest, and the severity of myopia, astigmatism and anisometropia in a school-aged population in Taiwan. METHODS: Cycloplegic autorefraction, best corrected monocular visual acuity and stereoacuity were measured in 6- to 18-year-old school children. Children with amblyopia (best corrected ...
Xiang Ping-Hua - - 2013
A Mott transistor that exhibits a large switching ratio of more than two orders at room temperature is demonstrated by using the electric double layer of an ionic liquid for gating on a strongly correlated electron system SmCoO(3) . From the thickness dependence of the on-state channel current, we estimate ...
Abrams Steven A - - 2013
Vitamin D is a key nutrient for both healthy children and those with chronic illnesses. Understanding its roles in health and disease has become one of the most important issues in the nutritional management of children. Formal guidelines related to nutrient requirements for vitamin D in healthy children, recommending dietary ...
Wu Menghao - - 2013
Using first-principles calculations based on gradient corrected density functional theory we show that an otherwise distorted icosahedric Mn(13) ferrimagnetic cluster, when doped with six B or C atoms, transforms into a ferromagnetic cuboctahedral cluster with a magnetic moment that is an order of magnitude larger than that of the pure ...
Berger Peter B PB Geisinger Clinic, Danville, Pennsylvania, USA. - - 2013
To investigate whether tirofiban would have been non-inferior to abciximab had the trial completed enrollment and place the termination of this trial in a broader research ethics context. TENACITY was terminated by the sponsor for financial reasons. At the time, event rates for the 2 treatment arms were unknown. TENACITY ...
Sarnat Harvey B - - 2013
Predictable temporal and spatial patterns of synaptophysin expression previously were demonstrated in the normally developing fetal cerebral cortex, reflecting synaptogenesis without regard to neurotransmitters. We studied 6 human fetal brains with holoprosencephaly in the mid-2nd and 3rd trimesters with immunocytochemical antibodies against synaptophysin and other markers of neuronal maturation. We ...
Nyadong Leonard - - 2013
We present the first coupling of laser spray ionization inlet (LSII) and matrix assisted ionization inlet (MAII) to high-field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) for generation of electrospray-like ions to take advantage of increased sensitivity, mass range, and mass resolving power afforded by multiple charging. We ...
Lanner Fredrik - - 2013
Hypoxia (low oxygen) and Notch signaling are two important regulators of vascular development, but how they interact in controlling the choice between arterial and venous fates for endothelial cells during vasculogenesis is less well understood. In this report, we show that hypoxia and Notch signaling intersect in promotion of arterial ...
Batai Ken K Cancer Education and Career Development Program, Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, IL 60607, USA. - - 2013
The Bantu languages are widely distributed throughout sub-Saharan Africa. Genetic research supports linguists and historians who argue that migration played an important role in the spread of this language family, but the genetic data also indicates a more complex process involving substantial gene flow with resident populations. In order to ...
Sharma Verinder - - 2013
We describe case histories of three women with post-abortion mania, including two women who underwent a change in diagnosis from bipolar II to bipolar I disorder and another woman who had no prior history of psychiatric disturbance. It is argued that the study of post-abortion mania should provide an opportunity ...
Jurko Alexander A - - 2013
Congenital absence of pericardium is a rare malformation. We report 2 young patients with a diagnosis of congenital absence of the pericardium. The posteroanterior view of the chest X-ray showed displacement of the left cardiac border into the left hemithorax. Unusual acoustical windows and abnormal cardiac and septal motion during ...
Montealegre Cristina - - 2013
A nonaqueous capillary electrophoresis method with electrospray-mass spectrometry detection was developed to study the glycerophospholipid fraction in olive fruit and olive oil samples. In olive fruits, where the information available about its phospholipids fraction was very scarce, results obtained in this work allowed to complete and improve this knowledge. The ...
Mavros M N - - 2013
Surgical site infection (SSI) after pilonidal disease surgery can lead to serious complications. We systematically searched the PubMed, Scopus, and ClinicalTrials.gov databases for studies evaluating the use of antimicrobials as an adjunct to pilonidal disease surgery. We identified 12 eligible studies [nine randomized controlled trials (RCTs), three retrospective cohort studies], ...
Obara Boguslaw - - 2013
Colocalisation, the overlap of subcellular structures labelled with different colours, is a key step to characterise cellular phenotypes. We have developed a novel bioimage informatics approach for quantifying colocalisation of round, blob-like structures in two-colour, highly resolved, three-dimensional fluorescence microscopy datasets. First, the algorithm identifies isotropic fluorescent particles, of relative ...
Zhou Xue - - 2013
Objective: Bone marrow mesenchymal stem cell (BMSC) is a potentially effective vehicle for the cell and gene therapy in clinical disease treatment. We studied whether the most commonly used anesthetic drugs have negative effects on rat BMSCs in vitro. Materials and methods: The cultured BMSCs were treated with sevoflurane (in ...
Allen Jennifer C - - 2013
Hemolyitic uremic syndrome (HUS), characterized by triad of acute kidney injury, thrombocytopenia, and hemolytic anemia, has considerable morbidity and mortality and is known to be associated with diarrheal illness. It usually occurs after a diarrheal illness due to Shiga-toxin-producing Escherichia coli. Streptococcus pneumoniae is a rare but well recognized trigger ...
Tang Xi - - 2013
Objective: To explore the long-term outcome and prognostic factors of primary focal segmental glomerulosclerosis (FSGS) in Chinese adults. Methods: A retrospective study was conducted in 104 adults with primary FSGS. Clinical records and renal biopsies were reviewed. The primary endpoint was end-stage renal disease (ESRD) and death. Results: The most ...
Raz Raanan - - 2013
We describe a survey of children with ASD aged 4-10 years. The main dependent variables were out-of-pocket expenditures for health services and hours of therapy. Multivariable logistic regression models were used in order to find independent predictors for service utilization. Parents of 178 of the children (87 %) agreed to participate. The ...
Adams K - - 2013
PURPOSE: The purposes of this study were to assess the working definition of a colorectal anastomotic leak among colorectal surgeons and to survey the current approach to investigation and management of a patient with a suspected anastomotic leak. METHODS: Online survey consisting of nine questions regarding the definition, assessment and ...
Thompson Stephen S Centre for Medical Image Computing, University College London, London, UK. - - 2013
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Systems for image guidance during laparoscopic surgery can be broadly defined as systems that enable the surgeon to refer to preoperatively gathered information during the procedure. For a laparoscopic system the preoperative information can be overlaid onto the laparoscopic ...
Maulana Ridwan - - 2013
Research consistently shows that the learning environment plays an important role for early adolescents' learning and outcomes and suggests that good teacher-student relationships can serve as a protective factor for maintaining young adolescents' interest and active engagement in learning. However, less is known about the dynamic nature of teacher-student relationships ...
Sauer Heinrich - - 2013
α2-macroglobulin (α2M) is an acute phase protein released upon challenges like cardiac hypertrophy and infarction. α2M signals via lipoprotein LDL receptor related protein (LRP-1) and may induce stem cell activation. In the present study, the effects of α2M on vasculogenesis/angiogenesis and underlying signalling cascades were investigated in mouse embryonic stem ...
Parks E P - - 2013
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: Adolescence is an important period of physiological growth. Loss of central adiposity with preservation of lean mass during weight loss is optimal. There are discrepancies in the literature concerning changes in lean mass during weight loss in adolescents. WHAT THIS STUDY ADDS: This ...
Hatano Hiroko - - 2013
Fibro-osseous lesions of the jaw are poorly understood because of a significant overlap of clinical, radiological and histological features among the various types, though they present distinct patterns of disease progression. An ossifying fibroma is associated with significant cosmetic and functional disturbances, as it shows expansive proliferation. Thus, it is ...
Bilder Leon - - 2013
The causative agents in periodontal disease are periopathogenic bacteria; however, viruses have been implicated. The aim of this study was to examine the prevalence of different HHVs in the saliva of chronic periodontitis patients and to compare it to two groups of healthy controls. Three groups were included: chronic periodontitis ...
Jantzen Sabine U - - 2013
ABSTRACT: BACKGROUND: Anti-NMDA-encephalitis is caused by antibodies against the N-methyl-D-aspartate receptor (NMDAR) and characterized by a severe encephalopathy with psychosis, epileptic seizures and autonomic disturbances. It predominantly occurs in young women and is associated in 59% with an ovarian teratoma. RESULTS: We describe effects of cerebrospinal fluid (CSF) from an ...
Clemmensen Peter - - 2013
For several years, clopidogrel plus aspirin has been the dual antiplatelet therapy (DAPT) of choice for patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) with stent implantation. More recently, prasugrel and ticagrelor have demonstrated greater efficacy than clopidogrel. In TRITON-TIMI 38, the risk of TIMI major bleeding ...
Kan Shigenori - - 2013
We focused our attention on the endotoxin present within and on the surface of white blood cells and attempted to establish a new sample preparation method for endotoxin assays in leukocyte-rich plasma (LRP), taking advantage of the erythrocyte-aggregating property of hydroxyethyl starch. We used an endotoxin-specific turbidimetric kinetic assay, which ...
Watanabe Makoto - - 2013
Protein glycosylation analysis is important for elucidating protein function and molecular mechanisms in various biological processes. We previously developed a glycan analysis method using a 3-aminoquinoline/α-cyano-4-hydroxycinnamic acid liquid matrix (3-AQ/CHCA LM) and applied it to the quantitative glycan profiling of glycoproteins. However, information concerning glycosylation sites is lost; glycopeptide analysis ...
Zerbini Livio - - 2013
The adjustment of pulmonary oxygen uptake (VO(2p)), heart rate (HR), limb blood flow (LBF), and muscle deoxygenation [HHb] was examined during the transition to moderate-intensity, knee-extension exercise in six older adults (70 ± 4 years) under two conditions: normoxia (FIO(2) = 20.9 %) and hypoxia (FIO(2) = 15 %). The subjects performed repeated step transitions from an active baseline ...
Sanner J E - - 2013
ACCESSIBLE SUMMARY: Depressive symptoms are common in women hospitalized for acute coronary syndrome, but symptom experience and severity may differ across a women's lifetime. Tiredness or fatigue, loss of energy and sleep disturbances were the three depressive symptoms most frequently reported by depressed women, hospitalized for acute coronary syndrome, across ...
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