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Results 301 - 350 of 3594
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Feng Fan - - 2013
With the continuous improvement of the living standards of human society, the number of diabetics worldwide is growing rapidly. To date, the main effective therapy for diabetic is intravenous injection of insulin, which is accompanied by a lot of shortage such as high cost and side effects. To obtain long-term ...
Halkett G K B - - 2013
PURPOSE: Although patients receive information prior to commencing radiotherapy, they often experience anxiety and distress. We conducted a pilot randomised controlled trial to determine whether a radiation therapist led psycho-educational intervention for breast cancer patients prior to radiotherapy is likely to be effective in reducing radiotherapy-related concerns, patient anxiety and ...
Chen Y-X - - 2013
PURPOSE: To identify independent predictors of survival in patients with lymph node (LN) metastases from hepatocellular carcinoma (HCC) after external beam radiotherapy (EBRT). METHODS: There were 191 patients with LN metastases from HCC received EBRT enrolled in the study cohort. EBRT was designed to focus on the LNs and a ...
Rohan Angela M - - 2013
Turning a ship requires small but steady and deliberate efforts over time. During the past 9 years, Wisconsin's Maternal and Child Health (MCH) Program has begun to utilize the life-course perspective as its framework for guiding efforts around women's health, early childhood systems, children and youth with special health care needs, ...
Zhou Zhi-Rui - - 2013
PURPOSE: To compare the efficacy and safety of short-term versus long-term hormonotherapy (HT) plus radiotherapy (RT) or prostatectomy (RP) for prostate cancer. METHODS: Literatures were searched from Embase, PubMed, Web of science and Cochrane Library up to October, 2012. Quality of the study was evaluated according to the Cochrane's risk ...
Gunter Stacey A - - 2013
Over 2 years, 32 beef cows nursing calves in southwest Arkansas were randomly selected from a herd of 120 that were managed in six groups and were assigned to six 5.1-ha bermudagrass (Cynodon dactylon [L.] Pers.) pastures. Treatments were assigned to pastures (two pastures/treatment) and cows had ad libitum access to ...
Al-Ghazawi Mutasim - - 2013
Objectives: To assess the bioequivalence of two Tizanidine 4 mg tablet formulations (Tizanidine® of the Pharma International company, as test product, and Sirdalud® of Novartis as a reference product), and to investigate possible effects of smoking on pharmacokinetics of tizanidine. Methods: A single-blind, randomized, single dose, two treatment, two-period, two-sequence, ...
Li Honglin - - 2013
Cyanamide was introduced into the rhodamine spirolactam framework to produce a colorless and non-fluorescent compound . It shows a reversible ring-opening/ring-closure process in response to the solution pH, which exhibits an "ON/OFF" switching in its fluorescence. Different from other rhodamine-type dyes, the ring-open form of is stable in protic solvents ...
Nazareth Alina - - 2013
Males consistently outperform females on mental rotation tasks, such as the Vandenberg and Kuse (1978) Perceptual and Motor Skills, 47(2), 599-604, mental rotation test (MRT; e.g. Voyer et al. 1995) in Psychological Bulletin, 117, 250-265. The present study investigates whether these sex differences in MRT scores can be explained in ...
Ogama Yoichiro - - 2013
Ruxolitinib (INC424), a potent and selective oral Janus kinase 1 and 2 inhibitor, was recently approved by the US food and drug administration for the treatment of intermediate or high-risk myelofibrosis. The safety, tolerability, and pharmacokinetics (PK) of ruxolitinib have been extensively evaluated in healthy subjects and patients. The present ...
Ravipati Srikanth - - 2013
A double-layer nanostructure comprising amorphous Si nanograss on top of Si nanofrustums (NFs) with a total height of 680 nm exhibits ultralow reflection. Almost near-unity absorption and near-zero reflectance result in this layered nanostructure over a broad range of wavelengths and a wide range of angles of incidence, due to ...
Zerbini Livio - - 2013
The adjustment of pulmonary oxygen uptake (VO(2p)), heart rate (HR), limb blood flow (LBF), and muscle deoxygenation [HHb] was examined during the transition to moderate-intensity, knee-extension exercise in six older adults (70 ± 4 years) under two conditions: normoxia (FIO(2) = 20.9 %) and hypoxia (FIO(2) = 15 %). The subjects performed repeated step transitions from an active baseline ...
Sanner J E - - 2013
ACCESSIBLE SUMMARY: Depressive symptoms are common in women hospitalized for acute coronary syndrome, but symptom experience and severity may differ across a women's lifetime. Tiredness or fatigue, loss of energy and sleep disturbances were the three depressive symptoms most frequently reported by depressed women, hospitalized for acute coronary syndrome, across ...
McLoone J K - - 2013
BACKGROUND: Providing ongoing clinical care that adequately addresses patients' medical, psychosocial and information needs is challenging, particularly for patient groups at increased risk of developing life-threatening disease such as malignant melanoma. This study examined a model of clinical care developed by the High Risk Clinic (HRC) of the Sydney Melanoma ...
Pacini Simone - - 2013
Mesechymal Stromal Cells (MSCs) are a heterogeneous cell population capable of differentiating towards several cell lines in vitro and, possibly, in vivo. Within cultured MSCs we identified and purified a precursor cell population (Mesodermal Progenitor Cells, MPCs) retaining robust proliferation potential and ability to differentiate into endothelial or mesenchymal cells. ...
Zhang Xinke - - 2013
Ag@zinc-tetraphenylporphyrin (Ag@ZnTPP) core-shell nanostructures have been fabricated by in situ chemical deposition. Unusual thickness-dependent fluorescence allowed their colour to be tuned from blue to red by simply increasing the shell thickness from ∼2 nm to ∼9 nm. The competition between metal enhancement and the self-absorption effect of ZnTPP has been ...
Xu Guobin - - 2013
Here we present the novel functionalization of detonation nanodiamond (dND) with amino-phenyl boronic acid (APBA) assisted by poly-l-lysine (PL) and PEG-diglycolic acid (PEG) (dND-p-APBA). With the assistance of biocompatible poly-l-lysine and PEG, dND-p-APBA particles show good dispersibility in aqueous solution and plentiful boronic acid functional groups on the surface, which ...
Leinonen Tuomas - - 2013
Comparative studies of the divergence of quantitative traits and neutral molecular markers, known as Q(ST)-F(ST) comparisons, provide a means for researchers to distinguish between natural selection and genetic drift as causes of population differentiation in complex polygenic traits. The use of Q(ST)-F(ST) comparisons has increased rapidly in the last few ...
Jakubowski Henry V - - 2013
To help faculty prepare and revise courses in all the disciplines represented in the MCAT(2015) , the American Association of Medical Colleges, through its MedEdPORTAL's iCollaborative, has established the Pre-health Collection, a repository of reviewed web resources that are openly and freely available to faculty, and indirectly through them to ...
Xue Pengchong - - 2013
Being different from common sensing molecules existing as monomer in solution, the gelators as sensing molecules self-assembled together in gels. Therefore, the interaction strength between gelators is believed as an important factor for gels to recognize selectively anions. In this paper, we choose two gelators, presenting similar binding sites for ...
Harris Tyler J - - 2013
We present this preliminary investigation into the safety and feasibility of endovascular therapy for morbid obesity in a swine model. A flow-limiting, balloon-expandable covered stent was placed in the superior mesenteric artery of three Yorkshire swine after femoral arterial cutdown. The pigs were monitored for between 15 and 51 days after ...
Radicioni Milko - - 2013
Background: Meloxicam is a non-steroidal anti-inflammatory drug, indicated for osteoarthritis exacerbations, rheumatoid arthritis and ankylosing spondylitis symptomatic treatment. Objective: To compare the bioavailability of a 15 mg meloxicam orodispersible tablet (ODT) and a reference 15 mg tablet in healthy volunteers. Methods: Two randomized, crossover, bioequivalence studies were conducted. In both ...
Liu Kang-Du - - 2013
The beneficial effects of subthalamic nucleus deep brain stimulation (STN-DBS) on motor symptoms and quality of life in Parkinson's disease (PD) are well known, but little is known of the effects on autonomic function. Diffusion of current during stimulation of the STN may simultaneously involve the motor and nonmotor, limbic ...
Dingemanse Jasper - - 2013
BACKGROUND AND OBJECTIVE: The cytochrome P450 (CYP) enzyme, CYP3A4, metabolizes ACT-178882, a new direct renin inhibitor. This study investigated the effect of diltiazem, a moderate inhibitor of CYP3A4, on the single-dose pharmacokinetics of ACT-178882 in healthy subjects. METHODS: In this open-label, two-way crossover, drug-drug interaction study, healthy young male subjects ...
Peterson Kathryn A - - 2013
OBJECTIVES:Elemental diets have not been studied in adults with eosinophilic esophagitis (EoE). The goal of this trial was to assess the efficacy of an elemental diet in adults with EoE.METHODS:A total of 18 adults with EoE were given an elemental diet for 4 weeks, or just 2 weeks if their ...
Banno Kouji - - 2013
MicroRNAs (miRNAs) are small non-coding ribonucleic acids (RNAs) of approximately 22 bp that induce RNA interference with a complementary messenger RNA (mRNA) and act in silencing of mRNA. miRNAs are strongly associated with cancer development and those involved in carcinogenesis are classified into oncogenic miRNAs and tumor suppressor miRNAs (tumor suppressor ...
Milner Rachel E - - 2013
The practice of using images in teaching is widespread, and in science education images are used so extensively that some have argued they are now the "main vehicle of communication" (C. Ferreira, A. Arroio Problems Educ. 21st Century 2009, 16, 48-53). Although this phenomenon is especially notable in the field ...
Sheikh Shahid - - 2013
Objective. This study was done to understand the demographics, clinical course, and outcomes of children with status asthmaticus treated in a tertiary care pediatric intensive care unit (PICU). Methods. The medical charts of all patients above 5 years of age admitted to the PICU at Nationwide Children's Hospital, Columbus, OH, ...
Concia Alda Lisa - - 2013
A chemo-enzymatic strategy for the preparation of 2-aminomethyl derivatives of (2R,3R,4R)-2-(hydroxymethyl)pyrrolidine-3,4-diol (also called 1,4-dideoxy-1,4-imino-d-arabinitol, DAB) and its enantiomer LAB is presented. The synthesis is based on the enzymatic preparation of DAB and LAB followed by the chemical modification of their hydroxymethyl functionality to afford diverse 2-aminomethyl derivatives. This strategy leads ...
Zhang Yi - - 2013
ABSTRACT: BACKGROUND: Malignant mesothelioma is an aggressive, treatment-resistant tumor arising from mesothelium of pleura, peritoneum and pericardium. Despite current combined regimen, its prognosis remains dismal, calling for more effective targeted therapies. We investigated whether aberrant Hh activation may play a role in mesothelioma. METHODS: SMO and SHH expression levels were ...
Wang Bin - - 2013
Diversification patterns and demography of montane species are affected by Pleistocene climate fluctuations. Empirical cases from the Qinling Mountains (QM) region, which is a major biogeographic divider of East Asia, are few. We used DNA sequence data of the complete mitochondrial ND2 gene to detect effects of the Pleistocene glaciations ...
Csordas Adam - - 2013
Cigarette smoke is an aerosol that contains >4,000 chemicals, including nicotine, carbon monoxide, acrolein, and oxidant compounds. Exposure to cigarette smoke induces multiple pathological effects in the endothelium, several of which are the result of oxidative stress initiated by reactive oxygen species, reactive nitrogen species, and other oxidant constituents of ...
Ji Shiliang - - 2013
A heterojunction device which has good transport characteristics and low sensitivity is obtained through two kinds of organic molecules inert to NO(2) . Using the heterojunction device, constructing more-sensitive double-heterojunction devices can get better room-temperature detection characteristics.
Matsumi Junya - - 2013
OBJECTIVES: To evaluate the risk of long-term dual antiplatelet therapy (DAT) following drug-eluting stent (DES) implantation in octogenarians. BACKGROUND: DES implantation requires DAT; however, DAT-associated risk in octogenarians remains unclear. METHODS: Two-hundred and six consecutive octogenarians (130 men, 83.3 ± 3.4 years) underwent stent implantation (104 bare metal stents [BMSs] and 102 ...
Roelen Corné Am - - 2013
ABSTRACT: BACKGROUND: Two models including age, self-rated health (SRH) and prior sickness absence (SA) were found to predict high SA in health care workers. The present study externally validated these prediction models in a population of office workers and investigated the effect of adding gender as a predictor. METHODS: SRH ...
Cero Ian - - 2013
Childhood physical abuse is a major risk factor for suicide attempt, but factors that moderate this risk remain largely unexamined. Moderated mediation analysis was used with 186 adolescents who responded to the Profiles of Student Life: Attitudes and Behavior survey. Physical abuse increased risk directly and indirectly through reduced self-esteem. ...
Raynal Caroline - - 2013
Molecular diagnosis of cystic fibrosis and CFTR-related disorders led to the worldwide identification of nearly 1900 sequence variations in the CFTR gene, that consist mainly in private point mutations and small insertions/deletions. Establishing their effect on the function of the encoded protein and therefore their involvement in the disease is ...
Nadeau-Fredette Annie-Claire - - 2013
Over the last years, the proportion of patients older than 80 years with end-stage renal disease has been constantly growing. Arteriovenous fistula (AVF) is known as the best vascular access for hemodialysis, but evidence for its added value is lacking for elderly. We retrospectively identified new vascular access (AVF and ...
Elsais Ahmed - - 2013
Myasthenia gravis (MG) is an autoimmune disease causing muscle weakness due to impaired transmission at the neuromuscular junction. MG or a MG-like condition may be triggered or exacerbated by several drugs used for treatment of other diseases. Drugs may interfere with the neuromuscular transmission through several mechanisms, either by affecting ...
Hong Yili - - 2013
System reliability depends on the reliability of the system's components and the structure of the system. For example, in a competing risks model, the system fails when the weakest component fails. The reliability function and the quantile function of a complicated system are two important metrics for characterizing the system's ...
Jev Nik Monika - - 2013
ABSTRACT: BACKGROUND: Human coronaviruses (HCoVs) are a well-known cause of respiratory infections but their role in gastrointestinal infections is unclear. The objective of our study was to assess the significance of HCoVs in the etiology of acute gastroenteritis (AGE) in children <6 years of age. METHODS: Stool samples and nasopharyngeal ...
Lamb Kathleen M - - 2013
BACKGROUND: The most frequent limb complications from peripheral veno-arterial extracorporeal membrane oxygenation (VA-ECMO) are limb ischemia and localized bleeding. To minimize these risks, perfusion of the distal limb with peripheral percutaneous cannulation was done. TECHNIQUE: Percutaneous cannulation with a distal perfusion port was performed in all patients. During the VA-ECMO, ...
Ryu Won Yeol - - 2013
PURPOSE:To verify whether central muscle sag actually induces excessive recession after recession of the rectus muscle in rabbit models. METHODS:Twenty-four eyes of 12 rabbits were divided into two groups. In the right eyes (the muscle sagging group), half of the width of the original insertion was used to create a ...
Aune Dagfinn - - 2013
BACKGROUND: Current evidence indicates that red and processed meat intake increases the risk of colorectal cancer; however, the association with colorectal adenomas is unclear. OBJECTIVE: To conduct a systematic review and meta-analysis of epidemiological studies of red and processed meat intake and risk of colorectal adenomas as part of the ...
Fuchimoto Jun - - 2013
Respiratory syncytial virus (RSV) is the major infectious agent causing serious respiratory tract inflammation in infants and young children. However, an effective vaccine and anti-viral therapy for RSV infection have not yet been developed. Hop-derived bitter acids have potent pharmacological effects on inflammation. Therefore, we investigated the effects of humulone, ...
Koutmani Y - - 2013
Neurogenesis during embryonic and adult life is tightly regulated by a network of transcriptional, growth and hormonal factors. Emerging evidence indicates that activation of the stress response, via the associated glucocorticoid increase, reduces neurogenesis and contributes to the development of adult diseases.As corticotrophin-releasing hormone (CRH) or factor is the major ...
van der Kraan A Gabrielle J - - 2013
The HSP90 inhibitor, 17-allylamino-demethoxygeldanamycin (17-AAG) increases osteoclast formation both in vitro and in vivo, an action that can enhance cancer invasion and growth in the bone microenvironment. The cellular mechanisms through which 17-AAG exerts this action are not understood. Thus, we sought to clarify 17-AAG actions on osteoclasts and determine ...
Gorelik Natalia - - 2013
Ewing's sarcoma is a relatively rare malignancy, occurring mainly between 4 and 25 years of age. It usually arises from the pelvis, followed by the femur, tibia, and remainder of both the long bones of the extremities and flat bones of the axial skeleton. To the best of our knowledge, ...
Kitagawa Munenori - - 2013
Cell-to-cell transport of molecules in plants must be properly regulated for plant growth and development. One specialized mechanism that plants have evolved involves transport through plasmodesmata (PD), but when and how transport of molecules via PD is regulated among individual cells remains largely unknown, particularly at the single-cell level. Here, ...
Adeeb Nimer - - 2013
INTRODUCTION: The pia mater has received less attention in the literature compared to the dura and arachnoid maters. However, its presence as a direct covering of the nervous system and direct relation to the blood vessels gives it a special importance in neurosurgery. METHOD: A comprehensive review of the literature ...
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