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Iwamoto S S Department of Pediatrics and Cell Transplantation, Mie University Graduate School of Medicine, Tsu, Mie, - - 2013
Acute graft-versus-host disease (GVHD) following allogeneic bone marrow transplantation (BMT) is initiated by donor T lymphocytes that recognize histocompatibility antigens presented by recipient dendritic cells (DCs). Current approaches to reduce GVHD are focused on suppressing donor T lymphocyte responses to alloantigens. However, these strategies may be inadequate in the setting ...
Peres Maria F S - - 2013
To clinically evaluate proximal furcations treated with hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) isolated or combined with enamel matrix derivative (EMD). Thirty patients, presenting at least one proximal class II furcation defect, probing pocket depth (PPD) ≥5 mm and bleeding on probing, were included. The defects were assigned to the HA/β-TCP group (n = 15); open-flap ...
Walther Ashley - - 2013
Recent studies have evaluated intestinal physiology following bowel resection; understanding changes in small bowel physiology after intestinal transplantation has received less attention. In this review, we will examine recent studies focused on changes in intestinal physiology following resection and intestinal transplantation. Absorption, immunity, and motility are fundamental components of small ...
Saksena Nitin K - - 2013
Immunomonitoring technologies are not only fast changing, but also have already revolutionized the way we look at treatments, diagnosis, and prognosis of a given disease. The purpose of the review is to provide a recent update on the use or possible use of array-based data in immunomonitoring of HIV patients. ...
Chun Tae-Wook - - 2013
Prolonged suppression of plasma viremia is now achievable in a majority of HIV-infected individuals receiving antiretroviral therapy (ART). However, ART alone cannot eradicate HIV in infected individuals. The purpose of this review is to discuss the importance of tracking levels of infected CD4 T cells carrying replication-competent HIV in basic ...
Hom Kellie K The Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201-1140, United - - 2013
Bacteria require iron for survival and virulence and employ several mechanisms including utilization of the host heme containing proteins. The final step in releasing iron is the oxidative cleavage of heme by HemO. A recent computer aided drug design (CADD) study identified several inhibitors of the bacterial HemOs. Herein we ...
Pandey J P JP Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425-2230, USA. - - 2013
Tumour-associated antigen human epidermal growth factor receptor 2 (HER2) is over-expressed in 25-30% of breast cancer patients and is associated with poor prognosis. Naturally occurring anti-HER2 antibody responses have been described in patients with HER2 over-expressing tumours. There is significant interindividual variability in antibody responsiveness, but the host genetic factors ...
King Stephanie L - - 2013
To summarize our current understanding of small intestinal stem cell biology and the current tools available for studying intestinal stem cells (ISCs). Recent reviews and original reports point toward the presence of two distinct populations of stem cells (ISCs) within the intestinal crypts. Until recently, the study of these two ...
Knoop Kathryn A KA Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, - - 2013
The intestinal epithelium is a dynamic barrier protecting the body from the multitudes of luminal micro-organisms present in the gut. However, this barrier is not impermeable and mechanisms exist that allow small amounts of antigen to traverse the epithelium in controlled manner to maintain tolerance and to mount immune responses. ...
Rubinstein M R MR Centro de Estudios Farmacológicos y Botánicos, Consejo Nacional de Investigaciones Científicas y Técnicas, Primera Cátedra de Farmacología, Universidad de Buenos Aires, Buenos Aires, - - 2013
Diabetes is associated with an increased risk of death from infectious disease. Hyperglycaemia has been identified as the main factor contributing to the development of diseases associated with diabetes mellitus. However, experimental evidence indicates individual susceptibility to develop complications of diabetes. In this context, the aim of this work was ...
Sano Y Y Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, - - 2013
Thymic stromal lymphopoietin (TSLP) is known for its capacity to induce CD11c(+) myeloid dendritic cells to promote T helper type 2 (Th2)-skewed inflammatory responses. Although increased expression of TSLP was reported in the lesional skin of limited numbers of patients with atopic dermatitis (AD), the relationships between the degree of ...
Hodges Kim - - 2013
The purpose of this study is to summarize the recent developments in small intestinal bacterial infections. This review focuses on aspects of intestinal bacterial infection concerning research developments related to pathogenesis, new therapeutic agents and approaches, as well as potential new vaccine targets. In terms of drug utilization, azithromycin was ...
Kärner J J Molecular Pathology Group, University of Tartu, Tartu, - - 2013
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a recessive disorder resulting from mutations in the autoimmune regulator (AIRE). The patients' autoantibodies recognize not only multiple organ-specific targets, but also many type I interferons (IFNs) and most T helper type 17 (Th17) cell-associated cytokines, whose biological actions they neutralize in vitro. ...
Cooper Myra J - - 2013
Positive core beliefs, compared with negative self or negative core beliefs, are relatively neglected in the eating disorder (ED) research literature, despite their significance in treatment. Using a sample of younger women and relevant to those who typically experience EDs, this study outlines a new measure of positive core beliefs ...
Francisco-Cruz A A Section of Experimental Pathology, Department of Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, - - 2013
BALB/c mice with pulmonary tuberculosis (TB) develop a T helper cell type 1 that temporarily controls bacterial growth. Bacterial proliferation increases, accompanied by decreasing expression of interferon (IFN)-γ, tumour necrosis factor (TNF)-α and inducible nitric oxide synthase (iNOS). Activation of dendritic cells (DCs) is delayed. Intratracheal administration of only one ...
Pesce B B Programa Disciplinario de Inmunología, Instituto de Ciencias Biomédicas, Universidad de Chile/Millennium Institute on Immunology and Immunotherapy-Chile, Santiago, - - 2013
A new paradigm has emerged relating the pathogenesis of rheumatoid arthritis (RA), focused on the balance between T helper type 17 cells and regulatory T cells (T(regs) ). In humans, both subpopulations depend on transforming growth factor (TGF)-β for their induction, but in the presence of inflammatory cytokines, such as ...
de Waal Yvonne C M - - 2013
The aim of this study was to compare peri-implant conditions between fully edentulous (FES) and partially edentulous subjects (PES). A systematic review was conducted. The MEDLINE, EMBASE and COCHRANE databases were searched for publications up to January 1st 2012. Studies reporting on the bleeding tendency of the peri-implant mucosa and/or ...
Kim Jin-Woo JW Bio/Nano Technology Laboratory, Institute for Nanoscience and Engineering, University of Arkansas, Fayetteville, Arkansas 72701, USA. - - 2013
Many life-threatening diseases are disseminated through biological fluids, such as blood, lymph, and cerebrospinal fluid. The migration of tumor cells through the vascular circulation is a mandatory step in metastasis, which is responsible for ∼90% of cancer-associated mortality. Circulating pathogenic bacteria, viruses, or blood clots lead to other serious conditions ...
Gross A A The Fritz Haber Research Center, Hebrew University, Jerusalem 91904, - - 2013
To describe the time course of cellular systems, we integrate ideas from thermodynamics and information theory to discuss the work needed to change the state of the cell. The biological example analyzed is experimental microarray transcription level oscillations of yeast in the different phases as characterized by oxygen consumption. Surprisal ...
Dang Zhao Z Surgical Science, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, United - - 2013
Bevirimat (1, BVM) is an anti-HIV agent that blocks HIV-1 replication by interfering with HIV-1 Gag-SP1 processing at a late stage of viral maturation. However, clinical trials of 1 have revealed a high baseline drug resistance that is attributed to naturally occurring polymorphisms in HIV-1 Gag. To overcome the drug ...
Nielsen Christian B CB Department of Chemistry and Centre for Plastic Electronics, Imperial College London, London SW7 2AZ, United Kingdom. - - 2013
A benzotrithiophene polymer with a new thermally cleavable ketal substituent is reported. It is shown how this functional group can be used to facilitate solvent processing and, subsequently, how it can be removed by a thermal annealing process to generate a structurally ordered and crystalline thin film with significantly improved ...
Cerutti David S DS Department of Chemistry and Chemical Biology and BioMaPS Institute, Rutgers, the State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854-8066, United States. - - 2013
We have developed the IPolQ method for fitting nonpolarizable point charges to implicitly represent the energy of polarization for systems in pure water. The method involves iterative cycles of molecular dynamics simulations to estimate the water charge density around the solute of interest, followed by quantum mechanical calculations at the ...
Zheng Guangrong G Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States. - - 2013
The M5 muscarinic acetylcholine receptor is suggested to be a potential pharmacotherapeutic target for the treatment of drug abuse. We describe herein the discovery of a series of M5-preferring orthosteric antagonists based on the scaffold of 1,2,5,6-tetrahydropyridine-3-carboxylic acid. Compound 56, the most selective compound in this series, possesses an 11-fold ...
Gorczynski Reginald - - 2013
CD200 overexpression in transgenic mice increases skin, cardiac, and renal allograft survival. Elevated levels of soluble CD200 (sCD200) are found in the serum of cancer individuals. We investigated whether sCD200 levels increase in mice with prolonged graft survival. Control or CD200 BL/6 recipients of BALB/c cardiac or skin grafts received ...
Everly Matthew J - - 2013
To date, limited information is available describing the incidence and impact of de novo donor-specific anti-human leukocyte antigen (HLA) antibodies (dnDSA) in the primary renal transplant patient. This report details the dnDSA incidence and actual 3-year post-dnDSA graft outcomes. The study includes 189 consecutive nonsensitized, non-HLA-identical patients who received a ...
Werzowa Johannes - - 2013
BACKGROUND: New-onset diabetes after transplantation (NODAT) is a serious complication after kidney transplantation affecting graft and patient survival. Currently, no guidelines exist for the management of renal transplant patients with impaired glucose tolerance (IGT), a risk factor for the development of NODAT and an independent predictor of death. METHODS: In ...
Alexopoulos Sophoclis - - 2013
Patients with Model for End-Stage Liver Disease (MELD) scores of 40 or higher are at high risk for liver transplantation. In some regions, the organ donor shortage has resulted in a substantial increase in the number of patients who underwent transplantation with MELD scores of 40 or higher. The objective ...
Labied Soraya - - 2013
BACKGROUND: Cryopreservation of cortex ovarian tissue before anticancer therapy is a promising technique for fertility preservation mainly in children and young women. Ischemia in the early stage after ovarian graft causes massive follicle loss by apoptosis. VEGF111 is a recently described vascular endothelial growth factor (VEGF) isoform that does not ...
Cheetham Andrew G AG Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, - - 2013
We report here a supramolecular strategy to directly assemble the small molecular hydrophobic anticancer drug camptothecin (CPT) into discrete, stable, well-defined nanostructures with a high and quantitative drug loading. Depending on the number of CPTs in the molecular design, the resulting nanostructures can be either nanofibers or nanotubes, and have ...
Yu Zhiqiang Z Center for BioEnergetics, Biodesign Institute, and Department of Chemistry & Biochemistry, Arizona State University, Tempe, Arizona 85287, - - 2013
In a recent study, the well-documented tumor targeting properties of the antitumor agent bleomycin (BLM) were studied in cell culture using microbubbles that had been derivatized with multiple copies of BLM. It was shown that BLM selectively targeted MCF-7 human breast carcinoma cells but not the "normal" breast cell line ...
Koes David Ryan DR Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. - - 2013
We describe a general methodology for designing an empirical scoring function and provide smina, a version of AutoDock Vina specially optimized to support high-throughput scoring and user-specified custom scoring functions. Using our general method, the unique capabilities of smina, a set of default interaction terms from AutoDock Vina, and the ...
Osathanon Thanaphum T Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, - - 2013
Notch signaling plays critical roles in stem cells by regulating cell fate determination and differentiation. The aim of this study was to evaluate the participation of Notch signaling in neurogenic commitment of human periodontal ligament-derived mesenchymal stem cells (hPDLSCs) and to examine the ability to control differentiation of these cells ...
Papavero L - - 2013
OBJECTIVE: To decompress the lumbar spinal nerve impinged peripherally to the lateral recess. To avoid in selected cases the pedicle screw fixation and fusion of the segment. INDICATION: Single level radiculopathy in degenerative scoliosis or in degenerative disc disease without segmental instability. CONTRAINDICATIONS: Scoliosis > 30° at the index level, lateral ...
Han Guangye - - 2013
The association between the cytochrome P450 1A1 (CYP1A1) Ile462Val polymorphism and prostate cancer risk remains inconclusive owing to the conflicting findings from previous studies. To get a more precise estimate of the possible association, we performed the present meta-analysis. We searched the PUBMED, EMBASE, and Wanfang databases for the studies ...
Sehmisch S - - 2013
OBJECTIVE: Restoration of function and anatomy of the proximal femur. Possibility of full weightbearing after surgery. Less invasive intramedullary osteosynthesis. INDICATIONS: Unstable trochanteric fracture (AO classification 31-A2, 31-A3), subtrochanteric fracture (AO classification 32-A1), fracture of the femoral shaft in the proximal region. CONTRAINDICATIONS: Ipsilateral coxarthrosis, open growth plate, hip fracture. ...
Scheurer Eva - - 2013
The purpose of this prospective study was to evaluate whether people approve radiological examinations specifically for the documentation of findings for the use in criminal proceedings. Forty two crime victims and 42 controls without a history of sustained violence were asked via telephone interview whether they would agree to forensic ...
Veits L - - 2013
The gross examination of cystic changes in chronic pancreatitis can cause diagnostic problems particularly in the absence of grossly detectable tumor tissue. Besides the more frequently encountered pancreatitis-associated pseudocysts, pancreatic cysts should always raise attention to the differential diagnosis of a true neoplastic process.
Ellouzi Hasna - - 2013
Plants are often exposed to a combination of stresses, which can occur simultaneously or at different times throughout their life. In this study, the effects of salinity, drought and cadmium pre-treatments were evaluated on the subsequent response of Cakile maritima, a halophytic species, to various levels of salinity (from 100 ...
Mielke A - - 2013
BACKGROUND: Age-related macular degeneration (AMD) often leads to visual impairment, loss of reading ability, reduced quality of life and secondary depression. The present study examined if visual rehabilitation has a preventive effect on secondary depression in these patients. MATERIAL AND METHODS: In a controlled pilot study 20 patients were randomized ...
Barrera Frederick J FJ Department of Physics and Astronomy, University of Texas at San Antonio, San Antonio, TX, 78249-0697, - - 2013
The optical properties of human whole blood and blood plasma with and without Y₂O₃ and Nd³⁺:Y₂O₃ nanoparticles are characterized in the near infrared region at 808 nm using a double integrating sphere technique. Using experimentally measured quantities of diffuse reflectance and diffuse transmittance, a computational analysis was conducted utilizing the ...
Palumbo-Roe Barbara - - 2013
General assessments of orebody types and associated mine wastes with regard to their environmental signature and human health hazards are needed to help in managing present and historical mine waste facilities. Bioaccessibility tests and mineralogical analysis were carried out on mine waste from a systematic sampling of mine sites from ...
Stefănescu Lucrina - - 2013
The environmental impact assessment of mining sites represents nowadays a large interest topic in Romania. Historical pollution in the Rosia Montana mining area of Romania caused extensive damage to environmental media. This paper has two goals: to investigate the environmental pollution induced by mining activities in the Rosia Montana area ...
Narod Steven A - - 2013
To estimate the 15-year survival following a diagnosis of stage I breast cancer among women who carry a BRCA1 mutation and to determine predictors of mortality, including the use of chemotherapy. Patients were 379 women with stage I breast cancer for whom a BRCA1 mutation had been identified, in herself ...
Morishige Junichi - - 2013
Lysophosphatidic acid (lysoPtdOH), a lysophospholipid mediator, exerts diverse physiological effects, including angiogenesis, through its specific G-protein-coupled receptors. Previously, we showed that unfertilized hen egg white contains polyunsaturated fatty acid-rich lysoPtdOH and lysophospholipase D (lysoPLD). Here, we examined whether lysoPtdOH was produced by lysoPLD in the presence and absence of a ...
Papavero L - - 2013
OBJECTIVE: To remove extruded disc fragments impinging the exiting root. To spare the interlaminar space and the facet joint. INDICATION: Cranially migrated disc herniation. CONTRAINDICATION: Severe spinal canal stenosis. SURGICAL TECHNIQUE: Microscope from skin to skin, 25 mm skin incision about 5 mm off the midline, conventional subperiosteal route or transmuscular access ...
Lemm H - - 2013
Dyspnea is a common symptom in emergency medicine and represents a diagnostic and therapeutic challenge. A multitude of differential diagnoses must be considered and checked but where there are indications of a life-threatening situation and also by rapidly reversible causes an (initial) treatment must be initiated without delay. Initially implemented ...
Jaakkola Panu M - - 2013
Abstract PHD3 prolyl 4-hydroxylase belongs to 2-oxoglutarate and iron-dependent dioxygenases. Together with the two closest paralogues, PHD1 and PHD2, these enzymes have been identified as cellular oxygen sensors that can mark the hypoxia-inducible factor-alpha (HIF-α) for pVHL-mediated proteasomal destruction. Although having overlapping functions with PHD1 and PHD2, PHD3 markedly differs ...
Preininger B - - 2013
BACKGROUND: Men show better functional results after total hip arthroplasty (THA). The aim of this study was a patient-specific analysis of the hip joint muscles in comparison to the joint geometry. METHODS: In this study 93 computed tomography (CT) scans of the pelvis (45 men, 48 women) were analyzed to ...
Däxle M - - 2013
BACKGROUND: Preservation of movement at the treated segment and possible reduction of adjacent segment effects is assumed to be an advantage of non-fusion technologies over fusion. The aim of this study was to compare the segmental range of motion (ROM) at the operative level, the cranial and caudal adjacent levels ...
Lü Wei - - 2013
Abstract The Formate/Nitrite Transporter family of integral membrane proteins comprises pentameric channels for monovalent anions that exhibit a broad specificity for small anions such as chlo-ride, the physiological cargo molecules formate, nitrite and hydrosulfide, and also larger or-ganic acids. Three-dimensional structures are available for the three known subtypes, FocA, NirC, ...
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