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Francisco-Cruz A A Section of Experimental Pathology, Department of Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, - - 2013
BALB/c mice with pulmonary tuberculosis (TB) develop a T helper cell type 1 that temporarily controls bacterial growth. Bacterial proliferation increases, accompanied by decreasing expression of interferon (IFN)-γ, tumour necrosis factor (TNF)-α and inducible nitric oxide synthase (iNOS). Activation of dendritic cells (DCs) is delayed. Intratracheal administration of only one ...
Zhu S S Paediatric Liver Disease Therapy and Research Center, 302 Hospital, Beijing, - - 2013
Interleukin (IL)-17-mediated immune response has been shown to play a critical role in inflammation-associated disease. However, its role in the pathogenesis of chronic hepatitis B virus (HBV) in paediatric patients remains unknown. We investigated the frequency of T helper type 17 (Th17) cells and evaluated the association between the Th17 ...
Rubinstein M R MR Centro de Estudios Farmacológicos y Botánicos, Consejo Nacional de Investigaciones Científicas y Técnicas, Primera Cátedra de Farmacología, Universidad de Buenos Aires, Buenos Aires, - - 2013
Diabetes is associated with an increased risk of death from infectious disease. Hyperglycaemia has been identified as the main factor contributing to the development of diseases associated with diabetes mellitus. However, experimental evidence indicates individual susceptibility to develop complications of diabetes. In this context, the aim of this work was ...
Sano Y Y Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, - - 2013
Thymic stromal lymphopoietin (TSLP) is known for its capacity to induce CD11c(+) myeloid dendritic cells to promote T helper type 2 (Th2)-skewed inflammatory responses. Although increased expression of TSLP was reported in the lesional skin of limited numbers of patients with atopic dermatitis (AD), the relationships between the degree of ...
Iwamoto S S Department of Pediatrics and Cell Transplantation, Mie University Graduate School of Medicine, Tsu, Mie, - - 2013
Acute graft-versus-host disease (GVHD) following allogeneic bone marrow transplantation (BMT) is initiated by donor T lymphocytes that recognize histocompatibility antigens presented by recipient dendritic cells (DCs). Current approaches to reduce GVHD are focused on suppressing donor T lymphocyte responses to alloantigens. However, these strategies may be inadequate in the setting ...
Knoop Kathryn A KA Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, - - 2013
The intestinal epithelium is a dynamic barrier protecting the body from the multitudes of luminal micro-organisms present in the gut. However, this barrier is not impermeable and mechanisms exist that allow small amounts of antigen to traverse the epithelium in controlled manner to maintain tolerance and to mount immune responses. ...
Kraljevic K K Department of Medicine, University of Sydney, Sydney, - - 2013
B-1 cells are innate-like lymphocytes characterized by spontaneous production of 'natural' polyspecific antibodies, often of self-specificity, and thought to be responsible for tissue homeostasis, mucosal protection, maintaining resting serum immunoglobulin (Ig)M levels and for early immunoglobulin production following infection. Although defined most clearly in mice, a human B-1 cell counterpart, ...
Li W-H WH YouAn Hospital, Capital Medical University, Beijing, - - 2013
In China, the majority of human immunodeficiency virus (HIV) infections are predominately subtype B. It is important to characterize the HIV-1 subtype B-specific and its T cell response within the Chinese population, with the aim of identifying protective correlates of immunity to control HIV-1 infections. In this study, we performed ...
Cooper S E J SE Department of Immunology, St James's Hospital and Trinity College Dublin, Dublin, - - 2013
Coeliac disease is a gluten-sensitive enteropathy that develops in genetically susceptible individuals. The disease exhibits many features of an autoimmune disorder. These include the production of highly specific anti-endomysial autoantibodies directed against the enzyme tissue transglutaminase. It is well accepted that wheat-, barley- and rye-based foods should be excluded in ...
Bosch Ronald J RJ Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts 02115, USA. - - 2013
The dramatic increase in the number and type of immune biomarkers that can be measured, particularly those assessing immune activation, has led to numerous investigations in HIV-infected individuals to explore pathogenesis and to assess therapeutic interventions that aim to attenuate immune activation. An overview is provided on study designs and ...
Hom Kellie K The Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201-1140, United - - 2013
Bacteria require iron for survival and virulence and employ several mechanisms including utilization of the host heme containing proteins. The final step in releasing iron is the oxidative cleavage of heme by HemO. A recent computer aided drug design (CADD) study identified several inhibitors of the bacterial HemOs. Herein we ...
Liu Min M Harvard NeuroDiscovery Center, Harvard University , 65 Landsdowne Street, #452, Cambridge, Massachusetts 02139, United - - 2013
A number of well-known type II inhibitors (ATP-noncompetitive) that bind kinases in their DFG-out conformation were tested against wild-type LRRK2 and the most common Parkinson's disease-linked mutation, G2019S. We found that traditional type II inhibitors exhibit surprising variability in their inhibition mechanism between the wild type (WT) and the G2019S ...
Buford Thomas W TW Department of Aging and Geriatric Research, College of Medicine, University of Florida, PO Box 112610, Gainesville, FL 32611, USA. - - 2013
The early 21st century has witnessed a steady push by scientists, industry leaders, and government officials to make medicine more personalized. To date, the concept of personalized medicine has referred largely to the field of pharmacogenomics. In contrast, relatively few data exist regarding the application of preventive strategies such as ...
Kim Jin-Woo JW Bio/Nano Technology Laboratory, Institute for Nanoscience and Engineering, University of Arkansas, Fayetteville, Arkansas 72701, USA. - - 2013
Many life-threatening diseases are disseminated through biological fluids, such as blood, lymph, and cerebrospinal fluid. The migration of tumor cells through the vascular circulation is a mandatory step in metastasis, which is responsible for ∼90% of cancer-associated mortality. Circulating pathogenic bacteria, viruses, or blood clots lead to other serious conditions ...
Gross A A The Fritz Haber Research Center, Hebrew University, Jerusalem 91904, - - 2013
To describe the time course of cellular systems, we integrate ideas from thermodynamics and information theory to discuss the work needed to change the state of the cell. The biological example analyzed is experimental microarray transcription level oscillations of yeast in the different phases as characterized by oxygen consumption. Surprisal ...
Dang Zhao Z Surgical Science, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, United - - 2013
Bevirimat (1, BVM) is an anti-HIV agent that blocks HIV-1 replication by interfering with HIV-1 Gag-SP1 processing at a late stage of viral maturation. However, clinical trials of 1 have revealed a high baseline drug resistance that is attributed to naturally occurring polymorphisms in HIV-1 Gag. To overcome the drug ...
Nielsen Christian B CB Department of Chemistry and Centre for Plastic Electronics, Imperial College London, London SW7 2AZ, United Kingdom. - - 2013
A benzotrithiophene polymer with a new thermally cleavable ketal substituent is reported. It is shown how this functional group can be used to facilitate solvent processing and, subsequently, how it can be removed by a thermal annealing process to generate a structurally ordered and crystalline thin film with significantly improved ...
Zheng Guangrong G Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States. - - 2013
The M5 muscarinic acetylcholine receptor is suggested to be a potential pharmacotherapeutic target for the treatment of drug abuse. We describe herein the discovery of a series of M5-preferring orthosteric antagonists based on the scaffold of 1,2,5,6-tetrahydropyridine-3-carboxylic acid. Compound 56, the most selective compound in this series, possesses an 11-fold ...
Cerutti David S DS Department of Chemistry and Chemical Biology and BioMaPS Institute, Rutgers, the State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854-8066, United States. - - 2013
We have developed the IPolQ method for fitting nonpolarizable point charges to implicitly represent the energy of polarization for systems in pure water. The method involves iterative cycles of molecular dynamics simulations to estimate the water charge density around the solute of interest, followed by quantum mechanical calculations at the ...
Werzowa Johannes - - 2013
BACKGROUND: New-onset diabetes after transplantation (NODAT) is a serious complication after kidney transplantation affecting graft and patient survival. Currently, no guidelines exist for the management of renal transplant patients with impaired glucose tolerance (IGT), a risk factor for the development of NODAT and an independent predictor of death. METHODS: In ...
Labied Soraya - - 2013
BACKGROUND: Cryopreservation of cortex ovarian tissue before anticancer therapy is a promising technique for fertility preservation mainly in children and young women. Ischemia in the early stage after ovarian graft causes massive follicle loss by apoptosis. VEGF111 is a recently described vascular endothelial growth factor (VEGF) isoform that does not ...
Alexopoulos Sophoclis - - 2013
Patients with Model for End-Stage Liver Disease (MELD) scores of 40 or higher are at high risk for liver transplantation. In some regions, the organ donor shortage has resulted in a substantial increase in the number of patients who underwent transplantation with MELD scores of 40 or higher. The objective ...
Everly Matthew J - - 2013
To date, limited information is available describing the incidence and impact of de novo donor-specific anti-human leukocyte antigen (HLA) antibodies (dnDSA) in the primary renal transplant patient. This report details the dnDSA incidence and actual 3-year post-dnDSA graft outcomes. The study includes 189 consecutive nonsensitized, non-HLA-identical patients who received a ...
Gorczynski Reginald - - 2013
CD200 overexpression in transgenic mice increases skin, cardiac, and renal allograft survival. Elevated levels of soluble CD200 (sCD200) are found in the serum of cancer individuals. We investigated whether sCD200 levels increase in mice with prolonged graft survival. Control or CD200 BL/6 recipients of BALB/c cardiac or skin grafts received ...
Yu Zhiqiang Z Center for BioEnergetics, Biodesign Institute, and Department of Chemistry & Biochemistry, Arizona State University, Tempe, Arizona 85287, - - 2013
In a recent study, the well-documented tumor targeting properties of the antitumor agent bleomycin (BLM) were studied in cell culture using microbubbles that had been derivatized with multiple copies of BLM. It was shown that BLM selectively targeted MCF-7 human breast carcinoma cells but not the "normal" breast cell line ...
Cheetham Andrew G AG Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, - - 2013
We report here a supramolecular strategy to directly assemble the small molecular hydrophobic anticancer drug camptothecin (CPT) into discrete, stable, well-defined nanostructures with a high and quantitative drug loading. Depending on the number of CPTs in the molecular design, the resulting nanostructures can be either nanofibers or nanotubes, and have ...
Osathanon Thanaphum T Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, - - 2013
Notch signaling plays critical roles in stem cells by regulating cell fate determination and differentiation. The aim of this study was to evaluate the participation of Notch signaling in neurogenic commitment of human periodontal ligament-derived mesenchymal stem cells (hPDLSCs) and to examine the ability to control differentiation of these cells ...
Lü Wei - - 2013
Abstract The Formate/Nitrite Transporter family of integral membrane proteins comprises pentameric channels for monovalent anions that exhibit a broad specificity for small anions such as chlo-ride, the physiological cargo molecules formate, nitrite and hydrosulfide, and also larger or-ganic acids. Three-dimensional structures are available for the three known subtypes, FocA, NirC, ...
Däxle M - - 2013
BACKGROUND: Preservation of movement at the treated segment and possible reduction of adjacent segment effects is assumed to be an advantage of non-fusion technologies over fusion. The aim of this study was to compare the segmental range of motion (ROM) at the operative level, the cranial and caudal adjacent levels ...
Preininger B - - 2013
BACKGROUND: Men show better functional results after total hip arthroplasty (THA). The aim of this study was a patient-specific analysis of the hip joint muscles in comparison to the joint geometry. METHODS: In this study 93 computed tomography (CT) scans of the pelvis (45 men, 48 women) were analyzed to ...
Sehmisch S - - 2013
OBJECTIVE: Restoration of function and anatomy of the proximal femur. Possibility of full weightbearing after surgery. Less invasive intramedullary osteosynthesis. INDICATIONS: Unstable trochanteric fracture (AO classification 31-A2, 31-A3), subtrochanteric fracture (AO classification 32-A1), fracture of the femoral shaft in the proximal region. CONTRAINDICATIONS: Ipsilateral coxarthrosis, open growth plate, hip fracture. ...
Scheurer Eva - - 2013
The purpose of this prospective study was to evaluate whether people approve radiological examinations specifically for the documentation of findings for the use in criminal proceedings. Forty two crime victims and 42 controls without a history of sustained violence were asked via telephone interview whether they would agree to forensic ...
Papavero L - - 2013
OBJECTIVE: To remove extruded disc fragments impinging the exiting root. To spare the interlaminar space and the facet joint. INDICATION: Cranially migrated disc herniation. CONTRAINDICATION: Severe spinal canal stenosis. SURGICAL TECHNIQUE: Microscope from skin to skin, 25 mm skin incision about 5 mm off the midline, conventional subperiosteal route or transmuscular access ...
Lemm H - - 2013
Dyspnea is a common symptom in emergency medicine and represents a diagnostic and therapeutic challenge. A multitude of differential diagnoses must be considered and checked but where there are indications of a life-threatening situation and also by rapidly reversible causes an (initial) treatment must be initiated without delay. Initially implemented ...
Papavero L - - 2013
OBJECTIVE: To decompress the lumbar spinal nerve impinged peripherally to the lateral recess. To avoid in selected cases the pedicle screw fixation and fusion of the segment. INDICATION: Single level radiculopathy in degenerative scoliosis or in degenerative disc disease without segmental instability. CONTRAINDICATIONS: Scoliosis > 30° at the index level, lateral ...
Han Guangye - - 2013
The association between the cytochrome P450 1A1 (CYP1A1) Ile462Val polymorphism and prostate cancer risk remains inconclusive owing to the conflicting findings from previous studies. To get a more precise estimate of the possible association, we performed the present meta-analysis. We searched the PUBMED, EMBASE, and Wanfang databases for the studies ...
Dou Yanyan - - 2013
Bicarbonate plays a crucial role in limiting the growth of submersed aquatic macrophytes in eutrophic lakes, and high ammonia is often toxic to macrophytes. In order to evaluate the combined effect of HCO(3) (-) and total ammonia (i.e., the total of NH(3) and NH(4) (+)) on submersed macrophytes Vallisneria natans, ...
Palumbo-Roe Barbara - - 2013
General assessments of orebody types and associated mine wastes with regard to their environmental signature and human health hazards are needed to help in managing present and historical mine waste facilities. Bioaccessibility tests and mineralogical analysis were carried out on mine waste from a systematic sampling of mine sites from ...
Verghese Priya - - 2013
BACKGROUND: Nephrotic syndrome (NS) is a recognized complication of immune tolerance induction (ITI) therapy, a treatment strategy used to treat inhibitors in patients with hemophilia B receiving factor IX concentrate. CASE DIAGNOSIS/TREATMENT: We present a 4-year-old boy with hemophilia B and an inhibitor who underwent ITI, and developed NS 19 months ...
Stef─ânescu Lucrina - - 2013
The environmental impact assessment of mining sites represents nowadays a large interest topic in Romania. Historical pollution in the Rosia Montana mining area of Romania caused extensive damage to environmental media. This paper has two goals: to investigate the environmental pollution induced by mining activities in the Rosia Montana area ...
Narod Steven A - - 2013
To estimate the 15-year survival following a diagnosis of stage I breast cancer among women who carry a BRCA1 mutation and to determine predictors of mortality, including the use of chemotherapy. Patients were 379 women with stage I breast cancer for whom a BRCA1 mutation had been identified, in herself ...
Veits L - - 2013
The gross examination of cystic changes in chronic pancreatitis can cause diagnostic problems particularly in the absence of grossly detectable tumor tissue. Besides the more frequently encountered pancreatitis-associated pseudocysts, pancreatic cysts should always raise attention to the differential diagnosis of a true neoplastic process.
Jaakkola Panu M - - 2013
Abstract PHD3 prolyl 4-hydroxylase belongs to 2-oxoglutarate and iron-dependent dioxygenases. Together with the two closest paralogues, PHD1 and PHD2, these enzymes have been identified as cellular oxygen sensors that can mark the hypoxia-inducible factor-alpha (HIF-α) for pVHL-mediated proteasomal destruction. Although having overlapping functions with PHD1 and PHD2, PHD3 markedly differs ...
Mielke A - - 2013
BACKGROUND: Age-related macular degeneration (AMD) often leads to visual impairment, loss of reading ability, reduced quality of life and secondary depression. The present study examined if visual rehabilitation has a preventive effect on secondary depression in these patients. MATERIAL AND METHODS: In a controlled pilot study 20 patients were randomized ...
Morishige Junichi - - 2013
Lysophosphatidic acid (lysoPtdOH), a lysophospholipid mediator, exerts diverse physiological effects, including angiogenesis, through its specific G-protein-coupled receptors. Previously, we showed that unfertilized hen egg white contains polyunsaturated fatty acid-rich lysoPtdOH and lysophospholipase D (lysoPLD). Here, we examined whether lysoPtdOH was produced by lysoPLD in the presence and absence of a ...
Barrera Frederick J - - 2013
The optical properties of human whole blood and blood plasma with and without Y(2)O(3) and Nd(3+):Y(2)O(3) nanoparticles are characterized in the near infrared region at 808 nm using a double integrating sphere technique. Using experimentally measured quantities of diffuse reflectance and diffuse transmittance, a computational analysis was conducted utilizing the Kubelka-Munk, ...
Marumoto Akira - - 2013
PURPOSE: The elderly population with severe aortic stenosis (AS) requiring aortic valve replacement (AVR) is increasing. The optimal timing of AVR in these patients has been under discussion. METHODS: We retrospectively reviewed the data from severe AS patients (n = 84) who underwent AVR with/without concomitant procedures from 2005 to 2010. The ...
Reich W - - 2013
Complex midfacial trauma requires interdisciplinary management. A wide range of reconstructive procedures are needed and if necessary secondary and even tertiary interventions should be performed at the appropriate time. We present the case of a 45-year-old man who was involved in a car accident and presented with severe injuries to ...
Zamboulis D E - - 2013
Purinergic pathways are considered important in pain transmission, and P2X receptors are a key part of this system which has received little attention in the horse. The aim of this study was to identify and characterise the distribution of P2X receptor subtypes in the equine digit and associated vasculature and ...
Liu Chuan - - 2013
Published data regarding the association between the XPC polymorphisms and lung cancer susceptibility remained controversial. This meta-analysis was performed to draw a precise estimation of the relationship. We systematically searched PubMed, Embase, Elsevier, and Web of Science with a time limit of September 10, 2012. Summary odds ratios (ORs) with ...
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