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Results 201 - 250 of 4954
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Ung Kjell-Arne - - 2013
Abstract Background. Self-expandable metallic stents (SEMS) placement is a standard treatment for inoperable malignant bile duct strictures. Covered SEMS have been introduced to avoid stent occlusion by tumor ingrowth. The aims were to compare covered and uncovered stents in terms of patency, efficacy and complication rate. Material and methods. Consecutive ...
Korehi Hananeh - - 2013
The marine shore sulfidic mine tailings dump at the Chañaral Bay in the Atacama Desert, northern Chile, is characterized by extreme acidity, high salinity and high heavy metals concentrations. Due to pyrite oxidation, metals (especially copper) are mobilized under acidic conditions and transported towards the tailings surface and precipitate as ...
Saeki Tohru - - 2013
ABSTRACT: BACKGROUND: SLC10A2-mediated reabsorption of bile acids at the distal end of the ileum is the first step in enterohepatic circulation. Because bile acids act not only as detergents but also as signaling molecules in lipid metabolism and energy production, SLC10A2 is important as the key transporter for understanding the ...
Cleveland Susan M - - 2013
LIM domain Only 2 (Lmo2) is frequently deregulated in sporadic and gene therapy-induced acute T-cell lymphoblastic leukemia (T-ALL) where its overexpression is an important initiating mutational event. In transgenic and retroviral mouse models, Lmo2 expression can be enforced in multiple hematopoietic lineages but leukemia only arises from T cells. These ...
Gershkovich Pavel - - 2013
Abstract Purpose: To develop and to validate a simple but sensitive method for determination of vitamins D(3) and K(1) in rat plasma. Methods: The sample treatment included protein precipitation by cold acetonitrile, evaporation, reconstitution with methanol and filtration. The chromatography conditions included Xterra RP18 3.5 µm 4.6 × 100 mm column at ambient temperature ...
Salinas Yolanda - - 2013
Mesoporous silica nanoparticles capped with TTF moieties and containing a ruthenium dye in the pores were used for the turn-on optical detection of the nitroaromatic explosives Tetryl and TNT via a selective pore uncapping and release of the entrapped dye.
Kalpana Deepa Priya D - - 2013
Abstract Context: Sulforaphane (SFN) [1-isothiocyanato-4-(methylsulfinyl)butane] is a naturally occurring isothiocyanate found in cruciferous vegetables such as broccoli [Brassica oleracea L. var. italica Plenck. (Brassicaceae)]. Since it is among the most potent bioactive components with antioxidant and antitumor properties, it has received intense attention in the recent years for its chemopreventive ...
Tanguy Ronan - - 2013
Brain metastases management is still controversial even though many trials are trying to define the respective roles of neurosurgery, whole-brain radiotherapy, single-dose stereotactic radiotherapy and fractionated stereotactic radiotherapy. In this article, we review data from trials that examine the role of radiosurgery and fractionated stereotactic radiotherapy in the management of ...
Iino Ichirota - - 2013
Control of liver metastasis is an important issue in the treatment of colorectal cancer (CRC). Micro RNAs (miRNA) have been shown to be involved in the development of many cancers, but little is known about their role in the process of colorectal liver metastasis. We compared miRNA expression between primary ...
Chen Hui - - 2013
Reactions of [Mn(6)O(2)(piv)(10)(py)(2.5)(piv)(1.5)], Ln(NO(3))(3)·6H(2)O and N-mdeaH(2) in MeCN in the presence of Me(3)SiCl generated a family of octanuclear Mn/Ln complexes [Mn(6)(III)Mn(II)Ln(N-mdea)(3)(N-mdeaH)(piv)(8)O(2)(OH)(3)(NO(3))(H(2)O)]·xCH(3)CN·xH(2)O [Ln = Gd (), Dy (), Er (), pivH = pivalic acid, N-mdeaH(2) = N-methyl diethanolamine]. Each complex possesses a [Mn(6)(III)Mn(II)Ln(μ(3)-O)(2)(μ(3)-OH)(3)](16+) core containing two butterfly-like subunits of [Mn(3)Ln(μ(3)-OH)(2)] and ...
Mautz Brian S - - 2013
There are two reasons why researchers are interested in the phenotypic relationship between the expression of male secondary sexual characters (SSCs) and 'ejaculate quality' (defined as sperm/ejaculate traits that are widely assumed to increase female fertility and/or sperm competitiveness). First, if the relationship is positive then females could gain a ...
Wang Jirui - - 2013
Hexaploid wheat (Triticum aestivum, genomes AABBDD) originated by hybridization of tetraploid Triticum turgidum (genomes AABB) with Aegilops tauschii (genomes DD). Genetic relationships between A. tauschii and the wheat D genome are of central importance for the understanding of wheat origin and subsequent evolution. Genetic relationships among 477 A. tauschii and wheat accessions ...
Sayed Nasreen - - 2013
Traumatic brain injury (TBI) in early to mid-life is associated with an increased risk of dementia in late life. It is unclear whether TBI results in acceleration of Alzheimer's disease (AD) like pathology, or has features of another dementing condition, such as Chronic Traumatic Encephalopathy (CTE), which is associated with ...
Tanaka Yoko - - 2013
The number and density of stomata is controlled by endogenous and environmental factors.Despite recent advances in our understandingof stomatal development, mechanismswhich preventstomatal lineage entry remain unclear. Here, we propose that abscisic acid (ABA), a phytohormone known to induce stomatal closure, limits initiation of stomatal developmentand induces enlargement of pavement cells ...
Santiago Piedad - - 2013
The benefits of iodine supplements during pregnancy remain controversial in areas with a mild-to-moderate iodine deficiency. The aim of the present study was to determine the effect of improving iodine intakes, with iodised salt (IS) or iodine supplements, in pregnant Spanish women. A total of 131 pregnant women in their ...
Rosenow F - - 2013
After allo-SCT, analysis of CD34(+) lineage-specific donor cell chimerism (DCC) is a sensitive method for monitoring minimal residual disease in patients with AML or myelodysplastic syndrome (MDS) with CD34 expression. To substantiate evidence of whether immune interventions in patients with impending relapse, defined by incomplete lineage-specific DCC, may prevent hematological ...
Yee Karen K - - 2013
Until recently, reliable markers for adult stem cells have been lacking for many regenerative mammalian tissues. Lgr5 (leucine-rich repeat-containing G-protein coupled receptor 5) has been identified as a marker for adult stem cells in intestine, stomach, and hair follicle; Lgr5-expressing cells give rise to all types of cells in these ...
Riehn K - - 2013
The trematode Alaria alata, an intestinal parasite of different carnivore species is widely distributed throughout Europe. The mesocercarial stages of Alaria spp. may infect almost all vertebrate species, including humans, and, in particular, omnivorous scavengers such as wild boars serve as paratenic hosts for the parasite. The introduction of the ...
Xiao Da - - 2013
AIMS: For four decades, 5-fluorouracil (5-FU) has been a major anticancer medicine. This drug is increasingly used with other anticancer agents such as irinotecan. Irinotecan and many others such as PPD (pentyl carbamate of p-aminobenzyl carbamate of doxazolidine) require activation by carboxylesterase-2 (CES2). 5-FU, on the other hand, reportedly induces ...
Kim Young Ran - - 2013
Vibrio vulnificus causes fatal septicemia in susceptible subjects after the ingestion of raw seafood. In the present study, we investigated the roles of the cAMP receptor protein (CRP) in V. vulnificus pathogenesis. A mutation in the V. vulnificus crp gene resulted in a significant down-regulation of various virulence phenotypes, except ...
Barwood Caroline H S - - 2013
Language impairments are reported in multiple sclerosis (MS). To date, the majority of studies have evaluated language differences between relapsing-remitting (RR) and chronic progressive (CP) clinical courses. Neurologists have distinguished two progressive courses of MS: primary progressive (PP) MS and secondary progressive (SP) MS. Recent evidence suggests that cognitive performance ...
Romano B - - 2013
BACKGROUND AND PURPOSE: The non-psychotropic cannabinoid cannabichromene is known to activate the transient receptor potential ankyrin-type1 (TRPA1) and to inhibit endocannabinoid inactivation, both of which are involved in inflammatory processes. We examined here the effects of this phytocannabinoid on peritoneal macrophages and its efficacy in an experimental model of colitis. ...
Shi Wei - - 2013
Aim:Living high training low" (LHTL) is an exercise-training protocol that refers living in hypoxia stress and training at normal level of O(2). In this study, we investigated whether LHTL caused physiological heart hypertrophy accompanied by changes of biomarkers in renin-angiotensin system in rats.Methods:Adult male SD rats were randomly assigned into ...
Hortolà Policarp - - 2013
Studies of human bloodstains on nonbiological materials have been previously carried out using a high-vacuum scanning electron microscope (HV-SEM) in secondary-electron mode without any sample treatment. To assess whether biological substrates can affect the morphology of human erythrocytes in bloodstains, three fragments of different biological material (bone, shell, and wood) ...
Randall Sue - - 2013
Aim To consider findings from a study that evaluated case management of individuals with long-term conditions (LTCs) by a community matron (CM) service. The paper highlights issues related to the implementation of a new role and the impact this had on the experience of care across hospital and community settings ...
Tseng L M - - 2013
Triple-negative breast cancer (TNBC) relapses more frequently than hormone receptor-positive subtypes and is often associated with poor outcomes. This retrospective study reviewed the pattern of distant metastasis with regard to survival in patients with TNBC. A total of 205 TNBC patients were analyzed. TNBC patients with lung metastases had the longest ...
Liu H - - 2013
Objectives: To explore the mechanism about how HMG-CoA reductase (HMGR) inhibitor inhibit proliferation and bone metastases of lung adenocarcinoma in vitro and in vivo. Methods: The HMGR inhibitor simvastatin, human lung cancer cell line A549 and Balb/c nude mouse were used in this study. The mice were randomly divided into ...
Jaul Efraim - - 2013
Atypical pressure ulcers (APU) are distinguished from common pressure ulcers (PU) with both unusual location and different aetiology. The occurrence and attempts to characterise APU remain unrecognised. The purpose of this cohort study was to analyse the occurrence of atypical location and the circumstances of the causation, and draw attention ...
Yang B - - 2013
The purpose of this study was to evaluate the association of expression level of α5β1-integrin and MMP-14 with clinicopathologic features and prognosis in colorectal cancer (CRC). The expressions of α5β1-integrin and MMP-14 in normal colorectal mucosa and CRC tissue were detected with immunohistochemistry. We estimated the five-year survival rate by ...
French Tracy - - 2013
OBJECTIVE: The Disease Activity Score in 28 joints (DAS28) is a key measure in clinical practice and clinical trials. There are at least five different versions of the 'Patient Global' Visual Analogue Scale (PG-VAS) being used in the DAS28. The developers suggested that the PG-VAS can be an assessment of ...
Rosen Raymond C - - 2013
Abstract Objective: Despite the prevalence of hypogonadism (HG) and widespread use of testosterone therapy, little is known about the safety/effectiveness of long-term testosterone use. The Registry of Hypogonadism in Men (RHYME) is a multi-national patient registry assessing prostate health and other outcomes associated with testosterone treatment in men. Design: Observational ...
Kim Sung-Dae - - 2013
The seriousness of metabolic syndrome is not due to the disease itself but its promotion of other diseases, such as erectile dysfunction and cardiovascular and cerebrovascular diseases. We investigated the effects of Korean red ginseng (KRG, Panax ginseng) extract on erectile function in a rat model of metabolic syndrome. We ...
Sborov Douglas W - - 2013
Acquired haemophilia A (AHA) is a potentially life-threatening bleeding disorder occurring in patients without a previous personal or family history of bleeding. Development of immune-mediated autoantibodies against coagulation factor VIII is associated with a wide range of clinical disorders including pregnancy, autoimmune disorders, malignancy, or with no apparent disease. There ...
Ku Janice J-Y - - 2013
To assess the accuracy of grading diabetic retinopathy (DR) using single-field digital fundus photography compared with clinical grading from a dilated slit-lamp fundus examination in Indigenous Australians living in Central Australia. Cross-sectional study comparing DR grades in participants with diabetes mellitus presenting for examination at remote community clinics from 1 July ...
Park Youn Hee - - 2013
ABSTRACT: BACKGROUND: Hypothermic protection against ischemic stroke has been reported by many studies. Hypothermia is supposed to mitigate the effects of deleterious genes and proteins and promote the activity of protective genes and proteins in the ischemic brain. Metallothionein (MT)-1/2 is thought to be a crucial factor for metal homeostasis, ...
Yamabe Soichiro - - 2013
Mammalian cells attempt to maintain their homeostasis under endoplasmic reticulum (ER) stress. If the stress cannot be alleviated, cells are led to apoptosis through C/EBP homologous protein (CHOP) induction. ER stress is provoked in osteoarthritis (OA) chondrocytes, and intracellular accumulation of advanced glycation end products (AGEs) in chondrocytes is a ...
Chen Ying Xuan - - 2013
An increased risk of colorectal cancer (CRC) has been revealed in ulcerative colitis (UC) patients. There are two patterns of growth of dysplasia in UC, commonly classified as adenoma-like dysplasia-associated lesion of mass (DALM) and non-adenoma-like DALM, the latter of which has a high risk of concurrent malignancy and often ...
Sobotka Roman - - 2013
Chlorophyll (Chl) is an essential component of the photosynthetic apparatus. Embedded into Chl-binding proteins, Chl molecules play a central role in light harvesting and charge separation within the photosystems. It is critical for the photosynthetic cell to not only ensure the synthesis of a sufficient amount of new Chl-binding proteins ...
Hu Fangyun - - 2013
Nanoscaled two-dimensional (2D) chiral architectures are increasingly receiving scientific interest because of their potential applications in many domains. In this paper, we present a new method for constructing 2D chiral architectures on surface. Based on in situ Schiff-base reaction of achiral dialdehyde with two kinds of achiral amines at the ...
Spaulding Tammie J - - 2013
The receptive vocabulary performance of pre-school children with specific language impairment (SLI) and typically-developing (TD) controls was compared on the Peabody Picture Vocabulary Test third and fourth edition (PPVT-III and PPVT-IV) to determine consistency in performance and the effect of test revision on identification of impairment. Participants included 40 pre-school ...
Runciman Phyllis - - 2013
Aim This article presents an interpretation of health promotion within the work of a district nurse (DN). BACKGROUND: Literature supports the centrality of health promotion within nursing. It also presents debate about its meaning and suggests uncertainties for educators and practitioners about its relationship to nursing care. Two studies in ...
Barberá Rafael - - 2013
BACKGROUND: Frey's syndrome (FS), facial depression, and noticeable scar may have an impact on patient's quality of life after a parotidectomy. The superficial musculoaponeurotic system (SMAS) flap has been used to ameliorate those effects. METHODS: Forty-seven consecutive parotidectomies were analyzed; SMAS flap was performed in 26 of them. We investigated ...
Aho Kevin A - - 2013
This paper integrates personal narratives with the methods of phenomenology in order to draw some general conclusions about 'what it means' and 'what it feels like' to be depressed. The analysis has three parts. First, it explores the ways in which depression disrupts everyday experiences of spatial orientation and motility. ...
Agache Ioana O - - 2013
ABSTRACT: Hypersensitivity pneumonitis (HP) is an interstitial lung disease due to a combined type III and IV reaction with a granulomatous inflammation, caused by cytotoxic delayed hypersensitivity lymphocytes, in a Th1/Th17 milieu, chaperoned by a deficient suppressor function of T regulatory cells. Skewing toward a Th2 phenotype is reported for ...
Valentino L A - - 2013
In haemophilia patients with well-established high-titer inhibitors, even seemingly minor acute bleeding episodes or surgical procedures may become refractory to treatment and transform into limb- or life-threatening situations. In the absence of evidence-based treatment guidelines, this article presents 10 cases of difficult to control acute and surgical bleeding and offers ...
Herculano L S - - 2013
Eosin Y is known to be a powerful probe of biological molecules and an efficient photosensitizing agent for the production of singlet molecular oxygen. Under continuous laser excitation, degradation through photobleaching is observed in aqueous solutions of eosin Y; this process is driven by the production of singlet oxygen. Optical ...
Hruskova Z - - 2013
Objectives: Alveolar haemorrhage (AH) is a major cause of early death in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). There is a paucity of information regarding the outcomes of AAV patients presenting with severe AH. Method: A retrospective cohort study. Patients with severe AH were identified from a case review of ...
Fernandes Geórgea Hermogenes - - 2013
Necrotizing autoimmune myopathy (NAM) is a severe adverse effect of statins. We report a 66-year-old Caucasian female who had progressive proximal muscle weakness after treatment with statins. Results of a muscle biopsy showed necrotizing myopathy with minimal inflammatory cell infiltrate and increased major histocompatibility class I antigen expression in muscle ...
Kutushov M - - 2013
Rhodamine-6G is a fluorescent dye binding to mitochondria, thus reducing the intact mitochondria number and inhibiting mitochondrial metabolic activity. Resultantly, the respiratory chain functioning becomes blocked, the cell "suffocated" and eventually destroyed. Unlike normal cells, malignant cells demonstrate a priori reduced mitochondrial numbers and aberrant metabolism. Therefore, a turning point might exist, when ...
Chang Chi-Hao - - 2013
Aim:To investigate whether sphingosine-1-phosphate (S1P), a potent angiogenic factor, induced vascular endothelial growth factor-C (VEGF-C) expression in endothelial cells in vitro and to examine its underlying mechanisms.Methods:Human umbilical vein endothelial cells (HUVECs) were examined. VEGF-C mRNA expression in the cells was assessed using real-time PCR. VEGF-C protein and FGFR-1 phosphorylation ...
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