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Serry Tanya - - 2013
There is a complex interplay between expectations for speech-language pathologists based in primary schools to work with low-progress readers and various factors that may preclude this from actually occurring. This qualitative study investigated experiences and perspectives of nine Australian speech-language pathologists based in primary schools about their capacity to work ...
Bromley Jennifer R - - 2013
Xylan comprises up to one third of plant cell walls, and it influences the properties and processing of biomass. Glucuronoxylan in Arabidopsis is characterised by a linear β-(1,4)-linked backbone of xylosyl residues substituted by glucuronic acid and 4-O-methylglucuronic acid (collectively termed [Me]GlcA). The role of these substitutions remains unclear. GUX1 ...
Liu Yuanyuan - - 2013
The role of collector surface charge heterogeneity on transport of Cryptosporidium parvum oocyst and carboxylate microsphere in 2-dimensional micromodels was studied. The cylindrical silica collectors within the micromodels were coated with 0, 10, 20, 50, and 100% Fe2O3 patches. The experimental values of average removal efficiencies (η) of the Fe2O3 ...
Sengupta S - - 2013
BACKGROUND AND PURPOSE: Estrogen receptor alpha (ERα) binds to different ligand which can function as complete / partial estrogen-agonist or antagonist. This depends on the chemical structure of the ligands which modulates the transcriptional activity of the estrogen-responsive genes by altering the conformation of the liganded-ERα complex. This study determined ...
Kolarik D - - 2013
The aim of this study is to determine the combination of characteristics in early breast cancer that could estimate the risk of occurrence of metastatic cells in axillary sentinel lymph node(s). If we were able to reliably predict the presence or absence of axillary sentinel involvement, we could spare a considerable ...
Liu Z W - - 2013
Objective: This study reports a case of a sinonasal inverted papilloma with spread to the temporal bone via the eustachian tube and subsequent transformation to squamous cell carcinoma. Method: An 81-year-old woman presented with sinonasal inverted papilloma which subsequently spread to the ear. A literature review of inverted papilloma was ...
Lv Dandan D Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, - - 2013
Breast cancer (BC) is a leading cause of mortality among women in the world. To date, a number of molecules have been established as disease status indicators and therapeutic targets. The best known among them are estrogen receptor-α (ER-α), progesterone receptor (PR) and HER-2/neu. About 15%-20% BC patients do not ...
Cauchie M - - 2013
The assessment of recombinant FVIII (rFVIII) activity (FVIII:C) in plasma of patients is dependent on the assay. Notably, a calibration with a product-specific laboratory standard is recommended when measuring Refacto-AF(R) activity in plasma with a one-stage assay. The objective of this study was to facilitate the measurement of rFVIII, taking ...
de Villiers Margaret J - - 2013
The inference of phylogenetic relationships is often complicated by differing evolutionary histories of independently-inherited markers. The causes of the resulting gene tree incongruence can be challenging to identify, often relying on coalescent simulations dependent on unverifiable assumptions. We investigated alternative techniques using the South African rosulate species of Streptocarpus as ...
Sheu Jim Jinn-Chyuan JJ Department of Pathology, Gynecology and Obstetrics and Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, - - 2013
Chromosome 11q13.5 containing RSF1 (HBXAP), a gene involved in chromatin remodelling, is amplified in several human cancers including ovarian carcinoma. Our previous studies demonstrated requirement of Rsf-1 for cell survival in cancer cells, which contributed to tumour progression; however, its role in tumourigenesis has not yet been elucidated. In this ...
Deschatrettes Elodie - - 2013
The C-type natriuretic peptide (CNP) exerts its action via stimulation of the cyclic GMP (cGMP) signalling pathway, which includes the activation of cGMP-dependent protein kinases. The pathway can also be activated by inhibitors of phosphodiesterases (PDE) that hydrolyse cGMP. The present report shows that activation of the cGMP pathway by ...
Saeed Asma - - 2013
The review discusses the development of loofa sponge (Luffa cylindrica) as a biotechnological tool and the diversity of applications in which it has been successfully used since it was first reported as a matrix for the immobilization of microbiological cells in 1993. The fibro-vascular reticulated structure, made up of an ...
Dong Wenna - - 2013
Objectives: This work aimed to evaluate pharmacokinetics, biodistribution, toxicity, and antitumor activities of a highly stable long-/medium-chain triglycerides (LCT/MCT)-based etoposide parenteral emulsion (EPE) in comparison to etoposide parenteral solution (EPS). Methods: Using high-pressure homogenization method, EPE was prepared and sterilized at 121°C for 10 min by autoclaving. The biological samples ...
Métellus Philippe - - 2013
Surgical excision in brain metastases has been well evaluated in unique metastases. Two randomized phase III trials have shown that combined with adjuvant whole brain radiotherapy, it significantly improves overall survival. However, even in the presence of multiple brain metastases, surgery may be useful in large, symptomatic or life-threatening lesions ...
Du Y - - 2013
Receptor tyrosine kinases (RTKs) are cell surface receptors that initiate signal cascades in response to ligand stimulation. Abnormal expression and dysregulated intracellular trafficking of RTKs have been shown to be involved in tumorigenesis. Recent evidence shows that these cell surface receptors translocate from cell surface to different cellular compartments, including ...
Deng Ping - - 2013
The present study evaluated the effects of fibre fermentability and viscosity in a morning meal on glucose, insulin and glucagon-like peptide-1 (GLP-1) responses to a glucose challenge later in the day in six healthy female dogs. For this purpose, two Latin square design experiments were performed. In Expt 1, dogs ...
Halder Debasish - - 2013
Fetal alcohol spectrum disorder (FASD) is a set of developmental malformations caused by excess alcohol consumption during pregnancy. Using an in vitro system, we examined the role that chronic ethanol (EtOH) exposure plays in gene expression changes during the early stage of embryonic differentiation. We demonstrated that EtOH affected the ...
Nadjar Agnes - - 2013
Activation of the immune system elicits several behavioral changes collectively called sickness. Among the behavioral changes, systemic infections induce an increase in time spent in nonrapid-eye-movement (NREM) sleep and an increase of slow wave activity (or "sleep pressure"). Using an inducible, astrocyte-specific transgenic dominant negative SNARE (dnSNARE) mouse line we ...
Cho Kyu Suk - - 2013
Tissue plasminogen activator (tPA) is expressed in several regions of brain and plays regulatory roles such as neurite outgrowth, synaptic plasticity and long term potentiation. The activity of tPA is regulated by an endogenous inhibitor plasminogen activator inhibitor-1 (PAI-1), which is expressed mainly in astrocytes. Valproic acid (VPA), a histone ...
Zhao Jingjin - - 2013
A novel label-free fluorescent strategy for the detection of glutathione (GSH) and cysteine (Cys) is presented. The system consists of two single stranded DNA (ssDNA) with thymine-thymine (T-T) mismatches and used Hg(2+) as a mediator, and N-methyl mesoporphyrin IX (NMM) as the signal reporter. The assay is based on the ...
Badrick Ellena - - 2013
BACKGROUND: This quality improvement project was set in Tower Hamlets, east London, with the aim of reducing health inequalities by ethnicity, age and gender in the management of three common chronic diseases. METHODS: Routinely collected clinical data were extracted from practice computer systems using Morbidity Information Query and Export Syntax ...
Syed M I - - 2013
Background: The key to avoiding damage to the horizontal facial nerve in middle-ear surgery is to formally identify the nerve in the early stages of the procedure. Methods: In the non-infected ear this can be achieved relatively easily by identifying the oval window niche. However, in the infected ear with ...
Lazenby Robert A - - 2013
Hopping intermittent contact-scanning electrochemical microscopy (HIC-SECM) is introduced as a powerful new technique for the quantitative visualization of redox activity and concentration at and above a surface of interest. HIC-SECM combines a hopping imaging mode, in which data are acquired at a tip as a function of distance (z) from ...
Sabova L - - 2013
NF1 proteins are a family of transcription factors that act either as repressors or as activators. Functional studies indicate that NF1 participate in signaling pathways that regulate cell viability, proliferation and differentiation. Participation in regulation of genes important for tumor progression and metastasizing suggests a potential value of NF1 as a prognostic factor ...
Ung Kjell-Arne - - 2013
Abstract Background. Self-expandable metallic stents (SEMS) placement is a standard treatment for inoperable malignant bile duct strictures. Covered SEMS have been introduced to avoid stent occlusion by tumor ingrowth. The aims were to compare covered and uncovered stents in terms of patency, efficacy and complication rate. Material and methods. Consecutive ...
Korehi Hananeh - - 2013
The marine shore sulfidic mine tailings dump at the Chañaral Bay in the Atacama Desert, northern Chile, is characterized by extreme acidity, high salinity and high heavy metals concentrations. Due to pyrite oxidation, metals (especially copper) are mobilized under acidic conditions and transported towards the tailings surface and precipitate as ...
Mrdovic Igor - - 2013
OBJECTIVES: The present trial aims at examining whether antiplatelet regimen modification, guided by assessment of the on-treatment platelet reactivity, might result with clinical benefit in moderate to high-risk patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). BACKGROUND: High platelet reactivity has been associated with an increased ...
Baczyk M - - 2013
Bone metastases in prostate cancer constitute the most frequent cause of systemic failure in treatment, which results in numerous complications and finally leads to patient's death. Pain is one of the first and most important clinical symptoms of bone metastases and can be found among more than 80% of patients. ...
Hong Catherine H L - - 2013
BACKGROUND: Singapore is unique in that it is a 100% urban community with majority of the population living in a homogeneous physical environment. She, however, has diverse ethnicities and cultures as such; there may be caries risk factors that are unique to this population. AIM: The aims were to assess ...
Bi Long - - 2013
Processed xenegeneic cancellous bone represents an alternative to bone autograft. In order to observe the effects of present prion inactivation treatments on the natural properties of xenogeneic cancellous bones, we treated bovine bone granules with sodium hydroxide (NaOH), sodium hypochlorite (NaOCl), and gaseous hydrogen peroxide (gH(2) O(2) ) respectively in ...
Yamabe Soichiro - - 2013
Mammalian cells attempt to maintain their homeostasis under endoplasmic reticulum (ER) stress. If the stress cannot be alleviated, cells are led to apoptosis through C/EBP homologous protein (CHOP) induction. ER stress is provoked in osteoarthritis (OA) chondrocytes, and intracellular accumulation of advanced glycation end products (AGEs) in chondrocytes is a ...
Chen Ying Xuan - - 2013
An increased risk of colorectal cancer (CRC) has been revealed in ulcerative colitis (UC) patients. There are two patterns of growth of dysplasia in UC, commonly classified as adenoma-like dysplasia-associated lesion of mass (DALM) and non-adenoma-like DALM, the latter of which has a high risk of concurrent malignancy and often ...
Sobotka Roman - - 2013
Chlorophyll (Chl) is an essential component of the photosynthetic apparatus. Embedded into Chl-binding proteins, Chl molecules play a central role in light harvesting and charge separation within the photosystems. It is critical for the photosynthetic cell to not only ensure the synthesis of a sufficient amount of new Chl-binding proteins ...
Hu Fangyun - - 2013
Nanoscaled two-dimensional (2D) chiral architectures are increasingly receiving scientific interest because of their potential applications in many domains. In this paper, we present a new method for constructing 2D chiral architectures on surface. Based on in situ Schiff-base reaction of achiral dialdehyde with two kinds of achiral amines at the ...
Lavergne Rose-Anne - - 2013
Candida spp. are an important cause of nosocomial bloodstream infections. Currently, complete identification of yeasts with conventional methods takes several days. We report here the first evaluation of an extraction method associated with the Vitek MS matrix-assisted laser desorption ionization time of flight mass spectrometry for direct identification of Candida ...
Hwang Seung-Lark - - 2013
BACKGROUND AND PURPOSE: ER stress has been implicated in the pathogeneses of insulin resistance and type 2 diabetes, and extracellular signal-regulated kinase (ERK) antagonist is an insulin sensitizer that can restore muscle insulin responsiveness in both tunicamycin-treated muscle cells and type 2 diabetic mice. The present study was undertaken to ...
Suzuki Kazushi - - 2013
Abstract We report a 14-year-old boy with a large intrahepatic portosystemic venous shunt. The shunt seemed to be difficult to coil embolize because it was so large and short. However, it was successfully treated by coil embolization with a new dual microcatheter-dual detachable coil technique.
Metgud R - - 2013
Xylene customarily has been used as a clearing agent for routine tissue processing. Because xylene is a relatively hazardous solvent, laboratories are under pressure to seek less toxic alternatives for routine use. We prepared 30 paired soft tissue specimens for routine histopathological evaluation using conventional xylene and xylene-free methods to ...
Chen Hui - - 2013
Reactions of [Mn(6)O(2)(piv)(10)(py)(2.5)(piv)(1.5)], Ln(NO(3))(3)·6H(2)O and N-mdeaH(2) in MeCN in the presence of Me(3)SiCl generated a family of octanuclear Mn/Ln complexes [Mn(6)(III)Mn(II)Ln(N-mdea)(3)(N-mdeaH)(piv)(8)O(2)(OH)(3)(NO(3))(H(2)O)]·xCH(3)CN·xH(2)O [Ln = Gd (), Dy (), Er (), pivH = pivalic acid, N-mdeaH(2) = N-methyl diethanolamine]. Each complex possesses a [Mn(6)(III)Mn(II)Ln(μ(3)-O)(2)(μ(3)-OH)(3)](16+) core containing two butterfly-like subunits of [Mn(3)Ln(μ(3)-OH)(2)] and ...
Mautz Brian S - - 2013
There are two reasons why researchers are interested in the phenotypic relationship between the expression of male secondary sexual characters (SSCs) and 'ejaculate quality' (defined as sperm/ejaculate traits that are widely assumed to increase female fertility and/or sperm competitiveness). First, if the relationship is positive then females could gain a ...
Wang Jirui - - 2013
Hexaploid wheat (Triticum aestivum, genomes AABBDD) originated by hybridization of tetraploid Triticum turgidum (genomes AABB) with Aegilops tauschii (genomes DD). Genetic relationships between A. tauschii and the wheat D genome are of central importance for the understanding of wheat origin and subsequent evolution. Genetic relationships among 477 A. tauschii and wheat accessions ...
Leone Roberti Maggiore Umberto - - 2013
Despite aggressive debulking surgery, intraperitoneal therapies and the use of new drugs for chemotherapy, patients with ovarian cancer (OC) still have poor prognosis and, therefore, new strategies for its management are needed. Molecular-targeted agents can be considered a new option in drug research. Several antigens related to OC have been ...
Tanaka Yoko - - 2013
The number and density of stomata is controlled by endogenous and environmental factors.Despite recent advances in our understandingof stomatal development, mechanismswhich preventstomatal lineage entry remain unclear. Here, we propose that abscisic acid (ABA), a phytohormone known to induce stomatal closure, limits initiation of stomatal developmentand induces enlargement of pavement cells ...
Sun Yi - - 2013
Reagent pre-storage in a microfluidic chip can enhance operator convenience, simplify the system design, reduce the cost of storage and shipment, and avoid the risk of cross-contamination. Although dry reagents have long been used in lateral flow immunoassays, they have rarely been used for nucleic acid-based point-of-care (POC) assays due ...
Ponnusamy Rajesh - - 2013
Collapsin Response Mediator Protein-5 (CRMP-5) is the latest identified member of the CRMP cytosolic phosphoprotein family, which is crucial for neuronal development and repair. CRMPs exist as homo- and/or hetero-tetramers in vivo and participate in signaling transduction, cytoskeleton rearrangements, and endocytosis. CRMP-5 antagonizes many of the other CRMPs' functions either ...
Nakib Sarah S Department of Dermatology, Johns Hopkins Medical Center , Baltimore, MD , - - 2013
Periodontal disease has been associated with systemic inflammation and may be a risk factor for autoimmune diseases. This study evaluated the association between periodontal disease and the risk of incident psoriasis in a large prospective cohort study. Self-reported history of periodontal bone loss, from 1998-2008, was evaluated as a risk ...
Barberá Rafael - - 2013
BACKGROUND: Frey's syndrome (FS), facial depression, and noticeable scar may have an impact on patient's quality of life after a parotidectomy. The superficial musculoaponeurotic system (SMAS) flap has been used to ameliorate those effects. METHODS: Forty-seven consecutive parotidectomies were analyzed; SMAS flap was performed in 26 of them. We investigated ...
Aho Kevin A - - 2013
This paper integrates personal narratives with the methods of phenomenology in order to draw some general conclusions about 'what it means' and 'what it feels like' to be depressed. The analysis has three parts. First, it explores the ways in which depression disrupts everyday experiences of spatial orientation and motility. ...
Agache Ioana O - - 2013
ABSTRACT: Hypersensitivity pneumonitis (HP) is an interstitial lung disease due to a combined type III and IV reaction with a granulomatous inflammation, caused by cytotoxic delayed hypersensitivity lymphocytes, in a Th1/Th17 milieu, chaperoned by a deficient suppressor function of T regulatory cells. Skewing toward a Th2 phenotype is reported for ...
Valentino L A - - 2013
In haemophilia patients with well-established high-titer inhibitors, even seemingly minor acute bleeding episodes or surgical procedures may become refractory to treatment and transform into limb- or life-threatening situations. In the absence of evidence-based treatment guidelines, this article presents 10 cases of difficult to control acute and surgical bleeding and offers ...
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