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Klinman Judith P JP Department of Chemistry, Department of Molecular and Cell Biology, and California Institute for Quantitative Biosciences (QB3), University of California , Berkeley, California 94720-3220, United - - 2013
Quantum tunneling and protein dynamics have emerged as important components of enzyme function. This review focuses on soybean lipoxygenase-1, to illustrate how the properties of enzymatic C-H bond activation link protein motions to the fundamental bond making-breaking processes.
Du Bingnan B Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, - - 2013
A palladium-catalyzed ortho-halogenation (I, Br, Cl) of arylnitrile is described. The optimal reaction conditions were identified after examining various factors such as catalyst, additive, solvent, and reaction temperature. Using cyano as the directing group, the halogenation reaction gave good to excellent yields. The method is compatible to the arylnitriles with ...
Rousselle Anthony - - 2013
The ELR(+)-CXCL chemokines have been described typically as potent chemoattractants and activators of neutrophils during the acute phase of inflammation. Their role in atherosclerosis, a chronic inflammatory vascular disease, has been largely unexplored. Using a mouse model of atherosclerosis, we found that CXCL5 expression was upregulated during disease progression, both ...
Leavenworth Jianmei W - - 2013
Current therapies to treat autoimmune disease focus mainly on downstream targets of autoimmune responses, including effector cells and cytokines. A potentially more effective approach would entail targeting autoreactive T cells that initiate the disease cascade and break self tolerance. The murine MHC class Ib molecule Qa-1b (HLA-E in humans) exhibits ...
Funai Katsuhiko K Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, - - 2013
Exogenous dietary fat can induce obesity and promote diabetes, but endogenous fat production is not thought to affect skeletal muscle insulin resistance, an antecedent of metabolic disease. Unexpectedly, the lipogenic enzyme fatty acid synthase (FAS) was increased in the skeletal muscle of mice with diet-induced obesity and insulin resistance. Skeletal ...
Kraft Matthew B MB Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United - - 2013
Mycobacteria and corynebacteria use decaprenylphosphoryl-β-D-arabinofuranose (DPA) as a critical cell wall building block. Arabinofuranosyltransferases that process this substrate to mediate cell wall assembly have served as drug targets, but little is known about the substrate specificity of any of these enzymes. To probe substrate recognition of DPA, we developed a ...
Cho Hoonsung H Center for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, United - - 2013
Attaching DNA binding fluorochromes to nanoparticles (NPs) provides a way of obtaining NPs that bind to DNA through fluorochrome mediated interactions. To obtain a nanoparticle (NP) that bound to the DNA in biological systems, we attached the DNA binding fluorochrome, TO-PRO 1 (TO), to the surface of the Feraheme (FH) ...
Scheele Dirk - - 2013
Although major depression is projected to be among the top three causes of disability-adjusted life years lost in 2030, relatively little is known concerning the extent to which depressed mood states can bias social-economic decision making away from optimal outcomes. One experimental framework to study the interaction between negative emotion ...
Toney Michael D MD Department of Chemistry, University of California-Davis, One Shields Avenue, Davis, California 95616, USA. - - 2013
The catalytic effects of perdeuterating the pyridoxal phosphate-dependent enzyme alanine racemase from Geobacillus stearothermophilus are reported. The mass of the heavy perdeuterated form is ~5.5% greater than that of the protiated form, causing kinetic isotope effects (KIEs) of ~1.3 on k(cat) and k(cat)/K(M) for both L- and D-alanine. These values ...
Schwartz Ann V AV University of California, 185 Berry St., Suite 5700, San Francisco, CA 94107, USA. - - 2013
Factors that contribute to bone fragility in type 2 diabetes are not well understood. We assessed the effects of intensive glycemic control, thiazolidinediones (TZDs), and A1C levels on bone geometry and strength at the radius and tibia. In a substudy of the Action to Control Cardiovascular Risk in Diabetes trial, ...
Sun Yi - - 2013
Reagent pre-storage in a microfluidic chip can enhance operator convenience, simplify the system design, reduce the cost of storage and shipment, and avoid the risk of cross-contamination. Although dry reagents have long been used in lateral flow immunoassays, they have rarely been used for nucleic acid-based point-of-care (POC) assays due ...
Ponnusamy Rajesh - - 2013
Collapsin Response Mediator Protein-5 (CRMP-5) is the latest identified member of the CRMP cytosolic phosphoprotein family, which is crucial for neuronal development and repair. CRMPs exist as homo- and/or hetero-tetramers in vivo and participate in signaling transduction, cytoskeleton rearrangements, and endocytosis. CRMP-5 antagonizes many of the other CRMPs' functions either ...
Nakib Sarah - - 2013
Abstract Objective. Periodontal disease has been associated with systemic inflammation and may be a risk factor for autoimmune diseases. This study evaluated the association between periodontal disease and the risk of incident psoriasis in a large prospective cohort study. Material and methods. Self-reported history of periodontal bone loss, from 1998-2008, ...
Unzué Leire - - 2013
The optimal percutaneous treatment strategy for coronary bifurcation lesions is still unknown. Several dedicated coronary bifurcation stents, such as the Tryton Side Branch Stent (TM) (Tryton Medical, Durham, NC, USA) have been developed to improve clinical outcomes. We present a double bifurcation lesion case treated with two Tryton sidebranch stents, ...
Coyer Fiona M - - 2013
The aim of this study was to determine the prevalence, severity, location, aetiology, treatment and healing of medical device-related pressure ulcers (PUs) in intensive care patients for up to 7 days. A prospective repeated measures study design was used. Patients in six intensive care units of two major medical centres, one ...
Przyrembel Daniel - - 2013
We have studied the adsorption of copper on the clean Re[Formula: see text] surface between 300 and 900 K by means of low- and medium-energy electron diffraction (LEED and MEED) and temperature-programmed thermal desorption (TPD). The persistence of a (1 × 1) LEED pattern during Cu deposition suggests the formation of pseudomorphic Cu ...
Glendor Ulf - - 2013
BACKGROUND/AIM: The most common method to study the use and attitudes of mouth and face guards is a limited number of preprepared questions. This approach, however, risks information restriction and lowers the general value of the study. The aim of this study was therefore to present a phenomenographic approach to ...
Vähämiko Sanna - - 2013
We aimed here to assess the impact of dietary counselling during pregnancy on dietary intake of vitamins and the vitamin status of women and their children. At the first trimester of pregnancy, 89 women from allergic families were randomized to a control group (n = 45) or to receive individual dietary counselling ...
Uwate Maki - - 2013
The NfxC-type mutant of Pseudomonas aeruginosa produces the MexEF-OprN efflux pump and down-regulates the expression of the quorum-sensing-dependent efflux pump MexAB-OprM and production of virulence factors in the presence of an active transcriptional regulator, MexT. Consequently, the cells are resistant to chloramphenicol and hypersusceptible to ß-lactam antibiotics. An upper negative ...
Yao Zhiyi - - 2013
A colorimetric probe for the detection of copper(ii) ions in aqueous media by the naked eye has been developed based on a supramolecular complex comprised of a cationic polythiophene derivative and ATP with a detection limit as low as 0.05 mM.
Nakano Takashi - - 2013
Background: Abnormal behavior and delirium are common in children with influenza. While abnormal behavior and delirium are considered to be associated with influenza encephalopathy, an increased risk of such neuropsychiatric symptoms in patients receiving neuraminidase inhibitor treatment is suspected. Laninamivir octanoate hydrate, recently approved in Japan, is a long-acting neuraminidase ...
Spang Christoph - - 2013
The plantaris tendon is often neglected in morphological/clinical studies on the lower extremity. There is, however, clinical evidence that the plantaris tendon is involved in cases with Achilles midportion tendinopathy/tendinosis. It is nevertheless unclear if the plantaris tendon exhibits tendinosis-like features in this situation. We therefore investigated the plantaris tendon ...
Cheung Paul Km - - 2013
An 85-year-old gentlemen with a history of previous triple vessel coronary bypass grafting presented with severe aortic stenosis and occlusion of the previous saphenous vein grafts but with patent LIMA-LAD. The patient underwent uncomplicated repeat sternotomy and aortic valve replacement with repeated coronary bypass. On post-op day 21 the patient ...
Florea Adrian - - 2013
Ultrastructural answer of bone marrow erythroid series and of red blood cells (RBCs) in Wistar rats to bee venom (BV) was analyzed by transmission and scanning electron microscopy, and corroborated with hematological data. A 5-day and a 30-day treatment with daily doses of 700 μg BV/kg and an acute-lethal treatment ...
Collins Stuart G - - 2013
Diazo transfer adjacent to a sulfoxide moiety to provide stable, isolable α-diazo-β-oxo sulfoxides has been achieved. Use of monocyclic and bicyclic sulfoxide precursors is critical in enabling isolation of stable derivatives, through introduction of conformational constraint, while acyclic α-diazo-β-oxo sulfoxides are too labile to isolate and characterize.
Roberts Alexander J - - 2013
Birnessite nanotubes and activated carbon electrodes have been used in supercapacitor cells to assess the performance of new aqueous based electrolyte systems at temperatures as low as -30 °C. The addition of ethylene glycol to aqueous sodium, lithium, potassium and ammonium sulfates has resulted in electrolytes that are still in ...
Macfarlane Anne - - 2013
The development of a high-quality primary healthcare system requires multidisciplinary perspectives and collaborations between clinicians and non-clinicians. Academic primary care departments across the United Kingdom and Ireland employ academics from a range of disciplines. However, questions remain about the parity of opportunity for career progression with a consistent trend to ...
Dickhaus Thorsten - - 2013
Connecting multiple testing with binary classification, we derive a false discovery rate-based classification approach for two-class mixture models, where the available data (represented as feature vectors) for each individual comparison take values in Rd for some d≥1 and may exhibit certain forms of autocorrelation. This generalizes previous findings for the ...
Burton Edward D - - 2013
The effect of SO42- availability on the microbially-mediated reductive transformation of As(V)-coprecipitated schwertmannite (Fe8O8(OH)3.2(SO4)2.4(AsO4)0.004) was examined in long-term (up to 400 days) incubation experiments. Iron EXAFS spectroscopy showed siderite (FeCO3) and mackinawite (FeS) were the dominant secondary Fe(II) minerals produced via reductive schwertmannite transformation. In addition, ~25% to ~65% of ...
Bernard Frédéric - - 2013
The thermal performance curve is an ecological concept relating the phenotype of organisms and temperature. It requires characterization of the leaf temperature for foliar fungal pathogens. Epidemiologists, however, use air temperature to assess the impacts of temperature on such pathogens. Leaf temperature can differ greatly from air temperature, either in ...
Koucky Ellen M - - 2013
Cognitive-behavioral therapy (CBT) is currently the most empirically supported intervention for posttraumatic stress disorder (PTSD) and includes both specific manualized treatments (e.g., cognitive processing therapy, prolonged exposure) and less standardized applications. As CBT for PTSD has become increasingly popular, more advanced questions have emerged regarding its use, including how existing ...
Vu Lan Th - - 2013
ABSTRACT: BACKGROUND: The Expanded Program on Immunization currently considers offering Human Papilomavirus vaccine on a routine basis in Vietnam. However, as the current available vaccine can prevent only two types HPV 16 and 18, before implementing a large-scale vaccine campaign we need information about the prevalence of infection with only ...
Zhou Xia - - 2013
A gold monolayer film and cysteine layer-by-layer self-assemble onto modified glasses, and through the use of optical waveguide spectroscopy (OWGS) and a dynamic SERS technique for the first time to study the dynamic generation process of the Meisenheimer complex between TNT and cysteine. This strategy can detect TNT down to ...
Hu R - - 2013
We investigated the source of fungi in the lungs of patients with hematological malignancies who had invasive pulmonary fungal infections (IPFI). We also conducted a prospective study to evaluate the efficacy of different mouthwash solutions in preventing IPFI in patients with hematologic malignancies. In order to determine the source of fungi ...
Veeramani Harish - - 2013
During subsurface bioremediation of uranium-contaminated sites, indigenous metal and sulfate-reducing bacteria may utilize a variety of electron acceptors, including ferric iron and sulfate that could lead to the formation of various biogenic minerals in-situ. Sulfides, as well as structural and adsorbed Fe(II) associated with biogenic Fe(II)-sulfide phases, can potentially catalyze ...
Harrison Robert V - - 2013
Abstract Conclusion: In the neonatal chinchilla, the degree of contralateral distortion product otoacoustic emission (DPOAE) suppression and the latency and time constants of suppression are immature for 40-60 days. This suggests that olivocochlear efferent innervation of outer hair cells is not fully mature at birth in this animal model, and ...
Keniya Mikhail V - - 2013
Candida albicans is a major cause of opportunistic and life-threatening systemic fungal infections, especially in the immunocompromised. The plasma membrane proton pumping ATPase (Pma1p) is an essential enzyme that generates the electrochemical gradient required for cell growth. We expressed C. albicans Pma1p (CaPma1p) in Saccharomyces cerevisiae to facilitate screening for ...
Ray K C - - 2013
Pancreatic cancer remains as one of the most deadly cancers with few treatment options at late stages and little information about how it develops through earlier stages. Activating mutation of the Kras gene has been implicated in, but is not sufficient for, tumorigenesis. In mouse models of pancreatic cancer, loss ...
Fan Ting Ting - - 2013
AIM: Liver Cirrhosis is the final stage of chronic liver damage from various etiologies. It is controversial on the reversibility of cirrhosis. The aim of this study was to determine whether cirrhosis was reversible after treatment by hepatocyte nuclear factor 4α (HNF4α), a key transcriptional regulator of hepatocyte differentiation and ...
Nie Guangming - - 2013
A signal-on electrochemiluminescence (ECL) biosensor devoted to the detection of Ramos cells was fabricated based on a novel conducting polymer, poly(5-formylindole) (P5FIn), which was synthesized electrochemically by direct anodic oxidation of 5-formylindole (5FIn). This ECL platform was presented by covalently coupling the 18-mer amino-substituted oligonucleotide (ODN) probes with aldehyde groups ...
Wu Bei - - 2013
Objective: To compare overall survival and technical survival in diabetic mellitus (DM) and non-DM (N-DM) Chinese patients undergoing peritoneal dialysis (PD), and to discuss the factors involved. Methods: Clinical data were analyzed for all adult patients (age >18 years) with chronic renal failure who had commenced PD between 2006 and ...
Eidi Akram - - 2013
Abstract Context: Different parts of the walnut [Juglans regia L. (Juglandaceae)] have been used in folk medicine for protection against liver injury, although its actual efficacy remains uncertain. Objective: The present study investigated the protective effect of walnut leaf extract against carbon tetrachloride (CCl(4))-induced liver damage in rats. Materials and ...
Stournaras Kalliope E - - 2013
The colors of fleshy fruits are considered to be a signal to seed-dispersing animals, but their diversity remains poorly understood. Using an avian color space to derive a sensory morphospace for fruit color, we tested four hypotheses of fruit color diversity: fruit colors occupy a limited area of the color ...
Momen Natalie - - 2013
Graphical displays of investigations are increasingly used in clinical care. Summaries of medical records for research or clinical review purposes can generate unmanageably large amounts of data, which may be helpfully summarised and displayed using timelines. During a prospective study of cancer care in primary care, care timelines were generated ...
Yang Yi - - 2013
We report a general strategy for synthesis of gallium nitride (GaN) and indium nitride (InN) nanowires on conductive and flexible carbon cloth substrates. GaN and InN nanowires were prepared via a nanocluster-mediated growth method using a home built chemical vapor deposition (CVD) system with Ga and In metals as group ...
Dikbas Idil - - 2013
AIM: The aim of this study was to assess fracture resistances of simulated immature single-rooted teeth whose roots have been backfilled using 3 different post systems after a 4 mm apical mineral trioxide aggregate (MTA) placement. MATERIALS AND METHODS: Forty-eight maxillary anterior teeth were assigned into four groups. The lengths of ...
Eskes Anne M - - 2013
Health care professionals responsible for patients with complex wounds need a particular level of expertise and education to ensure optimum wound care. However, uniform education for those working as wound care nurses is lacking. We aimed to reach consensus among experts from six European countries as to the competencies for ...
Tripathi V - - 2013
E-cadherin is a cell-cell adhesion molecule that acts as a suppressor of cancer cell invasion and its expression is downregulated in many advanced, poorly differentiated, human cancers. In this study, we found that the expression of DLC1 (deleted in liver cancer 1) tumor-suppressor gene in metastatic prostate carcinoma (PCA) cells ...
Tong Sheng - - 2013
An acetic acid based sol-gel method was used to deposit lead lanthanum zirconate titanate (PLZT, 8/52/48) thin films on either platinized silicon (Pt/Si) or nickel buffered by a lanthanum nickel oxide buffer layer (LNO/Ni). X-ray diffraction and scanning electron microscopy of the samples revealed that dense polycrystalline PLZT thin films ...
Moreno Lucas - - 2013
Attrition is a major issue in anticancer drug development with up to 95% of drugs tested in Phase I trials not reaching a marketing authorisation making the drug development process enormously costly and inefficient. It is essential that this problem is addressed throughout the whole drug development process to improve ...
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