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Kruser Tim J TJ Departments of *Human Oncology †Medical Physics, University of Wisconsin Carbone Cancer Center ∥Department of Medicine, Division of Hematology and Oncology, University of Wisconsin Carbone Cancer Center, Madison, WI ‡Department of Radiation Oncology, Northwestern Memorial Hospital, Chicago, IL §Western Radiation Oncology, Mountain View, - - 2014
To our knowledge this is the largest report analyzing outcomes for re-irradiation (reRT) for locoregionally recurrent lung cancer, and the first to assess thoracic reRT outcomes in patients with small cell lung cancer (SCLC). Forty-eight patients (11 SCLC, 37 non-small cell lung cancer [NSCLC]) receiving reRT to the thorax were ...
Zhang Zhuo Z Department of Chemical Engineering, University of Michigan, 2300 Hayward Street, Ann Arbor, MI 48109, - - 2013
More than two decades ago, microfluidics began to show its impact in biological research. Since then, the field of microfluidics has evolving rapidly. Cancer is one of the leading causes of death worldwide. Microfluidics holds great promise in cancer diagnosis and also serves as an emerging tool for understanding cancer ...
Lu Zufu Z Biomaterials and Tissue Engineering Research Unit, School of AMME, the University of Sydney, Sydney, - - 2013
There is a major medical need for developing novel and effective approaches for repairing non-union and critical-sized bone defects. Although the mechanisms remain to be determined, it is known that inflammation plays a crucial role in initiating bone repair and regeneration. This study investigated the effect of short-term (3 days) ...
Chrobak Izabela I Boston University School of Medicine, Arthritis Center, Boston, Massachusetts 02118, - - 2013
Systemic sclerosis (SSc) is a complex disease characterized by vascular alterations, activation of the immune system and tissue fibrosis. Previous studies have implicated activation of the interferon pathways in the pathogenesis of SSc. The goal of this study was to determine whether interferon type I and/or type II could play ...
Kacena Melissa A MA Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. - - 2013
Mice deficient in GATA-1 or NF-E2, transcription factors required for normal megakaryocyte (MK) development, have increased numbers of MKs, reduced numbers of platelets, and a striking high bone mass phenotype. Here, we show the bone geometry, microarchitecture, biomechanical, biochemical, and mineral properties from these mutant mice. We found that the ...
Das Falguni F Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, - - 2013
Transforming growth factorβ (TGFβ)-induced canonical signal transduction is involved in glomerular mesangial cell hypertrophy; however, the role played by the noncanonical TGFβ signaling remains largely unexplored. TGFβ time-dependently stimulated eIF4E phosphorylation at Ser-209 concomitant with enhanced phosphorylation of Erk1/2 (extracellular signal regulated kinase1/2) and MEK (mitogen-activated and extracellular signal-regulated kinase ...
Goel Hira Lal HL Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, - - 2013
This study was carried out to dissect the mechanism by which β1 integrins promote resistance to radiation. For this purpose, we conditionally ablated β1 integrins in the prostatic epithelium of transgenic adenocarcinoma of mouse prostate (TRAMP) mice. The ability of β1 to promote resistance to radiation was also analyzed by ...
Hsuchou Hung H Blood-Brain Barrier Group, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, - - 2013
Hyperleptinemia is usually associated with obesity and leptin resistance. Endothelial cell leptin receptor knockout (ELKO) mice without a signaling membrane-bound leptin receptor in endothelia, however, have profound hyperleptinemia without signs of leptin resistance. Leptin mRNA in adipose tissue was unchanged. To test the hypothesis that the ELKO mutation results in ...
Jones Meghan C MC Department of Biomedical Engineering, University of Rochester, Rochester, NY, - - 2013
Development of micro-well array systems for use in high-throughput screening of rare cells requires a detailed understanding of the factors that impact the specific capture of cells in wells and the distribution statistics of the number of cells deposited into wells. In this study we investigate the development of microbubble ...
Rector R Scott RS Harry S Truman Memorial Veterans Medical Center, Columbia, MO, USA. - - 2013
Earlier reports suggest a link between mitochondrial dysfunction and development of hepatic insulin resistance. Here we used a murine model heterozygous (HET) for a mitochondrial trifunctional protein (MTP) gene defect to determine if a primary defect in mitochondrial long-chain fatty acid oxidation disrupts hepatic insulin action. Hyperinsulinemic-euglycemic clamps and signaling ...
Lee Jee Min JM Departments of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, - - 2013
We present a patient with metastatic BRAF-mutated melanoma who achieved long-term stabilization of leptomeningeal disease (LMD) with sequential whole-brain radiation therapy and vemurafenib. A 53-year-old woman with melanoma that harbored the BRAF V600E mutation and had that metastasized to multiple lymph nodes, lungs, breast, and subcutaneous tissue had developed symptomatic ...
Goldman L Elizabeth LE Department of Medicine, University of California San Francisco, San Francisco, CA 94110, USA. - - 2013
Whether timeliness of follow-up after abnormal mammography differs at facilities serving vulnerable populations, such as women with limited education or income, in rural areas, and racial/ethnic minorities is unknown. We examined receipt of diagnostic evaluation after abnormal mammography using 1998-2006 Breast Cancer Surveillance Consortium-linked Medicare claims. We compared whether time ...
Kadaba Raghu R Centre for Tumour Biology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, - - 2013
Epithelial tissues have sparse stroma, in contrast to their corresponding tumours. The effect of cancer cells on stromal cells is well recognized. Increasingly, stromal components, such as endothelial and immune cells, are considered indispensable for cancer progression. The role of desmoplastic stroma, in contrast, is poorly understood. Targeting such cellular ...
Davila Jessica A JA Houston VA Health Services Research Center of Excellence, Section of Health Services Research, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA. - - 2013
The delivery of treatment for hepatocellular carcinoma (HCC) could be influenced by the place of HCC diagnosis (hospitalization versus outpatient), subspecialty referral following diagnosis, as well as physician and facility factors. We conducted a study to examine the effect of patient and nonpatient factors on the place of HCC diagnosis, ...
Fu Cary C Division of Child Neurology and Epilepsy, Vanderbilt Kennedy Center, Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, TN, - - 2013
Tuberous sclerosis complex (TSC) is a genetic disease characterized by multiorgan benign tumors as well as neurological manifestations. Epilepsy and autism are two of the more prevalent neurological complications and are usually severe. TSC is caused by mutations in either the TSC1 (encodes hamartin) or the TSC2 (encodes tuberin) genes ...
Yang Youngran - - 2013
: Local health departments (LHDs) are expected to address health disparities. Little is known, however, about what factors influence the activities used by an LHD in addressing health disparities. The objective of this study was to examine factors such as an LHD's leader, jurisdiction, and organizational characteristics that could be ...
Noël Alexandra - - 2013
This study assessed the contribution of electron microscopy to the characterization of nanoparticles and compared the degree of variability in sizes observed within each stage when sampled by two cascade impactors: an Electrical Low Pressure Impactor (ELPI) and a Micro-Orifice Uniform Deposit Impactor (MOUDI). A TiO(2) nanoparticle (5 nm) suspension was ...
Katgi Abdullah - - 2013
Gray platelet syndrome (GPS) is a rare inherited disorder characterized by the absence of α-granules and their constituents. It may be present with thrombocytopenia and bleeding tendency. Platelets have a large and gray appearance under light and electron microscope. A 19-year old female patient with her second relapse acute lymphoblastic ...
Shi Lu - - 2013
We use the UCLA Health Forecasting Tool to forecast the 2011-2050 health trends in Milwaukee County. We first simulate a baseline scenario (S-1) that assumes no health behavior change, and compare this with three simulated intervention scenarios: expansion of Quitline reach to enhance smoking cessation (S-2), an increased penetration of ...
Infed Nacera - - 2013
Abstract The increasing number of multidrug-resistant pathogenic microorganisms is a serious public health issue. Among the multitude of mechanisms that lead to multidrug resistance, the active extrusion of toxic compounds, mediated by MDR efflux pumps, plays an important role. In our study we analyzed the inhibitory capability of 26 synthesized ...
Mishra Shashikant - - 2013
Training in percutaneous nephrolithotomy (PCNL) necessitates the trainee to climb the steep learning curve of this procedure sequentially. The initial steps of the process should be the acquisition of the necessary skills in a nonintimidating skills lab. We review the current scenario of the training in PCNL and advocate the ...
Benz Jennifer - - 2013
OBJECTIVE:: After 30 years of implementation, this study provides the first assessment of how the nation's preeminent health promotion and disease prevention initiative, Healthy People, is utilized by key stakeholders in state, local, and tribal health organizations. METHODS:: Surveys of state, local, and tribal health organizations were conducted in 2005 ...
Szymańska Magdalena - - 2013
Type I antithrombin deficiency is an autosomal dominant disorder associated with high risk for venous thromboembolism. Data on the association between antithrombin deficiency and arterial thromboembolism are inconsistent. We report here the case of AT deficiency in a 43-year-old man free of cardiovascular risk factors who experienced venous thromboembolism and ...
Rousseau-Nepton Isabelle - - 2013
Glucocorticoids (GC) are a standard treatment for pediatric rheumatic disease. Recent literature highlights skeletal vulnerability in children with rheumatic illness, including vertebral and peripheral fractures and reductions in bone mineral density in longitudinal follow-up. Annual vertebral fracture incidence of 4-6 % in those recently diagnosed and prevalence of 7-28 % in those ...
Guven Aytekin - - 2013
Masked hypertension is associated with an increase in cardiovascular risk. Mean platelet volume (MPV), a determinant of platelet function, is a new risk factor for atherothrombosis. High-sensitive C-reactive protein (CRP) is an exquisitely sensitive systemic marker of inflammatory response. We designed this study to evaluate MPV and CRP in masked ...
Harris Jennie L - - 2013
This article describes a process evaluation conducted as part of a proof-of-concept study to develop, implement, and test a text messaging program to promote medication and appointment adherence, sexual and substance use risk reduction, general health and well-being, social support, and patient involvement. The text-messaging program was implemented in Chicago, ...
Franco David - - 2013
Brodifacoum poisoning occurs as a result of ingestion of rodenticide compounds. It acts as a superwarfarin, inhibiting vitamin K epoxide reductase, in an irreversible fashion much like warfarin but with a much longer half-life. A 48-year-old female patient reported 4 days of mild dyspnea, dry cough, bilateral popliteal fossae pain ...
Williams Nancy J - - 2013
: Early in the 2009 pandemic influenza A (H1N1) experience, children aged 5 to 17 years were determined to be disproportionately affected compared with recent influenza seasons. : To characterize the pandemic among school-aged children, to enable timely influenza outbreak identification, and to determine which school-based influenza surveillance indicator correlated ...
Hus Iwona - - 2013
The pathogenesis of Buerger' disease (thrombangiitis obliterans; TAO) remains unknown, although a strong association with tobacco use has been established. Blood coagulation and fibrinolytic factors as well as selected clinical chemistry parameters have been evaluated in 37 patients with Buerger's disease. Median levels of prothrombotic factors were higher in patients ...
Lang Rosalyn - - 2013
: To elucidate factors that influence African American willingness to participate in health-related research studies. : The African American Alzheimer disease research study group at North Carolina A&T State University designed an in-person questionnaire and surveyed more than 700 African American adults on their willingness to participate in health-related research ...
Kar Rakhee - - 2013
Hemostatic defect in chronic liver disease (CLD) is complex involving opposing factors of primary hemostasis, coagulation, and fibrinolysis. The concept of causal relationship between abnormal tests and clinical bleeding is unclear. This study was undertaken to evaluate and correlate clinical bleeding and the commonly used laboratory tests for hemostasis in ...
Bennett April Young - - 2013
: Analyses of Utah vital records indicated that Utah Pacific Islanders had unique health problems that merited further investigation through a behavioral survey. However, statewide surveys did not reach a large enough sample of Pacific Islanders and were not administered in Samoan or Tongan. : The authors sought to complete ...
Gin June L - - 2013
Emergency managers are often charged with prioritizing the relative importance of key issues and tasks associated with disaster response. However, little work has been done to identify specific ways that the decision-making process can be improved. This exercise was conducted with 220 employees of the US Department of Veterans Affairs, ...
Carvalhosa Ana Monteiro - - 2013
With the increased life expectancy and associated comorbidities in haemophilic patients, greater awareness is needed to avoid being misled by symptoms mimicking haemophilia-related conditions. Here, we discuss the case of a 77-year-old man with congenital moderate haemophilia complicated by diffuse haemophilic arthropathy. He presented with persistent pain and stiffness affecting ...
Sugawara Yumi - - 2013
Although breastfeeding is associated with a reduction in the risk for breast cancer, its relationship with another hormone-related female cancer, endometrial cancer, has not been fully investigated. The objective of the present study was to prospectively examine the association between lactation pattern and the risk for incidence of breast cancer ...
Dirige Ofelia V - - 2013
: Intervening in organizations allows for targeting multiple levels of influence and greater potential for sustainability. : To evaluate an 18-month nutrition and physical activity (NPA) intervention (Siglang Buhay) conducted through culturally specific organizations. : Site randomized trial with an active control group. : Eighteen Filipino-American social clubs in San ...
Simforoosh Nasser - - 2013
While most renal and ureteral stones can be efficiently managed using endourologic techniques, the use of laparoscopy for the management of urolithiasis is increasing. The application of laparoscopy for stone removal will further reduce the need for open stone surgery. Laparoscopic ureterolithotomy, pyelolithotomy, and anatrophic nephrolithotomy are highly successful techniques ...
Heinrich Katie M - - 2013
: State-level policymakers play an important role in the fight against obesity because of their ability to create policies that influence opportunities for physical activity and nutrition. : In 2011, we investigated how Kansas policymakers regarded obesity, nutrition, and physical activity in comparison to other issues. : This study used ...
Collins Justin W - - 2013
To provide discussion on several recently published case series describing complete intracorporeal robotic cystectomy. Are we making a complex and expensive procedure more challenging or are there patient benefits to be realized from a complete minimally invasive approach? We discuss how effective and cost-efficient a complete intracorporeal approach is, review ...
McAuliffe Kathryn - - 2013
CONTEXT:: In 2008, about 40% of the US population eligible for influenza vaccine was vaccinated, which was below Healthy People 2020 goals. Little emphasis has been put on late-season vaccination efforts by medical providers. OBJECTIVE:: Evaluate use of evidence-based practices (EBP) and their association with influenza vaccination for children younger ...
Harris Jenine K - - 2013
Public health policy is among the most effective and cost-effective interventions in some areas of public health and is emerging as effective in others. Policy may be especially important for rural communities, where residents face serious health and economic disparities and local health departments (LHDs) lack resources to provide necessary ...
Li Min - - 2013
A 25-year-old Chinese woman who had a history of easy bruising was admitted to hospital due to uncontrolled epistaxis. She showed factor VII activity level of 2% and factor VII antigen level of 4% of the normal value. We detected a novel missense mutation g.8355 A>T (p.Gln100Leu) in the second ...
Andrade-Campos Marcio M - - 2013
Pediatric deep vein thrombosis (DVT) is an emerging problem in tertiary care hospitals, recent reviews shows a rate of 40.2/10 000 admissions. Experts affirm that enoxaparin has become in the drug of choice for DVT therapy. Despite this, there is a little information regarding the optimal dose schedule for enoxaparin therapy ...
Santomauro Michael - - 2013
To provide an overview of the current concepts regarding telementoring with robotic surgery highlighting recent advances with respect to urological minimally invasive surgery (MIS). As robotic surgery continues to evolve, telementoring will become a viable alternative to traditional on-site surgical proctoring. MIS represents one of the most important breakthroughs in ...
Kong Darryl G - - 2013
: Human immunodeficiency virus (HIV) infection complicates care and contributes to poor outcomes among tuberculosis (TB) patients. The Centers for Disease Control and Prevention recommends that providers test all TB patients for HIV. : We assessed completeness of HIV status determination among TB patients and identified key gaps in adherence. ...
Turan Onur - - 2013
Inherited thrombophilias are thought to play an important role in the cause of pulmonary embolism and its recurrence. Ninety of 281 patients objectively diagnosed as pulmonary embolism between 2006 and 2009 were included in the study. The screening for thrombophilia included mutations of factor V Leiden (FVL), prothrombin (PTM) G20210A, ...
Tao Zhen - - 2013
: Hospitals and physicians are required to submit case reports with confirmatory diagnosis information to the New York State Congenital Malformations Registry (CMR) on children who are born or reside in New York State and are diagnosed with major birth defects. However, the majority of the cases with chromosomal anomalies ...
Marín P - - 2013
Passive sampling is a well-established methodology for the evaluation of exposures to environmental volatile organic compounds (VOCs). The solid-phase microextraction (SPME) technique is a reliable means of sampling VOCs in air. SPME is also being applied as a passive sampler to determine time-weighted average exposure. The use of SPME as ...
Samoff Erika - - 2013
: Delivery of essential public health services requires collection and analysis of public health surveillance data and delivery of these data to program managers, policy makers, and the community in accessible and useable formats. Much of this work is done by local health department (LHD) staff. We define local surveillance ...
Dasgupta Ranan - - 2013
The evolution of percutaneous renal stone surgery has recently seen an increasing number undergoing surgery in the supine position rather than just the classical prone technique. Several advantages have been proposed with the supine approach, including benefits for anaesthesia (cardiovascular and airway), the patient (reduced transfer-related injuries), and surgeon (combined ...
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