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Ahmed Kamran A KA *Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL Departments of †Radiation Oncology ‡Radiology §Internal Medicine ∥Neurologic Surgery, Mayo Clinic, Rochester, - - 2014
To evaluate long-term overall survival (OS), progression-free survival (PFS), and outcomes in pathologically proven brainstem low-grade gliomas (BS-LGG) in children. The Mayo Clinic tumor registry identified 48 consecutive children (≤20 y, 52% female) with biopsy-proven BS-LGG treated at Mayo Clinic between January 1971 and December 2004. Medical records were retrospectively ...
Kruser Tim J TJ Departments of *Human Oncology †Medical Physics, University of Wisconsin Carbone Cancer Center ∥Department of Medicine, Division of Hematology and Oncology, University of Wisconsin Carbone Cancer Center, Madison, WI ‡Department of Radiation Oncology, Northwestern Memorial Hospital, Chicago, IL §Western Radiation Oncology, Mountain View, - - 2014
To our knowledge this is the largest report analyzing outcomes for re-irradiation (reRT) for locoregionally recurrent lung cancer, and the first to assess thoracic reRT outcomes in patients with small cell lung cancer (SCLC). Forty-eight patients (11 SCLC, 37 non-small cell lung cancer [NSCLC]) receiving reRT to the thorax were ...
Shalbaf Ahmad A Department of Biomedical Engineering, School of Electrical Engineering, Iran University of Science and Technology, Tehran, Iran, - - 2013
Identification and classification of left ventricular (LV) regional wall motion (RWM) abnormalities on echocardiograms has fundamental clinical importance for various cardiovascular disease assessments especially in ischemia. In clinical practice, this evaluation is still performed visually which is highly dependent on training and experience of the echocardiographers and therefore suffers from ...
Hu Dale J DJ Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STDs and TB Prevention (NCHHSTP), Atlanta, GA, - - 2013
Hepatitis B virus (HBV) infection is widely prevalent among racial and ethnic minorities in the United States; however, few data have been available regarding HBV testing and referral to care for these populations. Using survey data collected in 2009-2010 from the Racial and Ethnic Approaches to Community Health (REACH) across ...
Chrobak Izabela I Boston University School of Medicine, Arthritis Center, Boston, Massachusetts 02118, - - 2013
Systemic sclerosis (SSc) is a complex disease characterized by vascular alterations, activation of the immune system and tissue fibrosis. Previous studies have implicated activation of the interferon pathways in the pathogenesis of SSc. The goal of this study was to determine whether interferon type I and/or type II could play ...
Lu Zufu Z Biomaterials and Tissue Engineering Research Unit, School of AMME, the University of Sydney, Sydney, - - 2013
There is a major medical need for developing novel and effective approaches for repairing non-union and critical-sized bone defects. Although the mechanisms remain to be determined, it is known that inflammation plays a crucial role in initiating bone repair and regeneration. This study investigated the effect of short-term (3 days) ...
Zhang Zhuo Z Department of Chemical Engineering, University of Michigan, 2300 Hayward Street, Ann Arbor, MI 48109, - - 2013
More than two decades ago, microfluidics began to show its impact in biological research. Since then, the field of microfluidics has evolving rapidly. Cancer is one of the leading causes of death worldwide. Microfluidics holds great promise in cancer diagnosis and also serves as an emerging tool for understanding cancer ...
Cook Tessa S TS Department of Radiology, Hospital of the University of Pennsylvania, 1 Silverstein 3400 Spruce Street, Philadelphia, PA, 19104, USA. - - 2013
The need for tools to monitor imaging-related radiation has grown dramatically in recent years. RADIANCE, a freely available open-source dose-monitoring tool, was developed in response to the need for an informatics solution in this realm. A number of open-source as well as commercial solutions have since been developed to enable ...
Romero Lauro Gonzalo G Clinical Department Systems-Pathology Informatics, Information Services Division, University of Pittsburgh Medical Center (UPMC), 450 Melwood Avenue, Pittsburgh, PA 15213, USA. - - 2013
Digital pathology has grown dramatically in the last 10 years and has created opportunities to not only support the triaging of difficult cases among specialists within an organization, but also enable remote pathology consultations with external organizations across the world. This study investigated one organization's need for a vendor agnostic ...
Das Falguni F Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, - - 2013
Transforming growth factorβ (TGFβ)-induced canonical signal transduction is involved in glomerular mesangial cell hypertrophy; however, the role played by the noncanonical TGFβ signaling remains largely unexplored. TGFβ time-dependently stimulated eIF4E phosphorylation at Ser-209 concomitant with enhanced phosphorylation of Erk1/2 (extracellular signal regulated kinase1/2) and MEK (mitogen-activated and extracellular signal-regulated kinase ...
Goel Hira Lal HL Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, - - 2013
This study was carried out to dissect the mechanism by which β1 integrins promote resistance to radiation. For this purpose, we conditionally ablated β1 integrins in the prostatic epithelium of transgenic adenocarcinoma of mouse prostate (TRAMP) mice. The ability of β1 to promote resistance to radiation was also analyzed by ...
Hsuchou Hung H Blood-Brain Barrier Group, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, - - 2013
Hyperleptinemia is usually associated with obesity and leptin resistance. Endothelial cell leptin receptor knockout (ELKO) mice without a signaling membrane-bound leptin receptor in endothelia, however, have profound hyperleptinemia without signs of leptin resistance. Leptin mRNA in adipose tissue was unchanged. To test the hypothesis that the ELKO mutation results in ...
Kacena Melissa A MA Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. - - 2013
Mice deficient in GATA-1 or NF-E2, transcription factors required for normal megakaryocyte (MK) development, have increased numbers of MKs, reduced numbers of platelets, and a striking high bone mass phenotype. Here, we show the bone geometry, microarchitecture, biomechanical, biochemical, and mineral properties from these mutant mice. We found that the ...
Pockros Paul J PJ Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA, - - 2013
Mericitabine is a selective nucleoside analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, with activity across all HCV genotypes. Treatment-naïve patients infected with HCV genotype 1 or 4 were randomized to 24 weeks of double-blind treatment with either mericitabine 1,000 mg (N = 81) or placebo ...
Yin Zi Z General Surgery Department of Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, - - 2013
The optimal surgical strategy for treatment of patients with synchronous colorectal liver metastases (SCLRM) remains controversial. We conducted a systematic review and meta-analysis of all observational studies to define the safety and efficacy of simultaneous versus delayed resection of the colon and liver. A search for all major databases and ...
Jones Meghan C MC Department of Biomedical Engineering, University of Rochester, Rochester, NY, - - 2013
Development of micro-well array systems for use in high-throughput screening of rare cells requires a detailed understanding of the factors that impact the specific capture of cells in wells and the distribution statistics of the number of cells deposited into wells. In this study we investigate the development of microbubble ...
Sulkowski Mark S MS Johns Hopkins University, Baltimore, MD, USA. - - 2013
Faldaprevir (BI 201335) is a potent, hepatitis C virus (HCV) NS3/4A protease inhibitor with pharmacokinetic properties supportive of once-daily (QD) dosing. Four hundred and twenty-nine HCV genotype (GT)-1 treatment-naïve patients without cirrhosis were randomized 1:1:2:2 to receive 24 weeks of pegylated interferon alfa-2a and ribavirin (PegIFN/RBV) in combination with placebo, ...
Ngu Jing Hieng JH Department of Gastroenterology, Christchurch Hospital, Christchurch, Canterbury, New - - 2013
Autoimmune hepatitis (AIH) can lead to cirrhosis, hepatic failure, and death. We aimed to identify predictors of advanced liver fibrosis at presentation, predictors of incomplete response to initial immunosuppression, and predictors of poor liver-related outcomes in the population-based AIH cohort from Canterbury, New Zealand. Cases diagnosed after 1980 that fulfilled ...
Rector R Scott RS Harry S Truman Memorial Veterans Medical Center, Columbia, MO, USA. - - 2013
Earlier reports suggest a link between mitochondrial dysfunction and development of hepatic insulin resistance. Here we used a murine model heterozygous (HET) for a mitochondrial trifunctional protein (MTP) gene defect to determine if a primary defect in mitochondrial long-chain fatty acid oxidation disrupts hepatic insulin action. Hyperinsulinemic-euglycemic clamps and signaling ...
Goldman L Elizabeth LE Department of Medicine, University of California San Francisco, San Francisco, CA 94110, USA. - - 2013
Whether timeliness of follow-up after abnormal mammography differs at facilities serving vulnerable populations, such as women with limited education or income, in rural areas, and racial/ethnic minorities is unknown. We examined receipt of diagnostic evaluation after abnormal mammography using 1998-2006 Breast Cancer Surveillance Consortium-linked Medicare claims. We compared whether time ...
Lee Jee Min JM Departments of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, - - 2013
We present a patient with metastatic BRAF-mutated melanoma who achieved long-term stabilization of leptomeningeal disease (LMD) with sequential whole-brain radiation therapy and vemurafenib. A 53-year-old woman with melanoma that harbored the BRAF V600E mutation and had that metastasized to multiple lymph nodes, lungs, breast, and subcutaneous tissue had developed symptomatic ...
Kadaba Raghu R Centre for Tumour Biology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, - - 2013
Epithelial tissues have sparse stroma, in contrast to their corresponding tumours. The effect of cancer cells on stromal cells is well recognized. Increasingly, stromal components, such as endothelial and immune cells, are considered indispensable for cancer progression. The role of desmoplastic stroma, in contrast, is poorly understood. Targeting such cellular ...
Davila Jessica A JA Houston VA Health Services Research Center of Excellence, Section of Health Services Research, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA. - - 2013
The delivery of treatment for hepatocellular carcinoma (HCC) could be influenced by the place of HCC diagnosis (hospitalization versus outpatient), subspecialty referral following diagnosis, as well as physician and facility factors. We conducted a study to examine the effect of patient and nonpatient factors on the place of HCC diagnosis, ...
Fu Cary C Division of Child Neurology and Epilepsy, Vanderbilt Kennedy Center, Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, TN, - - 2013
Tuberous sclerosis complex (TSC) is a genetic disease characterized by multiorgan benign tumors as well as neurological manifestations. Epilepsy and autism are two of the more prevalent neurological complications and are usually severe. TSC is caused by mutations in either the TSC1 (encodes hamartin) or the TSC2 (encodes tuberin) genes ...
Song Ken K Ariosa Diagnostics, Inc., San Jose, CA, USA. - - 2013
Evaluate the clinical and economic consequences of fetal trisomy 21 (T21) screening with non-invasive prenatal testing (NIPT) in high-risk pregnant women. Using a decision-analytic model, we estimated the number of T21 cases detected, the number of invasive procedures performed, corresponding euploid fetal losses and total costs for three screening strategies: ...
Guven Aytekin - - 2013
Masked hypertension is associated with an increase in cardiovascular risk. Mean platelet volume (MPV), a determinant of platelet function, is a new risk factor for atherothrombosis. High-sensitive C-reactive protein (CRP) is an exquisitely sensitive systemic marker of inflammatory response. We designed this study to evaluate MPV and CRP in masked ...
Harris Jennie L - - 2013
This article describes a process evaluation conducted as part of a proof-of-concept study to develop, implement, and test a text messaging program to promote medication and appointment adherence, sexual and substance use risk reduction, general health and well-being, social support, and patient involvement. The text-messaging program was implemented in Chicago, ...
Sugawara Yumi - - 2013
Although breastfeeding is associated with a reduction in the risk for breast cancer, its relationship with another hormone-related female cancer, endometrial cancer, has not been fully investigated. The objective of the present study was to prospectively examine the association between lactation pattern and the risk for incidence of breast cancer ...
Amann Stephen T ST North Mississippi Medical Center, Tupelo, MS 38801, USA. - - 2013
The objective of this study was to define the quality of life (QOL) in patients with chronic pancreatitis (CP). We studied 443 well-phenotyped CP subjects and 611 control subjects prospectively enrolled from 20 US centers between 2000 and 2006 in the North American Pancreatitis Study 2. Responses to the SF-12 ...
Li Min - - 2013
A 25-year-old Chinese woman who had a history of easy bruising was admitted to hospital due to uncontrolled epistaxis. She showed factor VII activity level of 2% and factor VII antigen level of 4% of the normal value. We detected a novel missense mutation g.8355 A>T (p.Gln100Leu) in the second ...
Pierce J Thomas - - 2013
Access "The Action Level"® Questions online at: http://www.acgih.org/products/joeh/alquestions.htm Access "The Action Level"® Answers online at: http://www.acgih.org/products/joeh/alanswers.htm Access "The Action Level"®, Registration Form online at: https://www.acgih.org/products/joeh/alregfrm.htm "The Action Level,"® a self-study, continuing education program, provides a convenient and interesting opportunity for individuals to expand their knowledge in relevant areas of industrial ...
Roberts Rosebud O RO Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. - - 2013
To investigate the association of cardiac disease with amnestic and nonamnestic mild cognitive impairment (aMCI and naMCI, respectively). Nonamnestic mild cognitive impairment, a putative precursor of vascular and other non-Alzheimer dementias, is hypothesized to have a vascular etiology. A prospective, population-based, cohort study with a median 4.0 years of follow-up. ...
Lang Rosalyn - - 2013
: To elucidate factors that influence African American willingness to participate in health-related research studies. : The African American Alzheimer disease research study group at North Carolina A&T State University designed an in-person questionnaire and surveyed more than 700 African American adults on their willingness to participate in health-related research ...
Szymańska Magdalena - - 2013
Type I antithrombin deficiency is an autosomal dominant disorder associated with high risk for venous thromboembolism. Data on the association between antithrombin deficiency and arterial thromboembolism are inconsistent. We report here the case of AT deficiency in a 43-year-old man free of cardiovascular risk factors who experienced venous thromboembolism and ...
Santomauro Michael - - 2013
To provide an overview of the current concepts regarding telementoring with robotic surgery highlighting recent advances with respect to urological minimally invasive surgery (MIS). As robotic surgery continues to evolve, telementoring will become a viable alternative to traditional on-site surgical proctoring. MIS represents one of the most important breakthroughs in ...
Algren D Adam DA Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Environmental Hazards and Health Effects, Health Studies Branch, Atlanta, GA, USA. - - 2013
During the summer of 2005, multiple cities in the United States began to report outbreaks of fentanyl-associated fatalities among illicit drug users. The objectives of this study were to (1) determine if an outbreak of fentanyl-associated fatalities occurred in mid-2005 to mid-2006 and (2) to examine trends and compare features ...
Bennett April Young - - 2013
: Analyses of Utah vital records indicated that Utah Pacific Islanders had unique health problems that merited further investigation through a behavioral survey. However, statewide surveys did not reach a large enough sample of Pacific Islanders and were not administered in Samoan or Tongan. : The authors sought to complete ...
Yang Youngran - - 2013
: Local health departments (LHDs) are expected to address health disparities. Little is known, however, about what factors influence the activities used by an LHD in addressing health disparities. The objective of this study was to examine factors such as an LHD's leader, jurisdiction, and organizational characteristics that could be ...
Simforoosh Nasser - - 2013
While most renal and ureteral stones can be efficiently managed using endourologic techniques, the use of laparoscopy for the management of urolithiasis is increasing. The application of laparoscopy for stone removal will further reduce the need for open stone surgery. Laparoscopic ureterolithotomy, pyelolithotomy, and anatrophic nephrolithotomy are highly successful techniques ...
Andrade-Campos Marcio M - - 2013
Pediatric deep vein thrombosis (DVT) is an emerging problem in tertiary care hospitals, recent reviews shows a rate of 40.2/10 000 admissions. Experts affirm that enoxaparin has become in the drug of choice for DVT therapy. Despite this, there is a little information regarding the optimal dose schedule for enoxaparin therapy ...
Franco David - - 2013
Brodifacoum poisoning occurs as a result of ingestion of rodenticide compounds. It acts as a superwarfarin, inhibiting vitamin K epoxide reductase, in an irreversible fashion much like warfarin but with a much longer half-life. A 48-year-old female patient reported 4 days of mild dyspnea, dry cough, bilateral popliteal fossae pain ...
Dirige Ofelia V - - 2013
: Intervening in organizations allows for targeting multiple levels of influence and greater potential for sustainability. : To evaluate an 18-month nutrition and physical activity (NPA) intervention (Siglang Buhay) conducted through culturally specific organizations. : Site randomized trial with an active control group. : Eighteen Filipino-American social clubs in San ...
Hus Iwona - - 2013
The pathogenesis of Buerger' disease (thrombangiitis obliterans; TAO) remains unknown, although a strong association with tobacco use has been established. Blood coagulation and fibrinolytic factors as well as selected clinical chemistry parameters have been evaluated in 37 patients with Buerger's disease. Median levels of prothrombotic factors were higher in patients ...
Arun Sasikumar S Department of Nuclear Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, - - 2013
Scintigraphy is a simple technique for the demonstration of gastroesophageal reflux, and is particularly suitable in neonates and infants. The authors describe a rare case of achalasia cardia in a 3-year-old child incidentally detected as a dilated esophagus with a stricture at the lower end during a scintigraphic study.
Williams Nancy J - - 2013
: Early in the 2009 pandemic influenza A (H1N1) experience, children aged 5 to 17 years were determined to be disproportionately affected compared with recent influenza seasons. : To characterize the pandemic among school-aged children, to enable timely influenza outbreak identification, and to determine which school-based influenza surveillance indicator correlated ...
Harris Jenine K - - 2013
Public health policy is among the most effective and cost-effective interventions in some areas of public health and is emerging as effective in others. Policy may be especially important for rural communities, where residents face serious health and economic disparities and local health departments (LHDs) lack resources to provide necessary ...
Chondrogiannis Sotirios S Department of Nuclear Medicine-PET/CT Center, Santa Maria della Misericordia Hospital, Rovigo, Italy. - - 2013
This study aimed to assess the feasibility and potential usefulness of a new intraoperative portable high-resolution imaging γ-camera for the localization of sentinel lymph node in patients with breast cancer. Sixteen T1 to T2 breast cancer female patients were evaluated (mean age, 62 years) with preoperative lymphoscintigraphy, acquired 30 minutes ...
Noël Alexandra - - 2013
This study assessed the contribution of electron microscopy to the characterization of nanoparticles and compared the degree of variability in sizes observed within each stage when sampled by two cascade impactors: an Electrical Low Pressure Impactor (ELPI) and a Micro-Orifice Uniform Deposit Impactor (MOUDI). A TiO(2) nanoparticle (5 nm) suspension was ...
El-Chammas Khalil - - 2013
OBJECTIVE To assess the effectiveness of prophylactic headache treatment in children and adolescents. DATA SOURCES PubMed, EMBASE, Cochrane Database of Clinical Trials, and bibliography of retrieved articles through August 11, 2012. STUDY SELECTION Randomized trials of headache treatment among children and adolescents (<18 years old). INTERVENTION Any placebo-controlled trial or ...
Heinrich Katie M - - 2013
: State-level policymakers play an important role in the fight against obesity because of their ability to create policies that influence opportunities for physical activity and nutrition. : In 2011, we investigated how Kansas policymakers regarded obesity, nutrition, and physical activity in comparison to other issues. : This study used ...
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