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Results 251 - 300 of 3242
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Seshagiri Somasekar - - 2013
Our understanding of inherited risk factors for colorectal cancer (CRC) is incomplete. A new study reports the identification of germline CRC risk variants that adversely affect the proofreading function of DNA polymerases encoded by POLE and POLD1.
Kahokehr Arman - - 2013
To assess the effects of non-steroidal anti-inflammatory drugs (NSAIDs) in men with benign prostatic hyperplasia (BPH) using systematic review and meta-analysis of clinical trials. Men treated with NSAIDs in comparison with placebo or other BPH medications. All aspects of the Preferred Reporting for Systematic Reviews and Meta-Analyses (PRISMA) statement were ...
Thomas Gareth M GM Shriners Hospital Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University Medical School, 3500 N. Broad Street, Philadelphia, PA 19130, USA. - - 2013
In recent years, it has become clear that both AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid)- and NMDA (N-methyl-D-aspartate)-type glutamate receptors, and many of their interacting partners, are palmitoylated proteins. Interfering with palmitoylation dramatically affects receptor trafficking and distribution and, in turn, can profoundly alter synaptic transmission. Increased knowledge of synaptic palmitoylation not only ...
Sorace Anna G AG Department of Biomedical Engineering, University of Alabama at Birmingham, - - 2013
Microbubble-mediated ultrasound therapy can noninvasively enhance drug delivery to localized regions in the body. This technique can be beneficial in cancer therapy, but currently there are limitations to tracking the therapeutic effects. The purpose of this experiment was to investigate the potential of fluorescent imaging for monitoring the temporal effects ...
Lima Marina Guimarães MG Departamento de Farmácia Social, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. - - 2013
Congenital syphilis continues to be a public health problem in Brazil. The scope of this study is to describe the trends in the incidence of congenital syphilis in Belo Horizonte between 2001 and 2008 and determine risk factors associated with disease diagnosis. Data on cases of congenital syphilis and on ...
Ballinger Scott W SW Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. - - 2013
Although there is general agreement that most forms of common disease develop as a consequence of a combination of factors, including genetic, environmental and behavioural contributors, the actual mechanistic basis of how these factors initiate or promote diabetes, cancer, neurodegenerative and cardiovascular diseases in some individuals but not in others ...
Mueller Sven C SC Development and Affective Neuroscience, National Institute of Mental Health (NIMH), University of Ghent, Belgium. - - 2013
Minimal research links anxiety disorders in adolescents to regional gray matter volume (GMV) abnormalities and their modulation by genetic factors. Prior research suggests that a brain-derived neurotrophic factor (BNDF) Val(66)Met polymorphism may modulate such brain morphometry profiles. Using voxel-based morphometry and magnetic resonance imaging, associations of BDNF and clinical anxiety ...
Mitchell Tanecia T Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, - - 2013
Mitochondrial dysfunction is associated with a broad range of pathologies including diabetes, ethanol toxicity, metabolic syndrome and cardiac failure. It is now becoming clear that maintaining mitochondrial quality through a balance between biogenesis, reserve capacity and mitophagy is critical in determining the response to metabolic or xenobiotic stress. In diseases ...
Warne Tony T MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, - - 2013
Structures of the inactive state of the thermostabilized β1-adrenoceptor have been determined bound to eight different ligands, including full agonists, partial agonists, inverse agonists and biased agonists. Comparison of the structures shows distinct differences within the binding pocket that correlate with the pharmacological properties of the ligands. These data suggest ...
Howie Jacqueline J Division of Cardiovascular & Diabetes Medicine, Medical Research Institute, College of Medicine Dentistry & Nursing, University of Dundee, Dundee DD1 9SY, - - 2013
The Na+/K+-ATPase (Na+ pump) is the principal consumer of ATP in multicellular organisms. In the heart, the Na+ gradient established by the pump is essential for all aspects of cardiac function, and appropriate regulation of the cardiac Na+ pump is therefore crucial to match cardiac output to the physiological requirements ...
Cunningham Margaret R MR School of Physiology and Pharmacology, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, - - 2013
Platelets are critical for haemostasis, however inappropriate activation can lead to the development of arterial thrombosis, which can result in heart attack and stroke. ADP is a key platelet agonist that exerts its actions via stimulation of two surface GPCRs (G-protein-coupled receptors), P2Y(1) and P2Y(12). Similar to most GPCRs, P2Y ...
Kremer Thomas T Department of Orthopedic Surgery, Microsurgery Research Laboratory, Mayo Clinic, Rochester, Minn, - - 2013
Vascularized composite allotransplantation has the potential for reconstruction of joint defects but requires lifelong immunosuppression, with substantial risks. This study evaluates an alternative, using surgical angiogenesis from implanted autogenous vessels to maintain viability without long-term immunotherapy. Vascularized knee joints were transplanted from Dutch Belted donors to New Zealand White rabbit ...
Whiteside Theresa L TL Departments of Pathology, Immunology and Otolaryngology, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA. - - 2013
Body fluids of cancer patients contain TEXs (tumour-derived exosomes). Tumours release large quantities of TEXs, and the protein content of exosome or MV (microvesicle) fractions isolated from patients' sera is high. TEXs down-regulate functions of immune cells, thus promoting tumour progression. We isolated TEXs from tumour cell supernatants and sera ...
Musser Erica D ED Oregon Health and Science University, Portland, OR 97239, USA. - - 2013
How best to capture heterogeneity in attention-deficit/hyperactivity disorder (ADHD) using biomarkers has been elusive. This study evaluated whether emotion reactivity and regulation provide a means to achieve this. Participants were classified into three groups: children with ADHD plus low prosocial behavior (hypothesized to be high in callous/unemotional traits; n = ...
Nelson Amanda E AE Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, 3300 Doc J. Thurston Building, CB #7280, Chapel Hill, NC 27599, USA. - - 2013
To determine differences in the phenotypes (patterns) of multiple-joint symptomatic osteoarthritis (OA) involvement by race and sex. A cross-sectional analysis of symptomatic OA phenotypes was performed in a community-based cohort, comprising subjects for whom data were collected from 4 sites of symptomatic OA involvement (the hands, knees, hips, and lumbosacral ...
Shipston Michael J MJ Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH8 9XD, UK. - - 2013
BK (large conductance calcium- and voltage-activated potassium) channels are important determinants of physiological control in the nervous, endocrine and vascular systems with channel dysfunction associated with major disorders ranging from epilepsy to hypertension and obesity. Thus the mechanisms that control channel surface expression and/or activity are important determinants of their ...
Jin Byung-Ju BJ Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, - - 2013
Secretory diarrheas such as cholera are a major cause of morbidity and mortality in developing countries. We previously introduced the concept of antisecretory therapy for diarrhea using chloride channel inhibitors targeting the cystic fibrosis transmembrane conductance regulator channel pore on the extracellular surface of enterocytes. However, a concern with this ...
Redman Emily K EK School of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, - - 2013
High glucose inhibits mitochondrial respiration, known as the 'Crabtree effect', in cancer cells and possibly other cell types. The upstream pathways regulating this phenomenon are poorly understood. In diabetes, where glucose levels are elevated, the p90(RSK) (p90 ribosomal S6 kinase) has received much attention as a potential upstream mediator of ...
Blackwood John K JK Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, - - 2013
During DNA repair by HR (homologous recombination), the ends of a DNA DSB (double-strand break) must be resected to generate single-stranded tails, which are required for strand invasion and exchange with homologous chromosomes. This 5'-3' end-resection of the DNA duplex is an essential process, conserved across all three domains of ...
Witwer Kenneth W KW Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. - - 2013
Public sharing of scientific data has assumed greater importance in the omics era. Transparency is necessary for confirmation and validation, and multiple examiners aid in extracting maximal value from large data sets. Accordingly, database submission and provision of the Minimum Information About a Microarray Experiment (MIAME)(3) are required by most ...
Walker John E JE MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK. - - 2013
The ATP synthases are multiprotein complexes found in the energy-transducing membranes of bacteria, chloroplasts and mitochondria. They employ a transmembrane protonmotive force, Δp, as a source of energy to drive a mechanical rotary mechanism that leads to the chemical synthesis of ATP from ADP and Pi. Their overall architecture, organization ...
Silberstein Jonathan L JL Department of Surgery, Urology Service, New York, NY, USA. - - 2013
To compare early oncological outcomes of robot assisted laparoscopic prostatectomy (RALP) and open radical prostatectomy (ORP) performed by high volume surgeons in a contemporary cohort. We reviewed patients who underwent radical prostatectomy for prostate cancer by high volume surgeons performing RALP or ORP. Biochemical recurrence (BCR) was defined as PSA ...
Chamberlain Luke H LH Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK. - - 2013
Palmitoylation, the attachment of palmitate and other fatty acids on to cysteine residues, is a common post-translational modification of both integral and peripheral membrane proteins. Dynamic palmitoylation controls the intracellular distribution of peripheral membrane proteins by regulating membrane-cytosol exchange and/or by modifying the flux of the proteins through vesicular transport ...
Fischer John P JP Division of Plastic Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pa, - - 2013
Free tissue transfer is standard for postoncologic reconstruction, yet it entails a lengthy operation and significant recovery. The authors present their longitudinal experience of free tissue breast reconstructions with an emphasis on predictors of major surgical and medical complications. The authors reviewed their prospectively maintained free flap database and identified ...
Fernandes Justin R JR Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, Mass 02114, - - 2013
The most commonly performed skin rejuvenation procedure, laser resurfacing, is associated with adverse events and significant expense. The authors have developed a novel device that uses micro-coring needles to remove tissue in a fractional pattern and avoid the side effects of laser therapy. The authors compare the efficacy of these ...
Seth Akhil K AK Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Ill 60611, - - 2013
Bacterial biofilms, which are critical mediators of chronic wounds, remain difficult to treat with traditional methods. Bacteriophage therapy against biofilm has not been rigorously studied in vivo. The authors evaluate the efficacy of a species-specific bacteriophage against Staphylococcus aureus biofilm-infected wounds using a validated, quantitative, rabbit ear model. Six-millimeter dermal ...
Dorafshar Amir H AH The Johns Hopkins Medical Institute, Baltimore, Md 21231, USA. - - 2013
The anatomy of the facial nerve and its branches has been well documented. The course of the extratemporal facial nerve, its anatomical planes, and the surface landmarks of the temporal division and marginal mandibular division are well known. However, the surface landmark of the middle division of the facial nerve ...
Wu Di D Department of Cleft Lip and Palate, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of - - 2013
The Abbe flap has been used for full-thickness defects of the upper lip with the inferior labial artery as the pedicle. Using the fine artery anatomy of the lower lip, the authors developed an innovative partial-thickness myocutaneous flap based on the vascular network of the submucosal and subcutaneous layers, which ...
Akita Shinsuke S Department of Plastic, Reconstructive, and Aesthetic Surgery, Chiba University, Faculty of Medicine, Chiba City, Japan. - - 2013
Although early diagnosis is important for selecting an effective surgical treatment for secondary lymphedema, an efficient screening test for detecting early-stage lymphedema has not yet been established. Serial changes of lymphatic function before and after lymph node dissection and risk factors for secondary lymphedema are important indicators. A prospective cohort ...
Klinkenberg Marek M Department of Hand, Plastic, and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, Ludwigshafen, - - 2013
The purpose of this study was to compare the morbidity and the aesthetic and functional outcomes of primarily closed donor sites of three commonly used free flaps. Sixty patients who had undergone free flap reconstruction (20 anterolateral thigh, 20 parascapular, and 20 lateral arm flaps) were included in this study. ...
Vegas Manuel R MR Plastic Surgery and Reconstructive Microsurgery, Hospital Quirón, Madrid, Spain. - - 2013
There are few references to the reconstructive possibilities of the ascending branch of the lateral circumflex femoral artery other than the tensor fasciae latae muscle flap and the so-called muscle pedicle bone grafting technique. An anatomical study was performed to evaluate the ascending branch of the lateral circumflex femoral artery ...
Alajmi Hasan H HB Williams Craniofacial and Cleft Surgery Unit, Montreal Children's Hospital, Montreal, Quebec, - - 2013
For cleft teams that use nasoalveolar molding for presurgical treatment of cleft lips, the determination of desired cleft-nasal height correction is a subjective assessment. The latter, however, is complicated by a noncleft nasal height that itself is depressed by the shifted nasal pyramid native to the deformity. The authors introduce ...
Iblher Niklas N Department of Plastic and Hand Surgery, University Medical Center Freiburg, Freiburg, Germany. - - 2013
Reliable evaluation of the complex three-dimensional anatomy of the face has proven to be extremely difficult. Three-dimensional surface scanning technology has not yet reached widespread acceptance in clinical research in plastic surgery. This study aimed to describe two parameters that allow quantification of soft-tissue movements and to compare the surface ...
Coon Devin D Department of Plastic and Reconstructive Surgery, The Johns Hopkins Medical Institutions, Baltimore, Md 21287, - - 2013
Tobacco use remains a persistent risk factor in elective plastic surgery. Although nicotine is thought to increase complications, which procedures are affected and the reliability of patient-provided histories remain poorly defined. The authors sought to examine nicotine use and its impact on outcomes. All patients in a single-surgeon practice undergoing ...
Tanna Neil N Institute of Reconstructive Plastic Surgery, New York University, New York, NY, - - 2013
Nipple-sparing mastectomy warrants thorough preoperative evaluation to effectively achieve risk reduction, high patient satisfaction, and improved aesthetic outcome. To the authors' knowledge, this review represents the largest series of microsurgical breast reconstructions following nipple-sparing mastectomies. All patients undergoing nipple-sparing mastectomy with microsurgical immediate breast reconstruction treated at New York University ...
Suarez Edna E Plastic and Reconstructive Surgery Research, School of Translational Medicine, Manchester Institute of Biotechnology, University of Manchester, Manchester, United - - 2013
Keloid disease is a fibroproliferative disorder, with an ill-defined treatment that is characterized by excessive extracellular matrix deposition. Mechanical tension promotes deposition of extracellular matrix and overexpression of tension-related proteins, which is associated with keloid disease. The aim of this study was to investigate the effect of tension-related proteins on ...
Wang Jie-Qing JQ Department of Tissue Engineering, College of Basic Medicine, China Medical University, Shenyang, People's Republic of - - 2013
The extracellular matrix is an essential microenvironment for cell survival activity. The adipose tissue extract microparticle scaffolds from human adipose tissue and small intestine submucosa microparticle scaffolds from porcine jejunum were prepared. Their effects on the adipogenic capabilities of human adipose-derived stem cells were compared in vivo. A combination of ...
Song Baoqiang B Institute of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, Fujian, People's Republic of China. - - 2013
Facial scars caused by burns and trauma severely affect patients' function and appearance. The expanded deltopectoral flap to local shift is the traditional method of repair, but for patients with the compulsive position after pedicle transfer, the therapeutic outcome is not satisfactory. The authors explored the surgical procedures for repairing ...
Lee Justine C JC Sections of Plastic and Reconstructive Surgery, Department of Surgery, University of Chicago Medical Center, Chicago, Ill, - - 2013
Primary abdominal wall reconstruction after liver transplantation presents a challenge in patients with size mismatch, multivisceral transplants, and prior recipient abdominal surgery. The authors report their experience with a novel technique for abdominal wall reconstruction with a new vascular composite allotransplant. Five posterior rectus sheath-liver composite vascular allotransplants were procured ...
Greig Aina V H AV Department of Craniofacial Surgery, Great Ormond Street Hospital, and Cavendish Imaging, London, United - - 2013
Bipartition distraction is a novel procedure combining frontofacial bipartition and monobloc distraction. Apert syndrome and other syndromic craniofacial dysostoses are often characterized by hypertelorism, with a negative canthal axis and counterrotated orbits. Central midface hypoplasia can result in a biconcave face in both midsagittal and axial planes. Bipartition distraction can ...
Fuller Jennifer C JC Alameda Hospital, Alameda, Los Angeles, Calif, - - 2013
The question of whether or not abdominoplasty is associated with permanent weight reduction remains controversial. In coalition, should abdominoplasty be used as an adjunct for weight reduction in the overweight/obese patient? This retrospective patient case series attempts to determine the most important factors associated with weight reduction. All patients undergoing ...
Alghoul Mohammed M Department of Plastic Surgery, Cleveland Clinic, Cleveland, Ohio 44195, - - 2013
The transition zone between cheek superficial musculoaponeurotic system (SMAS) and malar SMAS is difficult to raise because of proximity of zygomatic nerve branches. The authors attempted to clarify the three-dimensional anatomy of the retaining ligaments in relation to nerve branches in this area. Facial dissection was performed on 22 cadaver ...
Serra Fernando F Plastic Surgery Service, Pedro Ernesto University Hospital, Rio de Janeiro, Brazil. - - 2013
New surgical techniques for gluteal augmentation have improved final results. It is estimated that more than 35,000 patients have undergone augmentation gluteoplasty using implants. The authors sought to determine and quantify the presence of muscle atrophy, and to evaluate implant positioning using the intramuscular technique. Twenty-three female patients were selected ...
Neligan Peter C PC Division of Plastic Surgery, University of Washington, Seattle, Wash, USA. - - 2013
After reading this article, the participant should be able to: 1. Discuss the principles behind the choice of reconstructive techniques for all major head and neck regions. 2. Differentiate between the optimal choices for reconstruction of the different mandibulectomy defects. 3. List the requirements for successful reconstruction of the skull ...
Aoki Shimpo S Clinic of Ichigaya, Ministry of Defense, Tokyo, - - 2013
The authors evaluated the efficacy of an ultrathin nanosheet consisting of poly-L-lactic acid (75 nm thick) as a wound dressing material. A full-thickness skin defect was made on the backs of mice and overlapped with or without the poly-L-lactic acid nanosheet. Wound healing was more rapidly improved by overlapping with ...
Feng Kuan-Ming KM Department of Plastic Surgery, E-Da Hospital, I-Shou University, Yan-Chao District, Kaohsiung, - - 2013
Theoretically, a flap can be supplied by any perforator based on the angiosome theory. In this study, the technique of free-style perforator flap dissection was used to harvest a pedicled or free skin flap from a previous free flap for a second difficult reconstruction. The authors call this a free-style ...
Brown Benjamin J BJ MedStar Georgetown University Hospital, Washington, DC 20007, - - 2013
Distal tibiofibular bridging (Ertl modification) in a below-knee amputation can provide an improved transmission of torque from the distal femur to the prosthesis. Without this bridge, the distal tibia and fibula are left freely rotating and translating in the soft-tissue envelope. The distal fibular segment creates a bone bridge that ...
D'Amico Richard A RA Department of Plastic Surgery, Englewood Hospital and Medical Center, University of Pittsburgh, Englewood, NJ, - - 2013
In 2011, the American Society of Plastic Surgeons (ASPS) created the Task Force on Regenerative Medicine to address the Society's strong interest in the emerging field of regenerative medicine, particularly cell- and tissue-based therapies applicable to plastic surgery procedures. The Task Force's U.S. Food and Drug Administration's Workgroup is informing ...
Konofaos Petros P Department of Plastic Surgery, University of Tennessee, Memphis, Tenn 38103, - - 2013
Although the use of transoral robotic surgery for tumor extirpation is expanding, little is known about national trends in the reconstruction of resultant defects. An 18-question electronic survey was created by an expert panel of surgeons from the Department of Otolaryngology-Head and Neck Surgery and the Department of Plastic and ...
Choi Bong-Kyoon BK Maxillofacial Center, Korea International Esthetic Surgery Union, Plastic Surgery Clinic, Seoul, Republic of - - 2013
The authors studied whether the incidence of inferior alveolar nerve injury in patients undergoing sagittal split ramus osteotomy differs in patients with a history of previous mandibular contouring surgery. A retrospective chart review was completed on all patients who underwent orthognathic surgery, including bilateral sagittal split osteotomy and Le Fort ...
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