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Storck Elisabeth M - - 2013
The study of post-translational modifications such as protein lipidation is a non-trivial challenge of the post-genomic era. In recent years the field of chemical proteomics has greatly advanced our ability to identify and quantify protein lipidation. In the present review, we give a brief overview of the tools available to ...
Cooke Robert M - - 2013
Since the publication of the first X-ray structure of a GPCR (G-protein couple receptor) in 2000, the rate at which subsequent ones have appeared has steadily increased. This has required the development of new methodology to overcome the challenges presented by instability of isolated GPCRs, combined with a systematic optimization ...
Driessen Rosalie P C - - 2013
Crenarchaeal genomes are organized into a compact nucleoid by a set of small chromatin proteins. Although there is little knowledge of chromatin structure in Archaea, similarities between crenarchaeal and bacterial chromatin proteins suggest that organization and regulation could be achieved by similar mechanisms. In the present review, we describe the ...
Cattaruzza Fiore - - 2013
GPCR (G-protein-coupled receptor) signalling at the plasma membrane is under tight control. In the case of neuropeptides such as SP (substance P), plasma membrane signalling is regulated by cell-surface endopeptidases (e.g. neprilysin) that degrade extracellular neuropeptides, and receptor interaction with β-arrestins, which uncouple receptors from heterotrimeric G-proteins and mediate receptor ...
Schlegel Katharina - - 2013
Methanogenic archaea live at the thermodynamic limit of life and use sophisticated mechanisms for ATP synthesis and energy coupling. The group of methanogens without cytochromes use an Na+ current across the membrane for ATP synthesis, whereas the cytochrome-containing methanogens have additional coupling sites that also translocate protons. The ATP synthase ...
Booth David - - 2013
Attempts to elucidate the mechanism underpinning the genetic association between IFNL3, previously called IL28B, and clearance of hepatitis C virus have, by and large, been unsuccessful. A study in this issue suggests that a new gene, IFNL4, may be responsible.
Pickwell Andrew - - 2013
Acoustic emission (AE) monitoring is a technique of growing interest in the field of nondestructive testing (NDT). The use of AE devices to monitor the health of structural components is currently limited by the cost of AE equipment, which prohibits the permanent placement of AE devices on structures for the ...
Silva Elaine Cristina da - - 2013
Community participation is considered a key condition for communities to assume control of their health within the scope of health promotion. This study sought to identify and analyze the perceptions of residents of the watershed areas of Santo André/São Paulo with respect to the actions of health education and environmental ...
Montreuil Tina C - - 2013
In psychotic disorders, a limited number of studies have documented the presence of symptoms of anxiety, especially in first-episode psychosis (FEP). There is a growing interest in better understanding how these symptoms may affect the severity of psychotic symptoms and clinical outcome. This study examined the association between symptoms of ...
Chang Chih-Hsiung - - 2013
The synthetic aperture focusing technique (SAFT), employing a scanned focused transducer as a virtual source, is commonly used to image flaws in immersion testing. The position of a virtual source is estimated from rays emitted from the rim of a focused transducer. However, it is often found that the virtual ...
Park Sunhee - - 2013
This study explores the trajectory of suicidal ideation in childhood and adolescence and identifies its strong predictors. Secondary data obtained from two nationally representative cohorts of South Korean youth were longitudinally analyzed using frequencies, percentages, and discrete time survival analysis. This study revealed an increase in the occurrence of suicidal ...
Kennedy Maureen Shawn - - 2013
Opportunities for leadership abound-and we need to step up.
Malta Maíra Barreto - - 2013
The scope of this paper was to evaluate the quality of the diet of the elderly in the city of Avaré, São Paulo state, using the Healthy Eating Index (HEI). A cross-sectional population-based study was conducted by home interviews. The sample consisted of 73 individuals, randomly selected among elderly people ...
Baker Daniel G - - 2013
ABSTRACT: Baker, DG. 10-year changes in upper body strength and power in elite professional rugby league players-The effect of training age, stage, and content. J Strength Cond Res 27(2): 285-292, 2013-The purpose of this investigation was to observe changes in maximal upper body strength and power across a 10-year period ...
Burke Wendy - - 2013
Nurse leaders and telemetry unit staff work together to change the way nurses conduct shift report.This is the first article in a new series on leadership, coordinated by the American Organization of Nurse Executives (AONE), highlighting how nurses are leading change efforts in hospitals. It describes work done in conjunction ...
Linder Maurine E - - 2013
Protein S-palmitoylation is a reversible post-translational modification of proteins with fatty acids. In the last 5 years, improved proteomic methods have increased the number of proteins identified as substrates for palmitoylation from tens to hundreds. Palmitoylation regulates protein membrane interactions, activity, trafficking and stability and can be constitutive or regulated by ...
Onal Cem - - 2013
This study aimed to evaluate the degree of mediastinal involvement in patients with cervical cancer with isolated mediastinal [F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) positivity as verified by histopathologic examination. Two hundred twenty-eight patients with newly diagnosed cervical cancer and who underwent FDG-PET imaging were analyzed. Twenty-nine patients (17%) had disseminated disease ...
Martijn Joran - - 2013
The evolutionary origin of the eukaryotic cell represents an enigmatic, yet largely incomplete, puzzle. Several mutually incompatible scenarios have been proposed to explain how the eukaryotic domain of life could have emerged. To date, convincing evidence for these scenarios in the form of intermediate stages of the proposed eukaryogenesis trajectories ...
Carneiro Maria Fernanda Hornos - - 2013
Recent studies reported elevated blood lead (Pb) levels in riparian populations of the Amazon. For this reason, the aim of the present study was to assess the risk to riparians in the Brazilian Amazon to Pb exposure due to the intake of contaminated manioc flour. Lead levels were determined in ...
Alves Vera Lucia Pereira - - 2013
Magazines sold on newsstands have become self-help texts, and the study of the topics covered makes it possible to understand how the discourses are constructed, how they become repositories used to give meaning to life. In the case of magazines that deal with the sphere of health, prescribing methods of ...
Zharikov Sergey - - 2013
Circulating blood platelets contain small numbers of fully functional mitochondria. Accumulating evidence demonstrates that these mitochondria regulate the pro-thrombotic function of platelets through not only energy generation, but also redox signalling and the initiation of apoptosis. Beyond its regulation of haemostasis, platelet mitochondrial function has also traditionally been used to ...
Korukonda Sanghamithra - - 2013
Stroke may occur when an atherosclerotic plaque ruptures in the carotid artery. Noninvasive vascular elastography (NIVE) visualizes the strain distribution within the carotid artery, which is related to its mechanical properties that govern plaque rupture. Strain elastograms obtained from the transverse plane of the carotid artery are difficult to interpret, ...
Talsma Akkeneel - - 2013
The purpose of this cross-sectional cohort study was to evaluate the relationship between the number of OR personnel involved in a surgery and subsequent postoperative outcomes. We collected data from a sample of general surgery patients (N = 911) by using the American College of Surgeons National Surgical Quality Improvement Project ...
Worley Michael J MJ - - 2013
To evaluate the impact of preoperative leukocytosis among patients with nonendometrioid endometrial carcinoma. The medical records of all patients with nonendometrioid endometrial carcinoma who underwent surgical treatment between January 2005 and December 2010 were retrospectively reviewed. The patients were separated into 2 groups based on the presence or absence of ...
Jorfi Samireh - - 2013
Microvesicles are shed constitutively, or upon activation, from both normal and malignant cells. The process is dependent on an increase in cytosolic Ca2+, which activates different enzymes, resulting in depolymerization of the actin cytoskeleton and release of the vesicles. Drug resistance can be defined as the ability of cancer cells ...
Chen Yangyang - - 2013
We study theoretically the effects of air resistance on an AT-cut quartz plate thickness-shear mode resonator. Mindlin¿s two-dimensional equations for coupled thickness-shear and flexural motions of piezoelectric plates are employed for the crystal resonator. The equations of a Newtonian fluid and the equations of linear acoustics are used for the ...
Chivet Mathilde - - 2013
Exosomes are small extracellular vesicles which stem from endosomes fusing with the plasma membrane; they contain lipids, proteins and RNAs that are able to modify receiving cells. Functioning of the brain relies on synapses, and certain patterns of synaptic activity can change the strength of responses at sparse groups of ...
Evguenieva-Hackenberg Elena - - 2013
RNA stability control and degradation are employed by cells to control gene expression and to adjust the level of protein synthesis in response to physiological needs. In all domains of life, mRNA decay can commence in the 5'-3' as well as in the 3'-5'-direction. Consequently, mechanisms are in place conferring ...
Perfetti Charles A - - 2013
Do differences in writing systems translate into differences in the brain's reading network? Or is this network universal, relatively impervious to variation in writing systems? A new study adds intriguing evidence to these questions by showing that reading handwritten words activates a pre-motor area across writing systems.
Jayasekara Rasika - - 2013
Editor's note: This is the ninth in a series of summaries of nursing care-related systematic reviews from the Cochrane Library.
Carvalho Alice Teles de - - 2013
The development of methods that enable analysis of programs and public policies is a key point for their objectives to be attained. This study presents a Brazilian experience of analysis of two food and nutritional security programs in cities in Brazil's northeast region, namely the National Program for Vitamin A ...
Martin Brent R - - 2013
Protein palmitoylation is a critical post-translational modification important for membrane compartmentalization, trafficking and regulation of many key signalling proteins. Recent non-radioactive chemo-proteomic labelling methods have enabled a new focus on this emerging regulatory modification. Palmitoylated proteins can now be profiled in complex biological systems by MS for direct annotation and ...
Koole Cassandra - - 2013
Type 2 diabetes is a major global health problem and there is ongoing research for new treatments to manage the disease. The GLP-1R (glucagon-like peptide-1 receptor) controls the physiological response to the incretin peptide, GLP-1, and is currently a major target for the development of therapeutics owing to the broad ...
Moura Marcoeli Silva de - - 2013
The objective of this cross-sectional study was to assess the professional profile of dental-surgeons (DS) who work in the Family Health Strategy (FHS), and on the basis of this reflect upon aspects of the development of dental actions in primary health care in municipalities of a health region of the ...
Gietl Andreas - - 2013
The genetic information of every living organism is stored in its genomic DNA that is perceived as a chemically stable and robust macromolecule. But at the same time, to fulfil its functions properly, it also needs to be highly dynamic and flexible. This includes partial melting of the double helix ...
Heck Maria Antonia - - 2013
The scope of this study was to describe the trends of tuberculosis indicators in relation to their prevalence, incidence and the case outcome percentages (cure, abandonment of treatment or death) for the patients who entered in the Program in Sapucaia do Sul, state of Rio Grande do Sul, between 2000 ...
Inal Jameel M - - 2013
The important roles of extracellular vesicles in the pathogenesis of various diseases are rapidly being elucidated. As important vehicles of intercellular communication, extracellular vesicles, which comprise microvesicles and exosomes, are revealing important roles in cancer tumorigenesis and metastases and in the spread of infectious disease. The September 2012 Focused Meeting ...
Bessonova Olga - - 2013
For the characterization of high-intensity focused ultrasound (HIFU) fields, hydrophone measurements should be performed in water in the whole range of the radiated power; however, cavitation occurs at high output, leading to the destruction of the hydrophone. To avoid this problem, a new hydrophone with additional protective layers covering the ...
Bagatto Marlene P - - 2013
Background: The Parents' Evaluation of Aural/Oral Performance of Children (PEACH) is a caregiver report questionnaire that is suitable for use with children who wear hearing aids. It is available in both a Diary format and a Rating Scale format. Following a critical review of subjective outcome evaluation tools for infants, ...
Simões Bárbara Dos Santos Bdos - - 2013
The scope of this study was to evaluate the nutritional profile of indigenous Xukuru-Kariri villagers in the state of Minas Gerais between seven and seventy-eight years of age in accordance with the different anthropometric and body composition indicator. The measurements were: weight, height, waist circumference (WC) and body fat percentage ...
Hoyer Inna - - 2013
The TSHR (thyrotropin receptor) is activated endogenously by the large hormone thyrotropin and activated pathologically by auto-antibodies. Both activate and bind at the extracellular domain. Recently, SMLs (small-molecule ligands) have been identified, which bind in an allosteric binding pocket within the transmembrane domain. Modelling driven site-directed mutagenesis of amino acids ...
Jacobson Joy - - 2013
After the disaster at four New York City hospitals.
Longo-Silva Giovana - - 2013
This article stresses the importance of the qualification of professionals involved in thefeeding of children in daycare centers, such that they offeradequate food and programs are developed in order to fosterhealthy food habits in infantsfrom birth. Thus, the scope of this paper was to evaluate the impact of a training ...
Inal Jameel M - - 2013
The release of extracellular vesicles, whether MVs (microvesicles) or exosomes, from host cells or intracellular pathogens is likely to play a significant role in the infection process. Host MVs may fuse with pathogen surfaces to deliver host complement regulatory proteins. They may also deliver cytokines that enhance invasion. Decoy functions ...
Esser Dominik - - 2013
Atypical protein kinases of the RIO (right open reading frame) kinase family are found in all three domains of life, emphasizing their essential function. In all archaeal genomes sequenced to date, typically two, but at least one, members of the RIO kinase family have been identified. Although the function of ...
Horon Robert - - 2013
The reliability, validity, and utility of the Adult Suicidal Ideation Questionnaire (ASIQ), Beck Hopelessness Scale (BHS), Beck Scale for Suicide Ideation (BSS), and Reasons for Attempting Suicide Questionnaire (RASQ) with correctional mental health populations was evaluated. Evidence was found indicating good to excellent reliability for all measures. Each of the ...
Lins Ana Paula Machado - - 2013
The scope of this study was to analyze the factors associated with the prevalence of being overweight and obesity in a population of low-income adult women living in a metropolitan region and its association with socioeconomic, demographic, reproductive and lifestyle variables, highlighting the importance of healthy eating. A population-based, cross-sectional ...
Peeters Eveline - - 2013
For cellular fitness and survival, gene expression levels need to be regulated in response to a wealth of cellular and environmental signals. TFs (transcription factors) execute a large part of this regulation by interacting with the basal transcription machinery at promoter regions. Archaea are characterized by a simplified eukaryote-like basal ...
Cottet Martin - - 2013
Fluorescent ligands for GPCRs (G-protein-coupled receptors) have been synthesized for a long time but their use was usually restricted to receptor localization in the cell by fluorescent imaging microscopy. During the last two decades, the emergence of new fluorescence-based strategies and the concomitant development of fluorescent measurement apparatus have dramatically ...
Kaminski Lina - - 2013
Although performed by members of all three domains of life, the archaeal version of N-glycosylation remains the least understood. Studies on Haloferax volcanii have, however, begun to correct this situation. A combination of bioinformatics, molecular biology, biochemical and mass spectrometry approaches have served to delineate the Agl pathway responsible for ...
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