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Suarez Edna E Plastic and Reconstructive Surgery Research, School of Translational Medicine, Manchester Institute of Biotechnology, University of Manchester, Manchester, United - - 2013
Keloid disease is a fibroproliferative disorder, with an ill-defined treatment that is characterized by excessive extracellular matrix deposition. Mechanical tension promotes deposition of extracellular matrix and overexpression of tension-related proteins, which is associated with keloid disease. The aim of this study was to investigate the effect of tension-related proteins on ...
Todd Betsy - - 2013
How hospitals, clinics, and the public health system responded to the outbreak.
Canella Daniela Silva - - 2013
Nutrition campaigns in Primary Health Care (PHC) play an important role in health promotion and the prevention and treatment of injuries. The scope of this paper is to chart and evaluate the scientific output of nutrition in Brazilian PHC. A search and review of the literature and papers was conducted ...
Bochud Arlette - - 2013
Most integral membrane proteins of yeast with two or more membrane-spanning sequences have not yet been crystallized and for many of them the side on which the active sites or ligand-binding domains reside is unknown. Also, bioinformatic topology predictions are not yet fully reliable. However, so-called low-resolution biochemical methods can ...
Busnelli Marta - - 2013
Receptor coupling to different G-proteins and β-arrestins has been described for a number of GPCRs (G-protein-coupled receptors), suggesting a multi-state model of receptor activation in which each receptor can assume a number of different active conformations, each capable of promoting the coupling to a specific effector. Consistently, functional-selective ligands and ...
Zhang Changyi - - 2013
Sulfolobus islandicus has been developed as a model system for combining approaches of evolutionary and molecular biology in Archaea. We describe how the application of this interdisciplinary approach can lead to novel hypotheses derived from patterns of natural variation that can be tested in the laboratory when combined with a ...
Jayasekara Rasika - - 2013
Editor's note: This is the ninth in a series of summaries of nursing care-related systematic reviews from the Cochrane Library.
Carvalho Alice Teles de - - 2013
The development of methods that enable analysis of programs and public policies is a key point for their objectives to be attained. This study presents a Brazilian experience of analysis of two food and nutritional security programs in cities in Brazil's northeast region, namely the National Program for Vitamin A ...
Martin Brent R - - 2013
Protein palmitoylation is a critical post-translational modification important for membrane compartmentalization, trafficking and regulation of many key signalling proteins. Recent non-radioactive chemo-proteomic labelling methods have enabled a new focus on this emerging regulatory modification. Palmitoylated proteins can now be profiled in complex biological systems by MS for direct annotation and ...
Koole Cassandra - - 2013
Type 2 diabetes is a major global health problem and there is ongoing research for new treatments to manage the disease. The GLP-1R (glucagon-like peptide-1 receptor) controls the physiological response to the incretin peptide, GLP-1, and is currently a major target for the development of therapeutics owing to the broad ...
Fischer John P JP Division of Plastic Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pa, - - 2013
Free tissue transfer is standard for postoncologic reconstruction, yet it entails a lengthy operation and significant recovery. The authors present their longitudinal experience of free tissue breast reconstructions with an emphasis on predictors of major surgical and medical complications. The authors reviewed their prospectively maintained free flap database and identified ...
Tanna Neil N Institute of Reconstructive Plastic Surgery, New York University, New York, NY, - - 2013
Nipple-sparing mastectomy warrants thorough preoperative evaluation to effectively achieve risk reduction, high patient satisfaction, and improved aesthetic outcome. To the authors' knowledge, this review represents the largest series of microsurgical breast reconstructions following nipple-sparing mastectomies. All patients undergoing nipple-sparing mastectomy with microsurgical immediate breast reconstruction treated at New York University ...
Potera Carol - - 2013
Older maternal age and poor health increase poor outcomes.
Eisenberg Sharon - - 2013
Ras GTPases are important regulators of pathways controlling proliferation, differentiation and transformation. Three ubiquitously expressed almost identical Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that ...
Kelly Eamonn - - 2013
Ligand bias refers to the ability of a drug at a receptor to activate selectively particular cell signalling pathways over others, in a way that cannot be explained by traditional models of receptor theory. For a physiologically and therapeutically important GPCR (G-protein-coupled receptor) such as the MOPr (μ-opioid receptor), the ...
Nichols Eric - - 2013
A framework for describing anion displacements from perfect octahedra in perovskites has been developed for use with neutron diffraction data sets. We describe the distortions as noncoplanar arrangements, or buckling, of oxygen ions in any central plane of the octahedron, ignoring the central cation. Nonplanar distortions of octahedra have been ...
Bogle Jamie M - - 2013
Background: The cervical vestibular evoked myogenic potential (cVEMP) is a reflexive change in sternocleidomastoid (SCM) muscle contraction activity thought to be mediated by a saccular vestibulo-collic reflex. CVEMP amplitude varies with the state of the afferent (vestibular) limb of the vestibulo-collic reflex pathway, as well as with the level of ...
Akita Shinsuke S Department of Plastic, Reconstructive, and Aesthetic Surgery, Chiba University, Faculty of Medicine, Chiba City, Japan. - - 2013
Although early diagnosis is important for selecting an effective surgical treatment for secondary lymphedema, an efficient screening test for detecting early-stage lymphedema has not yet been established. Serial changes of lymphatic function before and after lymph node dissection and risk factors for secondary lymphedema are important indicators. A prospective cohort ...
Ortega-Aznar A - - 2013
INTRODUCTION. Diffuse infiltrative gliomas, the most common primary brain tumours, account for almost 80% of malignant brain tumours. 60-70% of gliomas are astrocytic and over 80% of these tumours is considered high grade malignancy (grade III and IV) according to current World Health Organization classification. Infiltrating gliomas include diffuse astrocytomas, ...
Silva Elaine Cristina da - - 2013
Community participation is considered a key condition for communities to assume control of their health within the scope of health promotion. This study sought to identify and analyze the perceptions of residents of the watershed areas of Santo André/São Paulo with respect to the actions of health education and environmental ...
Mitchell Tanecia T Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, - - 2013
Mitochondrial dysfunction is associated with a broad range of pathologies including diabetes, ethanol toxicity, metabolic syndrome and cardiac failure. It is now becoming clear that maintaining mitochondrial quality through a balance between biogenesis, reserve capacity and mitophagy is critical in determining the response to metabolic or xenobiotic stress. In diseases ...
Montreuil Tina C - - 2013
In psychotic disorders, a limited number of studies have documented the presence of symptoms of anxiety, especially in first-episode psychosis (FEP). There is a growing interest in better understanding how these symptoms may affect the severity of psychotic symptoms and clinical outcome. This study examined the association between symptoms of ...
Chang Chih-Hsiung - - 2013
The synthetic aperture focusing technique (SAFT), employing a scanned focused transducer as a virtual source, is commonly used to image flaws in immersion testing. The position of a virtual source is estimated from rays emitted from the rim of a focused transducer. However, it is often found that the virtual ...
Park Sunhee - - 2013
This study explores the trajectory of suicidal ideation in childhood and adolescence and identifies its strong predictors. Secondary data obtained from two nationally representative cohorts of South Korean youth were longitudinally analyzed using frequencies, percentages, and discrete time survival analysis. This study revealed an increase in the occurrence of suicidal ...
Wallis Laura - - 2013
Truth in advertising shows what you really get when you smoke.
Costa Anna Paula Serêjo da - - 2013
Tooth loss is highly prevalent in Brazil, especially among the elderly, where more than three million need bimaxillary dentures. The federal government instituted Specialized Dental Care Centers (SDCC) to remedy this situation. The scope of this study was to evaluate one attribute of these Centers, namely the provision of full ...
Blombach Fabian - - 2013
All RNAPs (RNA polymerases) repeatedly make use of their DNA template by progressing through the transcription cycle multiple times. During transcription initiation and elongation, distinct sets of transcription factors associate with multisubunit RNAPs and modulate their nucleic-acid-binding and catalytic properties. Between the initiation and elongation phases of the cycle, the ...
Klinkenberg Marek M Department of Hand, Plastic, and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, Ludwigshafen, - - 2013
The purpose of this study was to compare the morbidity and the aesthetic and functional outcomes of primarily closed donor sites of three commonly used free flaps. Sixty patients who had undergone free flap reconstruction (20 anterolateral thigh, 20 parascapular, and 20 lateral arm flaps) were included in this study. ...
Choi Bong-Kyoon BK Maxillofacial Center, Korea International Esthetic Surgery Union, Plastic Surgery Clinic, Seoul, Republic of - - 2013
The authors studied whether the incidence of inferior alveolar nerve injury in patients undergoing sagittal split ramus osteotomy differs in patients with a history of previous mandibular contouring surgery. A retrospective chart review was completed on all patients who underwent orthognathic surgery, including bilateral sagittal split osteotomy and Le Fort ...
Heck Maria Antonia - - 2013
The scope of this study was to describe the trends of tuberculosis indicators in relation to their prevalence, incidence and the case outcome percentages (cure, abandonment of treatment or death) for the patients who entered in the Program in Sapucaia do Sul, state of Rio Grande do Sul, between 2000 ...
Howie Jacqueline J Division of Cardiovascular & Diabetes Medicine, Medical Research Institute, College of Medicine Dentistry & Nursing, University of Dundee, Dundee DD1 9SY, - - 2013
The Na+/K+-ATPase (Na+ pump) is the principal consumer of ATP in multicellular organisms. In the heart, the Na+ gradient established by the pump is essential for all aspects of cardiac function, and appropriate regulation of the cardiac Na+ pump is therefore crucial to match cardiac output to the physiological requirements ...
Inal Jameel M - - 2013
The important roles of extracellular vesicles in the pathogenesis of various diseases are rapidly being elucidated. As important vehicles of intercellular communication, extracellular vesicles, which comprise microvesicles and exosomes, are revealing important roles in cancer tumorigenesis and metastases and in the spread of infectious disease. The September 2012 Focused Meeting ...
Bessonova Olga - - 2013
For the characterization of high-intensity focused ultrasound (HIFU) fields, hydrophone measurements should be performed in water in the whole range of the radiated power; however, cavitation occurs at high output, leading to the destruction of the hydrophone. To avoid this problem, a new hydrophone with additional protective layers covering the ...
Bagatto Marlene P - - 2013
Background: The Parents' Evaluation of Aural/Oral Performance of Children (PEACH) is a caregiver report questionnaire that is suitable for use with children who wear hearing aids. It is available in both a Diary format and a Rating Scale format. Following a critical review of subjective outcome evaluation tools for infants, ...
Paduch Darius A - - 2013
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Disorders of ejaculation and orgasm are common, even in men with only mild erectile dysfunction (ED). Treatment with the phosphodiesterase type-5 inhibitor tadalafil was associated with improvements in ejaculatory and orgasmic function. Patients with residual ejaculatory or orgasmic dysfunction ...
Mary Sophie - - 2013
The dynamic character of GPCRs (G-protein-coupled receptors) is essential to their function. However, the details of how ligands and signalling proteins stabilize a receptor conformation to trigger the activation of a given signalling pathway remain largely unexplored. Multiple data, including recent results obtained with the purified ghrelin receptor, suggest a ...
Atomi Haruyuki - - 2013
CoA is a ubiquitous molecule in all three domains of life and is involved in various metabolic pathways. The enzymes and reactions involved in CoA biosynthesis in eukaryotes and bacteria have been identified. By contrast, the proteins/genes involved in CoA biosynthesis in archaea have not been fully clarified, and much ...
Seshagiri Somasekar - - 2013
Our understanding of inherited risk factors for colorectal cancer (CRC) is incomplete. A new study reports the identification of germline CRC risk variants that adversely affect the proofreading function of DNA polymerases encoded by POLE and POLD1.
Taylor John F - - 2013
The use of dietary adsorbents to reduce arsenic (As) exposure is innovative. Ferrihydrite successfully sorbs arsenite and asenate over a wide range of pH conditions and the As-ferrihydrite complexes are stable in gastrointestinal (GIT) models. Our objectives were to (1) compare structural characteristics (using x-ray diffraction and Fourier-transform infrared [FTIR] ...
Walker John E JE MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK. - - 2013
The ATP synthases are multiprotein complexes found in the energy-transducing membranes of bacteria, chloroplasts and mitochondria. They employ a transmembrane protonmotive force, Δp, as a source of energy to drive a mechanical rotary mechanism that leads to the chemical synthesis of ATP from ADP and Pi. Their overall architecture, organization ...
Miller Laurence J - - 2013
Class B GPCRs (G-protein-coupled receptors) share heptahelical topology and G-protein binding with other superfamily members, yet have unique structures and modes of activation. Natural ligands for these receptors are moderate-length peptides with C-terminal α-helices. NMR and crystal structures of the peptide-bound disulfide-bonded receptor N-terminal domains demonstrate that these helices occupy ...
Marguet Evelyne - - 2013
Thermococcus species produce MVs (membrane vesicles) into their culture medium. These MVs are formed by a budding process from the cell envelope, similar to ectosome formation in eukaryotic cells. The major protein present in MVs of Thermococci is a peptide-binding receptor of the OppA (oligopeptide-binding protein A) family. In addition, ...
Liao Yen-Hsiung - - 2013
The objective of this study was to explore whether magnesium (Mg) levels in drinking water modified the effects of nitrate on esophageal cancer risk occurrence. A matched cancer case-control study was used to investigate the relationship between the risk of death from esophageal cancer and exposure to nitrate in drinking ...
Moura Marcoeli Silva de - - 2013
The objective of this cross-sectional study was to assess the professional profile of dental-surgeons (DS) who work in the Family Health Strategy (FHS), and on the basis of this reflect upon aspects of the development of dental actions in primary health care in municipalities of a health region of the ...
Gietl Andreas - - 2013
The genetic information of every living organism is stored in its genomic DNA that is perceived as a chemically stable and robust macromolecule. But at the same time, to fulfil its functions properly, it also needs to be highly dynamic and flexible. This includes partial melting of the double helix ...
Vegas Manuel R MR Plastic Surgery and Reconstructive Microsurgery, Hospital Quirón, Madrid, Spain. - - 2013
There are few references to the reconstructive possibilities of the ascending branch of the lateral circumflex femoral artery other than the tensor fasciae latae muscle flap and the so-called muscle pedicle bone grafting technique. An anatomical study was performed to evaluate the ascending branch of the lateral circumflex femoral artery ...
Fuller Jennifer C JC Alameda Hospital, Alameda, Los Angeles, Calif, - - 2013
The question of whether or not abdominoplasty is associated with permanent weight reduction remains controversial. In coalition, should abdominoplasty be used as an adjunct for weight reduction in the overweight/obese patient? This retrospective patient case series attempts to determine the most important factors associated with weight reduction. All patients undergoing ...
Redman Emily K EK School of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, - - 2013
High glucose inhibits mitochondrial respiration, known as the 'Crabtree effect', in cancer cells and possibly other cell types. The upstream pathways regulating this phenomenon are poorly understood. In diabetes, where glucose levels are elevated, the p90(RSK) (p90 ribosomal S6 kinase) has received much attention as a potential upstream mediator of ...
Jackson Joseph - - 2013
Airborne ultrasonic ranging is used in a variety of different engineering applications for which other positional metrology techniques cannot be used, for example in closed-cell locations, when optical line of sight is limited, and when multipath effects preclude electromagnetic-based wireless systems. Although subject to fundamental physical limitations, e.g., because of ...
Iblher Niklas N Department of Plastic and Hand Surgery, University Medical Center Freiburg, Freiburg, Germany. - - 2013
Reliable evaluation of the complex three-dimensional anatomy of the face has proven to be extremely difficult. Three-dimensional surface scanning technology has not yet reached widespread acceptance in clinical research in plastic surgery. This study aimed to describe two parameters that allow quantification of soft-tissue movements and to compare the surface ...
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