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Kulp Maria - - 2013
In this study, the synergistic biological action of five celandine alkaloids in normal and cancer cells was investigated by capillary electrophoresis with light-emitting diode-induced native fluorescence detection. The specific capacity of each alkaloid to penetrate into the cells was estimated by monitoring alkaloid concentration decreases in the cell medium during ...
Rahman Cheryl V - - 2013
Biodegradable polymer scaffolds have great potential for regenerative medicine applications such as the repair of musculoskeletal tissues. Here, we describe the development of scaffolds that blend hydrogel components with thermoplastic materials, combining the unique properties of both components to create mouldable formulations. This study focuses on the structural and mechanical ...
Dixon Andrea L - - 2013
The abundant centre hypothesis (ACH) assumes that population abundance, population size, density and per-capita reproductive output should peak at the centre of a species' geographic range and decline towards the periphery. Increased isolation among and decreased reproductive output within edge populations should reduce within-population genetic diversity and increase genetic differentiation ...
Park Sook Ryun - - 2013
The plethora of novel molecular-targeted agents (MTAs) has provided an opportunity to selectively target pathways involved in carcinogenesis and tumour progression. Combination strategies of MTAs are being used to inhibit multiple aberrant pathways in the hope of optimizing antitumour efficacy and to prevent development of resistance. While the selection of ...
Nathues C - - 2013
Switzerland is currently porcine reproductive and respiratory syndrome virus (PRRSV) free, but semen imports from PRRSV-infected European countries are increasing. As the virus can be transmitted via semen, for example, when a free boar stud becomes infected, and the risk of its import in terms of PRRSV introduction is unknown, ...
Lee Su-Jun - - 2013
SULT1A1 and SULT1A2 are encoded on the same chromatid, and exhibit a 96% amino acid similarity. To screen for genetic variants in these two closely related genes, SULT1A1 and SULT1A2 were directly sequenced in 50 healthy Koreans. A total of 30 variations were identified in SULT1A1: eight in exons, thirteen ...
Olds Tim - - 2013
Abstract Somatotyping is the quantification of human body shape, independent of body size. Hitherto, somatotyping (including the most popular method, the Heath-Carter system) has been based on subjective visual ratings, sometimes supported by surface anthropometry. This study used data derived from three-dimensional (3D) whole-body scans as inputs for cluster analysis ...
Mourand Isabelle - - 2013
A 77-year-old man presented with 2 episodes of waking up with symptoms of vertebrobasilar ischemia (figure, A and B) within 6 months. A CT angiogram showed narrowing of the right vertebral artery due to extrinsic compression by an osteophyte of the superior articular process of the fourth cervical vertebra, compromising ...
Azhakar Ramachandran - - 2013
The first metal free selective C-F bond activation of a CF(3) group was observed with N-heterocyclic silylenes [PhC(NtBu)(2)SiCl] () and [CH{(C[double bond, length as m-dash]CH(2))(CMe)(2,6-iPr(2)C(6)H(3)N)(2)}Si] () with PhN[double bond, length as m-dash]C(CF(3))(2). The reaction proceeds in a 1 : 1 molar ratio to yield the mono C-F bond activated products and with ...
Fujino Yusuke - - 2013
OBJECTIVES: To investigate safety and feasibility of imaging unprotected left main (ULM) using frequency-domain optical coherence tomography (FD-OCT) compared with intravascular ultrasound (IVUS). BACKGROUND: IVUS has been used to assess and guide percutaneous coronary intervention (PCI) of ULM disease. FD-OCT offers 10-fold higher axial resolution than IVUS and its high-speed ...
Qiu Youai - - 2013
Naturally occurring carbazole alkaloids such as isomukonidine, clausine L, mukonidine, glycosinine, mukonal, and clausine V have been synthesized through a gold-catalyzed cyclization reaction of 1-(indol-2-yl)-2-methoxy-2,3-allenols, which are readily available from indolecarbaldehydes and methoxypropadiene. Compared to the reported procedures, our approach is general, atom economic, highly selective, and the starting materials ...
Liao Xiao-Lin - - 2013
Two new compounds, (2R)-7,3'-dihydroxy-6,4'-methoxyflavan (1) and (3R)-7,4'-dihydroxy-2'-methoxyisoflavan (2), along with 12 known flavonoids (3-14), were isolated from the vine stems of Millettia nitida var. hirsutissima. The structures of the isolated compounds were elucidated based on spectroscopic analyses and comparison of literature data. All of the isolates were evaluated for their ...
Duymus Zeynep Yesil - - 2013
The aim of this study was to evaluate of flexural strength of some adhesive resin cements. Three dual-cure composite resin cements (Nexus 3; Variolink II, Panavia F) were prepared. The manufacturer's mixing directions for the cements were followed. Adhesive resin cement was mixed, placed in the rectangular portion of the ...
Schiedel Anke C - - 2013
The effects of standard adenosine receptor (AR) agonists and antagonists on the proliferation of human T lymphocytes, unstimulated and phytohemagglutinin-stimulated human peripheral blood lymphocytes (PBL), and Jurkat T cells were investigated. Real-time PCR measurements confirmed the presence of all four AR subtypes on the investigated cells, although at different expression ...
Moran Emily V - - 2013
The world's forests are currently exposed to increasing concentrations of carbon dioxide (CO(2) ) and ozone (O(3) ). Both pollutants can potentially exert a selective effect on plant populations. This, in turn, may lead to changes in ecosystem properties, such as carbon sequestration. Here, we report how elevated CO(2) and ...
Verdano Michele Arcangelo - - 2013
The rotator cuff tear is one of the most frequent musculoskeletal disorders, but the real incidence is not clearly known because it's usually asymptomatic, even if it's more common in patients with shoulder pain (36 %). The prevalence of the complete tear among general population is estimated approximately around 20.7 % and ...
Kim Jae Hyun - - 2013
BACKGROUND: An enlarged left atrium (LA) is a major risk factor for atrial fibrillation (AF) recurrence after a maze operation. METHODS: Between 2000 and 2009, 35 patients underwent circumferential left atrium resection (CLAR), during mitral valve surgery. All patients had continuous AF. RESULTS: Hospital mortalities occurred in two patients (5.7%). ...
Mikami Akiko - - 2013
Objective: To develop a pharmacokinetic model able to describe the nonlinear pharmacokinetics of paroxetine (PRX) and to predict the drug-drug interaction between PRX and metoprolol under various dosage regimens. Methods: A pharmacokinetic model of PRX incorporating mechanism-based inhibition was developed. This model was fitted to the drug concentration profiles obtained ...
Yuan Zhonghai - - 2013
Plasma von Willebrand factor (vWF) is an important factor involving in hemostasis and various cardiovascular diseases. Air pollution is related to many respiratory and cardiovascular diseases. During the Olympic Games Beijing 2008 period (August 8 to September 17, 2008) when air quality in Beijing improved greatly, we studied the relationship ...
van den Bent Martin J - - 2013
Isocitrate dehydrogenase (IDH) mutational testing is becoming increasingly important. For this, robust and reliable assays are needed. We tested the variation of results between six laboratories of testing for IDH mutations. Each laboratory received five unstained slides from 31 formalin-fixed paraffin-embedded (FFPE) glioma samples, and followed its own standard IDH ...
Bayraktar Soley - - 2013
Triple-negative breast cancer (TNBC) refers to a heterogeneous group of tumors that do not express the estrogen/progesterone-receptor (ER/PR), and human epidermal growth factor receptor-2 (HER2). TNBC is an aggressive histological subtype with limited treatment options and very poor prognosis following progression after standard chemotherapy regimens. There have been significant improvements ...
Matsuo Hitoshi - - 2013
In this case report, physiological changes of myocardial perfusion in the collateral recipient right coronary artery (RCA) and the collateral donor left anterior descending artery (LAD) with an intermediate lesion were assessed using intracoronary pressure measurement, before and after revascularization of chronic total occlusion (CTO). A 44 year old male ...
Liao Ping-Kuei - - 2013
The neutral metalloligand [CpFe(CO)(2)P(Se)(O(i)Pr)(2)] (Cp = η(5)-C(5)H(5)), which contains the rare secondary phosphite selenide moiety, reacts with different metal complex precursors to form six new heterobimetallic complexes containing M-Se-P-Fe(Cp) bond connectivity. The complexes [M(CO)(5){CpFe(CO)(2)P(Se)(O(i)Pr)(2)}] (M = Cr, ; M = W, ), [MCl(2){CpFe(CO)(2)P(Se)(O(i)Pr)(2)}(2)] (M = Pd, ; M = Pt, ...
Tokumoto Junko - - 2013
Clothianidin (CTD) is a neonicotinoid developed in the 1990s as an insecticide having selective toxicity, but it was later found to cause reproductive abnormalities in rats through oxidative stress. There is an attempt to preserve endangered animals, including the Japanese crested ibis, in Japan. However, there is a concern that ...
Rossi Umberto G - - 2013
Central venous catheterization is a routine vascular access procedure; however, it may be associated with life-threating complications such as arterial puncture, leading to pseudoaneurysm formation.We report a case of a 41-year-old female that developed an iatrogenic left subclavian pseudoaneurysm complicating the attempt of left internal jugular vein cannulation for temporary ...
Macias V - - 2013
PURPOSE: To prospectively study acute genitourinary (GU) and gastrointestinal (GI) toxicity during hypofractionated radiotherapy. PATIENTS AND MATERIALS: One-hundred and seventy-one consecutive men with cT1-T3cN0cM0 prostate cancer were treated at 2.6 Gy/fraction to a total dose of 67.6 for low risk (EQD2 = 79 Gy) and 70.2 Gy for intermediate-high risk (EQD2 = 82 Gy) over 5.2-5.4 weeks (α/β 1.5). ...
Schütze Dina - - 2013
BACKGROUND: Carbonic anhydrase IX (CAIX) is involved in pH homeostasis, growth and survival of tumor cells. Besides the membranous form of CAIX, a soluble form is detectable in serum (s-CAIX). Overexpression of CAIX in tumors offers the opportunity for therapeutic strategies such as CAIX targeting antibodies. The aim of this ...
Martín Mariana - - 2013
Temperature sensing is essential for the survival of living cells. The membrane-bound thermosensor DesK from Bacillus subtilis is a key representative of histidine kinases receptors suited to remodel membrane lipid composition when the temperature drops below ~30ºC. Although the receptor is well studied, a central issue remains: How does the ...
Flynn Colleen - - 2013
Chronic kidney disease (CKD) is a common complication of diabetes mellitus and the most common cause of end-stage renal disease (ESRD). As the worldwide prevalence of diabetes continues to increase, the number of patients with CKD will also increase. Therefore, it is essential that physicians know how to safely and ...
Weiss Nicole H - - 2013
Abstract Despite findings that the co-occurrence of posttraumatic stress disorder (PTSD) and substance use disorders (SUD) is associated with heightened risk for a variety of risky behaviors, few studies have examined behaviors linked to heightened risk for HIV infection and transmission in particular, or explored the unique associations between specific ...
Shin Kwang-Hee - - 2013
BACKGROUND: HM10460A is a newly developed recombinant human granulocyte colony-stimulating factor with long-lasting characteristics. This factor is expected to be used for chemotherapy-related neutropenic conditions. OBJECTIVE: The aim of the present study was to evaluate the pharmacokinetics and pharmacodynamics of HM10460A following subcutaneous administration to healthy Korean subjects. METHODS: A ...
Degirmenci Eylem - - 2013
This study investigates the correlation between brain magnetic resonance imaging findings and blink reflex abnormalities in patients with relapsing remitting multiple sclerosis. Twenty-six patients and 17 healthy subjects were included in this study. Blink reflex test (BRT) results were obtained using right and left stimulations; thus, 52 BRT results were ...
Viegas Aldino - - 2013
Non-catalytic cellulosomal carbohydrate-binding modules (CBMs) are responsible for increasing the catalytic efficiency of cellulosic enzymes by selectively putting the substrate (a wide range of poly- and oligosaccharides) and enzyme into close contact. In the present work we carried out an atomistic rationalization of the molecular determinants of ligand specificity of ...
Tsai Jack - - 2013
Purpose Concerns that disability benefits may create disincentives for employment may be especially relevant for young American military veterans, particularly veterans of the recent wars in Iraq and Afghanistan who are facing a current economic recession and turning in large numbers to the Department of Veterans Affairs (VA) for disability ...
Kolbus Daniel - - 2013
OBJECTIVES: The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8(+) T cells and carotid disease as well as development of ...
Paula Nascimento Panigassi Ana - - 2013
Abstract Objective: To evaluate the influence of different races over the measurement of the frontomaxillary facial angle between 11 and 13+6 weeks of pregnancy in a Brazilian population. Methods: A cross-sectional study was conducted with 332 healthy pregnant women, with a crown-rump length (CRL) between 47 and 84 mm. Such ...
Spiess Bernhard M - - 2013
OBJECTIVE: UV-A/riboflavin cross-linking (CXL) of corneal collagen fibers is an established, highly promising therapy for corneal melting in physician-based ophthalmology. A prospective pilot study was conducted to demonstrate proof of principle of this novel method for the treatment of melting corneal ulcers in dogs and cats. PROCEDURES: After obtaining owner ...
Bleibel Wissam - - 2013
Several studies have shown a direct role of liver atrophy in the pathogenesis of thrombocytopenia of cirrhosis via reduced production of thrombopoeitin. About 181 patients listed for liver transplantation at a single transplant center were evaluated at the time of listing with laboratory tests and volumetric liver measurements using computed ...
Mangalam R V K - - 2013
Synthesis of compositionally graded versions of PbZr(1-x) Ti(x) O(3) thin films results in unprecedented strains (as large as ≈4.5 × 10(5) m(-1) ) and correspondingly unexpected crystal structures, ferroelectric domain structures, and properties. This includes the observation of built-in electric fields in films as large as 200 kV/cm. Compositional and ...
Bärthel Erik - - 2013
ABSTRACT: BACKGROUND: Liver graft dysfunction can deteriorate to complete organ failure and increases perioperative morbidity and mortality after liver transplantation. Therapeutic strategies reducing the rate of graft dysfunction are of current clinical relevance. One approach is the systemic application of prostaglandins, which were demonstrated to be beneficial in reducing ischemia-reperfusion ...
Phalgune U D - - 2013
The process of phenol biodegradation by the yeast Candida tropicalis NCIM 3556 in aqueous medium was studied by (1)H, (13)C, and DOSY NMR techniques. Samples at regular intervals were centrifuged to separate the cells, and (1)H spectral data were collected at 400 MHz. Though a gradual decrease in the concentration of ...
Tung Patricia - - 2013
Sudden cardiac death (SCD) is a major cause of mortality in elderly individuals owing to a high prevalence of coronary heart disease, systolic dysfunction, and congestive heart failure (CHF). Although the incidence of SCD increases with age, the proportion of cardiac deaths that are sudden decreases owing to high numbers ...
Da Silva Ivan Rocha Ferreira - - 2013
Neurology is traditionally recognized as primarily an outpatient or consultative specialty, usually attracting candidates whose main focus may not necessarily be the management of complex critically ill patients or the performance of invasive procedures. However, the advent of modern mechanical ventilation and, more recently, effective therapies for the treatment of ...
Rafiee Mohammad - - 2013
A novel and simple method for the electrochemical modification of ordered mesoporous silica is described. A well-organized thin film of amine-functionalized ordered mesoporous silica has been deposited electrochemically on the electrode surface. The resulting amine-functionalized electrodes were then subjected to post-functionalization with catechol moieties through electrochemical generation of reactive o-quinone ...
Jiménez-González M - - 2013
AIMS/HYPOTHESIS: Cardiotrophin 1 (CT-1) is a recently described cytokine originally isolated from the heart where it has been shown to play an important role in apoptotic protection of cardiomyocytes and heart hypertrophy. Its beneficial properties have also been described in other organs such as liver and neuromuscular tissue. In the ...
Abdel Raheem Amr - - 2013
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: The management of patients with non-obstructive azoospermia (NOA) and some cases of obstructive azoospermia involves testicular sperm extraction (TESE or micro-dissection TESE) combined with intracytoplasmic sperm injection (ICSI). Several studies have investigated the effect of the male age, the ...
Kim Sung-Koo - - 2013
The acidic hydrolysis of biomass generates numerous inhibitors of fermentation, which adversely affect cell growth and metabolism. The goal of the present study was to determine the effects of fermentation inhibitors on growth and glucose consumption by Saccharomyces cerevisiae. We also conducted in situ adsorption during cell cultivation in synthetic ...
Hreinsson Jóhann P - - 2013
Abstract Objective. The authors aimed to investigate the incidence and outcomes of acute upper gastrointestinal bleeding (AUGIB) and to examine the role of drugs potentially associated with AUGIB. Methods. The study was prospective, population-based and consisted of all patients who underwent upper gastrointestinal endoscopy (UGE), during the year of 2010 ...
Kische Stephan - - 2013
OBJECTIVES: To summarize our single Institution experience with staged total percutaneous management of aorto-mitral pathology. BACKGROUND: Percutaneous treatment of aortic valve stenosis (AVS) and mitral valve regurgitation (MVR) has been recently proposed for patients at high surgical risk. METHODS: Data concerning consecutive patients undergoing percutaneous transcatheter AV implantation (TAVI) followed ...
Lin Hong-Ru - - 2013
Pluronic micelles were prepared for ophthalmic delivery by incorporation of ethyl acetate as a dispersion agent and their surfaces were modified by chitosan to improve their bioavailability. The micelles disperse well in the solution and have a core-shell like structure with a particle size ranging from 93 to 181 nm ...
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