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Chain Anne S Y AS Leiden/Amsterdam Center for Drug Research, Division of Pharmacology, Leiden University, Leiden, the - - 2013
Given the similarities in QTc response between dogs and humans, dogs are used in pre-clinical cardiovascular safety studies. The objective of our investigation was to characterize the PKPD relationships and identify translational gaps across species following the administration of three compounds known to cause QTc interval prolongation, namely cisapride, d, ...
Bodalia Pritesh N PN Genetic Epidemiology Group, Department of Epidemiology & Public Health, Division of Population Health, University College London, London, WC1E 6BT, UK; Department of Pharmacy, Royal National Orthopaedic Hospital, Middlesex, HA7 4LP, - - 2013
To evaluate the comparative efficacy (50% reduction in seizure frequency) and tolerability (premature withdrawal due to adverse events) of anti-epileptic drugs (AEDs) for refractory epilepsy. We searched Cochrane Central Register of Controlled Trials (Cochrane Library 2009, issue 2) including Epilepsy Group's specialized register, MEDLINE (1950 to March 2009), EMBASE (1980 ...
Mahapatra Dwarikanath D Department of Computer Science, Swiss Federal Institute of Technology (ETH) Zurich, Room CAB F 61.1 Universitätstrasse, 68092, Zurich, Switzerland, - - 2013
In this paper, we propose a graphcut method to segment the cardiac right ventricle (RV) and left ventricle (LV) by using context information from each other. Contextual information is very helpful in medical image segmentation because the relative arrangement of different organs is the same. In addition to the conventional ...
Renno Patricia P Department of Education, University of California, Los Angeles, Moore Hall, Los Angeles, CA 90095, USA. - - 2013
Despite reports of high anxiety in children with autism spectrum disorders (ASD), there is controversy regarding differential diagnosis of ASD symptoms and anxiety symptoms. This study examined 88 children, aged 7-11 years, with ASD referred for concerns about anxiety. A multitrait-(social anxiety, separation anxiety, overall anxiety severity, and overall ASD ...
Nobles Jenna J Department of Sociology, University of Wisconsin, Madison, WI 53706, USA. - - 2013
Despite many changing demographic processes in Mexico-declining adult mortality, rising divorce, and rising nonmarital fertility-Mexican children's family structure has been most affected by rising migration rates. Data from five national surveys spanning three decades demonstrate that since 1976, migration has shifted from the least common to the most common form ...
Rosen Jennifer E JE 1 Department of Surgery, Boston University School of Medicine ; Boston, - - 2013
To report on the incidence and predictors of use of complementary and alternative medicine (CAM) among patients with thyroid cancer. Data were collected using a web-based online anonymous survey under Institutional Review Board approval from Boston University. This report is based on 1327 responses from subjects with thyroid cancer. Patient ...
Genders Amanda J AJ Division of Endocrinology, Department of Medicine, University of Virginia, School of Medicine, Charlottesville, VA 22908, - - 2013
We examined insulins uptake and transendothelial transport by endothelial cells in order to: (i) ascertain whether insulin accumulates within the cells to concentrations greater than in the media; (ii) compare trans endothelial insulin transport to that of inulin (using the latter as a tracer for passive transport or leaked); and; ...
Johnston Derek W DW School of Psychology, University of Aberdeen, Aberdeen, UK. - - 2013
Nurses are a stressed group and this may affect their health and work performance. The determinants of occupational stress in nurses and other occupational groups have almost invariably been examined in between subject studies. This study aimed to determine if the main determinants of occupation stress, i.e. demand, control, effort ...
Peinado Carlos C Department of Pathology, University of California, San Diego, La Jolla, CA, - - 2013
NKG2D ligands are cell surface proteins that activate NKG2D, a receptor used by natural killer (NK) cells to detect virus-infected and transformed cells. When tumour cells express high levels of NKG2D ligands, they are rejected by the immune system. Hence, reagents that increase NKG2D ligand expression on tumour cells can ...
Oh Jonghyun J Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02115, - - 2013
Chitosan has been used as a scaffolding material in tissue engineering due to its mechanical properties and biocompatibility. With increased appreciation of the effect of micro- and nanoscale environments on cellular behavior, there is increased emphasis on generating microfabricated chitosan structures. Here we employed a microfluidic coaxial flow-focusing system to ...
Fisher Celia B CB Fordham University Center for Ethics Education, Dealy Hall, 441 East Fordham Road, Bronx, NY 10458, USA. - - 2013
The Human Genome Project and rapid technological advances in genomics have begun to enrich prevention science's contributions to understanding the role of genetic factors in the etiology, onset and escalation of mental disorders, allowing for more precise descriptions of the interplay between genetic and non-genetic influences. Understanding of ethical challenges ...
Bugg Julie M JM Department of Psychology, Washington University in St. Louis, St. Louis, MO 63130-4899, USA. - - 2013
Prospective memory refers to the ability to remember to execute future intentions (e.g., taking medication with dinner). Although most prior research on prospective memory errors has focused on omission errors (i.e., failures to perform an intention in response to a target cue), there has been a recent surge in research ...
Han Yu-Chen YC Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, - - 2013
Metallothioneins (MTs) are a group of metal binding proteins thought to play a role in the detoxification of heavy metals. Here we showed by microarray and validation analyses that MT1h, a member of MT, is down-regulated in many human malignancies. Low expression of MT1h was associated with poor clinical outcomes ...
Lad Shivanand P SP Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA. - - 2013
Retrospective cohort study using Thomson Reuter's MarketScan database. To evaluate the extent to which Medicaid versus commercial insurance status affects outcomes after lumbar stenosis surgery. The Affordable Care Act aims to expand health insurance and to help narrow existing health care disparities. Medicaid patients have previously been noted to be ...
Karjalainen Ulla U Oulu Center for Cell-Matrix Research, Biocenter and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland. - - 2013
Cross-sectional study in a subcohort of the 1986 Northern Finland Birth Cohort (n = 1987). To investigate the role of environmental factors and LBP history in sciatica symptoms among Finnish young adults. History of low back pain (LBP), smoking, and male sex are associated with sciatica in adult populations. The ...
Crandall Dennis G DG Sonoran Spine Center, Phoenix, AZ, USA. - - 2013
Retrospective review of prospectively collected data. Without industry funding, the study evaluated short- and long-term complications related to off-label bone morphogenetic protein (BMP) used with transforaminal lumbar interbody fusion (TLIF) from a large consecutive series. Complications and results were analyzed by BMP dose, fusion length, and primary versus revision surgery. ...
Chapman Jens J Department of Orthopedic Surgery, University of Washington, Seattle, WA, - - 2013
Retrospective, multicenter cohort study. Assess for differences in short- and long-term mortality between operative and nonoperative treatment for elderly patients with type II odontoid fractures. There is controversy regarding whether operative or nonoperative management is the best treatment for elderly patients with type II odontoid fractures. This is a retrospective ...
Giatromanolaki A A Department of Pathology, University General Hospital of Alexandroupolis, Alexandroupolis, Greece. - - 2013
The study investigated whether autophagic activity and hypoxia parallel the adenoma-carcinoma sequence. The study comprised 120 tubular adenomas with high-grade dysplasia, including 22 with questionable evidence of invasion, 37 with definite stromal invasion and 29 with severely dysplastic adenoma, 10 traditional serrated adenomas and 22 classical tubular adenomas lacking aggressive ...
Robertson S M SM Houston Health Services Research and Development Center of Excellence, Michael E DeBakey Veterans Affairs Medical Center, University of Houston, Houston, TX, USA. - - 2013
To examine the role of baseline depression, anxiety and stress symptoms on post-intervention diabetes self-efficacy and glycaemic control (HbA(1c)). The current study analysed data from patients (n = 85) with treated but uncontrolled Type 2 diabetes who participated in a comparative effectiveness study of two diabetes self-management interventions. Hierarchical linear ...
Robertson Claire C Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92697-2730, - - 2013
Human pluripotent stem cell-derived cardiomyocytes (hPS-CM) may offer a number of advantages over previous cardiac models, however, questions of their immaturity complicate their adoption as a new in vitro model. hPS-CM differ from adult cardiomyocytes with respect to structure, proliferation, metabolism and electrophysiology, better approximating fetal cardiomyocytes. Time in culture ...
Yoshimura M M Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, - - 2013
We have previously shown that an acute osmotic stimulation induces the expression of a c-fos and monomeric red fluorescent protein 1 (mRFP1) fusion transgene in osmosensitive rat brain areas, including the supraoptic (SON) and paraventricular nuclei (PVN). However, the effects of chronic stimuli, such as dehydration, have not been investigated. ...
Manson Neil A - - 2013
The median orthopedic surgery wait time in Canada is 33.7 weeks, thus alternative treatments for pathologies such as lumbar disc herniations (LDH) are needed. We sought to determine whether transforaminal epidural steroid injections (TFESIs) alleviate or merely delay the need for surgery. We retrospectively reviewed the charts of patients with ...
Stall Nathan M - - 2013
Operating rooms (ORs) are estimated to generate up to one-third of hospital waste. At the London Health Sciences Centre, prosthetics and implants represent 17% of the institution's ecological footprint. To investigate waste production associated with total knee arthroplasties (TKAs), we performed a surgical waste audit to gauge the environmental impact ...
Azari-Rad Solmaz - - 2013
In Canadian hospitals, which are typically financed by global annual budgets, overuse of operating rooms is a financial risk that is frequently managed by cancelling elective surgical procedures. It is uncertain how different scheduling rules affect the rate of elective surgery cancellations. We used discrete event simulation modelling to represent ...
Acuna Sergio A - - 2013
Eleven quality indicators (QI) for sentinel lymph node biopsy (SLNB) were previously developed through a consensus-based approach, yet still need to be incorporated into clinical practice. We sought to evaluate the applicability and clinical relevance for surgeons. Breast cancer patients undergoing SLNB between 2004 and 2008 at Mount Sinai Hospital, ...
Poonai Naveen - - 2013
Ovarian torsion in children is an uncommon cause of acute abdominal pain but mandates early surgical management to prevent further adnexal damage. The clinical presentation mimics other pathologies, such as appendicitis. We sought to more completely characterize ovarian torsion with respect to pain and ancillary studies, such as urinalysis. We ...
Zacharias Céline - - 2013
Quality of life data after digestive surgery in malnourished, elderly patients are rarely reported. What can we expect as 1-year outcomes in these high-risk patients after digestive surgery? We conducted a prospective observational study in a digestive surgery department in a tertiary, nonacademic hospital in Mulhouse, France. Malnourished, older patients ...
Pally Elliott - - 2013
Orthopedic surgeons depend on the intraoperative use of fluoroscopy to facilitate procedures across all subspecialties. The versatility of the C-arm fluoroscope allows acquisition of nearly any radiographic view. This versatility, however, creates the opportunity for difficulty in communication between surgeon and radiation technologist. Poor communication leads to delays, frustration and ...
Huang Xin-sheng - - 2013
In patients with coronary disease and aneurysm, ventricular reconstruction with revascularization is a surgical option. Details of patient selection and optimal surgical technique are still debated. We report our results with off-pump aneurysm plication after ventricular aneurysm with relative wall thinning. We retrospectively reviewed the records of 248 patients who ...
Goldstein Amy A Division of Child Neurology, Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA 20892, - - 2013
The incidence of mitochondrial diseases has been estimated at 11.5/100,000 (1:8500) worldwide. In the USA up to 4000 newborns annually are expected to develop a mitochondrial disease. More than 50 million adults in the USA also suffer from diseases in which primary or secondary mitochondrial dysfunction is involved. Mitochondrial dysfunction ...
Khalaf Khaled Imad KI Department of Internal Medicine, Division of Cardiology, The University of Texas Medical School at Houston, Houston, TX 77030, USA. - - 2013
Obesity is a state of metabolic dysregulation of the whole organism and a major contributing factor to the epidemic of insulin resistant diabetes. The nonpharmacologic treatment of obesity with bariatric surgery results in a dramatic and almost instantaneous reversal of insulin resistance. The present review collectively addresses the evidence for ...
McDonough Caitrin W CW Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, College of Pharmacy, Gainesville, Florida 32610-0486, - - 2013
Single-nucleotide polymorphisms (SNPs) in NEDD4L may influence the ability of the NEDD4L protein to reduce epithelial sodium channel expression. A variant in NEDD4L, rs4149601, was associated with antihypertensive response and cardiovascular outcomes during treatment with thiazide diuretics and β-blockers in a Swedish population. We sought to further evaluate associations between ...
Wong Frances F Division of Genetics and Genomics, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United - - 2013
The precise control of gene expression is critical in embryonic development. Quantitative assays, such as microarrays and RNA sequencing, provide gene expression levels for a large number of genes, but do not contain spatial information. In contrast, in situ methods, such as in situ hybridization and immunohistochemistry, provide spatial resolution, ...
Khan Mohsin A F MA Department of Cell & Developmental Biology, University College London, London, United - - 2013
The discovery of cis-regulatory elements is a challenging problem in bioinformatics, owing to distal locations and context-specific roles of these elements in controlling gene regulation. Here we review the current bioinformatics methodologies and resources available for systematic discovery of cis-acting regulatory elements and conserved transcription factor binding sites in the ...
Lee Christopher S D CS Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, - - 2013
Recent endeavors to use stem cells as trophic factor production sources have the potential to translate into viable therapies for damaged or diseased musculoskeletal tissues. Adipose stem cells (ASCs) can be differentiated into chondrocytes using the chondrogenic medium (CM), but it is unknown if this approach can optimize ASC growth ...
Vidoni Sara S INSERM U1051, Institut des Neurosciences de Montpellier, Université de Montpellier I et II, Montpellier, - - 2013
The maintenance of mitochondrial genome integrity is a major challenge for cells to sustain energy production by respiration. Recently, mitochondrial membrane dynamics emerged as a key process contributing to prevent mitochondrial DNA (mtDNA) alterations. Indeed, both fundamental and clinical data suggest that disruption of mitochondrial fusion, related to mutations in ...
Hou Ya-Ming YM Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. - - 2013
Both transfer RNA (tRNA) and cytochrome c are essential molecules for the survival of cells. tRNA decodes mRNA codons into amino-acid-building blocks in protein in all organisms, whereas cytochrome c functions in the electron transport chain that powers ATP synthesis in mitochondrion-containing eukaryotes. Additionally, in vertebrates, cytochrome c that is ...
Zheng Songmao S Department of Pharmaceutics, University of Washington, Seattle, WA 98195-7610, - - 2013
Higher concentrations of AM19 and AM1c9, secondary metabolites of cyclosporine A (CsA), have been associated with nephrotoxicity in organ transplant patients. The risk of renal toxicity may depend on the accumulation of CsA and its metabolites in the renal tissue. We evaluated the hypothesis that CYP3A5 genotype, and inferred enzyme ...
Vollset Stein Emil SE Norwegian Institute of Public Health and Department of Public Health and Primary Health Care, University of Bergen, Bergen, - - 2013
Some countries fortify flour with folic acid to prevent neural tube defects but others do not, partly because of concerns about possible cancer risks. We aimed to assess any effects on site-specific cancer rates in the randomised trials of folic acid supplementation, at doses higher than those from fortification. In ...
Roman Heather B HB 1 Division of Nutritional Sciences, Cornell University , Ithaca, New - - 2013
To define the consequences of loss of cysteine dioxygenase (CDO) on cysteine metabolism at the tissue level, we determined levels of relevant metabolites and enzymes and evidence of H2S/HS(-) (gaseous hydrogen sulfide and its conjugate base) toxicity in liver, pancreas, kidney, and lung of CDO(-/-) mice that were fed either ...
Petsche Connell Jennifer J Department of Bioengineering, Rice University, Houston, Texas 77005, - - 2013
Recent research has demonstrated that a population of stem cells can be isolated from amniotic fluid removed by amniocentesis that are broadly multipotent and nontumorogenic. These amniotic fluid-derived stem cells (AFSC) could potentially provide an autologous cell source for treatment of congenital defects identified during gestation, particularly cardiovascular defects. In ...
Östgren C J CJ Department of Medical and Health Sciences, Linköping University, Linköping, - - 2013
To explore the association of HbA1c and educational level with risk of cardiovascular events and mortality in patients with Type 2 diabetes. A cohort of 32 871 patients with Type 2 diabetes aged 35 years and older identified by extracting data from electronic patient records for all patients who had ...
Ehsan Seema M SM Department of Chemical Engineering and Materials Science, University of California, Irvine, California 92697-2715, - - 2013
Engineered tissue constructs are limited in size, and thus clinical relevance, when diffusion is the primary mode of oxygen transport. Understanding the extent of oxygen diffusion and cellular consumption is necessary for the design of engineered tissues, particularly those intended for implantation into hypoxic wound sites. This study presents a ...
Chang J J University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, SA, - - 2013
To evaluate the prognosis of diabetic gastroparesis. Eighty-six patients with diabetes had measurements of gastric emptying of a mixed meal using a dual isotope test of solid and liquid meal components, mean blood glucose levels, HbA1c , upper gastrointestinal symptoms and autonomic nerve function performed in 1984-1989. These patients were ...
Lee Guinevere Q GQ BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, - - 2013
HIV-1 tropism can be predicted using V3 genotypic algorithms. The performance of these prediction algorithms for non-B subtypes is poorly characterized. Here, we use these genotypic algorithms to predict viral tropism of HIV-1 subtype A, B, C, and D to find apparent sensitivity, specificity, and concordance against a recombinant phenotypic ...
Corbett Chris - - 2013
Variceal bleeding has a 6-week mortality of 20%. Recent evidence suggests that early covered transjugular intrahepatic portosystemic stent shunts (TIPSS) can improve outcomes following a variceal bleed in selected patients. We aim to assess the outcomes following the insertion of covered TIPSS in a real-life intensive care setting. This is ...
Berkenstadt Haim - - 2013
Simulation-based medical education (SBME) offers a safe and "mistake-forgiving" environment to teach and train medical professionals. The diverse range of medical-simulation modalities enables trainees to acquire and practice an array of tasks and skills. SBME offers the field of trauma training multiple opportunities to enhance the effectiveness of the education ...
Zallot Camille - - 2013
Inflammatory bowel diseases (IBD) are chronic and disabling conditions. Accumulating evidence indicates that we need to look beyond clinical symptoms as current therapeutic strategies have not modified the course of IBD. Therapeutic goals for IBD have evolved from a mere control of symptoms to mucosal healing (MH). Achieving deep remission ...
Freeman Jonathan B - - 2013
Social categorization is often thought to be based on facial features and immune to visual context. Moreover, East Asians have been argued to attend to context more than Westerners. American and Chinese participants were presented with faces varying along a White-Asian morph continuum either in American, neutral, or Chinese contexts. ...
Young Andy M - - 2013
Answers to common nuclear medicine radiation safety questions often involve the consideration of dose rates from injected patients and the inverse square law. For staff, lead aprons are available as an option, although they are not routinely used and their effectiveness varies depending on the isotope. New tests and procedures ...
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