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Results 351 - 400 of 4464
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Chave Jérôme - - 2013
Over the past 20 years, major advances have clarified how ecological patterns inform theory, and how in turn theory informs applied ecology. Also, there has been an increased recognition that the problem of scale at which ecological processes should be considered is critical if we are to produce general predictions. Ecological ...
Airan Raag D RD Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, - - 2013
Advances in molecular biology in the early 1970s revolutionized research strategies for the study of complex biological processes, which, in turn, created a high demand for new means to visualize these dynamic biological changes noninvasively and in real time. In this respect, MRI was a perfect fit, because of the ...
Jamilloux Yvan - - 2013
Microglial cells constitute the first line of defense of the central nervous system (CNS) against microbial invasion. Pathogens are detected thanks to an array of innate immune receptors termed pattern recognition receptors (PRRs). PRRs have been thoroughly characterized in bone marrow-derived macrophages, but the PRRs repertoire and functionality in microglial ...
Watkins H A - - 2013
BACKGROUND AND PURPOSE: Adrenomedullin (AM) is a peptide hormone whose receptors are members of the class B G protein-coupled receptor (GPCR) family. They comprise a heteromer between the GPCR, the calcitonin receptor-like receptor (CLR) and one of the receptor activity-modifying proteins (RAMPs) 1-3. AM plays a significant role in angiogenesis ...
Fujimoto Chisato - - 2013
Abstract Conclusions: Foam posturography reveals that idiopathic bilateral vestibulopathy (IBV) significantly affects postural stability. Instability was more severe in patients with damage to both of the vestibular nerve systems. Residual function in the spared vestibular nerve system might contribute to postural stability in IBV. Objective: Postural stability was assessed using ...
Stark C - - 2013
Rural Scotland has an ageing population. There has been an increase in the number of people with dementia and as the proportion of people aged over 75 years continues to rise, this will increase still further. The Scottish Government has produced a dementia strategy and implementing this will be a ...
Schacter Daniel L - - 2013
A recent decision in the United States by the New Jersey Supreme Court has led to improved jury instructions that incorporate psychological research showing that memory does not operate like a video recording. Here we consider how cognitive neuroscience could contribute to addressing memory in the courtroom. We discuss conditions ...
Sonntag Diana - - 2013
The International AIDS Vaccine Initiative recommends targeting resources to research institutions in developing countries in order to accelerate the development of an effective HIV vaccine. In contrast, this paper shows that neither lump-sum nor in-kind transfers are an effective policy. We analyze several financing mechanisms as a means to overcome ...
Grosset K A - - 2013
BACKGROUND AND PURPOSE: In this first study of inhaled apomorphine (VR040) in patients with Parkinson's disease, the primary objective was to find the minimum efficacious dose of apomorphine that was useful in rescuing patients during 'off' periods. Safety, tolerability and pharmacokinetics of inhaled apomorphine were assessed during the study. METHODS: ...
de Oliveira Mota Mânlio Tasso - - 2013
Two cases of patients with high-risk human papillomavirus-related squamous cell carcinomas of the penis are reported. In both patients, a second high-risk human papillomavirus-related squamous cell carcinoma, of the same type (genotype 16), was detected: a carcinoma of the oropharynx 2 years after treatment of the squamous cell carcinomas of ...
Wu Dahai - - 2013
Abstract Conclusions: The lingua/pharynx (L/P) ratio has high sensitivity and specificity in predicting the severity of retroglossal obstruction in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Objective: To evaluate the diagnostic value of the L/P ratio in predicting the severity of retroglossal obstruction in patients with OSAHS. Methods: Airway ...
Gilboa Yinon - - 2013
Objectives: To evaluate the clinical significance of the head progression distance (HPD), measured by trans- perineal ultrasound, during prolonged second stage of labor. Methods: This is a prospective study of women, at 37 or more weeks of gestation, with failure to progress in the second stage of labor. Trans-perineal ultrasound ...
Aschebrook-Kilfoy Briseis - - 2013
Abstract Although an increased incidence of mantle cell lymphoma (MCL) has been reported, age-specific incidence patterns have not been described. Further analyses could inform investigation into the etiology of this disease. We conducted an epidemiologic study using the 13 SEER registries to evaluate MCL incidence from 1992 through 2009. We ...
Heymann Julia - - 2013
Chlamydiae are obligate intracellular bacterial pathogens that cause trachoma, sexually transmitted diseases and respiratory infections in humans. Fragmentation of the host cell Golgi apparatus (GA) is essential for chlamydial development, whereas the consequences for host cell functions, including cell migration are not well understood. We could show that Chlamydia trachomatis-infected ...
Larkum Matthew E - - 2013
Distinct populations of layer 1 inhibitory neurons inhibit or disinhibit layer 5 pyramidal cells. A massive patch-clamp recording effort, tapping up to eight cells simultaneously, maps their influences on the cortical network.
Farzinpour Pouyan - - 2013
A substrate-based templated assembly route has been devised which offers large-area, high-throughput capabilities for the fabrication of periodic arrays of sub-micrometer and nanometer-scale structures. The approach overcomes a significant technological barrier to the widespread use of substrate-based templated assembly by eliminating the need for periodic templates having nanoscale features. Instead, ...
Hofmeyr Lou - - 2013
BACKGROUND.: Multiple muscular ventricular septal defects (VSDs) in children can be difficult to treat and a range of techniques has been advocated. These include pulmonary artery banding, interventional catheter closure, and a variety of surgical approaches. When there are apical muscular defects and associated coarse trabeculations in the right ventricle ...
Bijelic Jasmina - - 2013
Abstract Objective. To evaluate the static-load-bearing capacity of severely damaged endodontically-treated incisors restored with short fiber composite (SFC) as a direct post-core-crown complex and to investigate the effect of SFC on the failure mode of the restorations. Materials and methods. The clinical crowns of 40 maxillary incisors were prepared by ...
Melamed Nir - - 2013
Abstract OBJECTIVE: To determine whether a low GCT result is predictive of low birthweight and to identify the lower GCT threshold for prediction of fetal growth restriction. METHODS: A retrospective cohort study of 12,899 women who underwent a GCT (24 to 28 weeks). Women with a low GCT result (<10(th) ...
Ludwig A - - 2013
The White Park Cattle (WPC) is an indigenous ancient breed from the British Isles which has a long-standing history in heroic sagas and documents. The WPC has retained many primitive traits, especially in their grazing behaviour and preferences. Altogether, the aura of this breed has led to much speculation surrounding ...
Gascón Cristina - - 2013
Abstract Conclusion: A reduction in the percentage of correct responses in the olfactory test indirectly indicated increased albuminuria and worse glomerular filtration rate (GFR) in diabetic patients. The olfactory function test is an indirect indicator of early microvascular complications in diabetic patients. Objectives: Diabetes mellitus is a highly prevalent disease ...
Meng Luyan - - 2013
Two guanosine analogues have been designed and synthesized by connecting one () or three adamantane branches (). The compound containing a single adamantane branch formed G-quartets in acetonitrile solution, and was then transformed into a G-ribbon gel at concentrations higher than the critical gelation concentration. In contrast, the compound with ...
Schiehser Dawn M - - 2013
Parkinson's disease (PD) patient and caregiver reports of patient functioning are often used interchangeably in clinical and research settings; however, the consistency of these reports is largely unknown. This study aimed to investigate the consistency and predictors of discrepancy between self- and caregiver reports of patient apathy, disinhibition, and executive ...
Duszynski Robert J RJ Department of Biological Sciences, DePaul University, Chicago, IL 60614, - - 2013
The zebrafish maxillary barbel is an integumentary organ containing skin, glands, pigment cells, taste buds, nerves, and endothelial vessels. The maxillary barbel can regenerate (LeClair & Topczewski 2010); however, little is known about its molecular regulation. We have studied fibroblast growth factor (FGF) pathway molecules during barbel regeneration, comparing this ...
Leikam C - - 2013
The development of malignant melanoma is a highly complex process, which is still poorly understood. A majority of human melanomas are found to express a few oncogenic proteins, such as mutant RAS and BRAF variants. However, these oncogenes are also found in nevi, and it is now a well-accepted fact ...
Aydın Gökay - - 2013
The efficient synthesis of gala-, epi-, neo-, and muco-quercitols and some brominated quercitols starting from cyclohexa-1,4-diene is reported. Treatment of the dibromide, obtained by the addition of bromine to cyclohexa-1,4-diene, with m-chloroperbenzoic acid (m-CPBA) yielded the dibromoepoxide, which was successfully converted to the desired dibromodiol by treatment with sulfuric acid. ...
Zucchi Alessandro - - 2013
The surgical techniques used by Austoni and Egydio in the treatment of Peyronie's disease are based on geometric principles. The aim of this paper is to report our multicentric experience and technical changes to Austoni's original technique, focusing on several tips and tricks to make this technique easy to perform, ...
Ferwana M - - 2013
OBJECTIVE: Pioglitazone, a thiazolidinedione, was approved for treatment of Type 2 diabetes. However, several observational studies suggest an association of pioglitazone with an increased risk of bladder cancer in patients with diabetes. Therefore, we sought to perform a systematic review and meta-analysis to evaluate the magnitude of this association and the ...
Jones Mitchell L - - 2013
Cardiovascular diseases (CVD) are the leading cause of global mortality and morbidity. Current CVD treatment methods include dietary intervention, statins, fibrates, niacin, cholesterol absorption inhibitors, and bile acid sequestrants. These formulations have limitations and, thus, additional treatment modalities are needed. Probiotic bacteria, especially bile salt hydrolase (BSH)-active probiotic bacteria, have ...
Shiffman C A CA Department of Physics, Northeastern University, Boston, MA, USA. - - 2013
Multifrequency electrical impedance myography (MFEIM) in the 3-300 kHz range was applied to 68 subjects representing 19 different neuromuscular diseases, and the impedances analyzed using the 5-element circuit model. Depending on severity, the 'cellular' parameters r(2), r(3), 1/c(1) and 1/c(2) were found to be as much as 10- to 20-fold ...
Mullan Barbara - - 2013
Consumption of saturated fat (SF) is associated with obesity, cardiovascular disease and cancer; which are among the leading causes of death in Australia and worldwide. A causal relationship between subjective well-being and positive health outcomes has been established, although few studies have specifically focused on health-enhancing or health-risk behaviours. The ...
Jeon Hee-Yeon - - 2013
Aurora-A is a serine/threonine mitotic kinase that is required for centrosome maturation. Many cancer cells overexpress Aurora-A, and several reports have suggested that Aurora-A has prognostic value in the clinical treatment of cancer. Therefore, inhibitors for Aurora-A kinase have been developed. However, studies on Aurora-A are largely done in cancer ...
Marques Igor D B - - 2013
BACKGROUND: Among kidney transplant recipients (KTRs), tuberculosis is one of the most common opportunistic infections and is associated with high morbidity and mortality. The aim of this study was to describe the incidence, clinical features, and prognosis of tuberculosis in KTRs. METHODS: Retrospective single-center observational study involving all cases of ...
Sheng Shijun - - 2013
In this report, a graphene/poly(ethylene-co-vinyl acetate) composite electrode was fabricated by melt compounding for the amperometric detection of capillary electrophoresis. The composite electrode was fabricated by packing a mixture of graphene and melted poly(ethylene-co-vinyl acetate) in a piece of fused silica capillary under heat. The structure of the composite was ...
Heneghan Cara - - 2013
Background Reflective practice groups have been recommended for improving staff wellbeing and team functioning in inpatient psychiatric services, and clinical psychologists have been identified as potential leaders in this type of work. Research is limited with little information about reflective practice group guidelines, prevalence and effectiveness. Aims The aims of ...
Shoham Yaron - - 2013
Abstract We describe a 53-year-old woman who had a huge pleomorphic liposarcoma of the left breast. She had a left Halstead mastectomy, which left a huge defect in the chest wall. We did an immediate reconstruction of the chest wall with combined latissimuss dorsi musculocutaneous (for the upper half of ...
Eriste Elo - - 2013
Gliomas are therapeutically challenging cancers with poor patient prognosis. New drug delivery strategies are needed to achieve more efficient chemotherapy-based approach against brain tumors. The current paper demonstrates development of a tumor-targeted delivery vector that is based on a cell-penetrating peptide pVEC and a novel glioma-targeting peptide sequence gHo. The ...
Hou Hui - - 2013
We present a new method for specific detection of oxytetracycline (OTC) at nanomolar concentrations based on a microfabricated cantilever array. The sensing cantilevers in the array are functionalized with self-assembled monolayers (SAMs) of OTC-specific aptamer, which acts as a recognition molecule for OTC. While the reference cantilevers in the array ...
Guzman Marco - - 2013
This study sought to measure any acoustic changes in the speaking voice immediately after phonation exercises involving plastic straws versus phonation exercises with the open vowel /a/. Forty-one primary school teachers with slightly dysphonic voices were asked to participate in four phonatory tasks. Phonetically balanced text at habitual intensity level ...
Kielhorn Caitlin E - - 2013
When a marine mammal dives, breathing and locomotion are mechanically uncoupled, and its locomotor muscle must power swimming when oxygen is limited. The morphology of that muscle provides insight into both its oxygen storage capacity and its rate of oxygen consumption. This study investigated the m. longissimus dorsi, an epaxial ...
Onoue Satomi - - 2013
The generation of reactive oxygen species (ROS) from an ultraviolet (UV)-exposed chemical can be an experimental indicator of phototoxic potential. The aim of the present study was to develop a new ROS assay using serum albumin to provide photosafety assessment under experimental biomimetic conditions. To assess assay robustness, a validation ...
Gariepy G - - 2013
We would like to thank Dr Kawada for his thoughtful comments on our studies. In his letter, Dr Kawada first highlights the potential contribution of age in the association between depression and self-rated health in people with diabetes. Specifically, he suggests that the association between depression and self-rated health may ...
Chen Liang-Yih - - 2013
In this study, ZnO nanoparticles (ZnO NPs) were conformally covered on the surfaces of ZnO nanowires (ZnO NWs) with high diffusion coefficient (1.2 × 10(-2) cm(2) s(-1)) to make a composite photoanode. By using N719 to sensitize the composite photoanode, the conversion efficiency can reach 7.14%.
Jeong Hyeonju - - 2013
This study is based on the theory of reasoned action and self-efficacy, and it examines the mediating role of attitude, subjective norm, and self-efficacy between parasocial interaction and the intention to donate organs. Judgment sampling was used and 329 respondents were participated in the survey. Participants consisted of 102 males ...
Rhodes Lesley E - - 2013
Green tea catechins (GTC) reduce UV radiation (UVR)-induced inflammation in experimental models, but human studies are scarce and their cutaneous bioavailability and mechanism of photoprotection are unknown. We aimed to examine oral GTC cutaneous uptake, ability to protect human skin against erythema induced by a UVR dose range and impact ...
Stawarczyk B - - 2013
Abstract Objectives. The aims of this study were to test whether the bond strength of a hybrid composite and a PMMA-based veneer to CAD/CAM polymers would improve after pre-treatment and to evaluate the failure types after debonding. Materials and methods. Three types of PMMA-based (CAD-Temp, artBloc Temp and TelioCAD) CAD/CAM ...
De Deyn Peter Paul - - 2013
Psychosis is a common and difficult to treat symptom in Alzheimer's disease (AD). It is a cause of diminished quality of life and caregiver distress. Atypical antipsychotics are frequently used for the treatment of dementia-related psychosis, despite FDA warnings because of increased mortality associated with the use of these medications ...
Ye Qiong - - 2013
Obesity is associated with insulin resistance (IR) and hepatosteatosis. Understanding the link between IR and hepatosteatosis could be relevant to chronic clinical outcomes. The objective of this study was to quantitatively assess lipid deposition (fractional lipid mass, fLM) and composition (fraction of polyunsaturated lipids, fPUL and mean chain length, MCL) ...
Ginn Samantha L - - 2013
To date, over 1800 gene therapy clinical trials have been completed, are ongoing or have been approved worldwide. Our database brings together global information on gene therapy clinical trials from official agency sources, published literature, conference presentations and posters kindly provided to us by individual investigators or trial sponsors. This ...
Qin Guo-Dong - - 2013
The combination of levofloxacin and α(1) adrenergic antagonist treatment is the current preferred choice for both bacterial and non-bacterial prostatitis. The aim of this study is to explore the influence of α(1) adrenergic antagonists on the pharmacokinetics of levofloxacin using rat models with acute bacterial prostatitis (ABP) induced by direct ...
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