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Grimster Neil P NP Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, - - 2013
Molecules that bind selectively to a given protein and then undergo a rapid chemoselective reaction to form a covalent conjugate have utility in drug development. Herein a library of 1,3,4-oxadiazoles substituted at the 2 position with an aryl sulfonyl fluoride and at the 5 position with a substituted aryl known ...
Martinez Gloria - - 2013
The HOPO vinyl sulfonamide 3 and the corresponding HOPO acrylamide 10, were easily prepared by short synthetic sequences. Investigation of the aza-Michael reactions of these linkers showed that they proceed at a higher rate in solvent systems containing water. The scope and limits of the aza-Michael reactions of 3 and ...
Hiser Carrie C Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, United - - 2013
A conserved, crystallographically defined bile acid binding site was originally identified in the membrane domain of mammalian and bacterial cytochrome c oxidase (CcO). Current studies show other amphipathic molecules including detergents, fatty acids, steroids, and porphyrins bind to this site and affect the already 50% inhibited activity of the E101A ...
Vincent Catherine E CE Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United - - 2013
Label-free quantification is a powerful tool for the measurement of protein abundances by mass spectrometric methods. To maximize quantifiable identifications, MS(1)-based methods must balance the collection of survey scans and fragmentation spectra while maintaining reproducible extracted ion chromatograms (XIC). Here we present a method which increases the depth of proteome ...
Egli Martin M Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232, USA. - - 2013
The Synechococcus elongatus KaiA, KaiB, and KaiC proteins in the presence of ATP generate a post-translational oscillator that runs in a temperature-compensated manner with a period of 24 h. KaiA dimer stimulates phosphorylation of KaiC hexamer at two sites per subunit, T432 and S431, and KaiB dimers antagonize KaiA action ...
Houston Douglas R DR Institute of Structural and Molecular Biology, University of Edinburgh, Edinburgh, United Kingdom. - - 2013
Structure-based virtual screening relies on scoring the predicted binding modes of compounds docked into the target. Because the accuracy of this scoring relies on the accuracy of the docking, methods that increase docking accuracy are valuable. Here, we present a relatively straightforward method for improving the probability of identifying accurately ...
Atkins Tonya M TM Department of Chemistry, University of California, Davis, California 95616, - - 2013
We describe the synthesis, materials characterization, and dynamic nuclear polarization (DNP) of amorphous and crystalline silicon nanoparticles for use as hyperpolarized magnetic resonance imaging (MRI) agents. The particles were synthesized by means of a metathesis reaction between sodium silicide (Na₄Si₄) and silicon tetrachloride (SiCl₄) and were surface functionalized with a ...
Han Chao C Electrical Engineering, California Institute of Technology, Pasadena, California 91125, United States. - - 2013
Time-lapse or longitudinal fluorescence microscopy is broadly used in cell biology. However, current available time-lapse fluorescence microscopy systems are bulky and costly. The limited field-of-view (FOV) associated with the microscope objective necessitates mechanical scanning if a larger FOV is required. Here we demonstrate a wide FOV time-lapse fluorescence self-imaging Petri ...
Kamens H M HM Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, - - 2013
Nicotine binds to nicotinic acetylcholine receptors and studies in animal models have shown that α4β2 receptors mediate many behavioral effects of nicotine. Human genetics studies have provided support that variation in the gene that codes for the α4 subunit influences nicotine dependence (ND), but the evidence for the involvement of ...
Korala Lasantha L Department of Chemistry, Wayne State University, Detroit, Michigan 48202, - - 2013
Optoelectronic properties of quantum dot (QD) films are limited by (1) poor interfacial chemistry and (2) nonradiative recombination due to surface traps. To address these performance issues, sol-gel methods are applied to fabricate thin films of CdSe and core(shell) CdSe(ZnS) QDs. High-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM) imaging ...
Wu Jeffrey - - 2013
Immunohistochemical expression of napsin A in primary pulmonary mucinous tumors is not well established. Napsin A immunoreactivity was evaluated in 43 mucin-producing adenocarcinomas of the lung consisting of 18 tumors formerly classified as mucinous bronchioloalveolar carcinoma, 15 colloid adenocarcinomas, 5 solid predominant adenocarcinomas with mucin production, and 5 adenocarcinomas with ...
Kazama Junichiro James - - 2013
Complication of osteopenia and vascular calcification are often observed among elderly, diabetes, or chronic kidney disease patients. It remains obscure whether these two conditions merely share common risk factors or they have clear cause-result relationship. So called Moenckeberg type vascular calcification is classified into vascular ossification from the perspective of ...
Pourtova Elena - - 2013
Nostalgia for the Soviet Union is a major social phenomenon in Russia today due to the irrevocable losses of the recent past in which Soviet citizens involuntarily became immigrants in their own country. With reference to discussions of nostalgia in philosophical and psychoanalytic literature, I suggest that nostalgia may represent ...
Wolniak Kristy L - - 2013
Clonal expansions of large granular lymphocytes (LGLs) have been identified in patients following stem cell transplants and may represent posttransplant LGL leukemias or reactive immune responses. To differentiate between these 2 possibilities, we assessed peripheral blood and bone marrow of patients with myeloma after autologous stem cell transplant. All patients ...
Liu Shen - - 2013
Limited forearm rotation is a frequent combined disorder in elbow stiffness. If the radial head cannot be saved during open arthrolysis, prosthetic replacement might be considered because it enhances stability and allows early motion. In this study we retrospectively analyzed the outcome of 8 patients (7 men, 1 woman) who ...
Bailey-Davis Lisa - - 2013
Universal free access to school breakfast is available in large urban schools, but participation rates are less than half of what they are at lunch. The purpose of this qualitative study was to understand the discrepancy between access and participation in school breakfast in a low-income, urban school district. Youth ...
Castro-Núñez Jaime - - 2013
Maxillary and mandibular bone defects can result from injury, congenital defect, or accident, or as a consequence of surgical procedures when treating pathology or defects affecting jaw bones. The glandular odontogenic cyst is an infrequent type of odontogenic cyst that can leave a bony defect after being treated by aggressive ...
Takeda Shu - - 2013
The discovery that leptin regulates bone formation through the central nervous system shed light on a new regulatory system of bone metabolism, i.e., neuronal control. Of note, sympathetic nervous system and parasympathetic nervous system are intimately involved in bone remodeling separately and also in a coordinated manner. Moreover, orexigenic and ...
Murphy Kieran - - 2013
To review the medical literature for reports on the types of physical injuries in elder abuse with the aim of eliciting patterns that will aid its detection. The databases of PubMed, CINAHL, EMBASE, and TRIP were searched from 1975 to March 2012 for articles that contained the following phrases: "physical ...
Kuo Li-Na - - 2013
Objective: The safety and efficacy of warfarin therapeutic range in Asians remain to be ascertained. Physicians in Taiwan consider Asians are more likely to have bleeding complications rather than thromboembolic events from warfarin. The aim of this study was to determine if the proper INR range for patients in Taiwan ...
West Marcus - - 2013
This paper focuses on the transference-countertransference dynamics that manifest in work with those individuals who experienced severe early relational trauma and, in particular, childhood sexual abuse. The literature is surveyed from Davies and Frawley's (1992a) seminal paper through to more current trauma-related and sensorimotor approaches, which deepen our understanding greatly. ...
Sahoo Nanda Kishore - - 2013
The aim of this retrospective study was to evaluate the increase in height and change in position of neo-articular tubercle in cases treated by Dautrey's procedure. 10 cases of Tempromandibular joint (TMJ) disorders satisfying the inclusion criteria were included in this study, out of which 8 had bilateral chronic recurrent ...
Sándor George K - - 2013
This report describes the management of the case of an 11-year-old girl with serious compressive pathology of the craniocervical junction using a navigation-guided Le Fort I level maxillotomy and midline split. In this pediatric case, image guidance significantly enhanced intraoperative orientation and helped to determine the correct location of the ...
Kido Aki - - 2013
Conventional magnetic resonance imaging (MRI) such as T1-weighted and T2-weighted images of the female pelvis provide morphological information with excellent tissue contrast, which reflects the pathology of malignant diseases of the uterus. Owing to the recent improvement in hardware and software, in combination with extensive research in imaging techniques, not ...
Aranha Karen M - - 2013
Guided by Bourdieu's theory of practice and symbolic violence, this qualitative study explored experiences and perceptions of elderly beneficiaries who had been denied rehabilitation services by Medicare. In semistructured interviews, 12 beneficiaries or family members told of the physical, psychological, and financial consequences of service denial/termination. The resulting perception of ...
Hara Shingo - - 2013
The Le Fort II midfacial advancement appears to be an effective surgical method for the treatment of severe midfacial-nose hypoplasia with a skeletal class III malocclusion, which is usually combined with syndromic midfacial anomalies. However, the conventional surgical method requires the coronal approach, including a coronal incision, together with other ...
Hirai Toyohiro - - 2013
In the relationship between pulmonary diseases and bone, the systemic effects of pulmonary disease on bone metabolism, such as osteoporosis in COPD, have been recently investigated as well as abnormal bone metabolism induced by the therapy for lung diseases such as glucocorticoid-induced osteoporosis. However, the effective strategy for risk assessment, ...
Briefel Ronette R - - 2013
Because childhood obesity is such a threat to the physical, mental, and social health of youth, there is a great need to identify effective strategies to reduce its prevalence. The objective of this study was to estimate the mean calories from added sugars that are saved by switching sugar-sweetened beverages ...
Thompson Elaine Adams - - 2013
Effective prevention requires understanding vulnerable populations, early signs of health risks, and the impact of social contexts. We tested a model of co-occurring mental health risks among at-risk youth experiencing school difficulties. We analyzed data from a random sample of 336 at-risk youth, grades 9-12, who completed a comprehensive risk/protective ...
Harel Noga - - 2013
The aim of this 10 year retrospective study was to evaluate the crestal bone loss around immediate implant placed in tricalcium phosphate (TCP) grafted extraction sockets Data were collected from files of 58 patients (33 females, 25 males, average age 54.78 years) undergoing immediate implant placement into fresh extraction socket ...
Feldman David - - 2013
CO-CHAIRS: Feldman D: Minneapolis Heart Institute, Minneapolis, Minnesota, Georgia Institute of Technology and Morehouse School of Medicine; Pamboukian SV: University of Alabama at Birmingham, Birmingham, Alabama; Teuteberg JJ: University of Pittsburgh, Pittsburgh, Pennsylvania TASK FORCE CHAIRS: Birks E: University of Louisville, Louisville, Kentucky; Lietz K: Loyola University, Chicago, Maywood, Illinois; ...
Tabrizi Reza - - 2013
The aim of this study was to evaluate the relation between angulated implants and the bone loss around implants in the anterior maxilla. The subjects studied had a missing tooth in the anterior maxilla and a bone deficiency that required restoration with an angulated dental implant. After mounting the casts ...
Jaberi Joby - - 2013
The goal of secondary cranioplasty is permanent cerebral protection in an esthetically acceptable fashion. Reconstruction of cranial defects can be performed with several different materials. Alloplastic materials, such as preformed methyl-methacrylate (PMMA) cranioplasties, are an alternative frequently used at our institution. This retrospective analysis was designed to review the outcomes ...
Imai Yuuki - - 2013
Based on the progress of researches in bone biology field, it has been clarified that bone metabolism can be regulated by complex network between various tissues and organs. Among them, sex steroid hormones, including estrogen and androgen, are known as one of the players in bone metabolism. Sex steroid hormones ...
Germain Lucie - - 2013
We aimed to estimate, in a large French cohort of middle-aged adults derived from the Supplémentation en Vitamines et Minéraux Antioxydants trial, the association of compliance with the guidelines of the French Nutrition and Health Program (PNNS) assessed at inclusion and change in health-related quality of life (HRQoL) over 12 ...
Yama Megumi - - 2013
With globalization, modern Western consciousness has spread across the world. This influx has affected the Japanese culture but ego consciousness has emerged through a long history and different course from that of the West. At a personal level, I have been interested in the establishment of a subject in a ...
Shinohara Takaaki - - 2013
To give a detailed clinical outcome analysis of a consecutive series of patients treated arthroscopically for traumatic triangular fibrocartilage complex (TFCC) foveal tears. This study was a consecutive case series of 11 patients who underwent arthroscopically assisted repair for traumatic TFCC foveal lesions. The mean age at the time of ...
Gray Terri A - - 2013
As a part of the surgical process, patients are screened in the preanesthesia services department before surgery. Often phone messages are left in English. The nurses will continue to make multiple calls trying to reach patients. As the patient population continues to diversify, problems in contacting patients have been noted. ...
Suzuki Mari Hotta - - 2013
Osteoporosis associated with anorexia nervosa (AN) is common, and tends to be severe, slow to recover from, and sometimes irreversible. The abnormal bone metabolism in severely emaciated AN patients involves both a reduction in bone formation and an increase in bone resorption. The annual change in lumbar bone mineral density ...
Leschik Johannes J - - 2013
The analytical performance and the clinical utility of a thyrotropin receptor (TSHR)-stimulating immunoglobulin (TSI) bioassay were compared with those of a TSHR-binding inhibitory immunoglobulin (TBII) assay. Limits of detection (LoD) and quantitation (LoQ), assay cutoff, and the half-maximal effective concentration (EC(50)) were measured. Dilution analysis was performed in sera of ...
Liu Jinyu - - 2013
Nationally representative data from a sample (n = 928) of full-time nursing home social services directors were used to investigate whether knowing characteristics of the social environment at work can help to explain which directors report job thriving. Two-thirds of directors reported they were thriving in their jobs. Multiple regression results show ...
Tanaka Yoshiya - - 2013
Glucocorticoid (GC) is widely used to treat a variety of inflammatory and allergic diseases and about one million people in Japan are known to take oral GC. GC causes a number of significant side effects and among them osteoporosis and degenerative bone fracture are major complications of GC therapy. GC ...
Jockel Christopher R - - 2013
There are limited outcome studies describing floating elbow injuries. The purpose of this report is to describe patient outcomes after floating elbow injury using the American Shoulder and Elbow Surgeons (ASES) elbow assessment form. From 1994 to 2004, 19 patients were retrospectively identified at 3 Level I trauma centers and ...
Connolly Angela M - - 2013
Jung's contribution to the understanding of the relevance of psychology to alchemy has become increasingly invalidated by the ahistorical nature of his approach, just as his tendency to ignore the importance of cognitive aesthetics for an improved comprehension of the functions of alchemical images has prevented Jungians from further extending ...
Erkilet Gülsüm - - 2013
During screening of heart transplantation (HTx) candidates supported by ventricular assist devices (VADs) for plasma biomarkers we found that galectin-3 (Gal-3) was increased pre-operatively in patients who later died during VAD support. Therefore, we analyzed the predictive value of plasma Gal-3 in the context of other potential clinical risk factors ...
Rhyou In Hyeok - - 2013
The purpose of our study was to correlate the morphology of displaced radial head and neck (DRHN) fractures with associated ligament injuries and evaluate the outcomes of management of the torn ulnar collateral ligament (UCL). Twenty-nine surgically treated patients presenting with a DRHN fracture were classified using the Charalambous classification ...
Rose Nicholas E - - 2013
Chronic lateral epicondylitis remains a treatment challenge. Traditional surgical treatments for lateral epicondylitis involve variations of the classic Nirschl lateral release. Anatomic studies reveal that the posterior branch or branches of the posterior cutaneous nerve of the forearm consistently innervate the lateral humeral epicondyle. We undertook the present study to ...
Carabetta Melissa - - 2013
As surgical patients pass through the perianesthesia continuum, the nurses they encounter rarely have time to develop a nurse-patient relationship, or identify patient needs and concerns and pass this information along to other providers. In the preprocedural period of the care continuum, however, patients and their families often express information ...
Krusche-Mandl Irena - - 2013
To analyze the management of Seymour fractures (juxta-epiphyseal fractures of the terminal phalanx of the finger in conjunction with flexion deformity at the fracture site, laceration of the nail bed, and frequently ungual subluxation) and to determine clinical and radiographic results following operative or conservative treatment. Clinical and radiological results ...
Russell Rebecca Ann - - 2013
A lack of standardized nursing procedures regarding the management of patients receiving preoperative regional anesthesia in the perianesthesia setting raises a number of issues for perianesthesia nurses. In January 2010, Duke University Hospital's perianesthesia care unit implemented a regional anesthesia "block nurse" team in the preoperative holding area as a ...
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