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Berghoff Anna S - - 2013
Upon disease progression on trastuzumab-based therapy, patients with HER-2 positive metastatic breast cancer (MBC) may switch to lapatinib or continue on trastuzumab. We aimed to assess the impact of both strategies on overall survival (OS) in all patients treated for HER-2 positive MBC at the Medical University Vienna from 1999 ...
Kingma Boris R M - - 2013
Skin blood flow (SBF) is a key player in human thermoregulation during mild thermal challenges. Various numerical models of SBF regulation exist. However, none explicitly incorporates the neurophysiology of thermal reception. This study tested a new SBF model that is in line with experimental data on thermal reception and the ...
Fatmi Wided - - 2013
Diabetes mellitus is associated to a reduction of antioxidant defenses that leads to oxidative stress and complications in diabetic individuals. The present study was undertaken to investigate the effect of selenium on blood biochemical parameters, antioxidant enzyme activities, and tissue zinc levels in alloxan-induced diabetic rats fed a zinc-deficient diet. ...
Fadloun Anas - - 2013
How a more plastic chromatin state is maintained and reversed during development is unknown. Heterochromatin-mediated silencing of repetitive elements occurs in differentiated cells. Here, we used repetitive elements, including retrotransposons, as model loci to address how and when heterochromatin forms during development. RNA sequencing throughout early mouse embryogenesis revealed that ...
Talirz Leopold - - 2013
Atomically precise graphene nanoribbons (GNRs) can be obtained via thermally induced polymerization of suitable precursor molecules on a metal surface. This communication discusses the atomic structure found at the termini of armchair GNRs obtained via this bottom-up approach. The short zigzag edge at the termini of the GNRs under study ...
Quansah Joycelyn K - - 2013
The effect of thermal and ultrasonic treatment of cowpea proteins (CP) on amino acid composition, radical scavenging and reducing potential of hydrolysates (CPH) obtained from in vitro simulated gastrointestinal digestion of CP was evaluated. Hydrolysis of native and treated CP with gastrointestinal pepsin and pancreatin yielded CPH that displayed antioxidant ...
Yu Shimeng - - 2013
Neuromorphic computing is an emerging computing paradigm beyond the conventional digital von Neumann computation. An oxide-based resistive switching memory has been engineered to emulate synaptic devices. At the device level, the gradual resistance modulation has been characterized by hundreds of identical pulses, achieving a low energy consumption of less than ...
Han Dong-Wook - - 2013
Porous and coarse (5 ~ 10 μm) LiFePO4/C composites with excellent electrochemical performance were synthesized by a growth technology using nano-structured (100 ~ 200 nm) LiFePO4 as seed crystals for 2nd crystallization process. The porous and coarse LiFePO4/C presented high initial discharge capacity (~ 155 mA h g-1 at 0.1 ...
Murphy Grainne - - 2013
OBJECTIVE: We describe a new imaging sign, the "superior cleft sign", identified at both symphysography and MRI, which should be used as a marker of rectus abdominis/adductor longus attachment tearing. MATERIALS AND METHODS: A study population of 25 patients presenting with clinically suspected sportsman's hernia, who had undergone both symphysography ...
Wakim Linda M - - 2013
Infection with influenza virus results in the deposition of anti-influenza CD8(+) resident memory T cells (T(RM) cells) in the lung. As a consequence of their location in the lung mucosal tissue, these cells are exposed to cytopathic pathogens over the life of the organism and may themselves be susceptible to ...
Alex A F - - 2013
Resveratrol is a polyphenol with various properties. Oncological studies have shown an excellent anti-carcinogenic effect. Due to many overlaps between tumor-mediating signaling pathways and those which mediate neovascularization and proliferation in retinal diseases, this review intends to focus on studies about the application of resveratrol in diseases of the eye ...
Erken Martina - - 2013
Bacteria in the environment must survive predation from bacteriophage, heterotrophic protists, and predatory bacteria. This selective pressure has resulted in the evolution of a variety of defense mechanisms, which can also function as virulence factors. Here we discuss the potential dual function of some of the mechanisms, which protect against ...
Zhang Shu-Yu - - 2013
We report an efficient method for the alkylation of γ-C(sp3)-H bonds of picolinamide (PA)-protected aliphatic amine substrates with primary alkyl iodides via palladium catalysis. Ag2CO3 and dibenzyl phosphate (BnO)2PO2H are critical promoters of this reaction. These reactions provide a convenient and straightforward method for the preparation of high-value N-containing products ...
Lee Seung Goo - - 2013
The evaporation-induced self-alignment of semiconductor nanowires is achieved using wrinkled elastomeric templates. The wrinkled templates, which have a surface topography that can be tuned via changes in the mechanical strain, are used as both a template to align the nanowires and as a stamp to transfer the aligned nanowires to ...
Laborie Lene Bjerke - - 2013
OBJECTIVE: Normative references for radiographic measurements commonly used in the diagnosis of developmental dysplasia of the hip at skeletal maturity are incomplete. The present study therefore aimed to establish new gender-specific standards for measurements reflecting the acetabular morphology, namely Sharp's angle, the acetabular roof angle of Tönnis (AA) and the ...
Shulan Mollie - - 2013
Hospital readmission rate has been broadly accepted as a quality measure and cost driver. However, success in reducing readmissions has been elusive. In the US, almost 20 % of Medicare inpatients are rehospitalized within 30 days, which amounts to a cost of $17 billion. Given the skyrocketing healthcare cost, policymakers, researchers and ...
Tischer S - - 2013
The new human leukocyte antigen (HLA)-B*58:21 allele differs from B*58:01:01 by an amino acid exchange at codon 90.
Geifman Nophar - - 2013
Age is an important factor when considering phenotypic changes in health and disease. Currently, the use of age information in medicine is somewhat simplistic, with ages commonly being grouped into a small number of crude ranges reflecting the major stages of development and aging, such as childhood or adolescence. Here, ...
Zheng Weiqing - - 2013
Constant CO(x)-free H(2) production from the catalytic decomposition of ammonia could be achieved over a high surface area molybdenum carbide catalyst prepared by a temperature programmed reduction-carburization method. The fresh and used catalyst was characterized by N(2)-adsorption/desorption, powder X-ray diffraction, scanning and transmission electron microscopes and electron energy-loss spectroscopy at ...
Kolle Mathias - - 2013
The concentrically-layered photonic structure found in the tropical fruit Margaritaria nobilis serves as inspiration for photonic fibers with mechanically tunable band-gap. The fibers show the spectral filtering capabilities of a planar Bragg stack while the microscopic curvature decreases the strong directional chromaticity associated with flat multilayers. Elongation of the elastic ...
Li Haohong - - 2013
The amygdala is essential for fear learning and expression. The central amygdala (CeA), once viewed as a passive relay between the amygdala complex and downstream fear effectors, has emerged as an active participant in fear conditioning. However, the mechanism by which CeA contributes to the learning and expression of fear ...
Youn Je-In - - 2013
Two major populations of myeloid-derived suppressor cells (MDSCs), monocytic MDSCs (M-MDSCs) and polymorphonuclear MDSCs (PMN-MDSCs) regulate immune responses in cancer and other pathologic conditions. Under physiologic conditions, Ly6C(hi)Ly6G(-) inflammatory monocytes, which are the normal counterpart of M-MDSCs, differentiate into macrophages and dendritic cells. PMN-MDSCs are the predominant group of MDSCs ...
Chan Kannie W Y - - 2013
Biocompatible nanomaterials and hydrogels have become an important tool for improving cell-based therapies by promoting cell survival and protecting cell transplants from immune rejection. Although their potential benefit has been widely evaluated, at present it is not possible to determine, in vivo, if and how long cells remain viable following ...
Alamillo Christina M L - - 2013
This study aimed to assess the efficacy of first-trimester aneuploidy screening in a single clinical setting. Maternal age, nuchal translucency, and maternal serum levels of pregnancy-associated plasma protein A and free beta human chorionic gonadotrophin comprised first-trimester risk assessment for Down syndrome and trisomies 13/18. Means, screen positive rates, detection ...
Wirschell Maureen - - 2013
Primary ciliary dyskinesia (PCD) is characterized by dysfunction of respiratory cilia and sperm flagella and random determination of visceral asymmetry. Here, we identify the DRC1 subunit of the nexin-dynein regulatory complex (N-DRC), an axonemal structure critical for the regulation of dynein motors, and show that mutations in the gene encoding ...
Tao Yanmei Y Institute of Developmental and Regenerative Biology, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, - - 2013
Inhibitory neurons control the firing of glutamatergic neurons and synchronize brain activity. However, little is known about mechanisms of excitatory synapse formation in inhibitory neurons. Here we demonstrate that Erbin is specifically expressed in cortical inhibitory neurons. It localizes at excitatory synapses and regulates AMPA receptor (AMPAR) surface expression. Erbin ...
Twigg Stephen R F SR Clinical Genetics Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, - - 2013
The extracellular signal-related kinases 1 and 2 (ERK1/2) are key proteins mediating mitogen-activated protein kinase signaling downstream of RAS: phosphorylation of ERK1/2 leads to nuclear uptake and modulation of multiple targets. Here, we show that reduced dosage of ERF, which encodes an inhibitory ETS transcription factor directly bound by ERK1/2 ...
Huch Meritxell M Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, - - 2013
The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as small intestine and colon, stomach and hair follicles. A three-dimensional culture system allows long-term clonal expansion of single Lgr5(+) stem cells into transplantable organoids (budding cysts) that retain many characteristics ...
Eschenlohr A A Institut für Methoden und Instrumentierung der Forschung mit Synchrotronstrahlung, Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Berlin, - - 2013
Irradiating a ferromagnet with a femtosecond laser pulse is known to induce an ultrafast demagnetization within a few hundred femtoseconds. Here we demonstrate that direct laser irradiation is in fact not essential for ultrafast demagnetization, and that electron cascades caused by hot electron currents accomplish it very efficiently. We optically ...
Lomniczi Alejandro A Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA. - - 2013
The timing of puberty is controlled by many genes. The elements coordinating this process have not, however, been identified. Here we show that an epigenetic mechanism of transcriptional repression times the initiation of female puberty in rats. We identify silencers of the Polycomb group (PcG) as principal contributors to this ...
Radivojac Predrag P School of Informatics and Computing, Indiana University, Bloomington, Indiana, - - 2013
Automated annotation of protein function is challenging. As the number of sequenced genomes rapidly grows, the overwhelming majority of protein products can only be annotated computationally. If computational predictions are to be relied upon, it is crucial that the accuracy of these methods be high. Here we report the results ...
Kim Changsung C Del E. Webb Neuroscience, Aging & Stem Cell Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, - - 2013
Cellular reprogramming of somatic cells to patient-specific induced pluripotent stem cells (iPSCs) enables in vitro modelling of human genetic disorders for pathogenic investigations and therapeutic screens. However, using iPSC-derived cardiomyocytes (iPSC-CMs) to model an adult-onset heart disease remains challenging owing to the uncertainty regarding the ability of relatively immature iPSC-CMs ...
Weirauch Matthew T MT Banting and Best Department of Medical Research and Donnelly Centre, University of Toronto, Toronto, Ontario, - - 2013
Genomic analyses often involve scanning for potential transcription factor (TF) binding sites using models of the sequence specificity of DNA binding proteins. Many approaches have been developed to model and learn a protein's DNA-binding specificity, but these methods have not been systematically compared. Here we applied 26 such approaches to ...
DeMuth Peter C PC Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, - - 2013
DNA vaccines have many potential benefits but have failed to generate robust immune responses in humans. Recently, methods such as in vivo electroporation have demonstrated improved performance, but an optimal strategy for safe, reproducible, and pain-free DNA vaccination remains elusive. Here we report an approach for rapid implantation of vaccine-loaded ...
Chou Jonathan J Department of Anatomy, University of California, San Francisco, 94143-0452, - - 2013
Despite advances in our understanding of breast cancer, patients with metastatic disease have poor prognoses. GATA3 is a transcription factor that specifies and maintains mammary luminal epithelial cell fate, and its expression is lost in breast cancer, correlating with a worse prognosis in human patients. Here, we show that GATA3 ...
Januschke J J Institute for Research in Biomedicine (IRB-Barcelona), Baldiri Reixac 10, 08028 Barcelona, - - 2013
During interphase in Drosophila neuroblasts, the Centrobin (CNB)-positive daughter centriole retains pericentriolar material (PCM) and organizes an aster that is a key determinant of the orientation of cell division. Here we show that daughter centrioles depleted of CNB cannot fulfil this function whereas mother centrioles that carry ectopic CNB can. ...
Nakayama Masanori M Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Muenster, Faculty of Medicine, D-48149 Muenster, Germany. - - 2013
Activities as diverse as migration, proliferation and patterning occur simultaneously and in a coordinated fashion during tissue morphogenesis. In the growing vasculature, the formation of motile, invasive and filopodia-carrying endothelial sprouts is balanced with the stabilization of blood-transporting vessels. Here, we show that sprouting endothelial cells in the retina have ...
LeBleu Valerie S VS Department of Medicine, Beth Israel Deaconess Medical Center, Division of Matrix Biology, Boston, Massachusetts, - - 2013
The functional contribution of myofibroblasts in fibrosis is not well understood. Using a new genetic mouse model to track and isolate myofibroblasts, we performed gene expression profiling followed by biological validation to identify HE4 (encoding human epididymis protein 4, also known as WAP 4-disulfide core domain-2 or Wfdc2) as the ...
Watrous Andrew J AJ Neuroscience Graduate Group, University of California, Davis, California, - - 2013
The medial temporal lobes, prefrontal cortex and parts of parietal cortex form the neural underpinnings of episodic memory, which includes remembering both where and when an event occurred. However, the manner in which these three regions interact during retrieval of spatial and temporal context remains untested. We employed simultaneous electrocorticographical ...
Israni Ajay K AK Nephrology Division, Department of Medicine, Hennepin County Medical Center, University of Minnesota, Minneapolis, MN 55415-1829, USA. - - 2013
Chronic allograft dysfunction (CGD) is a common outcome in kidney transplants, but its pathogenesis is unclear. We investigated the CGD phenotype and single-nucleotide polymorphisms (SNPs) associated with CGD. This prospective study enrolled 2336 transplants from seven transplant centers in North America. CGD was defined as a >25% rise in serum ...
Eyo Ukpong B UB Department of Biology, University of Iowa, Iowa City, IA 52242, - - 2013
A century after Cajal identified a "third element" of the nervous system, many issues have been clarified about the identity and function of one of its major components, the microglia. Here, we review recent findings by microgliologists, highlighting results from imaging studies that are helping provide new views of microglial ...
Sharma Vikram P VP Clinical Genetics Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, - - 2013
Craniosynostosis, the premature fusion of the cranial sutures, is a heterogeneous disorder with a prevalence of ∼1 in 2,200 (refs. 1,2). A specific genetic etiology can be identified in ∼21% of cases, including mutations of TWIST1, which encodes a class II basic helix-loop-helix (bHLH) transcription factor, and causes Saethre-Chotzen syndrome, ...
Fu Yue Y Department of Chemistry, Indiana University, Bloomington, Indiana, - - 2013
Copper resistance has emerged as an important virulence determinant of microbial pathogens. In Streptococcus pneumoniae, copper resistance is mediated by the copper-responsive repressor CopY, CupA and the copper-effluxing P(1B)-type ATPase CopA. We show here that CupA is a previously uncharacterized cell membrane-anchored Cu(I) chaperone and that a Cu(I) binding-competent, membrane-localized ...
Labouèbe Gwenaël G Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, British Columbia, - - 2013
The prevalence of obesity has markedly increased over the past few decades. Exploration of how hunger and satiety signals influence the reward system can help us understand non-homeostatic feeding. Insulin may act in the ventral tegmental area (VTA), a critical site for reward-seeking behavior, to suppress feeding. However, the neural ...
Shorter E E Faculty of Medicine, University of Toronto, Toronto, Canada. - - 2013
To explore the possibility that autism, catatonia and psychoses in children are different manifestations of a single underlying form of brain pathology - a kind of 'Iron Triangle' of symptomatology - rather than three separate illnesses. Systematic evaluation of historical case literature on autism to determine if catatonic and psychotic ...
Morris Luc G T LG Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, - - 2013
Aberrant Wnt signaling can drive cancer development. In many cancer types, the genetic basis of Wnt pathway activation remains incompletely understood. Here, we report recurrent somatic mutations of the Drosophila melanogaster tumor suppressor-related gene FAT1 in glioblastoma (20.5%), colorectal cancer (7.7%), and head and neck cancer (6.7%). FAT1 encodes a ...
Stout Molly J MJ Department of Obstetrics and Gynecology, Washington University in Saint Louis, St. Louis, MO, USA. - - 2013
The aim of this study was to estimate the incidence of single umbilical artery (SUA) in twin pregnancies and to investigate whether SUA in twin gestations is associated with adverse obstetric outcomes. We performed a retrospective cohort study of consecutive twin pregnancies over 17 years at a tertiary care hospital. ...
McWilliams J Michael JM Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA. - - 2013
To determine how the inclusion of post-acute evaluation and management (E&M) services as primary care affects assignment of Medicare beneficiaries to accountable care organizations (ACOs). Medicare claims for a random 5 percent sample of 2009 Medicare beneficiaries linked to American Medical Association Group Practice data identifying provider groups sufficiently large ...
Manfredini Fabio F Department of Entomology, Center for Pollinator Research, Pennsylvania State University, University Park, PA 16802, USA. - - 2013
Successful invaders often become established in new ranges by outcompeting native species. The "evolution of increased competitive ability" hypothesis predicts that invasive species are subjected to less predation and parasitization than sympatric native species, and thus can allocate resources from defence and immunity to growth and fecundity, thereby achieving higher ...
Parizotto Eneida A EA Department of Biochemistry, University of Oxford, Oxford, - - 2013
Oligomeric complexes of Trax and Translin proteins, known as C3POs, participate in several eukaryotic nucleic acid metabolism pathways, including RNA interference and tRNA processing. In RNA interference in humans and Drosophila, C3PO activates the RNA-induced silencing complex (RISC) by removing the passenger strand of the small interfering RNA precursor duplex, ...
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