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Results 601 - 650 of 4464
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Heilbronn Cherie - - 2013
INTRODUCTION AND AIMS: Concern about the non-medical use of quetiapine and related acute harms is growing. Case series cite quetiapine as a potential drug of misuse, while recent research questions its relative safety in comparison with other atypical antipsychotic preparations. This paper explores population-level patterns of quetiapine-related ambulance attendances over ...
Fernandes Nikhil J - - 2013
We report an ionic hybrid based on silica nanoparticles as the anion and amine-terminated polyethylene glycol (PEG) as a cation. The charge on the nanoparticle anion is carried by the surface hydroxyls. SAXS and TEM reveal an exceptional degree of dispersion of the silica in the polymer and high degree ...
Lee Sun-Mi - - 2013
Antitumor and antiangiogenic active dendritic compounds conjugated with 5-fluorouracil (5-FU) were synthesized and characterized. First, the core structure based on ascorbic acid and dicarboxylic acid was synthesized, amidated with ethylenediamine. For the synthesis of higher generated dendrimer, it was reacted further with methyl acrylate to increase molecular weight through Michael ...
Januschke J J Institute for Research in Biomedicine (IRB-Barcelona), Baldiri Reixac 10, 08028 Barcelona, - - 2013
During interphase in Drosophila neuroblasts, the Centrobin (CNB)-positive daughter centriole retains pericentriolar material (PCM) and organizes an aster that is a key determinant of the orientation of cell division. Here we show that daughter centrioles depleted of CNB cannot fulfil this function whereas mother centrioles that carry ectopic CNB can. ...
McWilliams J Michael JM Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA. - - 2013
To determine how the inclusion of post-acute evaluation and management (E&M) services as primary care affects assignment of Medicare beneficiaries to accountable care organizations (ACOs). Medicare claims for a random 5 percent sample of 2009 Medicare beneficiaries linked to American Medical Association Group Practice data identifying provider groups sufficiently large ...
Hu Jinxuan - - 2013
Spent sorbents in water treatment processes have potential risks to the environment if released without proper treatment. The aim of this work was to investigate the potential regeneration of commercially prepared nano-TiO(2) (anatase) for the removal of Pb (II), Cu (II), and Zn (II) by pH 2 and ethylenediaminetetraacetic acid (EDTA) ...
Ido Shinichiro - - 2013
The DNA double helix was first elucidated by J. D. Watson and F. H. C. Crick over a half century ago. However, no one could actually "see" the well-known structure ever. Among all real-space observation methods, only atomic force microscopy (AFM) enables us to visualize the biologically active structure of ...
Koski Kristie J - - 2013
Spider silks possess nature's most exceptional mechanical properties, with unrivalled extensibility and high tensile strength. Unfortunately, our understanding of silks is limited because the complete elastic response has never been measured-leaving a stark lack of essential fundamental information. Using non-invasive, non-destructive Brillouin light scattering, we obtain the entire stiffness tensors ...
Saulou Claire - - 2013
The present work was focused on elucidating biochemical changes in the model bacterium Escherichia coli exposed to ionic silver mediated stress, at a single-cell scale. In order to achieve this, in situ synchrotron Fourier-transform infrared (sFTIR) microspectroscopy was performed, for the first time, on individual cells by attenuated total reflectance ...
Miernik A - - 2013
BACKGROUND: The recently introduced Freiburg index of patient satisfaction (FIPS) is a new questionnaire to assess treatment-related patient satisfaction after surgery and interventional procedures. The questionnaire had first been tested psychometrically in a mixed population of urology patients. The current study describes the results of an interdisciplinary validation. In addition, ...
Nishimura Takahiro - - 2013
Iridium-catalyzed [3 + 2] annulation of cyclic N-sulfonyl ketimines with 1,3-dienes proceeded to give aminoindane derivatives in high yields with high regio- and dia-stereoselectivity, where an aryliridium intermediate is formed via C-H activation.
Tao Yanmei Y Institute of Developmental and Regenerative Biology, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, - - 2013
Inhibitory neurons control the firing of glutamatergic neurons and synchronize brain activity. However, little is known about mechanisms of excitatory synapse formation in inhibitory neurons. Here we demonstrate that Erbin is specifically expressed in cortical inhibitory neurons. It localizes at excitatory synapses and regulates AMPA receptor (AMPAR) surface expression. Erbin ...
Jobst Karl J - - 2013
Mass defect is the difference between the nominal and exact mass of a chemical element or compound. An intrinsic property of polyhalogenated molecules is a uniquely negative mass defect, which readily distinguishes halogenated from non-halogenated compounds in a complex mass spectrum and can be visualized by constructing a mass defect ...
Twigg Stephen R F SR Clinical Genetics Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, - - 2013
The extracellular signal-related kinases 1 and 2 (ERK1/2) are key proteins mediating mitogen-activated protein kinase signaling downstream of RAS: phosphorylation of ERK1/2 leads to nuclear uptake and modulation of multiple targets. Here, we show that reduced dosage of ERF, which encodes an inhibitory ETS transcription factor directly bound by ERK1/2 ...
Kim Dong-Hyun - - 2013
Hybrid nanoarchitectures are among the most promising nanotechnology-enabled materials for biomedical applications. Interfacing of nanoparticles with active materials gives rise to the structures with unique multiple functionality. SPION particles are widely employed in the biology and in developing of advanced medical technologies. Polymeric micelles offer the advantage of multifunctional carriers ...
Nikom Jaru - - 2013
3D interconnected porous scaffolds of HA and HA with various additions of SiO(2) were fabricated using a polymeric template technique, to make bioceramic scaffolds consisting of macrostructures of the interconnected macropores. Three different sizes of the polyurethane template were used in the fabrication process to form different size interconnected macropores, ...
Kochanski Ryan - - 2013
Ethanol provides neuroprotection following ischemia/reperfusion. The present study assessed ethanol's effect on hyperglycolysis and NADPH oxidase (NOX) activation. Adult, male Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) for 2 hours. Three sets of experiments were conducted to determine ethanol's effect on: 1) conferring neuroprotection by measuring infarct ...
Hashemi M - - 2013
In this study we aimed to evaluate the possible association of PTPN22 rs2476601 as well as epidermal growth factor receptor (EGFR) rs17337023 gene polymorphism and rheumatoid arthritis (RA) in a sample of Iranian population. This case-control study was performed on 120 patients with RA and 120 healthy subjects. Genomic DNA ...
Chan Kannie W Y - - 2013
Biocompatible nanomaterials and hydrogels have become an important tool for improving cell-based therapies by promoting cell survival and protecting cell transplants from immune rejection. Although their potential benefit has been widely evaluated, at present it is not possible to determine, in vivo, if and how long cells remain viable following ...
Premraj A - - 2013
The mechanism by which type I interferon-mediated antiviral response is mounted by hosts against invading pathogen is an intriguing one. Of late, an endoplasmic reticulum transmembrane protein encoded by a gene called stimulator of interferon genes (STING) is implicated in the innate signalling pathways and has been identified and cloned ...
Maran Avudaiappan - - 2013
Osteosarcoma is a bone tumor that affects children and young adults. 2-Methoxyestradiol (2-ME), a naturally occurring estrogen metabolite, kills osteosarcoma cells, but does not affect normal osteoblasts. In order to effectively target osteosarcoma and improve the therapeutic index of the drug 2-ME, we have encapsulated 2-ME in a composite of ...
Bode Stefan - - 2013
Self-healing coating based on metallopolymers are prepared and fully characterized. Iron bisterpyridine complexes are incorporated into a polymer network based on methacrylates, resulting in self-healing properties of these materials. Moreover, the influence of the comonomers on the thermal properties is studied in detail.
Kim Changsung C Del E. Webb Neuroscience, Aging & Stem Cell Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, - - 2013
Cellular reprogramming of somatic cells to patient-specific induced pluripotent stem cells (iPSCs) enables in vitro modelling of human genetic disorders for pathogenic investigations and therapeutic screens. However, using iPSC-derived cardiomyocytes (iPSC-CMs) to model an adult-onset heart disease remains challenging owing to the uncertainty regarding the ability of relatively immature iPSC-CMs ...
Rose Nancy C - - 2013
OBJECTIVE: First-trimester aneuploidy screening has high detection rates and low false-positive rates. Their use as well as the implementation of non-invasive prenatal testing may affect specialty training in prenatal diagnosis procedures. STUDY DESIGN: Descriptive study of first-trimester aneuploidy screening and amniocentesis in an obstetric training program. Screening methods were tracked ...
Ranjbar M - - 2013
The case of a 57-year-old woman with a rapidly growing unpigmented conjunctival tumor is presented. Despite the clinical appearance the histology surprisingly confirmed a malignant melanoma of the conjunctiva. Various phenotypes and the rareness of this disease complicate a clinical diagnosis. Therapeutically, a complete excision of the tumor including a ...
Chamorro Eduardo E - - 2013
The formulation of the second-order perturbation approach to the stabilization energy of the A-B interacting species due to charge transfer is revisited. Intrinsic (i.e., electronic) theoretical indices for both relative electrophilicity and nucleophilicity are proposed for any electrophile (A) - nucleophile (B) pairs of combining species. Using the new descriptors, ...
Yang Nailiang - - 2013
The chemical structure and electronic properties of two-dimensional (2D) carbon supported TiO(2), TiO(2)-graphdiyne and TiO(2)-graphene composites have been studied by first-principles density functional theory. Calculation results show that TiO(2)(001)-graphdiyne composites possess superior charge separation and oxidation properties, having the longest lifetimes of photo-excited carriers among all the 2D composites containing ...
Laborie Lene Bjerke - - 2013
OBJECTIVE: Normative references for radiographic measurements commonly used in the diagnosis of developmental dysplasia of the hip at skeletal maturity are incomplete. The present study therefore aimed to establish new gender-specific standards for measurements reflecting the acetabular morphology, namely Sharp's angle, the acetabular roof angle of Tönnis (AA) and the ...
Shulan Mollie - - 2013
Hospital readmission rate has been broadly accepted as a quality measure and cost driver. However, success in reducing readmissions has been elusive. In the US, almost 20 % of Medicare inpatients are rehospitalized within 30 days, which amounts to a cost of $17 billion. Given the skyrocketing healthcare cost, policymakers, researchers and ...
Radivojac Predrag P School of Informatics and Computing, Indiana University, Bloomington, Indiana, - - 2013
Automated annotation of protein function is challenging. As the number of sequenced genomes rapidly grows, the overwhelming majority of protein products can only be annotated computationally. If computational predictions are to be relied upon, it is crucial that the accuracy of these methods be high. Here we report the results ...
Tischer S - - 2013
The new human leukocyte antigen (HLA)-B*58:21 allele differs from B*58:01:01 by an amino acid exchange at codon 90.
Kingma Boris R M - - 2013
Skin blood flow (SBF) is a key player in human thermoregulation during mild thermal challenges. Various numerical models of SBF regulation exist. However, none explicitly incorporates the neurophysiology of thermal reception. This study tested a new SBF model that is in line with experimental data on thermal reception and the ...
Fatmi Wided - - 2013
Diabetes mellitus is associated to a reduction of antioxidant defenses that leads to oxidative stress and complications in diabetic individuals. The present study was undertaken to investigate the effect of selenium on blood biochemical parameters, antioxidant enzyme activities, and tissue zinc levels in alloxan-induced diabetic rats fed a zinc-deficient diet. ...
Fadloun Anas - - 2013
How a more plastic chromatin state is maintained and reversed during development is unknown. Heterochromatin-mediated silencing of repetitive elements occurs in differentiated cells. Here, we used repetitive elements, including retrotransposons, as model loci to address how and when heterochromatin forms during development. RNA sequencing throughout early mouse embryogenesis revealed that ...
Kang Yijin - - 2013
Well-defined surfaces of Pt have been extensively studied for various catalytic processes. However, industrial catalysts are mostly composed of fine particles (e.g. nanocrystals), due to the desire for a high surface to volume ratio. Therefore, it is very important to explore and understand the catalytic processes both at nanoscale and ...
Greene Jessica - - 2013
OBJECTIVE: This study examines the impact of Australia's pay-for-performance (P4P) program for general practitioners (GPs). The voluntary program pays GPs A$40 and A$100 in addition to fee-for-service payment for providing patients recommended diabetes and asthma treatment over a year, and A$35 for screening women for cervical cancer who have not ...
Ameur S - - 2013
A cloud point extraction coupled with high performance liquid chromatography (HPLC/UV) method was developed for the determination of Δ(9)-tetrahydrocannabinol (THC) in micellar phase. The nonionic surfactant "Dowfax 20B102" was used to extract and pre-concentrate THC from cannabis resin, prior to its determination with a HPLC-UV system (diode array detector) with ...
Cheng Linli - - 2013
Methyl-3-quinoxaline-2-carboxylic acid (MQCA) is a possible residue marker for three quinoxaline veterinary medicines (olaquindox, mequindox, and quinocetone). The wide application of mequindox/quinocetone or the illegal use of olaquindox leads to MQCA residue in animal's original food, thereby threatening the safety of human food. The indirect competitive enzyme-linked immunosorbent assay (IC-ELISA) ...
Huch Meritxell M Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, - - 2013
The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as small intestine and colon, stomach and hair follicles. A three-dimensional culture system allows long-term clonal expansion of single Lgr5(+) stem cells into transplantable organoids (budding cysts) that retain many characteristics ...
Catalano Peter J - - 2013
Balloon dilation technology (BDT), also known as balloon sinuplasty, has been in clinical use since September, 2005. Prior to BDT, surgeons performed a procedure called FESS, or functional endoscopic sinus surgery, for patients with chronic sinusitis. As is true with any new technology or procedure in medicine, a debate often ...
Douglas R G - - 2013
The renin-angiotensin system (RAS) is central to regulation of blood pressure and electrolyte homeostasis. Angiotensin-converting enzyme (ACE), a key protease in the RAS, has a range of substrates, including N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP). Ac-SDKP is cleared almost exclusively by ACE and specifically by the N-domain active site of this enzyme. Ac-SDKP is ...
Doros Gheorghe - - 2013
Previous authors have proposed the sequential parallel comparison design (SPCD) to address the issue of high placebo response rate in clinical trials. The original use of SPCD focused on binary outcomes, but recent use has since been extended to continuous outcomes that arise more naturally in many fields, including psychiatry. ...
Rotaru Aurelian - - 2013
The nanoscale manipulation and charge transport properties of the [Fe(Htrz)(2) (trz)](BF(4) ) spin-crossover compound is demonstrated. Such 1D spin-crossover nanostructures are attractive building blocks for nanoelectronic switching and memory devices.
Terzaki Konstantina - - 2013
Engineering artificial scaffolds that enhance cell adhesion and growth in three dimensions is essential to successful bone tissue engineering. However, the fabrication of three-dimensional (3D) tissue scaffolds exhibiting complex micro- and nano-features still remains a challenge. Few materials can be structured in three dimensions, and even those have not been ...
Motoyama N - - 2013
BACKGROUND: Platelet-activating factor (PAF) has been implicated in the pathology of neuropathic pain. Previous studies reported that PAF receptor (PAF-R) antagonists have varied anti-allodynia effects by route of administration and nerve injury models in rats. METHODS: The present study elucidated the effectiveness of PAF antagonists against neuropathic pain in four ...
Wiedemann Dominik - - 2013
A CT-scan of a 75-year-old patient showed an aneurysm of the descending aorta with a maximum diameter of 4.8 cm involving the left subclavian artery. Due to the fact that the patient had several comorbidities including a severe chronic obstructive pulmonary disease he was treated only conservatively. However, there were ...
Bayer J - - 2013
BACKGROUND: The aim was to survey the radiological diagnostics and type of primary radiological examination of polytraumatized patients treated in German hospitals at various levels in the three-tiered system. MATERIAL AND METHODS: A questionnaire was sent in October 2007 to every traumatology department registered in the DGU (German Society for ...
Dieckmann Arne - - 2013
The Diels-Alder reactions of cyclic linear and cross-conjugated trienamines with oxindoles have been studied with density functional theory [M06-2X/def2-TZVPP/IEFPCM//B97D/6-31+G(d,p)/IEFPCM]. These reactions are found to proceed in a stepwise fashion. Computations revealed that these transformations involve complex mechanisms including zwitterionic intermediates and several unstable alternate cycloadducts arising from (2+2) cycloadditions and ...
Luo Jiayan - - 2013
Graphene is considered as a promising ultracapacitor material toward high power and energy density because of its high conductivity and high surface area without pore tortuosity. However, the two-dimensional (2D) sheets tend to aggregate during electrode fabrication process and align perpendicular to the flow direction of electrons and ions, which ...
Park Chan Sun - - 2013
Sodium ion batteries (SIBs) have many advantages such as the low price and abundance of sodium raw materials that are suitable for large-scale energy storage applications. Herein, we report a Mn-based pyrophosphate, Na2MnP2O7, as a new SIB cathode material. Unlike most Mn-based cathode materials that suffer severely from sluggish kinetics, ...
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