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Buzsáki György G NYU Neuroscience Institute and Center for Neural Sciences, New York University, New York, New York, USA. - - 2013
Theories on the functions of the hippocampal system are based largely on two fundamental discoveries: the amnestic consequences of removing the hippocampus and associated structures in the famous patient H.M. and the observation that spiking activity of hippocampal neurons is associated with the spatial position of the rat. In the ...
Scarmo Stephanie S Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College Street, PO Box 208034, New Haven, CT 06520-8034, - - 2013
Resonance Raman spectroscopy (RRS) is a non-invasive method of assessing carotenoid status in the skin, which has been suggested as an objective indicator of fruit/vegetable intake. The present study assessed agreement and identified predictors of single v. multiple RRS measures of skin carotenoid status. A total of seventy-four participants had ...
Walz J - - 2013
BACKGROUND: The aim of this study was to evaluate whether mild water-filtered near infrared whole body hyperthermia in patients with fibromyalgia produces a benefit when applied as an addition to a standard multimodal rehabilitation. PATIENTS AND METHODS: In this study 67 patients at a German rehabilitation clinic were included and ...
Zhang Haibo - - 2013
Polychlorinated biphenyls (PCBs) contamination in tropical and sub-tropical areas and the associated risks have attracted great concern. A total of 69 samples representing five distinct land types were collected to assess PCB concentrations in the Pearl River Delta (PRD), South China, including spatial distributions in soils of the area, the ...
Premraj A - - 2013
The mechanism by which type I interferon-mediated antiviral response is mounted by hosts against invading pathogen is an intriguing one. Of late, an endoplasmic reticulum transmembrane protein encoded by a gene called stimulator of interferon genes (STING) is implicated in the innate signalling pathways and has been identified and cloned ...
Jobst Karl J - - 2013
Mass defect is the difference between the nominal and exact mass of a chemical element or compound. An intrinsic property of polyhalogenated molecules is a uniquely negative mass defect, which readily distinguishes halogenated from non-halogenated compounds in a complex mass spectrum and can be visualized by constructing a mass defect ...
Lasarte-Aragonés Guillermo - - 2013
Extraction techniques are surface-dependent processes since their kinetic directly depends on the contact area between the sample and the extractant phase. The dispersion of the extractant (liquid or solid) increases this area improving the extraction efficiency. In this article, the dispersion of a nanostructured sorbent at the very low milligram ...
Coimbra Elaine S - - 2013
In this work, we report the antileishmanial evaluation of twenty 7-chloro-4-quinolinylhydrazone derivatives (1-20). Firstly, the compounds were tested against promastigotes of four different Leishmania species. After that, all derivatives were assayed against L. braziliensis amastigotes and murine macrophages. Furthermore, it was investigated if the antiamastigote L. braziliensis effect of the ...
Vidoni Sara - - 2013
Significance: The maintenance of mitochondrial genome integrity is a major challenge for cells in order to sustain energy production by respiration. Recent Advances: Recently, mitochondrial membrane dynamics has emerged as a key process contributing to prevent mitochondrial DNA alterations. Indeed, both fundamental and clinical data suggest that disruption of mitochondrial ...
Vaagt Franziska - - 2013
Toxic mushroom species like the death cap (Amanita phalloides) are responsible for most mushroom poisonings. In the present work, novel loop-mediated isothermal amplification (LAMP) assays were used for the differentiation of even closely related edible and toxic mushroom species. The applicability of these methods was tested by cross-reaction studies and ...
Liu Zheng - - 2013
Graphene and hexagonal boron nitride (h-BN) have similar crystal structures with a lattice constant difference of only 2%. However, graphene is a zero-bandgap semiconductor with remarkably high carrier mobility at room temperature, whereas an atomically thin layer of h-BN is a dielectric with a wide bandgap of ∼5.9 eV. Accordingly, if ...
Beduschi M G - - 2013
Septic shock is a systemic inflammatory response syndrome, and it is the leading cause of death in intensive care units. Mycophenolate mofetil (MMF) is an immunosuppressant that has been shown to be effective in the treatment of various inflammatory diseases. In this study, the anti-inflammatory effect of MMF in a ...
Mermans J F - - 2013
BACKGROUND/PURPOSE: The purpose of this study was to investigate the influence of different located post surgical scars on both perfusion and redness. The pattern of change and correlation between perfusion and redness of post surgical scars is also examined. METHODS: In this study, we measured redness and perfusion of the ...
Kubota Koji - - 2013
A borylative exo-cyclization of alkenyl halides has been reported. The reaction includes the regioselective addition of a borylcopper(I) intermediate to unactivated terminal alkenes, followed by the intramolecular substitution of the resulting alkyl-copper moiety for the halide leaving groups. This reaction provides a new method for the synthesis of alkylboronates containing ...
Cao Qing - - 2013
Single-walled carbon nanotubes have exceptional electronic properties and have been proposed as a replacement for silicon in applications such as low-cost thin-film transistors and high-performance logic devices. However, practical devices will require dense, aligned arrays of electronically pure nanotubes to optimize performance, maximize device packing density and provide sufficient drive ...
Lakshmi Jothinathan - - 2013
A batch adsorption process was applied to investigate the removal of perchlorate (ClO(4) (-)) from water by graphene. In doing so, the thermodynamic adsorption isotherm and kinetic studies were also carried out. Graphene was prepared by a facile liquid-phase exfoliation. Graphene was characterized by Raman spectroscopy, Fourier-transform infrared spectroscopy, powder ...
Marx S - - 2013
BACKGROUND: The etiology of chronic prostatitis chronic pelvic pain syndrome (CP/CPPS) is still unclear. As no pathological findings exist the diagnosis of CP/CPPS is essentially a diagnosis by exclusion and functional disorders, so-called somatoform disorders play a more important role. Osteopathy treats functional disorders of the musculoskeletal system including all ...
Krepl Miroslav - - 2013
Guanine to inosine (G→I) substitution has often been used to study various properties of nucleic acids. Inosine differs from guanine only by loss of the N2 amino group while both bases have similar electrostatic potentials. Therefore, G→I substitution appears to be optimally suited to probe structural and thermodynamics effects of ...
Poteet Steven A - - 2013
Visible light irradiation of a ruthenium(II) quinone-containing complex, [(phen)(2)Ru(phendione)](2+) (1(2+)), where phendione = 1,10-phenanthroline-5,6-dione, leads to DNA cleavage in an oxygen independent manner. A combination of NMR analyses, transient absorption spectroscopy, and fluorescence measurements in water and acetonitrile reveal that complex 1(2+) must be hydrated at the quinone functionality, giving ...
Sattar N - - 2013
Whilst the interplay between type 2 diabetes and cardiovascular disease (CVD) has been recognised for many years, recent analyses of existing studies have helped refine several aspects of this relationship with relevance to clinical practice. First, recent data demonstrate that fasting glucose is not linearly related to CVD risk in ...
Bürmann Frank - - 2013
Eukaryotic structural maintenance of chromosomes (SMC)-kleisin complexes form large, ring-shaped assemblies that promote accurate chromosome segregation. Their asymmetric structural core comprises SMC heterodimers that associate with both ends of a kleisin subunit. However, prokaryotic condensin Smc-ScpAB is composed of symmetric Smc homodimers associated with the kleisin ScpA in a postulated ...
Daruwalla Jurstine - - 2013
BACKGROUND: Fatigue has been shown to have a negative impact on surgical performance. However, there is a lack of research investigating its effect on laparoscopy, particularly in Australia. This study investigated whether fatigue associated with a surgeon's usual workday led to a measurable drop off in laparoscopic surgical skills as ...
Cheng Jinguang - - 2013
A new Bi(3)Ge(3)O(10.5) compound has been synthesized under high pressure, P = 7 GPa, and 700 °C. Instead of the pyrochlore that is normally stabilized under high pressure, the Bi(3)Ge(3)O(10.5) crystallizes in a KSbO(3)-ype crystal structure. The crystal structure has been refined by the Rietveld method from synchrotron X-ray diffraction ...
Liu G - - 2013
The high-temperature stability and mechanical properties of refractory molybdenum alloys are highly desirable for a wide range of critical applications. However, a long-standing problem for these alloys is that they suffer from low ductility and limited formability. Here we report a nanostructuring strategy that achieves Mo alloys with yield strength ...
Zhong Silin - - 2013
Ripening of tomato fruits is triggered by the plant hormone ethylene, but its effect is restricted by an unknown developmental cue to mature fruits containing viable seeds. To determine whether this cue involves epigenetic remodeling, we expose tomatoes to the methyltransferase inhibitor 5-azacytidine and find that they ripen prematurely. We ...
Bentsen Signe Berit - - 2013
This paper examines the prevalence of multiple symptoms and the relationships between future expectations and multiple symptoms in a cross-sectional study of 100 patients with chronic obstructive pulmonary disease. A questionnaire was used to examine the patients' symptoms of breathlessness, anxiety, depression, sleeplessness, fatigue, and pain, and their outlook for ...
Schwarz Frank - - 2013
OBJECTIVES: Mucosal recessions are a common finding following surgical treatment of peri-implantitis, thus compromising the overall esthetic outcome of implant therapy. This case series aimed at evaluating the clinical outcome of a combined surgical therapy of advanced peri-implantitis lesions with concomitant soft tissue volume augmentation. MATERIAL AND METHODS: Ten patients ...
Fischer N - - 2013
PURPOSE: Diurnal intraocular pressure (IOP) measurements are recommended in cases of visual field deterioration in glaucoma patients. In this study the rationale of 24 h versus 48 h IOP measurements was investigated. PATIENTS AND METHODS: Mean IOP and maximum IOP values were obtained in 80 patients over a period of 48 h. The ...
Mander Bryce A - - 2013
Aging has independently been associated with regional brain atrophy, reduced slow wave activity (SWA) during non-rapid eye movement (NREM) sleep and impaired long-term retention of episodic memories. However, whether the interaction of these factors represents a neuropatholgical pathway associated with cognitive decline in later life remains unknown. We found that ...
Rusbridge S L - - 2013
OBJECTIVE: The aim of this study was to examine the outcome of a vocational rehabilitation programme for patients with brain tumours and to determine whether the outcome could be predicted at point of referral to the service. METHODS: Data was collected for 34 patients with brain tumours referred to the ...
Ranjbar M - - 2013
The case of a 57-year-old woman with a rapidly growing unpigmented conjunctival tumor is presented. Despite the clinical appearance the histology surprisingly confirmed a malignant melanoma of the conjunctiva. Various phenotypes and the rareness of this disease complicate a clinical diagnosis. Therapeutically, a complete excision of the tumor including a ...
Chamorro Eduardo E - - 2013
The formulation of the second-order perturbation approach to the stabilization energy of the A-B interacting species due to charge transfer is revisited. Intrinsic (i.e., electronic) theoretical indices for both relative electrophilicity and nucleophilicity are proposed for any electrophile (A) - nucleophile (B) pairs of combining species. Using the new descriptors, ...
Yang Nailiang - - 2013
The chemical structure and electronic properties of two-dimensional (2D) carbon supported TiO(2), TiO(2)-graphdiyne and TiO(2)-graphene composites have been studied by first-principles density functional theory. Calculation results show that TiO(2)(001)-graphdiyne composites possess superior charge separation and oxidation properties, having the longest lifetimes of photo-excited carriers among all the 2D composites containing ...
Aghayeva Ulkar Firudin - - 2013
To date, a number of biomolecule-mediated nanoparticle self-assembly systems have been developed that are amenable to controllable disassembly under relatively gentle conditions. However, for some applications such as design of self-assembled multifunctional theragnostic agents, high stability of the assembled structures can be of primary importance. Here, we report extraordinarily high ...
Mauriège P - - 2013
This study was performed to examine whether changes in subcutaneous adipose tissue (SCAT) metabolism indices after weight loss were related to the magnitude of weight regain. Nine men and ten premenopausal women whose body mass index ranged from 30 to 42 kg/m(2), 35-48 years old, were studied before and after a 15-week ...
Joo Wonil - - 2013
The objective of this study is to clearly and precisely describe the topography and contents of the infratemporal fossa. Ten formalin-fixed, adult cadaveric specimens were studied. Twenty infratemporal fossa were dissected and examined using micro-operative techniques with magnifications of 3-40×. Information was obtained about the inter-relationships of the contents of ...
Steiner Martina - - 2013
Pretargeting approaches consist in the injection of bispecific antibodies capable of recognizing both an accessible disease marker and a small ligand, which is typically administered at a later stage and which serves as delivery vehicle of a payload for imaging or therapy applications. In the oncology field, pretargeting strategies have ...
Manfredini Fabio - - 2013
Successful invaders often become established in new ranges by outcompeting native species. The "evolution of increased competitive ability" hypothesis predicts that invasive species are subjected to less predation and parasitization than sympatric native species, and thus can allocate resources from defence and immunity to growth and fecundity, thereby achieving higher ...
van Dongen Stijn F M - - 2013
There's an APP for that: cell-repellent APP (azido-[polylysine-g-PEG]) is used to create substrates for spatially controlled dynamic cell adhesion. The simple addition of a functional peptide to the culture medium rapidly triggers cell adhesion. This highly accessible yet powerful technique allows diverse applications, demonstrated through tissue motility assays, patterned coculturing ...
Zhang Hui - - 2013
Intercropping and rotating banana (Musa spp.) with Chinese chive (Allium tuberosum Rottler) has been used as an effective method to control Panama disease (Fusarium wilt) of banana in South China. However, the underlying mechanism is unknown. In this study, we used aqueous leachates and volatiles from Chinese chive to evaluate ...
Varshney Rajeev K - - 2013
Chickpea (Cicer arietinum) is the second most widely grown legume crop after soybean, accounting for a substantial proportion of human dietary nitrogen intake and playing a crucial role in food security in developing countries. We report the ∼738-Mb draft whole genome shotgun sequence of CDC Frontier, a kabuli chickpea variety, ...
Hansen Pernille B L - - 2013
Calcium channel blockers are widely used to treat hypertension because they inhibit voltage-gated calcium channels that mediate transmembrane calcium influx in e.g. vascular smooth muscle and cardiomyocytes. The calcium channel family consists of several subfamilies, of which the L-type is usually associated with vascular contractility. However, the L-, T- and ...
Wiesner Melanie - - 2013
Thirteen different pak choi (Brassica rapa ssp. chinensis) cultivars were characterized regarding their glucosinolate profile analyzed by HPLC-DAD-MS. The identified glucosinolates were subjected to principal component analysis and three distinct groups of pak choi sprouts were identified. Group differences were marked mainly by variations in the aliphatic glucosinolate profile such ...
Qiu Huawei - - 2013
Recombinant human thyroid stimulating hormone (rhTSH or Thyrogen®) has been approved for thyroid cancer diagnostics and treatment under a multidose regimen due to its short circulating half-life. To reduce dosing frequency, PEGylation strategies were explored to increase the duration of action of rhTSH. Lysine and N-terminal PEGylation resulted in heterogeneous ...
Mohr Peter - - 2013
BACKGROUND: Previous studies have shown statistically significant differences in electrical impedance between various cutaneous lesions. Electrical impedance spectroscopy (EIS) may therefore be able to aid clinicians in differentiating between benign and malignant skin lesions. OBJECTIVES: The aim of the study was to develop a classification algorithm to distinguish between melanoma ...
Terzaki Konstantina - - 2013
Engineering artificial scaffolds that enhance cell adhesion and growth in three dimensions is essential to successful bone tissue engineering. However, the fabrication of three-dimensional (3D) tissue scaffolds exhibiting complex micro- and nano-features still remains a challenge. Few materials can be structured in three dimensions, and even those have not been ...
Motoyama N - - 2013
BACKGROUND: Platelet-activating factor (PAF) has been implicated in the pathology of neuropathic pain. Previous studies reported that PAF receptor (PAF-R) antagonists have varied anti-allodynia effects by route of administration and nerve injury models in rats. METHODS: The present study elucidated the effectiveness of PAF antagonists against neuropathic pain in four ...
Wiedemann Dominik - - 2013
A CT-scan of a 75-year-old patient showed an aneurysm of the descending aorta with a maximum diameter of 4.8 cm involving the left subclavian artery. Due to the fact that the patient had several comorbidities including a severe chronic obstructive pulmonary disease he was treated only conservatively. However, there were ...
Bayer J - - 2013
BACKGROUND: The aim was to survey the radiological diagnostics and type of primary radiological examination of polytraumatized patients treated in German hospitals at various levels in the three-tiered system. MATERIAL AND METHODS: A questionnaire was sent in October 2007 to every traumatology department registered in the DGU (German Society for ...
Dieckmann Arne - - 2013
The Diels-Alder reactions of cyclic linear and cross-conjugated trienamines with oxindoles have been studied with density functional theory [M06-2X/def2-TZVPP/IEFPCM//B97D/6-31+G(d,p)/IEFPCM]. These reactions are found to proceed in a stepwise fashion. Computations revealed that these transformations involve complex mechanisms including zwitterionic intermediates and several unstable alternate cycloadducts arising from (2+2) cycloadditions and ...
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