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Asano Miho - - 2013
Purpose: The primary objective of this study was to estimate the extent to which women and men with MS present different exercise barriers. The secondary objective was to estimate the extent to which women and men with MS present different perceived-health, depressive symptoms, and current exercise routines or preferences. Methods: ...
Jannot Anne-Sophie - - 2013
Statistically significant studies may be cited more than negative studies on the same topic. We aimed to assess here whether such citation bias is present across the medical literature. We conducted a cohort study of the association between statistical significance and citations. We selected all therapeutic intervention studies included in ...
Kim J-S - - 2013
Worldwide radiation exposure is increasing due to recent nuclear accidents, space travel, atomic weapons testing and use, and medical treatments. In adult animals, ionizing radiation can significantly impact hippocampal neurogenesis and negatively affect hippocampal functions such as cognition. However, there is considerable uncertainty regarding the mechanisms underlying these effects. This ...
Nozawa T - - 2013
Neoplasms of the epididymis are uncommon, and malignant tumors are extremely rare. We report a case of clear cell papillary cystadenocarcinoma of the epididymis presenting with a long history of painless scrotal mass on the left side. Immunohistochemical markers for clear cell renal cell carcinoma (RCC) were examined to distinguish ...
Ruiz-González I - - 2013
The present study compares two protocols for ovine estrus synchronization by assessing the caruncular angiogenic response to the establishment of pregnancy. The analysis consisted of the immunohistochemical evaluation of Vascular Endothelial Growth Factor (VEGF), Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1, CD31) and Von Willebrand Factor (vWF) in ovine caruncular stroma. ...
Golder Su - - 2013
An increasing amount of research and guidelines has been published on search methodology and the reporting of search strategies in systematic reviews. This research assessed whether this has lead to any improvements in the reporting and quality of searching in systematic reviews of adverse effects. All records within Cochrane Database ...
Gaisa N T - - 2013
Metabolic components like fatty acids and acyl-Coenzyme A (acyl-CoA) thioesters have been implicated in the pathogenesis of various tumours. The activation of fatty acids to acyl-CoAs is catalysed by long chain acyl-CoA synthetases (ACSLs), and impairment of ACSL expression levels has been associated with tumourigenesis and progression. Since ACSLs have ...
Geramizadeh B - - 2013
Background. Hirschsprung's disease (HD) is one of the most common motility disorders in pediatric age groups and it is very important that it be differentiated from other types of motility disorders, especially intestinal neuronal dysplasia B (IND B). Although many studies regarding the differences between the two disorders by immunohistochemical ...
Li M - - 2013
The purpose of this study was to examine histological alterations on osteoblasts from the alveolar bone of transgenic mice with targeted ablation of osteoctyes. Eighteen weeks-old transgenic mice based on the diphtheria toxin (DT) receptor-mediated cell knockout (TRECK) system were used in these experiments. Mice were injected intraperitoneally with 50 ...
Petersen Morten Aa - - 2013
The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group is developing a computer-adaptive test (CAT) version of the EORTC Quality of Life Questionnaire (QLQ-C30). We evaluated the measurement properties of the CAT versions of physical functioning (PF) and fatigue (FA) and compared these with the ...
Chuang W-Y - - 2013
Podoplanin, a type-1 transmembrane glycoprotein, was originally named due to its expression in renal podocytes of rats. It was subsequently detected in a variety of normal human tissues, including lymphatic endothelium. Although podoplanin has been identified as the endogenous ligand of C-type lectin-like receptor 2 (CLEC-2) on platelets, its physiological ...
Cornetta Kenneth K Medical and molecular genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. - - 2013
The current description of personalized medicine by the National Institutes of Health is "the science of individualized prevention and therapy." Although physicians are beginning to see the promise of genetic medicine coming to fruition, the rapid pace of sequencing technology, informatics, and computer science predict a revolution in the ability ...
van der Heijde Désirée - - 2013
The purpose of this 24-month phase III study was to examine structural preservation with tofacitinib in patients with rheumatoid arthritis (RA) with an inadequate response to methotrexate (MTX). Data from a planned 12-month interim analysis are reported. In this double-blind, parallel-group, placebo-controlled study, patients receiving background MTX were randomized 4:4:1:1 ...
Koopman Laura - - 2013
To find ways to improve response rates of medical and health surveys. We investigated whether a prenotification letter instead of a second reminder and varying senders of the questionnaires would affect response rates. We present the results of two studies. In the first study, four groups were compared that either ...
Hu Zhihong - - 2013
Changes in the choroid, in particular its thickness, are believed to be of importance in the pathophysiology of a number of retinal diseases. The purpose of this study was to adapt the graph search algorithm to semiautomatically identify the choroidal layer in spectral-domain optical coherence tomography (SD-OCT) volume scans and ...
Hudson Marie - - 2013
To determine the validity of the diagnostic algorithms for osteoporosis and fractures in administrative data. A systematic search was conducted to identify studies that reported the validity of a diagnostic algorithm for osteoporosis and/or fractures using administrative data. Twelve studies were reviewed. The validity of the diagnosis of osteoporosis in ...
Bala Malgorzata M MM 2nd Department of Internal Medicine, Jagiellonian University School of Medicine, Skawinska 8, 31-066 Krakow, - - 2013
To compare methodological characteristics of randomized controlled trials (RCTs) published in higher vs. lower impact Core Clinical Journals. We searched MEDLINE for RCTs published in 2007 in Core Clinical Journals. We randomly sampled 1,140 study reports in a 1:1 ratio in higher (five general medicine journals with the highest total ...
Liu Shiuh-Inn - - 2013
The effect of 2,4,6-trimethyl-N-(meta-3-trifluoromethyl-phenyl)-benzenesulfonamide (m-3M3FBS), a presumed phospholipase C activator, on cytosolic free Ca² ⁺ concentrations ([Ca² ⁺ ]i ) in HA59T human hepatoma cells is unclear. This study explored whether m-3M3FBS elevated basal [Ca² ⁺ ]i levels in suspended cells by using fura-2 as a Ca² ⁺ -sensitive fluorescent ...
Wang Hai-Long - - 2013
In this study, C6 glioma cells were used to test the effects of 2-azafluorenone and its related compounds on membrane phosphatidylinositol (PI) and phosphatidylcholine (PC) turnover. An increase of [³H]-labeled inositol phosphate (IP1) formation by histamine (100 μM) or A23187 (100 nM) via the activation of phosphatidylinositol-specific phospholipase C (PI-PLC) ...
Chia Michael - - 2013
Swimmers tend to have greater body fat than athletes from other sports. The purpose of the study was to examine changes in body composition after altitude hypoxia exposure and the role of blood distribution to the skeletal muscle in swimmers. With a constant training volume of 12.3 km/day, young male ...
Chen Yuanyuan - - 2013
Understanding the opening fluctuation of glottis is meaningful in diagnosing vocal cord dysfunction. Nasopharyngoscopy can offer a direct method for visualizing the opening and closing of the glottis. However, the large amount of image data presents a significant challenge for quantitative analysis of the video recordings. Thus, automatic image processing ...
Amstislavskaya Tamara G - - 2013
Reproductive functions in adult organism are known to be affected by different factors. Effects of social environment at the postnatal ontogenesis attract particular attention since it has deep impact on the development of physiological and emotional state of an individual. Effects of chronic social isolation at different ages on male ...
Lu Tsun-Jung - - 2013
The deduced memory consolidation and reconsolidation phases are sensitive to similar amnesic and memory-enhancing treatment. Electroconvulsive stimulus has been well known to impair memory consolidation. Therefore, we hypothesized that electroconvulsive stimulus might disrupt reconsolidation for conditioning-established memories. Delivery of a 200-msec electroconvulsive stimulus (500 V, 25 mA) between mouse pinnas ...
Rüst Christoph Alexander - - 2013
A personal best marathon time has been reported as a strong predictor variable for an Ironman race time in recreational female Ironman triathletes. This raises the question whether recreational female Ironman triathletes are similar to recreational female marathoners. We investigated similarities and differences in anthropometry and training between 53 recreational ...
Pillai Ajay D AD Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, - - 2013
Malaria parasites grow within erythrocytes, but are also free in host plasma between cycles of asexual replication. As a result, the parasite is exposed to fluctuating levels of Na(+) and K(+) , ions assumed to serve important roles for the human pathogen, Plasmodium falciparum. We examined these assumptions and the ...
Miller Daniel S DS Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United - - 2013
This Instructional Review describes methods and underlying principles that can be used to characterize both the orientations assumed spontaneously by liquid crystals (LCs) at interfaces and the strength with which the LCs are held in those orientations (so-called anchoring energies). The application of these methods to several different classes of ...
Ohtsuka Nobuhisa N Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA, - - 2013
Postmortem studies have revealed a downregulation of the transcription factor Pax5 in GABAergic neurons in bipolar disorder, a neurodevelopmental disorder, raising the question whether Pax5 in GABAergic neurons has a role in normal brain development. In a genetic approach to study functions of Pax5 in GABAergic neurons, Pax5 was specifically ...
Cornilescu Claudia C CC National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, Wisconsin 53706, - - 2013
The sweet protein brazzein, a member of the Csβα fold family, contains four disulfide bonds that lend a high degree of thermal and pH stability to its structure. Nevertheless, a variable temperature study has revealed that the protein undergoes a local, reversible conformational change between 37 and 3°C with a ...
Yang Shuying S Department of Oral Biology, School of Dental Medicine, University of Buffalo, State University of New York, Buffalo, NY 14214, USA. - - 2013
Regulators of G-protein Signaling (Rgs) proteins are the members of a multigene family of GTPase-accelerating proteins (GAP) for the Galpha subunit of heterotrimeric G-proteins. Rgs proteins play critical roles in the regulation of G protein couple receptor (GPCR) signaling in normal physiology and human diseases such as cancer, heart diseases, ...
Schrode Nadine N Developmental Biology Program, Sloan-Kettering Institute, New York, NY, - - 2013
The preimplantation period of mouse early embryonic development is devoted to the specification of two extraembryonic tissues and their spatial segregation from the pluripotent epiblast. During this period two cell fate decisions are made while cells gradually lose their totipotency. The first fate decision involves the segregation of the extraembryonic ...
Dey Fabian F Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Center for Computational Biology and Bioinformatics and Initiative in Systems Biology, Columbia University, New York, New York 10032, - - 2013
We outline a set of strategies to infer protein function from structure. The overall approach depends on extensive use of homology modeling, the exploitation of a wide range of global and local geometric relationships between protein structures and the use of machine learning techniques. The combination of modeling with broad ...
Jain Tarun T Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United - - 2013
Solid-state nanopores have emerged as versatile single-molecule sensors for applications including DNA sequencing, protein unfolding, micro-RNA detection, label-free detection of single nucleotide polymorphisms, and mapping of DNA-binding proteins involved in homologous recombination. While machining nanopores in dielectric membranes provides nanometer-scale precision, the rigid silicon support for the membrane contributes capacitive ...
Reiner Joseph E JE Department of Physics, Virginia Commonwealth University, Richmond, Virginia 23284, USA. - - 2013
The ability to perturb large ensembles of molecules from equilibrium led to major advances in understanding reaction mechanisms in chemistry and biology. Here, we demonstrate the ability to control, measure, and make use of rapid temperature changes in fluid volumes that are commensurate with the size of single molecules. The ...
Bibby Kyle K Department of Chemical and Environmental Engineering, Yale University, Mason Laboratory, 9 Hillhouse Avenue, P.O. Box 208286, New Haven, Connecticut 06520, - - 2013
The large diversity of viruses that exist in human populations are potentially excreted into sewage collection systems and concentrated in sewage sludge. In the U.S., the primary fate of processed sewage sludge (class B biosolids) is application to agricultural land as a soil amendment. To characterize and understand infectious risks ...
Pastrana-Ríos Belinda - - 2013
Centrins are calcium binding proteins that belong to the EF-hand superfamily with diverse biological functions. Herein we present the first systematic study that establishes the relative stability of related centrins via complementary biophysical techniques. Our results define the stepwise molecular behavior of human centrins by two-dimensional infrared (2D IR) correlation ...
Török Béla B Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125-3393, - - 2013
The design and application of an effective, new class of multifunctional small molecule inhibitors of amyloid self-assembly are described. Several compounds based on the diaryl hydrazone scaffold were designed. Forty-four substituted derivatives of this core structure were synthesized using a variety of benzaldehydes and phenylhydrazines and characterized. The inhibitor candidates ...
Cabanel Nicolas - - 2013
After 25 years of no cases of plague, this disease recurred near Tobruk, Libya, in 2009. An epidemiologic investigation identified 5 confirmed cases. We determined ribotypes, Not1 restriction profiles, and IS100 and IS1541 hybridization patterns of strains isolated during this outbreak. We also analyzed strains isolated during the 2003 plague ...
Tefferi Ayalew - - 2013
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by stem cell-derived clonal myeloproliferation, abnormal cytokine expression, bone marrow fibrosis, anemia, splenomegaly, extramedullary hematopoiesis (EMH), constitutional symptoms, cachexia, leukemic progression, and shortened survival. Diagnosis is based on bone marrow morphology. The presence of fibrosis, JAK2/MPL mutation, or +9/13q- cytogenetic abnormality is ...
Grković Desanka - - 2013
Acute posterior multifocal placoid pigment epitheliopathy- APMPPE is an acquired idiopathic inlammatory disease of the chorioretina. This case report presents a typical clinical manifestation of a very rare condition: a twenty ive-year old female complained of a sudden bilateral decrease of vision. She reported lu-like symptoms and taking antibiotics therapy. ...
Berto Alessandra - - 2013
We investigated viability of hepatitis E virus (HEV) identified in contaminated pork liver sausages obtained from France. HEV replication was demonstrated in 1 of 4 samples by using a 3-dimensional cell culture system. The risk for human infection with HEV by consumption of these sausages should be considered to be ...
Okur Mesut - - 2013
Aim To prevent possible chronic kidney diseases in healthy school- age children by screening for hematuria and proteinuria using a urine strip. Methods The incidence of hematuria and proteinuria was determined in 1848 healthy school-age children aged 7 to 14 years by urine screening in the eastern region of Turkey ...
Kan Carol C Institute of Psychiatry, King’s College London, London, UK. - - 2013
Depression is associated with the onset of type 2 diabetes. A systematic review and meta-analysis of observational studies, controlled trials, and unpublished data was conducted to examine the association between depression and insulin resistance (IR). Medline, EMBASE, and PsycINFO were searched for studies published up to September 2011. Two independent ...
Tadić Daliborka - - 2013
Aim To estimate health-related quality of life (HRQoL) in patients with multiple sclerosis (MS), and to investigate relationship between HRQoL and selected demographic and clinical parameters. Methods In this cross-sectional study HRQoL was measured using the MS-speciic MSQoL-54 questionnaire. Neurological impairment was assessed using the Expanded Disability Status Scale (EDSS), ...
Kodama Satoru S Department of Health Management Center, Mito Kyodo General Hospital, Mito City, - - 2013
The association between habitual physical activity (PA) and lowered risk of all-cause mortality (ACM) and cardiovascular disease (CVD) has been suggested in patients with diabetes. This meta-analysis summarizes the risk reduction in relation to PA, focusing on clarifying dose-response associations. Electronic literature searches were conducted for cohort studies that examined ...
Jevtić Tatjana - - 2013
Aim To compare clinical and cost outcomes of psoriasis in non-biological treatment of adherent and non-adherent patients in a developing Balkans country going through socio-economic transition. Methods The study was designed as a retrospective cohort study involving patients with psoriasis adherent and non-adherent to the prescribed treatment regimen. The patients ...
Spits Hergen H Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. - - 2013
Innate lymphoid cells (ILCs) are a family of developmentally related cells that are involved in immunity and in tissue development and remodelling. Recent research has identified several distinct members of this family. Confusingly, many different names have been used to characterize these newly identified ILC subsets. Here, we propose that ...
Ottuso Patrick - - 2013
Aquatic dermatoses encompass a broad spectrum of cutaneous injuries. These injuries may present through contact with invertebrate organisms such as jellyfish, sea urchins, corals, and molluscs. Each organism is equipped with a unique method of causing harm to man, therefore a myriad of presenting signs and symptoms should be recognized ...
Bach John R - - 2013
The purpose of this monograph is to describe noninvasive management of respiratory muscle weakness/paralysis for patients with neuromuscular disease (NMD) and spinal cord injury (SCI). Noninvasive ventilation (NIV) assists and supports inspiratory muscles, whereas mechanically assisted coughing (MAC) simulates an effective cough. Long-term outcomes will be reviewed as well as ...
Durmišević-Serdarević Jasminka - - 2013
Aim To determine the prevalence and etiological agents of signiicant bakteriuria in children younger than six, as well as the incidence of anatomical abnormalities of the urinary system in children with established signiicant bakteriuria. Methods Data were collected from hospital records of children treated at the Department for Preschool and ...
Brkić Harun - - 2013
The aim of the study was to analyze the prevalence, occurrence by gender, age, place of residence, location and pathohistological type, focusing on peculiarities of the surgically removed meningiomas in the irst post-war decade in Bosnia and Herzegovina. The study was conducted in the region comprising more than 600.000 inhabitants. ...
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