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Results 701 - 750 of 2825
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Crowe Sarah E - - 2013
The loss of cognitive function in Alzheimer's disease (AD) patients is strongly correlated with the loss of neurons in various regions of the brain. We have created a new fluorescent bigenic mouse model of AD by crossing "H-line" yellow fluorescent protein (YFP) mice with the 5xFAD mouse model, which we ...
Habib Charbel A - - 2013
PURPOSE: To evaluate the cerebral venous drainage system of the swine as a probable model to test whether extracranial venous abnormalities may play a role in neurodegenerative diseases as reported recently in multiple sclerosis. MATERIALS AND METHODS: Three Yucatan micropigs, 5 to 7 months old, were scanned with a comprehensive ...
Purchase Cromwell - - 2013
Nectarivores face a constant challenge in terms of water balance, experiencing water loading or dehydration when switching between food plants or between feeding and fasting. To understand how whitebellied sunbirds and New Holland honeyeaters meet the challenges of varying preformed water load, we used the elimination of Intramuscular-injected [(14)C]-L-glucose and ...
Vashisth Harish - - 2013
Insulin regulates blood glucose levels in higher organisms by binding to and activating insulin receptor (IR), a constitutively homodimeric glycoprotein of the receptor tyrosine kinase (RTK) superfamily. Therapeutic efforts in treating diabetes have been significantly impeded by the absence of structural information on the activated form of the insulin/IR complex. ...
Bajory Zoltán - - 2013
INTRODUCTION: Penile girth enhancement by the injection of Vaseline is an existing practice. Many cases develop severe complications that need surgery. AIM: To report on the reconstructive surgical solutions of the complications of Vaseline self-injection and the outcomes. To develop a modification of a one-step reconstruction method involving the use ...
Wong Jencia - - 2013
Since the initial discovery of Angiotensin converting enzyme inhibitors (ACEI) in the 1960s and the launch of Captopril as the first available for clinical use in the 1970s, there now exist three other classes of drugs that block the renin angiotensin aldosterone system (RAAS): the angiotensin II receptor blockers (ARB), ...
O'Sullivan David M - - 2013
BACKGROUND: With over 20 years of taekwondo concussion research highlighting the high incidence of injury, previous studies recommend an investigation of headgear impact attenuation performance. OBJECTIVE: To examine impact attenuation differences between the anterior, posterior and sides of selected taekwondo headgear brands. DESIGN: Between-groups. SETTING: Biomechanics laboratory. METHODS: Five different ...
Liu Zheng - - 2013
This paper reviews diverse capabilities offered by modern electron microscopy techniques in studying fine structures of nanoporous crystals such as zeolites, silica mesoporous crystals, metal organic frameworks and yolk-shell materials. For the case of silica mesoporous crystals, new approaches that have been developed recently to determine the three-dimensionally periodic average ...
Wu Jiang - - 2013
Much attention has been paid to the modification of a titanium surface with an alkylphosphonic acid (PA)-based self-assembled monolayer (SAM) to accelerate hydroxyapatite (HA) deposition on the surface. In order to further accelerate the rate of HA deposition, we examined here the effect of alkyl chain length of SAMs on ...
Kotsuchibashi Yohei - - 2013
Fluorescent silica nanoparticles are reported to be highly stable and biocompatible materials with high water solubility, which make them ideal candidates for biological applications. These nanoparticles can also be modified with biocompatible and targeting moieties and can be used for a variety of in vitro and in vivo applications, such ...
Zhang Wei - - 2013
The aggregation of soluble amyloid-beta (Aβ) peptide into oligomers/fibrils is one of the key pathological features in Alzheimer's disease (AD). The Aβ aggregates are considered to play a pivotal role in the pathogenesis of AD. Therefore, inhibiting Aβ aggregation and destabilizing preformed Aβ fibrils would be an attractive therapeutic target ...
Leman Julia Koehler - - 2013
Prediction of trans-membrane spans and secondary structure from the protein sequence is generally the first step in the structural characterization of (membrane) proteins. Preference of a stretch of amino acids in a protein to form secondary structure and being placed in the membrane are correlated. Nevertheless, current methods predict either ...
McNarry M A - - 2013
Various regulatory mechanisms of pulmonary oxygen uptake ( V ˙ O 2 ) kinetics have been postulated. The purpose of this study was to investigate the relationship between vagal withdrawal, measured using RMSSDRR, the root mean square of successive differences in cardiac interval (RR) kinetics, a mediator of oxygen delivery, ...
Herlihy Erin P - - 2013
IMPORTANCE Esotropia greater at distance than at near can be related to abducens palsy or to divergence insufficiency. Mild abduction weakness can be difficult to detect, blurring the distinction between these 2 conditions. OBJECTIVES To examine the clinical and eye movement findings that distinguish abducens palsy from divergence insufficiency and ...
Mandl József - - 2013
Endoplasmic reticulum (ER) stress is a regulatory mechanism that allows cells to adapt to a series of metabolic, redox, and other environmental changes. The role of ER stress was first identified in the maintenance of proteostasis. It has since been shown that ER stress is also critical to the regulation ...
Whaley Jonathan T - - 2013
ABSTRACT: OBJECTIVE: Proton therapy can result in clinically significant radiation dermatitis. In some clinical scenarios, such as lung or breast cancer, the risk of severe radiation dermatitis may limit beam arrangement and prescription doses. Patients undergoing proton therapy for prostate cancer commonly develop mild radiation dermatitis. Herein, we report the ...
Aversa Antonio - - 2013
INTRODUCTION: Weight loss in sexually active women improves their quality of life. At present, no studies have investigated whether weight loss may affect female sexual function in severe obese women. AIM: The aim of this study was to investigate the effects of different programs of weight loss on female sexual ...
Ladd Jennifer M - - 2013
Many professional societies and research studies recommend complete vaccination before pediatric solid organ transplantation. Nevertheless, incompletely vaccinated children often receive transplants. As the number of parents refusing to vaccinate children for nonmedical reasons increases, pediatric transplantation programs face difficult listing decisions. Given the importance of psychosocial criteria in listing decisions, ...
Maione Luigi - - 2013
Context:Kallmann syndrome (KS) is characterized by congenital hypogonadotropic hypogonadism (CHH) and an impaired sense of smell related to defective development of the olfactory system.Objective:The aim of the study was to use high-resolution computed tomography (CT) to detect specific abnormalities in the ethmoid bone region surrounding the olfactory bulbs in patients ...
Cleary Michelle - - 2013
AIMS AND OBJECTIVES: To explore recent Singapore nursing graduates' experience of and views about their career development and progress. BACKGROUND: The recruitment and retention of an adequate number of registered nurses is a continuing workforce issue in Singapore and other major cities. DESIGN: Survey of recent nursing graduates. METHODS: Recent ...
Provvidenza Christine - - 2013
OBJECTIVE: To: (1) provide a review of knowledge transfer (KT) and related concepts; (2) look at the impact of traditional and emerging KT strategies on concussion knowledge and education; (3) discuss the value and impact of KT to organisations and concussion-related decision making and (4) make recommendations for the future ...
Rai Dheeraj - - 2013
BACKGROUND: The prevalence and correlates of depression vary across countries. Contextual factors such as country-level income or income inequalities have been hypothesised to contribute to these differences. AIMS: To investigate associations of depression with socioeconomic factors at the country level (income inequality, gross national income) and individual (education, employment, assets ...
Zhang Min - - 2013
In randomized clinical trials, for example, on cancer patients, it is not uncommon that patients may voluntarily initiate a secondary treatment postrandomization, which needs to be properly adjusted for in estimating the "true" effects of randomized treatments. As an alternative to the approach based on a marginal structural Cox model ...
Mucaki Eliseos J - - 2013
Mutations that affect mRNA splicing often produce multiple mRNA isoforms, resulting in complex molecular phenotypes. Definition of an exon and its inclusion in mature mRNA relies on joint recognition of both acceptor and donor splice sites. This study predicts cryptic and exon skipping isoforms in mRNA produced by splicing mutations ...
Agius Ronald - - 2013
The performance of the previously validated LUCIO®-Direct-enzyme linked immunosorbent assay (direct ELISA) screening tests according to forensic guidelines is compared to that of cloned enzyme donor immunoassays (CEDIA) test for drugs of abuse in urine as defined in the new re-licensing German medical and psychological assessment (MPA) guidelines. The MPA ...
Pathan Meerakhan - - 2013
Ultrafast (UF) 2D NMR is a very promising methodology enabling the acquisition of 2D spectra in a single scan. In the last few years, the analytical performance of UF 2D NMR has been highly increased, consequently maximizing its range of applications. However, its implementation and use by non-specialists are far ...
Zhang Zifei - - 2013
Two ligands with different geometries have been prepared to synthesize new silver-ethynide complexes bearing pyridyl and carboxylate groups. Reactions of 5-ethynylnicotinic acid () and 5-ethynylpicolinic acid () with silver nitrate afforded [Ag(2)()·AgNO(3)](n) () and {[Ag(12)()(6)·12AgNO(3)]·5H(2)O}(n) (), respectively. Crystallographic studies revealed that in , the ligands connect linear silver chains to ...
Wang Nian - - 2013
PURPOSE: To study the anisotropic characteristics of both multi-component T(2) and T(1ρ) relaxation times in tendon. MATERIALS AND METHODS: T(2) and T(1ρ) were measured in tendon by NMR spectroscopy at different orientations and by microscopic MRI at the magic angle. Several experimental issues in the multi-component relaxation measurements were investigated, ...
Wedemeyer Heiner - - 2013
Mericitabine is a nucleoside analog polymerase inhibitor of HCV. Treatment-naive HCV genotype 1 or 4 patients were randomized to double-blind treatment with oral mericitabine at a dosage of 500 mg BID for 12 weeks (A); 1000 mg BID for 8 weeks (B), or 12 weeks (C, D); or placebo BID ...
Teo I - - 2013
The wide-awake hand surgery (WAHS) technique involves injecting lidocaine with adrenaline for hand surgical procedures that are done without the use of tourniquets, sedation, regional or general anaesthetic. This is a retrospective review of the first 100 consecutive patients who underwent operations using this technique at our centre. The operations ...
Coulson Michelle - - 2013
BACKGROUND: This study examined the correlation between Inhibin B and testicular pathology. METHODS: Male Han Wistar rats (approximately 10 weeks old) were administered either vehicle or an endothelin receptor antagonist (ET-An) orally for 28 days or a Gonadotropin Releasing Hormone (GnRH) agonist (GnRH-A) as a subcutaneous implant on day 1. ...
Alizon Samuel - - 2013
Infections that consist of multiple parasite strains or species are common in the wild and are a major public health concern. Theory suggests that these infections have a key influence on the evolution of infectious diseases and, more specifically, on virulence evolution. However, we still lack an overall vision of ...
Klein Julie - - 2013
In this study, we have developed Proteasix, an open-source peptide-centric tool that can be used to predict in silico the proteases involved in naturally-occurring peptide generation. We developed a curated cleavage site database, containing 3500 entries about human protease/cleavage site combinations. On top of this database, we built a tool, ...
Bocquillon E - - 2013
The on-demand emission of coherent and indistinguishable electrons by independent synchronized sources is a challenging task of quantum electronics, in particular regarding its application for quantum information processing. Using two independent on-demand electron sources, we trigger the emission of two single-electron wavepackets at different inputs of an electronic beamsplitter. Whereas ...
Kuo Ping-Chung - - 2013
Phytochemical investigation of the methanolic extract of Croton tonkinensis afforded two known kauranes (1, 2), eight new ent-kauranes (3-10), and 16 known ent-kaurane-type diterpenoids (12-27). In addition, 30 known compounds were identified by comparison of their physical and spectroscopic data with reported data. Among the isolated compounds, ent-18-acetoxykaur-16-en-15-one (20) displayed ...
Prabowo Avanita S - - 2013
ABSTRACT: Purpose: The expression of the major histocompatibility complex class I (MHC-I) in the brain has received considerable interest not only because of its fundamental role in the immune system, but also for its non-immune functions in the context of activity-dependent brain development and plasticity. METHODS: In the present study ...
Bashutski Jill D - - 2013
Background: Implant therapy is a highly predictable treatment option; however, insufficient data exist to show if flapless implant surgery provides better esthetic outcomes and less bone loss when compared to implant surgery with a flap approach. Methods: A randomized, controlled study comparing the flapless and traditional flap protocol for implant ...
Poms Abby M - - 2013
ABSTRACT BACKGROUND: Comorbidities can affect disease progression and/or response to treatment in various conditions. Comorbid conditions are prevalent in patients with pulmonary arterial hypertension (PAH); however, their effect on patient outcomes remains unknown. METHODS: We evaluated the effect on functional class (FC), 6-minute walk test distance (6MWD), and survival of ...
Scott Ryan T - - 2013
Degenerative joint disease of the ankle is a debilitating etiology, in which treatment has been disputed in the literature among healthy active patients. Total ankle arthroplasty had recently gained popularity as long-term outcomes are being reported and advancement in the design of the implants themselves evolves. Multiple implants are available ...
Yan Fangyong - - 2013
Ionic liquids are an emerging class of materials with applications in a variety of fields. Steady progress has been made in the creation of ionic liquids tailored to specific applications. However, the understanding of the underlying structure-property relationships has been slower to develop. As a step in the effort to ...
Michelena Hector I - - 2013
OBJECTIVE: Discrepancy in the echocardiographic severity grading of aortic stenosis (AS) based on current guidelines has been reported. We sought to investigate the left ventricular outflow tract diameter (LVOTd) as a source of inconsistencies, and to explore hypothetical alternatives for discrepancy improvement. DESIGN: Retrospective echocardiographic cross-sectional analysis. SETTING: From 2000 ...
Vitiello Michael V - - 2013
The efficacy of cognitive-behavioral therapy for insomnia (CBT-I) to improve both short- and long-term outcomes in both uncomplicated and comorbid insomnia patients has been repeatedly and conclusively demonstrated. Further demonstrations of efficacy, per se, in additional comorbid insomnia populations are likely not the best use of limited energy and resources. ...
de Freitas Renato Leonardo - - 2013
The aim of the present study was to investigate the involvement of N-methyl-d-aspartate (NMDA) and amino-3-hydroxy-5-methyl-isoxazole-4-proprionate (AMPA)/kainate receptors of the prelimbic (PL) division of the medial prefrontal cortex (MPFC) on the panic attack-like reactions evoked by γ-aminobutyric acid-A receptor blockade in the medial hypothalamus (MH). Rats were pretreated with NaCl ...
Miething Alexander - - 2013
Background: The aim of the present study is to explore whether the association between income and self-rated health in Sweden is similar to that in Germany. Both countries represent relatively similar economic contexts, but also different welfare traditions and historic experiences. Thus, the study compares Sweden with East Germany and ...
Stanczuk Andrzej - - 2013
5-(2-Aminopropyl)benzofuran (5-APB), a 'research chemical' that was first reported by UK authorities to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) in 2010, is anecdotally reported to produce a combination of stimulant and entactogenic effects. More recently, in 2011, 6-(2-aminopropyl)benzofuran (6-APB) was identified by Hungarian authorities. To confirm ...
Babiker Hassan - - 2013
Allogenic bone graft has been considered the gold standard in connection with bone graft material in revision joint arthroplasty. However, the lack of osteogenic potential and the risk of disease transmission are clinical challenges. The use of osteoinductive materials, such as demineralized bone matrix (DBM), alone or in combination with ...
Albanese C - - 2013
BACKGROUND & PURPOSE: Malignant gliomas, the most common primary brain tumors, are highly invasive and neurologically destructive neoplasms with a very bad prognosis due to the difficulty to remove completely the mass by surgery and the limited activity of current therapeutic agents. PHA-848125 is a multikinase inhibitor with broad antitumor ...
Bouloukaki Izolde - - 2013
ABSTRACT: BACKGROUND: The aim of our study was to validate a Greek translation of the Berlin Questionnaire (BQ) for obstructive sleep apnoea syndrome (OSAS) and to explore whether this screening questionnaire could be used to help identify primary care patients at greater risk of having OSAS. METHODS: We recruited 189 ...
Hjertstedt Jadwiga - - 2013
OBJECTIVE: This study investigated the impact of a community-based geriatric dentistry rotation on older adults' oral health literacy and oral hygiene. MATERIALS AND METHODS: A pre-post study design was used to assess the impact of the educational intervention. The study sample consisted of 67 older adults, who resided in independent ...
Zarpelon A C - - 2013
BACKGROUND AND PURPOSE: IL-33 signals through ST2 receptor and induces adaptive and innate inflammation. IL-33/ST2 is involved in adaptive inflammation-induced pain. Herein, it was investigated the contribution of IL-33/ST2-triggered mechanisms to carrageenin-induced innate inflammation. EXPERIMENTAL APPROACH: Carrageenin- and IL-33-induced inflammatory responses were addressed in balb/c (WT) and ST2 deficient ((-/-) ...
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