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Alizon Samuel - - 2013
Infections that consist of multiple parasite strains or species are common in the wild and are a major public health concern. Theory suggests that these infections have a key influence on the evolution of infectious diseases and, more specifically, on virulence evolution. However, we still lack an overall vision of ...
Klein Julie - - 2013
In this study, we have developed Proteasix, an open-source peptide-centric tool that can be used to predict in silico the proteases involved in naturally-occurring peptide generation. We developed a curated cleavage site database, containing 3500 entries about human protease/cleavage site combinations. On top of this database, we built a tool, ...
Sanders Deborah A - - 2013
ABSTRACT: BACKGROUND: The forkhead transcription factor FOXM1 is a key regulator of the cell cycle. It is frequently over-expressed in cancer and is emerging as an important therapeutic target. In breast cancer FOXM1 expression is linked with estrogen receptor (ERalpha) activity and resistance to endocrine therapies with high levels correlated ...
Ahlqvist Emma E Department of Clinical Sciences, Diabetes, and Endocrinology, University Hospital Malmö, Lund University, Malmö, - - 2013
Low-grade inflammation in obesity is associated with accumulation of the macrophage-derived cytokine osteopontin (OPN) in adipose tissue and induction of local as well as systemic insulin resistance. Since glucose-dependent insulinotropic polypeptide (GIP) is a strong stimulator of adipogenesis and may play a role in the development of obesity, we explored ...
Nakazawa Tadao - - 2013
Cribriform-morular variant of papillary thyroid carcinoma (CMVPTC) usually occurs in the setting of familial adenomatous polyposis (FAP) although it can rarely arise sporadically. Poorly differentiated thyroid carcinoma (PDTC) is a follicular cell-derived neoplasm with more aggressive behavior than well-differentiated carcinomas such as CMVPTC. We report the case of a 35-year-old ...
Squires Adam M - - 2013
We demonstrate a method by which we can produce an oriented film of an inverse bicontinuous cubic phase (QIID) formed by the lipid Monoolein (MO). By starting with the lipid as a disordered precursor (the L3 phase), in the presence of butanediol, we can obtain a film of QIID phase ...
Carels Robert A - - 2013
This study compared treatment outcomes for a new weight loss program that emphasized reducing unhealthy relationships with food, body image dissatisfaction, and internalized weight bias (New Perspectives) to a weight loss program that emphasizes environmental modification and habit formation and disruption (Transforming Your Life). Fifty-nine overweight and obese adults (body ...
Gomez-Lopez Nardhy N Research Direction and Department of Nutrition Research, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico. - - 2013
Spontaneous labor at term involves leukocyte recruitment and infiltration into the choriodecidua; yet, characterization of these leukocytes and their immunological mediators is incomplete. The purpose of this study was to characterize the immunophenotype of choriodecidual leukocytes as well as the expression of inflammatory mediators in human spontaneous parturition at term. ...
Arcenegui Juan J - - 2013
Electrorotation (ROT) data for solid titanium micrometer-sized spheres in an electrolyte are presented for three different ionic conductivities, over the frequency range of 10 Hz to 100 kHz. The direction of rotation was found to be opposite to the direction of rotation of the electric field vector (counter-field electrorotation), with ...
Lin Haijiang - - 2013
Contact tracing, coupled with molecular epidemiologic investigation, is especially useful for identifying an infection with few cases in the population, such as human immunodeficiency virus (HIV) infection in China. No such research is available on Chinese men who have sex with men (MSM). From 2008 to 2010 in Taizhou Prefecture ...
Melief Sara Marie - - 2013
Background Multipotent stromal cells exhibit immunomodulatory capacities and have been applied in transplantation and autoimmune diseases. One of the effects of MSC involves the inhibition of dendritic cell differentiation. Since IL-6 and IL-10 are known to play a role in inhibiting immature dendritic cell differentiation, we hypothesized that these cytokines ...
Vos J J - - 2013
BACKGROUND: /st>Dynamic preload variables to predict fluid responsiveness are based either on the arterial pressure waveform (APW) or on the plethysmographic waveform (PW). We compared the ability of APW-based variations in stroke volume (SVV) and pulse pressure (PPV) and of PW-based plethysmographic variability index (PVI) to predict fluid responsiveness and ...
Riwanto Meliana - - 2013
BACKGROUND: Endothelial dysfunction and injury are thought to play an important role in progression of coronary-artery-disease (CAD). High-density-lipoprotein from healthy subjects (HDLHealthy) has been proposed to exert endothelial anti-apoptotic effects that may represent an important anti-atherogenic property of the lipoprotein. The present study therefore aimed to compare effects of HDLCAD ...
Bhalla Vandana - - 2013
Nanoaggregates of a supramolecular ensemble of triphenylene derivative and Cu(2+) ions exhibit 'turn-on' response towards CN(-) ions in an aqueous medium and can detect the trace amount of inorganic cyanide ions (NaCN) in tap water and blood serum milieu.
Iwashita Jun - - 2013
In oocyte maturation in Xenopus laevis, nuclear material induces rapid maturation and is required for entry into meiosis II. Nuclear material contains a large number of RNAs and proteins, including histone deacetylase (HDAC); however, it is not known which materials induce accelerated maturation. The HDAC activity modifies transcription rate and ...
Meyerhoefer Chad D - - 2013
Chronic tooth decay is the most common chronic condition in the United States among children ages 5-17 and also affects a large percentage of adults. Oral health conditions are preventable, but less than half of the US population uses dental services annually. We seek to examine the extent to which ...
Sugimoto Yuki - - 2013
Scleraxis (Scx) is a basic helix-loop-helix transcription factor that is a marker for the tendon/ligament cell lineage. The approximately 11 kb genomic region from the mouse Scx gene locus faithfully recapitulates the endogenous Scx expression pattern in ScxGFP transgenic (Tg) mice. We have established two Tg mouse lines expressing Cre-recombinase ...
Corona Giovanni - - 2013
INTRODUCTION: Hypoactive sexual desire is defined as a persistent or recurrent deficient or absent sexual fantasies or desire for sexual activity that should not be comorbid with other medical conditions or with the use of psychoactive medications. Reduced libido is a symptom referring more to a reduction in sexual drive ...
Sasaki Eiji - - 2013
Glutamine is an important amino acid for immune function. Though high intensity and prolonged exercise decreases plasma glutamine concentration and causes immune suppression, the relationship between neutrophil functions and glutamine has not yet been found. The purpose of this study was to investigate the impacts of glutamine supplementation on neutrophil ...
Felix A S AS Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. - - 2013
Uterine sarcomas are characterised by early age at diagnosis, poor prognosis, and higher incidence among Black compared with White women, but their aetiology is poorly understood. Therefore, we performed a pooled analysis of data collected in the Epidemiology of Endometrial Cancer Consortium. We also examined risk factor associations for malignant ...
Hatchwell Ben J - - 2013
The evolution of cooperation is a persistent problem for evolutionary biologists. In particular, understanding of the factors that promote the expression of helping behaviour in cooperatively breeding species remains weak, presumably because of the diverse nature of ecological and demographic drivers that promote sociality. In this study, we use data ...
Kang Pauline - - 2013
PURPOSE: To describe the time course of changes in both peripheral refraction and corneal topography in myopic adults wearing myopic orthokeratology (OK) lenses. METHODS: Nineteen adult myopes were fitted with OK lenses in both eyes for overnight wear. Central and peripheral refraction and corneal topography were measured along the horizontal ...
Sammartino G - - 2013
Background: Potential nerve injury or loss of sensation can occur after mandibular implants placement or loading. To determine the proper distance from implants to the mandibular is critical nerve to avoid this type of damage. Hence, the purpose of this study was using biomechanical analyses to determine the safety distance ...
Roth M Y MY Departments of Internal Medicine, University of Washington, 1959 NE Pacific Street, Box 357138, Seattle, Washington 98195, USA. - - 2013
The concentration of intratesticular testosterone (IT-T) required for human spermatogenesis is unknown because spermatogenesis can persist despite the markedly reduced IT-T concentrations observed with LH suppression. Methods to lower IT-T further are needed to determine the relationship between IT-T and spermatogenesis. The objective of the study was to determine the ...
Piquet Jacques - - 2013
To assess long-term mortality and predictive factors of death after hospital admission for AECOPD.1,824 patients (female: 23.2%; mean age: 70.3+/-11.3 years) consecutively admitted for AECOPD in respiratory medicine departments of 68 general hospitals between October 2006 and June 2007 were prospectively enrolled in a follow-up cohort. Their vital status was ...
Sonee Manisha - - 2013
BACKGROUND: This study was conducted as part of an ILSI-HESI International Life Sciences Institute-Health & Environmental Sciences Institute consortium effort to assess the utility of circulating Inhibin B as an early biomarker of Sertoli cell-specific testicular toxicity in rats. 1, 3-Dinitrobenzene (1,3-DNB) was selected as a testicular toxicant in this ...
Yoshimura Naoko - - 2013
Melanocytes are pigment-producing cells generated from neural crest cells (NCCs) that delaminate from the dorsal neural tube. The widely accepted premise that NCCs migrating along the dorsolateral pathway are the main source of melanocytes in the skin was recently challenged by the finding that Schwann cell precursors are the major ...
Martin Geoffrey V - - 2013
AimThe aim of this article is to determine if lightning is associated with the frequency of headache in migraineurs.MethodsParticipants fulfilling diagnostic criteria for International Headache Society-defined migraine were recruited from sites located in Ohio (n = 23) and Missouri (n = 67). They recorded headache activity in a daily diary for three to six ...
Zhang Wanjun - - 2013
Protein glycosylation plays key roles in many biological processes, such as cell growth, differentiation and cell-cell recognition etc. Therefore, global structure profiling of glycans is very important for investigating the biological significance and roles of glycans in disease occurrence and development. Mass spectrometry (MS) is currently the most powerful technique ...
Kodela Ravinder R Department of Physiology, Pharmacology, and Neuroscience, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, New York 10031, - - 2013
We compared the differential effects of positional isomers of acetylsalicylic acid (o-ASA, m-ASA, and p-ASA) on cyclooxygenase (COX) inhibition, gastric prostaglandin E2 (PGE2), malondialdehyde, tumor necrosis factor-alpha (TNF-α) levels, superoxide dismutase (SOD) activity, human adenocarcinoma colon cancer cell growth inhibition, cell proliferation, apoptosis, and cell-cycle progression. We also evaluated the ...
Sabuncu Ahmet Can - - 2013
In this study a separability parameter is introduced to determine the selection of optimum operating parameters for dielectrophoretic (DEP) separation of a cell pair. The separability parameter is defined as a function of cells' Clausius-Mossotti (CM) factors. T-cell leukaemia Jurkat and mouse melanoma B16 cells are tested to validate the ...
Rastrelli Giulia - - 2013
INTRODUCTION.: Erectile dysfunction (ED) is considered an early surrogate marker of silent, or even overt, cardiovascular diseases (CVD). However, epidemiological studies take into account only sexual intercourse-related erections. Although autoeroticism is a very common practice, data on masturbation-induced erections as a possible predictor of major adverse cardiovascular events (MACE) are ...
Link Andreas - - 2013
AimsVascular integrity is disturbed in shock contributing to clinical appearance and serious outcomes. While angiopoietin (Ang)-1 protects from vascular inflammation and leakage, Ang-2 disrupts endothelial barrier function. The imbalance of Ang-1 and Ang-2, their association to haemodynamic deterioration, and their prognostic relevance are not known and, thus, were prospectively evaluated ...
Horwath-Winter Jutta - - 2013
AIM: To evaluate ocular surface and tear function in patients with choroidal melanoma treated with single-fraction radiosurgery. METHODS: 36 patients (median age 62 years; range 26-84 years) were enrolled between 2001 and 2006 at a single institution. They were treated with the Leksell Gamma Knife in one fraction with a ...
Miyoshi Hirokazu - - 2013
BACKGROUND: Two-dimensional speckle tracking echocardiography (2DSTE) has recently been applied to evaluate left atrial (LA) function in addition to left ventricular (LV) function. However, whether 2DSTE can provide insight into LA-LV interaction related to an increase in LV pressure overload remains unknown. METHODS: One hundred five asymptomatic patients with hypertension ...
Matsushima Ayano - - 2013
For each saccade, we select an object to direct gaze and to specify the direction and amplitude of eye movement. Although these 2 processes are inevitably interdependent when visual stimuli are held stationary, several lines of evidence suggest that the neuronal signals in the frontal eye fields (FEF) that underlie ...
Zeng Guang - - 2013
Heterogeneous reaction between ozone and linoleic acid (LA) thin film was investigated by a flow reactor coupled to attenuated total reflection infrared spectroscopy (FR-ATR-IR) over wide ranges of temperature, relative humidity (RH) and ozone concentration under atmospheric pressure condition. Pseudo-first-order rate constants kapp and overall reactive uptake coefficients γ were ...
Gray Françoise - - 2013
We report the neuropathological findings in 10 HIV-infected patients treated by combination anti-retroviral therapy who developed subacute encephalopathy of rapidly progressive onset. Brain biopsy showed encephalitic lesions variably associated with myelin loss and slight axonal damage. There was inconstant, weak expression of HIV protein p24; tests for other pathogens were ...
Moodley Yuben - - 2013
The lung is the largest organ exposed to the environment. It has an alveolar surface area of around 70m2 and comprises a complex series of branches leading to gas exchanging units that are critical to life1. It is a very adaptable organ and exchanges 10,000litres of air/day. In addition, it ...
Shield Kevin D - - 2013
AIMS: This study aimed to estimate the prevalence of lifetime abstainers, former drinkers and current drinkers, adult per capita consumption of alcohol, and pattern of drinking scores, by country and Global Burden of Disease region for 2005, and to forecast these indicators for 2010. DESIGN: Statistical modelling based on survey ...
Deng Fuli - - 2013
INTRODUCTION: Mogroside V is the main effective ingredient of Siraitia grosvenorii used as a natural sweet food as well as a traditional Chinese medicine. The sample pre-treatment prior to chromatographic analysis requires large amounts of toxic organic solvents and is time consuming. OBJECTIVE: To develop an effective and simple method ...
Dietrich A - - 2013
AIM: In the present study we aimed to elucidate the effects of chronic vasopressin administration on renal medullary oxygen levels. METHODS: Adult Sprague Dawley or vasopressin-deficient Brattleboro rats were treated with the vasopressin V(2) receptor agonist, desmopressin (5ng/h; 3d), or its vehicle via osmotic minipumps. Immunostaining for pimonidazole and the ...
Han Meilan K - - 2013
ABSTRACT BACKGROUND: Idiopathic pulmonary fibrosis is a progressive lung disease with pulmonary vasculopathy. OBJECTIVE: To determine whether sildenafil improves six minute walk distance (6MWD) in subjects with right ventricular dysfunction. MEASUREMENTS: The IPFnet conducted a randomized trial examining the effect of sildenafil on 6MWD in patients with advanced IPF, defined ...
Liu Gang G Clinical Research Center, Affiliated Hospital of Guangdong Medical College, Zhangjiang, China. - - 2013
Asbestos causes asbestosis and malignancies by molecular mechanisms that are not fully understood. The modes of action underlying asbestosis, lung cancer, and mesothelioma appear to differ depending on the fiber type, lung clearance, and genetics. After reviewing the key pathologic changes following asbestos exposure, we examine recently identified pathogenic pathways, ...
Raphael Kalani L KL Salt Lake City VA Healthcare System, Salt Lake City, UT, USA. - - 2013
Low serum bicarbonate concentration is a risk factor for death in people with chronic kidney disease (CKD). Whether low serum bicarbonate is a mortality risk factor for people without CKD is unknown. National Health and Nutrition Examination Survey III (NHANES III) adult participants were categorized into one of four serum ...
Fedin Matvey V - - 2013
We report on the synthesis and temperature-dependent magnetic properties observed in an exchange-coupled copper(ii) dimer using X/Q-band Electron Paramagnetic Resonance (EPR) spectroscopy (9/34 GHz). It has been found that the zero-field splitting (D) in the dimer changes gradually by a factor close to two in the temperature range from T ...
Kim Tae-Hoon - - 2013
INTRODUCTION: Numerous functional magnetic resonance imaging (fMRI) studies demonstrated the key brain areas associated with visual sexual arousal. However, the changes in brain metabolites involved in sexual stimuli have not been reported. AIM: This study utilized functional MR spectroscopy (fMRS) to evaluate the changes in brain metabolites associated with sexual ...
Alsulaiman Ayman - - 2013
OBJECTIVE: The aim of this study is to investigate whether the severity of a particular condition alone influences parents' attitudes toward prenatal diagnosis (PND) and termination of pregnancy (TOP) or are there other factors involved? METHODS: A questionnaire that mainly focuses on parent's attitude toward PND and TOP for 30 ...
McManus Francis P - - 2013
O(6)-alkylguanine-DNA alkyltransferases (AGT) are responsible for the removal of alkylation at both the O(6) atom of guanine and O(4) atom of thymine. AGT homologues show vast substrate differences with respect to the size of the adduct and which alkylated atoms they can restore. The human AGT (hAGT) has poor capabilities ...
McCarty Kristofor - - 2013
OBJECTIVES: Comparative research suggests that male courtship displays signal condition-dependent traits tofemales; these displays might also provide cues to potential male competitors. Although some associations betweenhuman movements and physical/behavioral qualities have been found, such research has typically only been conducted from a perspective of female mate choice. Here, using advanced ...
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